Research Topics
| D SchuppanSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Pathomechanisms in celiac diseaseWalburga Dieterich
Medical Department I, , Erlangen, Germany
Int Arch Allergy Immunol 132:98-108. 2003....
Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literatureShuhei Yoshida
Department of Gastroenterology, Internal Medicine, TMG Asakadai Central General Hospital, Saitama 351 8551, Japan
J Med Case Reports 4:307. 2010..However, acute hepatic failure with transaminase levels over 1000 IU/mL and deep coma are very rare complications and the mechanism of pathogenesis is largely unknown...- Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42Martin Ruehl
Department of Gastroenterology and Hepatology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
Fibrogenesis Tissue Repair 4:1. 2011..abstract:.. - Monitoring non-responsive patients with celiac diseaseDetlef Schuppan
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Gastrointest Endosc Clin N Am 16:593-603. 2006..At present the prognosis of RCd type II or EATL is poor due to lack of effective therapies. However, treatments that effectively target the aberrant lymphocytes can be anticipated... - Celiac disease: epidemiology, pathogenesis, diagnosis, and nutritional managementDetlef Schuppan
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nutr Clin Care 8:54-69. 2005..Current research focuses on non-dietary therapies and treatment of refractory (diet-unresponsive) CD... - Liver cirrhosisDetlef Schuppan
Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Lancet 371:838-51. 2008..This Seminar focuses on the diagnosis, complications, and management of cirrhosis, and new clinical and scientific developments... 
Rationale and targets for antifibrotic therapiesD Schuppan
Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana 501, 330, Brookline Avenue, Boston, MA 02215, USA
Gastroenterol Clin Biol 33:949-57. 2009....- Celiac disease: from pathogenesis to novel therapiesDetlef Schuppan
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Gastroenterology 137:1912-33. 2009..These and other experimental therapies will be discussed critically... - The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitisDetlef Schuppan
Beth Israel Deaconess Medical Center, Division of Gastroenterology, Harvard Medical School, Boston, MA 02215, USA
Liver Int 30:795-808. 2010..Combined with a better understanding of the pathophysiological processes that underlie the mechanisms of hepatic fibrogenesis in NASH, rapid clinical validation of novel therapies is expected... - Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic miceT L Freitag
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Gut 58:1597-605. 2009..We aimed to assess the pathogenic role of gluten-reactive T cells and to generate a model of gluten-induced enteropathy... - Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United StatesS Garud
The Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Aliment Pharmacol Ther 29:898-905. 2009..Previous studies yielded conflicting results regarding the presence of an association between coeliac disease (CD) and psychiatric disorders including depression. This association has not been studied in the United States... - The hedgehog pathway regulates remodelling responses to biliary obstruction in ratsA Omenetti
Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Gut 57:1275-82. 2008..The hedgehog (Hh) pathway becomes activated in liver after bile duct ligation (BDL), and might modulate hepatic remodelling because Hh ligands are potent morphogens... - A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac diseaseD A Leffler
The Celiac Center, Beth Israel Deaconess Medical Center, Department of Gastroenterology, Boston, MA 02215, USA
Aliment Pharmacol Ther 26:1227-35. 2007..The only accepted treatment for coeliac disease is lifelong adherence to a strict gluten-free diet (GFD). Individuals' ability to adhere to the GFD varies, but systematic studies guiding the assessment of adherence are currently lacking... - Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosisYury Popov
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Am J Physiol Gastrointest Liver Physiol 298:G323-34. 2010.... - Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cellsAnja Schulze-Krebs
Department of Medicine I, University of Erlangen-Nuremberg, Germany
Gastroenterology 129:246-58. 2005.... - Successful treatment of hepatitis C reinfection with interferon-alpha2b and ribavirin after liver transplantationSuleyman Yedibela
Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
Liver Int 25:717-22. 2005..The aim of this study was to evaluate the safety and efficacy of interferon (IFN)-alpha2b plus ribavirin (RIBA) in the treatment of recurrent HCV after OLT over the long term... - Hepatocellular carcinomas do not compromise quantitative tests of liver functionMarion Ganslmayer
