Joel D Schwartz

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The concentration-response relation between PM(2.5) and daily deaths
    Joel Schwartz
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 110:1025-9. 2002
  2. ncbi request reprint Hospital admissions for heart disease: the effects of temperature and humidity
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 00215, USA
    Epidemiology 15:755-61. 2004
  3. ncbi request reprint How sensitive is the association between ozone and daily deaths to control for temperature?
    Joel Schwartz
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415 West, P O Box 15698, Boston, MA 02215, USA
    Am J Respir Crit Care Med 171:627-31. 2005
  4. doi request reprint Effects of exposure measurement error on particle matter epidemiology: a simulation using data from a panel study in Baltimore, MD
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Expo Sci Environ Epidemiol 17:S2-10. 2007
  5. pmc Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study
    Hortensia Moreno-Macias
    Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco 186, edificio H 001, Col Vicentina, 09430, D F, Mexico City, Mexico
    Respir Res 14:14. 2013
  6. pmc Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study
    Lifang Hou
    Department of Preventive Medicine Feinberg, School of Medicine Northwestern University, Chicago, IL 60611, USA
    Part Fibre Toxicol 10:17. 2013
  7. pmc Public health impacts of secondary particulate formation from aromatic hydrocarbons in gasoline
    Katherine von Stackelberg
    Harvard Center for Risk Analysis, 401 Park Drive, Landmark 404J, Boston, MA 02215, USA
    Environ Health 12:19. 2013
  8. pmc Reference values for methacholine reactivity (SAPALDIA study)
    Pierre Yves Jayet
    Service of Pulmonology, University Hospital Lausanne, Switzerland
    Respir Res 6:131. 2005
  9. pmc Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    BMC Med Genet 12:150. 2011
  10. pmc Weather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia II. Weather-based prediction systems perform comparably to early detection systems in identifying times for interventions
    Hailay D Teklehaimanot
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Malar J 3:44. 2004

Detail Information

Publications124 found, 100 shown here

  1. pmc The concentration-response relation between PM(2.5) and daily deaths
    Joel Schwartz
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 110:1025-9. 2002
    ..Once again, the association showed no sign of a threshold. The magnitude of the association suggests that controlling fine particle pollution would result in thousands of fewer early deaths per year...
  2. ncbi request reprint Hospital admissions for heart disease: the effects of temperature and humidity
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 00215, USA
    Epidemiology 15:755-61. 2004
    ..S. cities with a wide range of climates. To account for possible delayed effects and harvesting, we examined the impact of weather up to 20 days before each admission...
  3. ncbi request reprint How sensitive is the association between ozone and daily deaths to control for temperature?
    Joel Schwartz
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415 West, P O Box 15698, Boston, MA 02215, USA
    Am J Respir Crit Care Med 171:627-31. 2005
    ..Air pollution has been associated with changes in daily mortality...
  4. doi request reprint Effects of exposure measurement error on particle matter epidemiology: a simulation using data from a panel study in Baltimore, MD
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Expo Sci Environ Epidemiol 17:S2-10. 2007
    ..Alternatively, the findings may suggest that in some locations, observed associations with the gaseous pollutants should be interpreted with caution, as they may be reflecting associations with PM or one of its chemical components...
  5. pmc Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study
    Hortensia Moreno-Macias
    Universidad Autonoma Metropolitana, Unidad Iztapalapa, Avenida San Rafael Atlixco 186, edificio H 001, Col Vicentina, 09430, D F, Mexico City, Mexico
    Respir Res 14:14. 2013
    ....
  6. pmc Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study
    Lifang Hou
    Department of Preventive Medicine Feinberg, School of Medicine Northwestern University, Chicago, IL 60611, USA
    Part Fibre Toxicol 10:17. 2013
    ..Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a highly-exposed population in Beijing, China...
