Dianne S Schwarz

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Designing siRNA that distinguish between genes that differ by a single nucleotide
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 2:e140. 2006
  2. ncbi request reprint Asymmetry in the assembly of the RNAi enzyme complex
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 115:199-208. 2003
  3. ncbi request reprint RISC assembly defects in the Drosophila RNAi mutant armitage
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 116:831-41. 2004
  4. ncbi request reprint The RNA-induced silencing complex is a Mg2+-dependent endonuclease
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Curr Biol 14:787-91. 2004
  5. ncbi request reprint Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis
    Hongliu Ding
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605 2324, USA
    Aging Cell 2:209-17. 2003
  6. ncbi request reprint Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 10:537-48. 2002

Detail Information

Publications6

  1. pmc Designing siRNA that distinguish between genes that differ by a single nucleotide
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 2:e140. 2006
    ..Our data suggest that siRNAs can be designed to discriminate between the wild-type and mutant alleles of many genes that differ by just a single nucleotide...
  2. ncbi request reprint Asymmetry in the assembly of the RNAi enzyme complex
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 115:199-208. 2003
    ..Thus, the common step of RISC assembly is an unexpected source of asymmetry for both siRNA function and miRNA biogenesis...
  3. ncbi request reprint RISC assembly defects in the Drosophila RNAi mutant armitage
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 116:831-41. 2004
    ..Our results suggest that armi is required for RISC maturation...
  4. ncbi request reprint The RNA-induced silencing complex is a Mg2+-dependent endonuclease
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Curr Biol 14:787-91. 2004
    ..Thus, the RISC-component that mediates endonucleolytic cleavage of the target RNA remains to be identified...
  5. ncbi request reprint Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis
    Hongliu Ding
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605 2324, USA
    Aging Cell 2:209-17. 2003
    ..Thus, RNAi is a promising therapy for ALS and other disorders caused by dominant, gain-of-function gene mutations...
  6. ncbi request reprint Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 10:537-48. 2002
    ..We conclude that the underlying mechanism of RNAi is conserved between flies and mammals and that RNA-dependent RNA polymerases are not required for RNAi in these organisms...