Daniel Schwartz

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases
    Sladjana Prisic
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:7521-6. 2010
  2. ncbi request reprint An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets
    Daniel Schwartz
    Department of Cell Biology, 240 Longwood Ave, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Biotechnol 23:1391-8. 2005
  3. pmc Using bacteria to determine protein kinase specificity and predict target substrates
    Michael F Chou
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e52747. 2012
  4. doi request reprint Using the scan-x Web site to predict protein post-translational modifications
    Michael F Chou
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Bioinformatics . 2011
  5. doi request reprint Biological sequence motif discovery using motif-x
    Michael F Chou
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Bioinformatics . 2011
  6. ncbi request reprint Phosphoproteomic analysis of the developing mouse brain
    Bryan A Ballif
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Proteomics 3:1093-101. 2004
  7. ncbi request reprint Identification of 14-3-3epsilon substrates from embryonic murine brain
    Bryan A Ballif
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Proteome Res 5:2372-9. 2006
  8. doi request reprint Collection and motif-based prediction of phosphorylation sites in human viruses
    Daniel Schwartz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 3:rs2. 2010
  9. pmc Predicting protein post-translational modifications using meta-analysis of proteome scale data sets
    Daniel Schwartz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Proteomics 8:365-79. 2009
  10. pmc Large-scale characterization of HeLa cell nuclear phosphoproteins
    Sean A Beausoleil
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:12130-5. 2004

Collaborators

Detail Information

Publications14

  1. pmc Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases
    Sladjana Prisic
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:7521-6. 2010
    ..tuberculosis and create a resource for understanding how specific phosphorylation events modulate protein activity. The results further provide the potential to predict likely cognate STPKs for newly identified phosphoproteins...
  2. ncbi request reprint An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets
    Daniel Schwartz
    Department of Cell Biology, 240 Longwood Ave, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Biotechnol 23:1391-8. 2005
    ....
  3. pmc Using bacteria to determine protein kinase specificity and predict target substrates
    Michael F Chou
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e52747. 2012
    ....
  4. doi request reprint Using the scan-x Web site to predict protein post-translational modifications
    Michael F Chou
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Bioinformatics . 2011
    ..This tool is accessible from virtually any computer with a Web browser. The only requirement is a means of searching for a protein of interest in one of the represented organisms...
  5. doi request reprint Biological sequence motif discovery using motif-x
    Michael F Chou
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Curr Protoc Bioinformatics . 2011
    ..The protocols presented demonstrate the use of motif-x in three common user scenarios...
  6. ncbi request reprint Phosphoproteomic analysis of the developing mouse brain
    Bryan A Ballif
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Proteomics 3:1093-101. 2004
    ....
  7. ncbi request reprint Identification of 14-3-3epsilon substrates from embryonic murine brain
    Bryan A Ballif
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Proteome Res 5:2372-9. 2006
    ..Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol...
  8. doi request reprint Collection and motif-based prediction of phosphorylation sites in human viruses
    Daniel Schwartz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Sci Signal 3:rs2. 2010
    ....
  9. pmc Predicting protein post-translational modifications using meta-analysis of proteome scale data sets
    Daniel Schwartz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Proteomics 8:365-79. 2009
    ..New motif discovery is a byproduct of this approach, and the phosphorylation motif analyses provide strong evidence of evolutionary conservation of both known and novel kinase motifs...
  10. pmc Large-scale characterization of HeLa cell nuclear phosphoproteins
    Sean A Beausoleil
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:12130-5. 2004
    ..From 967 proteins, 2,002 phosphorylation sites were determined by tandem MS. This unprecedented large collection of sites permitted a detailed accounting of known and unknown kinase motifs and substrates...
  11. pmc Chandra enables study of x-ray jets
    Daniel Schwartz
    Smithsonian Astrophysical Observatory, Cambridge, MA, USA
    Proc Natl Acad Sci U S A 107:7190-5. 2010
    ..The x-ray data play an essential role in deducing the emission mechanism of the jets, in revealing the interaction of jets with the intergalactic or intracluster media, and in studying the energy generation budget of black holes...
  12. ncbi request reprint CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival
    Hideki Shimura
    Department of Neurology, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 279:4869-76. 2004
    ..CHIP could rescue phosphorylated tau-induced cell death, and therefore the CHIP-Hsc70 complex may provide a new therapeutic target for the tauopathies...
  13. pmc Ultraconserved elements: analyses of dosage sensitivity, motifs and boundaries
    Charleston W K Chiang
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 180:2277-93. 2008
    ....
  14. ncbi request reprint A proteomics approach to understanding protein ubiquitination
    Junmin Peng
    Department of Cell Biology, 240 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Biotechnol 21:921-6. 2003
    ..The methodology described here provides a general tool for the large-scale analysis and characterization of protein ubiquitination...