  7. pmc Public health impacts of secondary particulate formation from aromatic hydrocarbons in gasoline
    Katherine von Stackelberg
    Harvard Center for Risk Analysis, 401 Park Drive, Landmark 404J, Boston, MA 02215, USA
    Environ Health 12:19. 2013
    ..5). Here we estimate the public health burden associated with exposures to the subset of PM2.5 that originates from vehicle emissions of aromatics under business as usual conditions...
  8. pmc Reference values for methacholine reactivity (SAPALDIA study)
    Pierre Yves Jayet
    Service of Pulmonology, University Hospital Lausanne, Switzerland
    Respir Res 6:131. 2005
    ..We derived reference equations depending on individual characteristics (i.e., sex, age, baseline lung function) for relevant percentiles of the methacholine two-point dose-response slope...
  9. pmc Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    BMC Med Genet 12:150. 2011
    ..Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease...
  10. pmc Weather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia II. Weather-based prediction systems perform comparably to early detection systems in identifying times for interventions
    Hailay D Teklehaimanot
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Malar J 3:44. 2004
    ..Early warning methods that provide earlier alerts (usually by the use of weather variables) may permit control measures to interrupt transmission earlier in the epidemic, perhaps at the expense of some level of accuracy...
  11. pmc Weather-based prediction of Plasmodium falciparum malaria in epidemic-prone regions of Ethiopia I. Patterns of lagged weather effects reflect biological mechanisms
    Hailay D Teklehaimanot
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Malar J 3:41. 2004
    ..The impact of temperature on the duration of a mosquito's life cycle and the sporogonic phase of the parasite could explain the inconsistent findings...
  12. pmc Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 10:97. 2011
    ..Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism...
  13. pmc Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study
    Elissa H Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Environ Health 10:45. 2011
    ..We also investigated whether single nucleotide polymorphisms (SNPs) in miRNA-processing genes modify these associations...
  14. pmc Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 9:78. 2010
    ..One suggested pathway is that pollution causes oxidative stress. If so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure...
  15. pmc PM2.5 metal exposures and nocturnal heart rate variability: a panel study of boilermaker construction workers
    Jennifer M Cavallari
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Environ Health 7:36. 2008
    ..We examined the association between daytime exposure to the metal content of PM2.5 and night HRV in a panel study of boilermaker construction workers exposed to metal-rich welding fumes...
  16. pmc Associations between outdoor temperature and markers of inflammation: a cohort study
    Jaana I Halonen
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 9:42. 2010
    ..Associations between ambient temperature and cardiovascular mortality are well established. This study investigated whether inflammation could be part of the mechanism leading to temperature-related cardiovascular deaths...
  17. pmc Modifiers of short-term effects of ozone on mortality in eastern Massachusetts--a case-crossover analysis at individual level
    Cizao Ren
    Department of Environmental Health, Harvard School of Public Health, Landmark Center, West, 4th Floor, 401 Park Street, Boston, MA 02215, USA
    Environ Health 9:3. 2010
    ..A few studies simply examine the modification of this ozone effect by individual characteristics and socioeconomic status, but socioeconomic status was usually coded at the city level...
  18. pmc A 10-year time-series analysis of respiratory and cardiovascular morbidity in Nicosia, Cyprus: the effect of short-term changes in air pollution and dust storms
    Nicos Middleton
    Department of Environmental Health, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
    Environ Health 7:39. 2008
    ..A particular feature in the region is dust blown from the Sahara a few times a year resulting in extreme PM10 concentrations. It is not entirely clear whether such natural phenomena pose the same risks...
  19. pmc Particulate air pollution and survival in a COPD cohort
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 7:48. 2008
    ..We investigated whether particles were associated with survival in a cohort of persons with COPD in 34 US cities, eliminating the usual cross-sectional exposure and treating PM10 as a within city time varying exposure...
  20. pmc Air pollution attributable postneonatal infant mortality in U.S. metropolitan areas: a risk assessment study
    Reinhard Kaiser
    Institute for Social and Preventive Medicine, University of Basel, Steinengraben 49, 4051 Basel, Switzerland
    Environ Health 3:4. 2004
    ..The impact of outdoor air pollution on infant mortality has not been quantified...
