D Schuppan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Pathomechanisms in celiac disease
    Walburga Dieterich
    Medical Department I, University of Erlangen Nurnberg, Erlangen, Germany
    Int Arch Allergy Immunol 132:98-108. 2003
  2. ncbi request reprint Monitoring non-responsive patients with celiac disease
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gastrointest Endosc Clin N Am 16:593-603. 2006
  3. pmc Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literature
    Shuhei Yoshida
    Department of Gastroenterology, Internal Medicine, TMG Asakadai Central General Hospital, Saitama 351 8551, Japan
    J Med Case Reports 4:307. 2010
  4. pmc Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42
    Martin Ruehl
    Department of Gastroenterology and Hepatology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Fibrogenesis Tissue Repair 4:1. 2011
  5. doi request reprint The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis
    Detlef Schuppan
    Beth Israel Deaconess Medical Center, Division of Gastroenterology, Harvard Medical School, Boston, MA 02215, USA
    Liver Int 30:795-808. 2010
  6. ncbi request reprint Celiac disease: epidemiology, pathogenesis, diagnosis, and nutritional management
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nutr Clin Care 8:54-69. 2005
  7. doi request reprint Celiac disease: from pathogenesis to novel therapies
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 137:1912-33. 2009
  8. doi request reprint Rationale and targets for antifibrotic therapies
    D Schuppan
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana 501, 330, Brookline Avenue, Boston, MA 02215, USA
    Gastroenterol Clin Biol 33:949-57. 2009
  9. pmc Liver cirrhosis
    Detlef Schuppan
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 371:838-51. 2008
  10. pmc Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice
    T L Freitag
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gut 58:1597-605. 2009

Research Grants

Detail Information

Publications73

  1. ncbi request reprint Pathomechanisms in celiac disease
    Walburga Dieterich
    Medical Department I, University of Erlangen Nurnberg, Erlangen, Germany
    Int Arch Allergy Immunol 132:98-108. 2003
    ....
  2. ncbi request reprint Monitoring non-responsive patients with celiac disease
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gastrointest Endosc Clin N Am 16:593-603. 2006
    ..At present the prognosis of RCd type II or EATL is poor due to lack of effective therapies. However, treatments that effectively target the aberrant lymphocytes can be anticipated...
  3. pmc Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case report and review of the literature
    Shuhei Yoshida
    Department of Gastroenterology, Internal Medicine, TMG Asakadai Central General Hospital, Saitama 351 8551, Japan
    J Med Case Reports 4:307. 2010
    ..However, acute hepatic failure with transaminase levels over 1000 IU/mL and deep coma are very rare complications and the mechanism of pathogenesis is largely unknown...
  4. pmc Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42
    Martin Ruehl
    Department of Gastroenterology and Hepatology, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, D 12200 Berlin, Germany
    Fibrogenesis Tissue Repair 4:1. 2011
    ..abstract:..
  5. doi request reprint The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis
    Detlef Schuppan
    Beth Israel Deaconess Medical Center, Division of Gastroenterology, Harvard Medical School, Boston, MA 02215, USA
    Liver Int 30:795-808. 2010
    ..Combined with a better understanding of the pathophysiological processes that underlie the mechanisms of hepatic fibrogenesis in NASH, rapid clinical validation of novel therapies is expected...
  6. ncbi request reprint Celiac disease: epidemiology, pathogenesis, diagnosis, and nutritional management
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nutr Clin Care 8:54-69. 2005
    ..Current research focuses on non-dietary therapies and treatment of refractory (diet-unresponsive) CD...
  7. doi request reprint Celiac disease: from pathogenesis to novel therapies
    Detlef Schuppan
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Gastroenterology 137:1912-33. 2009
    ..These and other experimental therapies will be discussed critically...
  8. doi request reprint Rationale and targets for antifibrotic therapies
    D Schuppan
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Dana 501, 330, Brookline Avenue, Boston, MA 02215, USA
    Gastroenterol Clin Biol 33:949-57. 2009
    ....
