Research Topics
Genomes and Genes | Daniel SchwartzSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinasesSladjana Prisic
Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:7521-6. 2010..tuberculosis and create a resource for understanding how specific phosphorylation events modulate protein activity. The results further provide the potential to predict likely cognate STPKs for newly identified phosphoproteins...
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data setsDaniel Schwartz
Department of Cell Biology, 240 Longwood Ave, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Biotechnol 23:1391-8. 2005....
Using the scan-x Web site to predict protein post-translational modificationsMichael F Chou
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Curr Protoc Bioinformatics . 2011..This tool is accessible from virtually any computer with a Web browser. The only requirement is a means of searching for a protein of interest in one of the represented organisms...- Biological sequence motif discovery using motif-xMichael F Chou
Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Curr Protoc Bioinformatics . 2011..The protocols presented demonstrate the use of motif-x in three common user scenarios... - Phosphoproteomic analysis of the developing mouse brainBryan A Ballif
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Proteomics 3:1093-101. 2004.... - Identification of 14-3-3epsilon substrates from embryonic murine brainBryan A Ballif
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
J Proteome Res 5:2372-9. 2006..Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol... - Using bacteria to determine protein kinase specificity and predict target substratesMichael F Chou
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e52747. 2012.... - Collection and motif-based prediction of phosphorylation sites in human virusesDaniel Schwartz
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Sci Signal 3:rs2. 2010.... - Predicting protein post-translational modifications using meta-analysis of proteome scale data setsDaniel Schwartz
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Proteomics 8:365-79. 2009..New motif discovery is a byproduct of this approach, and the phosphorylation motif analyses provide strong evidence of evolutionary conservation of both known and novel kinase motifs... - Large-scale characterization of HeLa cell nuclear phosphoproteinsSean A Beausoleil
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:12130-5. 2004..From 967 proteins, 2,002 phosphorylation sites were determined by tandem MS. This unprecedented large collection of sites permitted a detailed accounting of known and unknown kinase motifs and substrates... - Chandra enables study of x-ray jetsDaniel Schwartz
Smithsonian Astrophysical Observatory, Cambridge, MA, USA
Proc Natl Acad Sci U S A 107:7190-5. 2010..The x-ray data play an essential role in deducing the emission mechanism of the jets, in revealing the interaction of jets with the intergalactic or intracluster media, and in studying the energy generation budget of black holes... - CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survivalHideki Shimura
Department of Neurology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 279:4869-76. 2004..CHIP could rescue phosphorylated tau-induced cell death, and therefore the CHIP-Hsc70 complex may provide a new therapeutic target for the tauopathies... - Ultraconserved elements: analyses of dosage sensitivity, motifs and boundariesCharleston W K Chiang
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genetics 180:2277-93. 2008.... - A proteomics approach to understanding protein ubiquitinationJunmin Peng
Department of Cell Biology, 240 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Biotechnol 21:921-6. 2003..The methodology described here provides a general tool for the large-scale analysis and characterization of protein ubiquitination...