  21. pmc The effects of socioeconomic status and indices of physical environment on reduced birth weight and preterm births in Eastern Massachusetts
    Ariana Zeka
    Department of Environmental Health, Harvard School of Public Health, Harvard University, Landmark Suite 415 West, Boston, MA 02115, USA
    Environ Health 7:60. 2008
    ..While use of spatial methods to estimate exposure to air pollution has increased the power to detect effects, questions have been raised about potential for confounding by social factors...
  22. pmc Is there adaptation in the ozone mortality relationship: a multi-city case-crossover analysis
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA, USA
    Environ Health 7:22. 2008
    ....
  23. pmc Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: gene-by-drug-by-environment interaction
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Respir Crit Care Med 172:1529-33. 2005
    ..Air pollution by particulate matter (PM) has been associated with cardiovascular deaths, although the mechanism of action is unclear. One proposed pathway is through disturbances of the autonomic control of the heart...
  24. pmc The effects of particulate air pollution on daily deaths: a multi-city case crossover analysis
    J Schwartz
    Harvard School of Public Health, Exposure, Epidemiology, and Risk Program, 401 Park Drive, Suite 415 West, Boston, MA 02215, USA
    Occup Environ Med 61:956-61. 2004
    ..Recently, several reports have indicated that the software used to control for season and weather in some of these studies had deficiencies...
  25. ncbi request reprint Who is sensitive to extremes of temperature?: A case-only analysis
    Joel Schwartz
    Exposure, Epidemiology, and Risk Program Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Epidemiology 16:67-72. 2005
    ..Extremes of temperature are well known to be associated with excess mortality. Less is known about the characteristics of persons that put them at higher risk, particularly the role of medical conditions...
  26. pmc Traffic related pollution and heart rate variability in a panel of elderly subjects
    J Schwartz
    Department of Environmental Health, Environmental Epidemiology Program, Harvard School of Public Health, 401 Park Drive, P O Box 15677, Landmark Center, Suite 415, Boston, MA 02215, USA
    Thorax 60:455-61. 2005
    ....
  27. pmc The effect of dose and timing of dose on the association between airborne particles and survival
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Suite 415 W, P O Box 15698, Boston, MA 02215 USA
    Environ Health Perspect 116:64-9. 2008
    ..Similarly, the delay between changes in exposure and changes in health is also important in public health decision making. We addressed these issues using an extended follow-up of the Harvard Six Cities Study...
  28. pmc The concentration-response relation between air pollution and daily deaths
    J Schwartz
    Environmental Epidemiology Program, Harvard School of Public Health, Boston, MA 02115 6021, USA
    Environ Health Perspect 109:1001-6. 2001
    ..Linear models provide an adequate estimation of the effect of particulate air pollution on mortality at low to moderate concentrations...
  29. pmc Air pollution and blood markers of cardiovascular risk
    J Schwartz
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Environ Health Perspect 109:405-9. 2001
    ..PM(10), but not gaseous air pollutants, is associated with blood markers of cardiovascular risk, and this may explain epidemiologic associations with early deaths...
  30. pmc Assessing confounding, effect modification, and thresholds in the association between ambient particles and daily deaths
    J Schwartz
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 108:563-8. 2000
    ..It is also consistent with recent animal and human studies of the mechanisms of particle toxicity...
  31. ncbi request reprint Control for confounding in the presence of measurement error in hierarchical models
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Suite 415 L, 401 Park Drive West, Boston, Massachusetts 02115, USA
    Biostatistics 4:539-53. 2003
    ..The resulting effect size estimates were very small and the confidence intervals included zero...
  32. ncbi request reprint Air pollution and children's health
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, and Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Pediatrics 113:1037-43. 2004
    ..Although many of these associations seem likely to be causal, others require and warrant additional investigation...