  9. pmc Liver cirrhosis
    Detlef Schuppan
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Lancet 371:838-51. 2008
    ..This Seminar focuses on the diagnosis, complications, and management of cirrhosis, and new clinical and scientific developments...
  10. pmc Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice
    T L Freitag
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Gut 58:1597-605. 2009
    ..We aimed to assess the pathogenic role of gluten-reactive T cells and to generate a model of gluten-induced enteropathy...
  11. pmc Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States
    S Garud
    The Celiac Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Aliment Pharmacol Ther 29:898-905. 2009
    ..Previous studies yielded conflicting results regarding the presence of an association between coeliac disease (CD) and psychiatric disorders including depression. This association has not been studied in the United States...
  12. doi request reprint The hedgehog pathway regulates remodelling responses to biliary obstruction in rats
    A Omenetti
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Gut 57:1275-82. 2008
    ..The hedgehog (Hh) pathway becomes activated in liver after bile duct ligation (BDL), and might modulate hepatic remodelling because Hh ligands are potent morphogens...
  13. doi request reprint Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C
    K Yanagisawa
    Department of Medicine, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, MA, USA
    J Viral Hepat 20:556-65. 2013
    ..In contrast to hepatic iNKT, noninvariant IFNγ-producing type 2 CD1d-reactive NKT cells are commonly detected in CHC, together with cognate ligand CD1d, implicating them in CHC liver damage. ..
  14. ncbi request reprint A prospective comparative study of five measures of gluten-free diet adherence in adults with coeliac disease
    D A Leffler
    The Celiac Center, Beth Israel Deaconess Medical Center, Department of Gastroenterology, Boston, MA 02215, USA
    Aliment Pharmacol Ther 26:1227-35. 2007
    ..The only accepted treatment for coeliac disease is lifelong adherence to a strict gluten-free diet (GFD). Individuals' ability to adhere to the GFD varies, but systematic studies guiding the assessment of adherence are currently lacking...
  15. pmc Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis
    Yury Popov
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Physiol Gastrointest Liver Physiol 298:G323-34. 2010
    ....
  16. ncbi request reprint Turning swords into plowshares: transglutaminase to detoxify gluten
    Detlef Schuppan
    Gastroenterology 133:1025-8. 2007
  17. ncbi request reprint Hepatocellular carcinomas do not compromise quantitative tests of liver function
    Marion Ganslmayer
    Department of Internal Medicine I, University of Erlangen Nuernberg, Germany
    Hepatogastroenterology 52:881-4. 2005
    ..If and how far hepatoma growth influences liver function is unclear. Therefore, we compared a broad panel of quantitative tests of liver function in cirrhotic patients with and without hepatocellular carcinoma...
  18. ncbi request reprint Successful treatment of hepatitis C reinfection with interferon-alpha2b and ribavirin after liver transplantation
    Suleyman Yedibela
    Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    Liver Int 25:717-22. 2005
    ..The aim of this study was to evaluate the safety and efficacy of interferon (IFN)-alpha2b plus ribavirin (RIBA) in the treatment of recurrent HCV after OLT over the long term...
  19. ncbi request reprint Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells
    Anja Schulze-Krebs
    Department of Medicine I, University of Erlangen Nuremberg, Germany
    Gastroenterology 129:246-58. 2005
    ....
  20. ncbi request reprint Monitoring nonresponsive patients who have celiac disease
    Norbert Krauss
    Department of Medicine I Gastroenterology, Hepatology, Pneumonology and Endocrinology, University Hospital, Ulmenweg 18, Erlangen 91054, Germany
    Gastrointest Endosc Clin N Am 16:317-27. 2006
    ..At present there is no effective treatment for type II RCD.Fig. 3 presents a proposed algorithm for monitoring patients who have ce-liac disease...