Department of Internal Medicine I, University of Erlangen-Nuernberg, Germany
Hepatogastroenterology 52:881-4. 2005..Since these parameters are not affected by the occurrence of hepatocellular carcinoma, the emergence of hepatic neoplasia in cirrhotics does not appear to be determined by the degree of hepatic functional deterioration... - Monitoring nonresponsive patients who have celiac diseaseNorbert Krauss
Department of Medicine I Gastroenterology, Hepatology, Pneumonology and Endocrinology, University Hospital, Ulmenweg 18, Erlangen 91054, Germany
Gastrointest Endosc Clin N Am 16:317-27. 2006..At present there is no effective treatment for type II RCD.Fig. 3 presents a proposed algorithm for monitoring patients who have ce-liac disease... - Keratin variants associate with progression of fibrosis during chronic hepatitis C infectionPavel Strnad
Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
Hepatology 43:1354-63. 2006..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other... - Iron, HCV, and liver cancer: hard metal setting the pace?Sebastian Mueller
Gastroenterology 130:2229-34. 2006 - Etiologies and predictors of diagnosis in nonresponsive celiac diseaseDaniel A Leffler
Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Clin Gastroenterol Hepatol 5:445-50. 2007..The aim of this study was to determine the common etiologies of NRCD in a tertiary referral center... - Turning swords into plowshares: transglutaminase to detoxify glutenDetlef Schuppan
Gastroenterology 133:1025-8. 2007 - Factors that influence adherence to a gluten-free diet in adults with celiac diseaseDaniel A Leffler
Department of Gastroenterology, The Celiac Center, Dana 501, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Dig Dis Sci 53:1573-81. 2008..The purpose of this study was to determine factors influencing gluten-free diet adherence in adults with celiac disease... - Serum markers detect the presence of liver fibrosis: a cohort studyWilliam M C Rosenberg
Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, England SO16 6YD
Gastroenterology 127:1704-13. 2004..We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis... - Innate immunity and coeliac diseaseDetlef Schuppan
First Department of Medicine, University of Erlangen-Nuernberg, 91054, Erlangen, Germany
Lancet 362:3-4. 2003 - A molecular warhead and its target: tissue transglutaminase and Celiac SprueDetlef Schuppan
First Department of Medicine, University of Erlangen Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
Chem Biol 10:199-201. 2003..DON-modified peptides could be useful for the study and therapy of celiac sprue... - [Prevalence of circulating autoantibodies in healthy individuals]Andreas Teubner
, Klinikum Chemnitz gGmbH, , Chemnitz
Med Klin (Munich) 97:645-9. 2002..01). Since at least one in three or four healthy individuals tested positive for ANA or ASMA, the positive predictive value of these autoantibodies is low, and clinical interpretation should include additional information... - Biomedicine. Gluten and the gut-lessons for immune regulationDetlef Schuppan
First Department of Medicine, University of Erlangen-Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
Science 297:2218-20. 2002 - The role of the immune response against tissue transglutaminase in the pathogenesis of coeliac diseaseTobias Freitag
Medical Department I, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
Autoimmun Rev 3:13-20. 2004..Although no intestinal lesions were found, this observation lends support to the concept that the development of autoimmunity against TGase 2 is a pathological event that might ultimately lead to organ damage... - Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European centreChristoph Herold
Department of Medicine I, Department of Surgery, Institute for Medical Statistics, Biometry and Epidemiology, University of Erlangen Nuernberg, Germany
Liver 22:23-8. 2002..Only a few follow up data are available for patients with hepatocellular carcinoma (HCC) in Europe and the USA. Therefore, we analysed all HCC patients admitted to our hospital between 1988 and 1999... - Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cellsKrista Rombouts
Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
J Hepatol 38:564-72. 2003..We investigated the effect of two statins on the proliferation rate and protein steady state levels of hepatic stellate cells (HSC)... - Matrix metalloproteinases in necrotising enterocolitisSylvia Lin Foon Pender
Division of Infection, Inflammation and Repair, Mailpoint 813, Level E, South Academic Block, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