  33. pmc Is the association of airborne particles with daily deaths confounded by gaseous air pollutants? An approach to control by matching
    Joel Schwartz
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Environ Health Perspect 112:557-61. 2004
    ..12-0.79%] when matched on maximum hourly ozone levels, to a 0.81% increase per 10 microg/m3 increment of PM10 (95% CI, 0.47-1.16%) when matched on 24-hr average SO2...
  34. pmc Daily deaths are associated with combustion particles rather than SO(2) in Philadelphia
    J Schwartz
    Environmental Epidemiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston MA 02115, USA
    Occup Environ Med 57:692-7. 2000
    ..To assess whether the association between SO(2) and daily deaths in Philadelphia during the years 1974-88 is due to its correlation with airborne particles, and vice versa...
  35. pmc Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 50:1053-61. 2008
    ..We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men...
  36. ncbi request reprint Source location of air pollution and cardiac autonomic function: trajectory cluster analysis for exposure assessment
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Expo Sci Environ Epidemiol 17:488-97. 2007
    ..Independent effects of both these indicators of pollution exposure were seen on cardiac autonomic function...
  37. pmc Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study
    Emmanuel S Baja
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 118:840-6. 2010
    ..Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure...
  38. pmc Air conditioning and source-specific particles as modifiers of the effect of PM(10) on hospital admissions for heart and lung disease
    Nicole A H Janssen
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 110:43-9. 2002
    ..The results suggest that air conditioning and proportion of especially traffic-related particles significantly modify the effect of PM(10) on hospital admissions, especially for CVD...
  39. pmc Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men
    Elissa H Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, United States
    Atherosclerosis 206:480-5. 2009
    ..We hypothesized that candidate genes selected for a study of asthma and chronic obstructive pulmonary disorder (COPD) are associated with markers of systemic inflammation and endothelial dysfunction in an aging population...
  40. pmc Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution
    David Q Rich
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 114:120-3. 2006
    ..ICDs also detect paroxysmal atrial fibrillation episodes (PAF) that result in rapid ventricular rates. In this same cohort of ICD patients, we assessed the association between ambient air pollution and episodes of PAF...
  41. pmc Acute and chronic effects of particles on hospital admissions in New-England
    Itai Kloog
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e34664. 2012
    ..5) monitors in their study regions, which introduces exposure error, and excludes rural and suburban populations from locations in which monitors are not available, reducing generalizability and potentially creating selection bias...
  42. ncbi request reprint HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 114:2798-805. 2006
    ..Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system...
  43. ncbi request reprint The association between personal measurements of environmental exposure to particulates and heart rate variability
    Shannon R Magari
    Occupational Health Program, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 13:305-10. 2002
    ..This may occur through changes in the cardiac autonomic nervous system, witnessed by changes in heart rate variability...
  44. pmc Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline
    Florence T Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:1210-5. 2007
    ..As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship...
  45. pmc Low-level lead exposure, metabolic syndrome, and heart rate variability: the VA Normative Aging Study
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1718-24. 2006
    ..Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure...
  46. doi request reprint Who is more vulnerable to die from ozone air pollution?
    Mercedes Medina-Ramón
    Departments of Environmental Health, and bEpidemiology, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 19:672-9. 2008
    ..Daily increases in ambient ozone have been associated with increased mortality. However, little is known about which subpopulations are more susceptible to death related to ozone...
  47. doi request reprint Susceptibility to mortality in weather extremes: effect modification by personal and small-area characteristics
    Antonella Zanobetti
    From the aDepartment of Environmental Health, Harvard School of Public Health, Boston, MA bDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI and cDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI
    Epidemiology 24:809-19. 2013
    ..We identified subpopulations with increased susceptibility to dying during temperature extremes, based on personal demographics, small-area characteristics, and preexisting medical conditions...