  21. ncbi request reprint Keratin variants associate with progression of fibrosis during chronic hepatitis C infection
    Pavel Strnad
    Department of Medicine, Palo Alto VA Medical Center, Palo Alto, CA 94304, USA
    Hepatology 43:1354-63. 2006
    ..The unique 100% segregation of the most common K8 variant, R341H, with an intronic deletion suggests that one of these two genetic changes might lead to the other...
  22. ncbi request reprint Iron, HCV, and liver cancer: hard metal setting the pace?
    Sebastian Mueller
    Gastroenterology 130:2229-34. 2006
  23. ncbi request reprint Etiologies and predictors of diagnosis in nonresponsive celiac disease
    Daniel A Leffler
    Department of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Clin Gastroenterol Hepatol 5:445-50. 2007
    ..The aim of this study was to determine the common etiologies of NRCD in a tertiary referral center...
  24. pmc Factors that influence adherence to a gluten-free diet in adults with celiac disease
    Daniel A Leffler
    Department of Gastroenterology, The Celiac Center, Dana 501, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Dig Dis Sci 53:1573-81. 2008
    ..The purpose of this study was to determine factors influencing gluten-free diet adherence in adults with celiac disease...
  25. ncbi request reprint Serum markers detect the presence of liver fibrosis: a cohort study
    William M C Rosenberg
    Liver Group, Division of Infection, Inflammation and Repair, University of Southampton, England SO16 6YD
    Gastroenterology 127:1704-13. 2004
    ..We developed a panel of sensitive automated immunoassays to detect matrix constituents and mediators of matrix remodeling in serum to evaluate their performance in the detection of liver fibrosis...
  26. ncbi request reprint The role of the immune response against tissue transglutaminase in the pathogenesis of coeliac disease
    Tobias Freitag
    Medical Department I, University of Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
    Autoimmun Rev 3:13-20. 2004
    ..Although no intestinal lesions were found, this observation lends support to the concept that the development of autoimmunity against TGase 2 is a pathological event that might ultimately lead to organ damage...
  27. ncbi request reprint Prognosis of a large cohort of patients with hepatocellular carcinoma in a single European centre
    Christoph Herold
    Department of Medicine I, Department of Surgery, Institute for Medical Statistics, Biometry and Epidemiology, University of Erlangen Nuernberg, Germany
    Liver 22:23-8. 2002
    ..Only a few follow up data are available for patients with hepatocellular carcinoma (HCC) in Europe and the USA. Therefore, we analysed all HCC patients admitted to our hospital between 1988 and 1999...
  28. ncbi request reprint Biomedicine. Gluten and the gut-lessons for immune regulation
    Detlef Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
    Science 297:2218-20. 2002
  29. ncbi request reprint [Prevalence of circulating autoantibodies in healthy individuals]
    Andreas Teubner
    Klinik fur Innere Medizin II, Klinikum Chemnitz gGmbH, Akademisches Lehrkrankenhaus der Universität Leipzig, Chemnitz
    Med Klin (Munich) 97:645-9. 2002
    ..Since only view studies exist on individuals without known diseases, we analyzed the prevalence of frequently determined autoantibodies in "healthy" individuals...
  30. ncbi request reprint A molecular warhead and its target: tissue transglutaminase and Celiac Sprue
    Detlef Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, Ulmenweg 18, 91054 Erlangen, Germany
    Chem Biol 10:199-201. 2003
    ..DON-modified peptides could be useful for the study and therapy of celiac sprue...
  31. ncbi request reprint Innate immunity and coeliac disease
    Detlef Schuppan
    First Department of Medicine, University of Erlangen Nuernberg, 91054, Erlangen, Germany
    Lancet 362:3-4. 2003
  32. pmc Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
    Eleonora Patsenker
    Institute of Clinical Pharmacology, University of Bern, Bern, Switzerland
    Gastroenterology 135:660-70. 2008
    ..Because its role in liver fibrosis is unknown, we studied alphavbeta6 function in vitro and explored the antifibrotic potential of the specific alphavbeta6 antagonist EMD527040...