Pediatr Res 54:160-4. 2003..These results suggest that stromelysin-1, which has the ability to degrade the mucosal extra-cellular matrix, may be responsible for the extensive tissue injury in infants with NEC... - Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cellsBenjamin Schaefer
Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
Am J Pathol 162:1771-80. 2003..Overall, these findings strongly support the notion that alpha1(I) collagen and matrix metalloproteinase-13 mRNAs are reciprocally modulated... - Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastasesJohannes Hansler
Department of Medicine, Friedrich Alexander University, Erlangen Nuremberg, Germany
World J Gastroenterol 12:3716-21. 2006..CONCLUSION: Patients with primary and secondary tumors of the liver show a significant tumor-specific cytotoxic T-cell stimulation with a dramatically increased tumor specific cytolytic activity of CD8(+) T cells after RFA... - EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancerAlexander Huether
, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology/Infectious Diseases/Rheumatology, Hindenburgdamm 30, 12200 Berlin, Germany
Biochem Pharmacol 70:1568-78. 2005..To conclude, our study may provide a rationale for future clinical investigations of cetuximab combination therapy for growth control of hepatocellular cancer... - Synthesis of collagen I in collagenous sprueSeverin Daum
Department of Medicine I, Gastroenterology, Infectious Diseases and Rheumatology, Universitatsmedizin Berlin, Berlin, Germany
Clin Gastroenterol Hepatol 4:1232-6. 2006..We studied the expression patterns of genes involved in fibrogenesis and fibrolysis and analyzed the composition of the subepithelial collagen band in CS compared with untreated celiac diseases (CDs)... - Integrin-mediated control of cell growthDetlef Schuppan
Hepatology 38:289-91. 2003 - Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancerAlexander Huether
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Berlin, Germany
World J Gastroenterol 12:5160-7. 2006..To examine the underlying mechanisms of erlotinib-induced growth inhibition in hepatocellular carcinoma (HCC)... - Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancerMichael Hopfner
World J Gastroenterol 14:1-14. 2008.... - Autoimmunity and HCV infection in porphyria cutanea tarda: a controlled studyUlrich Stölzel
Department of Gastroenterology, Medizinische Klinik II, Klinikum Chernitz GmbH, Teaching Hospital of the University of Leipzig, Germany
Cell Mol Biol (Noisy-le-grand) 48:43-7. 2002..However, a higher prevalence of HCV infection and systemic lupus erythematosus in patients with porphyria cutanea tarda was confirmed... - Hepatic fibrosis: from bench to bedsideDetlef Schuppan
Department of Medicine I, Division of Gastroenterology, Hepatology and Infectiology, University of Erlangen Nuernberg, Germany
J Gastroenterol Hepatol 17:S300-5. 2002..Combined with the evolving validation of serological markers of fibrogenesis and fibrolysis an effective and individualized treatment of liver fibrosis can be anticipated... - Can quantitative tests of liver function discriminate between different etiologies of liver cirrhosis?Christoph Herold
Department of Medicine I, University of Erlangen Nuernberg, Germany
Dig Dis Sci 47:2669-73. 2002..In conclusion, QTLF in ALC and VIC patients was more reduced than in patients with PBC. This may be due to saturation of enzymes in ALC and ongoing inflammation in VIC... - Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progressionEleonora Patsenker
Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland
Gastroenterology 135:660-70. 2008..Because its role in liver fibrosis is unknown, we studied alphavbeta6 function in vitro and explored the antifibrotic potential of the specific alphavbeta6 antagonist EMD527040... - No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver diseaseFelix Stickel
Institute of Clinical Pharmacology, University of Berne, Switzerland
Alcohol Clin Exp Res 32:959-65. 2008..We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics... - Portal vein arterialisation as a technical option in liver transplantation: impact on function, regeneration, and morphology of the liver following hemihepatectomy in pigsRudolf Ott
Department of Surgery, University of Leipzig, Leipzig, Germany
Liver Int 23:54-62. 2003..Arterialisation of the portal vein has been propagated as a technical variant in liver transplantation. However, the consequences of this unphysiological vascular supply are insufficiently known... - Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitisHerbert Tilg
Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
J Hepatol 38:419-25. 2003..Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology... - Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapiesYury Popov
Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Hepatol 48:453-64. 2008..We studied alphavbeta6 expression in experimental and human liver fibrosis and the potential of its pharmacological inhibition for treatment of hepatic fibrosis... - Liver-homing of purified glucose oxidase: a novel in vivo model of physiological hepatic oxidative stress (H2O2)Daniel Rost
Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
J Hepatol 46:482-91. 2007..Reactive oxygen species (ROS), such as H2O2, are implicated in normal and pathological liver function. However, due to the lack of suitable in vivo models of ROS generation the (patho) physiological relevance of H2O2 remains controversial... - Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alphaDariusz-Marek Lebensztejn
IIIrd Department of Pediatrics, Medical University of Bialystok, Poland
World J Gastroenterol 12:3338-43. 2006..CONCLUSION: Tenascin reflects hepatic fibrogenesis and inflammation which decreases during IFN treatment of children with chronic hepatitis B. TIMP-1 correlates with nonresponse and hyaluronan with histological fibrosis... - A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cellsMarion Ganslmayer
Medical Department I, University of Erlangen-Nuernberg, D-91054 Erlangen, Germany
Oncol Rep 11:943-50. 2004..While the single substances were not effective on hepatoma cells in tolerable doses, their combination significantly increases anti-tumoral efficacy. Combination therapy with biomodulators is a promising treatment option for HCC... - Potentiated anticancer effects on hepatoma cells by the retinoid adapaleneMatthias Ocker
Department of Internal Medicine I, University Erlangen-Nuernberg, Ulmenweg 18, D-91054 Erlangen, Germany
Cancer Lett 208:51-8. 2004..3 in hepatoma cells. ADA inhibits hepatoma cell growth in vitro and is a powerful inducer of hepatoma cell apoptosis... - TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosisChristoph H Osterreicher
Department of Internal Medicine IV, Medical University of Vienna, Austria
Cytokine 31:142-8. 2005..8 (95% CI 1.4-5.7, p = 0.004). In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg... - Pathomechanisms in celiac diseaseFrits Koning
Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
Best Pract Res Clin Gastroenterol 19:373-87. 2005..Together, these observations provide a unique explanation for the disease inducing capacity of gluten... - Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosisChristoph H Osterreicher
Department of Internal Medicine IV, Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Wien, Austria
J Hepatol 42:914-9. 2005..This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC... - The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cellsMatthias Ocker
Department of Medicine I, University of Erlangen Nuernberg, Ulmenweg 18, 91054, Erlangen, Germany
J Cancer Res Clin Oncol 131:385-94. 2005..The use of the triple combination could optimize treatment results in vivo and needs further evaluation... - The combination of tamoxifen and 9cis retinoic acid exerts overadditive anti-tumoral efficacy in rat hepatocellular carcinomaMarion Ganslmayer
Department of Internal Medicine I, University Erlangen-Nuernberg, Ulmenweg 18, D-91054 Erlangen, Germany
J Hepatol 40:952-6. 2004..CONCLUSIONS: The combination of TAM and CRA enhances their anti-tumoral efficacy in vitro as well as in vivo, while monotherapy is ineffective. This combination could be a promising adjunctive therapy of HCC... - Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinomaMichael Hopfner
Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Hindenburgdamm 30, 12200 Berlin, Germany
J Hepatol 41:1008-16. 2004..We therefore studied the antineoplastic potency of gefitinib in human HCC cells... - Hepatocyte growth factor and c-Met expression in rat and human liver fibrosisThorsten Cramer
Institute of Pathology, University of Muenster, Germany
Liver Int 24:335-44. 2004..Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes in vitro... - Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1Andreas P Sutter
Medical Clinic I, , Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
J Hepatol 41:799-807. 2004..CONCLUSIONS: This is the first report on the induction of apoptosis and cell cycle arrest by PBR ligands in HCC cells. Moreover, PBR ligands sensitized HCC cells to taxans and doxorubicin... - Serum fibrosis markers as predictors of an antifibrotic effect of interferon alfa in children with chronic hepatitis BDariusz M Lebensztejn
IIIrd Dept of Pediatrics, Medical University, Bialystok, Poland
Eur J Gastroenterol Hepatol 17:843-8. 2005..The evolution of serum fibrosis markers suggests they may be more sensitive to detect minor antifibrotic effects than semiquantitative follow-up histology... - The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cellsChristoph Herold
Department of Medicine I, University of Erlangen-Nuernberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