  48. doi request reprint Structural equation modeling of the inflammatory response to traffic air pollution
    Emmanuel S Baja
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Expo Sci Environ Epidemiol 23:268-74. 2013
    ..Traffic pollution adversely impacts inflammation in the elderly. SEMs in a Bayesian framework can comprehensively incorporate multiple pollutants and health outcomes simultaneously in air pollution-cardiovascular epidemiological studies...
  49. pmc Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators
    Douglas W Dockery
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 113:670-4. 2005
    ..The associations with sulfate suggest a link with stationary fossil fuel combustion sources...
  50. pmc T-wave alternans, air pollution and traffic in high-risk subjects
    Antonella Zanobetti
    Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Cardiol 104:665-70. 2009
    ..6 for a 1 microg/m(3) increase in 6-hour mean BC). In conclusion, after hospitalization for coronary artery disease, being in traffic and short-term ambient or indoor BC exposure increased TWA, a marker of cardiac electrical instability...
  51. ncbi request reprint Focused exposures to airborne traffic particles and heart rate variability in the elderly
    Sara Dubowsky Adar
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Epidemiology 18:95-103. 2007
    ..Because these risks may be particularly great for traffic-related particles, we examined associations between particles and heart rate variability as 44 subjects participated in 4 repeated trips aboard a diesel bus...
  52. pmc Mortality risk associated with short-term exposure to traffic particles and sulfates
    Dan Maynard
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02215, USA
    Environ Health Perspect 115:751-5. 2007
    ..Geographic information system (GIS) approaches have recently been used to improve exposure assessment, particularly for traffic particles, but only for long-term exposure...
  53. doi request reprint Elemental carbon exposure at residence and survival after acute myocardial infarction
    Stephanie von Klot
    Department of Environmental Health, Boston, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:547-54. 2009
    ..Some evidence suggests that particulate matter may accelerate the atherosclerotic process. Effects of within-city variations of particulate air pollution on survival after an acute cardiovascular event have been little explored...
  54. pmc A delta-aminolevulinic acid dehydratase (ALAD) polymorphism may modify the relationship of low-level lead exposure to uricemia and renal function: the normative aging study
    Ming Tsang Wu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 111:335-41. 2003
    ..Additional research is needed to ascertain whether this constitutes a true gene-environment interaction and, if so, its clinical impact...
  55. pmc Cumulative community-level lead exposure and pulse pressure: the normative aging study
    Todd Perlstein
    Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Environ Health Perspect 115:1696-700. 2007
    ..Lead accumulates in the vasculature and is associated with vascular oxidative stress, which can promote functional and structural vascular disease...
  56. pmc Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1730-5. 2006
    ..The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure...
  57. pmc Effect of breast milk lead on infant blood lead levels at 1 month of age
    Adrienne S Ettinger
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, Boston, MA 02215, USA
    Environ Health Perspect 112:1381-5. 2004
    ..However, because human milk is the best and most complete nutritional source for young infants, breast-feeding should be encouraged because the absolute values of the effects are small within this range of lead concentrations...
  58. ncbi request reprint Predictors of methacholine responsiveness in a general population
    Joel Schwartz
    Harvard School of Public Health, USA
    Chest 122:812-20. 2002
    ..This study aims to quantify the relative importance of different predictors of responsiveness such as age, sex, airway caliber, smoking and atopic status, and potential interactions deserving further investigation...
  59. ncbi request reprint Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function
    Marie S O'Neill
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 111:2913-20. 2005
    ..We examined whether endothelium-dependent and -independent vascular reactivity was associated with particle exposure in individuals with and without diabetes...
  60. ncbi request reprint Dietary calcium as a potential modifier of the relationship of lead burden to blood pressure
    Sahar F Elmarsafawy
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 17:531-7. 2006
    ..There is evidence of an interaction between these factors. We tested the hypothesis that dietary calcium intake modifies the relationship between lead burden and hypertension...
  61. doi request reprint Long- and short-term exposure to PM2.5 and mortality: using novel exposure models
    Itai Kloog
    Department of Environmental Health Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 24:555-61. 2013
    ..5 exposures on population mortality in Massachusetts, United States, for the years 2000-2008...
  62. pmc Summer temperature variability and long-term survival among elderly people with chronic disease
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 109:6608-13. 2012
    ..Our data suggest that long-term increases in temperature variability may increase the risk of mortality in different subgroups of susceptible older populations...
  63. ncbi request reprint Smoothing in survival models: an application to workers exposed to metalworking fluids
    Sally W Thurston
    Department of Biostatistics, Harvard School of Mental Health, Boston, MA, USA
    Epidemiology 13:685-92. 2002
    ..CONCLUSIONS This example illustrates that the penalized spline methodology can be easily applied to cohort studies to estimate smooth exposure-response curves...
  64. pmc The effect of weather on respiratory and cardiovascular deaths in 12 U.S. cities
    Alfesio L F Braga
    Environmental Epidemiology Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 110:859-63. 2002
    ..We saw no clear pattern for the effect of humidity. In hierarchical models, greater variance of summer and winter temperature was associated with larger effects for hot and cold days, respectively, on respiratory deaths...
  65. ncbi request reprint Association of short-term ambient air pollution concentrations and ventricular arrhythmias
    David Q Rich
    Department of Environmental Health, Harvard School of Public Health, 401 Park Drive, Boston, MA 02215, USA
    Am J Epidemiol 161:1123-32. 2005
    ..These results confirm previous findings and suggest that matching of pollution periods to arrhythmias is important in detecting such associations...
  66. pmc Lead, diabetes, hypertension, and renal function: the normative aging study
    Shirng Wern Tsaih
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 112:1178-82. 2004
    ....
  67. pmc Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
    Teresa Chahine
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1617-22. 2007
    ..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter...
  68. doi request reprint Structural equation modeling of parasympathetic and sympathetic response to traffic air pollution in a repeated measures study
    Emmanuel S Baja
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 12:81. 2013
    ..In a Bayesian framework, we examined the effect of traffic pollution on HRV using structural equation models (SEMs) and looked at effect modification by participant characteristics...
  69. pmc Cumulative exposure to lead in relation to cognitive function in older women
    Jennifer Weuve
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 117:574-80. 2009
    ..Recent data indicate that chronic low-level exposure to lead is associated with accelerated declines in cognition in older age, but this has not been examined in women...
  70. pmc Maternal blood manganese levels and infant birth weight
    Ami R Zota
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:367-73. 2009
    ..High manganese exposures have been associated with negative reproductive outcomes in animals, but few epidemiologic studies have examined the effects of human fetal manganese exposure...
  71. pmc The association of particulate air metal concentrations with heart rate variability
    Shannon R Magari
    Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 110:875-80. 2002
    ..These results extend our understanding of the adverse health effects of the metals component of ambient PM(2.5)...
  72. pmc Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation
    Sara D Dubowsky
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:992-8. 2006
    ..We found modest positive associations between PM2.5 and indicators of systemic inflammation, with larger associations suggested for individuals with diabetes, obesity, hypertension, and elevated mean inflammatory markers...
  73. ncbi request reprint Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic
    Robert O Wright
    Department of Pediatrics, Children s Hospital, The Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 142:9-14. 2003
    ..To determine if iron deficiency (ID) is longitudinally associated with lead poisoning...
  74. pmc Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 166:1400-8. 2007
    ..004). These results augment evidence of a deleterious association between lead and psychiatric symptoms...
  75. pmc The effect of fine and coarse particulate air pollution on mortality: a national analysis
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:898-903. 2009
    ..5) and PM coarse on the increased risk of death for all causes, cardiovascular disease (CVD), myocardial infarction (MI), stroke, and respiratory mortality for the years 1999-2005...
  76. pmc Interaction of stress, lead burden, and age on cognition in older men: the VA Normative Aging Study
    Junenette L Peters
    Department of Environment Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:505-10. 2010
    ..However, the modifying potential of psychosocial stress on the neurotoxicity of lead and their combined relationship to aging-associated decline have not been fully examined...