J Hepatol 36:233-40. 2002..Its anti-proliferative activity is paralleled by a comparable rate of apoptosis. TSA may be a promising agent for treatment of hepatocellular carcinoma in vivo... - Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factorGernot Sellge
Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
J Immunol 172:260-7. 2004..Such interactions between MCs and FBs may explain why MCs accumulate at sites of inflammatory bowel disease and intestinal fibrosis... - Matrix metalloproteinase pattern in celiac duodenal mucosaRachele Ciccocioppo
Gastroenterology Unit, IRCCS Policlinico San Matteo, University of Pavia, Italy
Lab Invest 85:397-407. 2005..In conclusion, our results show the presence of a peculiar MMP pattern in active CD strongly dominated by MMP-12, correlating either with IFN-gamma or the degree of mucosal damage... - Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cellsMichael Hopfner
Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, 12200 Berlin, Germany
Biochem Pharmacol 71:1435-48. 2006..Thus, IGF-1R-TK inhibition may be a promising novel treatment approach in HCC... - Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaBYury Popov
Department of Medicine I, University of Erlangen-Nuernberg, 91054 Erlangen, Germany
J Biol Chem 281:15090-8. 2006..The remarkable induction of MMP-3 and -13 makes HAL a promising agent for antifibrotic combination therapies... - Efficacy and tolerability of pegylated IFN-alpha in patients with neuroendocrine gastroenteropancreatic carcinomasMarianne E Pavel
Department of Medicine I, University Hospital Erlangen Nuremberg, 91054 Erlangen, Germany
J Interferon Cytokine Res 26:8-13. 2006..Better tolerability of PEG-IFN-alpha2b improved patients' compliance, justifying its use in patients who do not tolerate conventional IFN-alpha treatment... - Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genesYury Popov
Laboratory of Liver Research, Department of Medicine I, University of Erlangen-Nuremberg, Germany; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Hepatol 43:1045-54. 2005..These mice are an attractive model to test potential antifibrotics for the treatment of (biliary) liver fibrosis... - Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosisFelix Stickel
Department of Medicine I, University of Erlangen Nurnberg, Erlangen, Germany
Arch Intern Med 165:1835-40. 2005..Our objective was to establish the role of the functional polymorphisms of GSTP1 (codon 105 Ile-->Val) and MnSOD (codon 16 of precursor protein Ala-->Val) on the evolution of cirrhosis in patients with HHC and CHC... - Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptorAndreas P Sutter
, Campus Benjamin Franklin, Medical Clinic I, Berlin, Germany
J Hepatol 43:808-16. 2005..CONCLUSIONS: Our data shed light on the signaling cascades mediating statin-induced growth inhibition of HCC cells. Moreover, PBR ligands sensitized HCC cells to statins, suggesting a new strategy to treat HCC... - Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostaticsAlexander Huether
Gastroenterology/Infectious Diseases/Rheumatology, Medical Clinic I, , Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
J Hepatol 43:661-9. 2005..Additionally, erlotinib enhances the antineoplastic activity of conventional cytostatic drugs. Thus, inhibiting EGFR-tyrosine kinase appears to be a promising treatment strategy in HCC... - Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoidsKarine Hellemans
Lab Molecular Liver Cell Biology, Free University Brussels, Brussels, Belgium
Hepatology 39:97-108. 2004..Our observations may explain prior divergent results obtained following retinoid administration to cultured stellate cells or to animals subjected to fibrogenic stimuli... - Enhancement of the immune response to residual intrahepatic tumor tissue by laser-induced thermotherapy (LITT) compared to hepatic resectionChristoph Isbert
Depatment of Surgery, Klinikum Nuernberg Nord, Prof Ernst Nathan Strasse 1, D 90419 Nuernberg, Germany
Lasers Surg Med 35:284-92. 2004..The aim of the study was to evaluate the effect of LITT and hepatic resection on the immune response to residual intrahepatic tumor tissue and the growth of untreated liver metastases...
Research Grants
- Mouse Models for Celiac DiseaseDetlef Schuppan; Fiscal Year: 2007..g. by immunomodulatory cytokines or by cytokine antagonists. It is anticipated that the results will improve our understanding and management of cd and related autoimmune diseases. ..
- Identification of Serum Markers of Liver Fibrogenesis/ Fibrolysis by ProteomicsDetlef Schuppan; Fiscal Year: 2007..Adaptation to the human proteome and prospective validation shall allow noninvasive monitoring of fibrosis progression and regression in patients with liver diseases. ..