  77. pmc Associations of PM10 with sleep and sleep-disordered breathing in adults from seven U.S. urban areas
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Drive, Landmark Center, Suite 415, PO Box 15698, Boston, MA 02215, USA
    Am J Respir Crit Care Med 182:819-25. 2010
    ..S. adults, and may be more prevalent in poor urban environments. SDB and air pollution have been linked to increased cardiovascular diseases and mortality, but the association between pollution and SDB is poorly understood...
  78. pmc Bone lead and endogenous exposure in an environmentally exposed elderly population: the normative aging study
    Huiling Nie
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 51:848-57. 2009
    ..The objective of this study is to investigate the mobilization of lead from bone to blood (endogenous exposure) in a large epidemiologic population...
  79. pmc A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study
    Marc G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Circulation 120:1056-64. 2009
    ..The association between bone lead levels and mortality has not been explored...
  80. pmc Gene-air pollution interaction and cardiovascular disease: a review
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02115, USA
    Prog Cardiovasc Dis 53:344-52. 2011
    ....
  81. pmc Maternal self-esteem, exposure to lead, and child neurodevelopment
    Pamela J Surkan
    Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 29:278-85. 2008
    ..Moreover, there was evidence that maternal self-esteem attenuated the negative effects of lead exposure, although the interaction fell short of conventional levels of statistical significance...
  82. ncbi request reprint Particulate air pollution and hospital admissions for congestive heart failure in seven United States cities
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 97:404-8. 2006
    ....
  83. ncbi request reprint Invited commentary: ripeness is all
    Joel Schwartz
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 164:434-6. 2006
  84. ncbi request reprint Modifiers of the temperature and mortality association in seven US cities
    Marie S O'Neill
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 157:1074-82. 2003
    ..Place of death, race, and educational attainment indicate vulnerability to temperature-related mortality, reflecting inequities in health impacts related to climate change...
  85. pmc Chimney stove intervention to reduce long-term wood smoke exposure lowers blood pressure among Guatemalan women
    John P McCracken
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:996-1001. 2007
    ..Given the evidence that ambient particles increase blood pressure, we hypothesized that the intervention would lower blood pressure...
  86. pmc Association between lung function and cognition among children in a prospective birth cohort study
    Shakira Franco Suglia
    Department of Environmental Health, Harvard School of Public Health, Landmark 415W, 401 Park Drive, Boston, MA 02215, USA
    Psychosom Med 70:356-62. 2008
    ..A number of studies have demonstrated a relationship between lung function and cognition among adults, but this relationship has not been studied among children...
  87. pmc The impact of secondary particles on the association between ambient ozone and mortality
    Meredith Franklin
    Department of Environmental Health, Harvard School of Public Health, Landmark Center West, Room 412 E, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 116:453-8. 2008
    ..Although several previous studies have found a positive association between ambient ozone and mortality, the observed effect may be confounded by other secondary pollutants that are produced concurrently with ozone...
  88. pmc Residential exposure to traffic-related air pollution and survival after heart failure
    Mercedes Medina-Ramón
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 116:481-5. 2008
    ....
  89. pmc 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water
    J Michael Wright
    Environmental Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Environ Health Perspect 110:157-64. 2002
    ..Seasonal variation was evident for MX and mutagenic activity, with higher levels occurring in the spring compared to the fall. In contrast, TTHM concentrations were greater in the fall...
  90. ncbi request reprint Correlates of bone and blood lead levels among middle-aged and elderly women
    Susan A Korrick
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 156:335-43. 2002
    ....
  91. ncbi request reprint Dustborne fungi in large office buildings
    Hsing Jasmine Chao
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Mycopathologia 154:93-106. 2002
    ..The results of this study provide essential information to further evaluate the effects of dustborne fungi on office workers' health...
  92. doi request reprint Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:198-206. 2010
    ..nondeletion), and HMOX-1 (any short vs. both long). We attempted to replicate identified genes in an analysis of heart rate variability and in other outcomes reported in the literature...
  93. pmc Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study
    Francine Laden
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Respir Crit Care Med 173:667-72. 2006
    ..A large body of epidemiologic literature has found an association of increased fine particulate air pollution (PM2.5) with acute and chronic mortality. The effect of improvements in particle exposure is less clear...
  94. pmc Ischemic heart disease and stroke in relation to blood DNA methylation
    Andrea Baccarelli
    Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano and IRCCS Ca, Granda Policlinico Maggiore Hospital Foundation, Milan, Italy
    Epidemiology 21:819-28. 2010
    ..We evaluated whether lower blood DNA methylation in heavily methylated repetitive sequences predicts the risk of ischemic heart disease and stroke...
  95. ncbi request reprint Influence of maternal bone lead burden and calcium intake on levels of lead in breast milk over the course of lactation
    Adrienne S Ettinger
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 163:48-56. 2006
    ....
  96. ncbi request reprint Air pollution and hospital admissions for ischemic and hemorrhagic stroke among medicare beneficiaries
    Gregory A Wellenius
    Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Stroke 36:2549-53. 2005
    ..The association between short-term elevations in ambient air particles and increased cardiovascular morbidity and mortality is well documented. Ambient particles may similarly increase the risk of stroke...
  97. pmc The effect of particulate air pollution on emergency admissions for myocardial infarction: a multicity case-crossover analysis
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 113:978-82. 2005
    ..We conclude that increased concentrations of ambient PM10 are associated with increased risk of MI among the elderly...
  98. pmc Effects of air pollution on heart rate variability: the VA normative aging study
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 113:304-9. 2005
    ..Exposures to PM2.5 and O3 are associated with decreased HRV, and history of IHD, hypertension, and diabetes may confer susceptibility to autonomic dysfunction by air pollution...
  99. ncbi request reprint Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study
    Marc G Weisskopf
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Landmark Center, 401 Park Drive, PO Box 15697, Boston, MA 02215, USA
    Am J Epidemiol 160:1184-93. 2004
    ..The data suggest that higher patella bone lead levels, a marker of mobilizable accumulated lead burden, are associated with a steeper decline over time in performance on the MMSE test among nonoccupationally exposed elderly men...
  100. pmc Estimating the independent effects of multiple pollutants in the presence of measurement error: an application of a measurement-error-resistant technique
    Ariana Zeka
    Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 112:1686-90. 2004
    ..24% increase in deaths per 10-microg/m3) increase in PM10). In addition, we report an important effect of carbon monoxide that had not been observed previously...
  101. ncbi request reprint Ambient pollution and blood pressure in cardiac rehabilitation patients
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Dr, Landmark Center, Suite 415, PO Box 15698, Boston, Mass 02215, USA
    Circulation 110:2184-9. 2004
    ..We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease...

Research Grants12

  1. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2009
    ..Quantitative DNA methylation analysis, based on PCR amplification and pyrosequencing of bisulphite-treated DNA, will be performed for each study subject on three blood DNA samples collected over a long time span. ..
  2. Epigenetic Effects of Particles and Metals on Cardiac Health of an Aging Cohort
    Joel Schwartz; Fiscal Year: 2007
    ..Quantitative DNA methylation analysis, based on PCR amplification and pyrosequencing of bisulphite-treated DNA, will be performed for each study subject on three blood DNA samples collected over a long time span. ..
  3. Heart Attacks and Traffic Pollution
    Joel Schwartz; Fiscal Year: 2006
    ..A preliminary analysis will use retrospective data, and not obtain questionnaire data. Effect modification by diabetes, prior MI, COPD, smoking, and angina will be tested using interaction terms. ..
  4. Cardiovascular Effects of Particles:The Role of Oxidative Stress and Metal Pathw
    Joel D Schwartz; Fiscal Year: 2010
    ....