  33. pmc Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells
    Benjamin Schaefer
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 162:1771-80. 2003
    ..Overall, these findings strongly support the notion that alpha1(I) collagen and matrix metalloproteinase-13 mRNAs are reciprocally modulated...
  34. ncbi request reprint Integrin-mediated control of cell growth
    Detlef Schuppan
    Hepatology 38:289-91. 2003
  35. ncbi request reprint Liver-homing of purified glucose oxidase: a novel in vivo model of physiological hepatic oxidative stress (H2O2)
    Daniel Rost
    Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    J Hepatol 46:482-91. 2007
    ..Reactive oxygen species (ROS), such as H2O2, are implicated in normal and pathological liver function. However, due to the lack of suitable in vivo models of ROS generation the (patho) physiological relevance of H2O2 remains controversial...
  36. ncbi request reprint Synthesis of collagen I in collagenous sprue
    Severin Daum
    Department of Medicine I, Gastroenterology, Infectious Diseases and Rheumatology, Universitatsmedizin Berlin, Berlin, Germany
    Clin Gastroenterol Hepatol 4:1232-6. 2006
    ..We studied the expression patterns of genes involved in fibrogenesis and fibrolysis and analyzed the composition of the subepithelial collagen band in CS compared with untreated celiac diseases (CDs)...
  37. ncbi request reprint Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer
    Alexander Huether
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Berlin, Germany
    World J Gastroenterol 12:5160-7. 2006
    ..To examine the underlying mechanisms of erlotinib-induced growth inhibition in hepatocellular carcinoma (HCC)...
  38. ncbi request reprint Matrix metalloproteinases in necrotising enterocolitis
    Sylvia Lin Foon Pender
    Division of Infection, Inflammation and Repair, Mailpoint 813, Level E, South Academic Block, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Pediatr Res 54:160-4. 2003
    ..These results suggest that stromelysin-1, which has the ability to degrade the mucosal extra-cellular matrix, may be responsible for the extensive tissue injury in infants with NEC...
  39. pmc Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer
    Michael Hopfner
    World J Gastroenterol 14:1-14. 2008
    ....
  40. doi request reprint Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
    Yury Popov
    Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Hepatol 48:453-64. 2008
    ..We studied alphavbeta6 expression in experimental and human liver fibrosis and the potential of its pharmacological inhibition for treatment of hepatic fibrosis...
  41. ncbi request reprint Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    Krista Rombouts
    Laboratory for Molecular Liver Cell Biology, Faculty of Medicine and Pharmacy, Free University of Brussels VUB, Laarbeeklaan 103, 1090 Brussels Jette, Belgium
    J Hepatol 38:564-72. 2003
    ..We investigated the effect of two statins on the proliferation rate and protein steady state levels of hepatic stellate cells (HSC)...
  42. doi request reprint No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Switzerland
    Alcohol Clin Exp Res 32:959-65. 2008
    ..We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics...
  43. ncbi request reprint Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis
    Herbert Tilg
    Department of Medicine, Division of Gastroenterology and Hepatology, University Hospital Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    J Hepatol 38:419-25. 2003
    ..Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNFalpha) has been demonstrated to play an important role in its pathophysiology...
  44. ncbi request reprint Portal vein arterialisation as a technical option in liver transplantation: impact on function, regeneration, and morphology of the liver following hemihepatectomy in pigs
    Rudolf Ott
    Department of Surgery, University of Leipzig, Leipzig, Germany
    Liver Int 23:54-62. 2003
    ..Arterialisation of the portal vein has been propagated as a technical variant in liver transplantation. However, the consequences of this unphysiological vascular supply are insufficiently known...
  45. ncbi request reprint Can quantitative tests of liver function discriminate between different etiologies of liver cirrhosis?
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Germany
    Dig Dis Sci 47:2669-73. 2002
    ..In conclusion, QTLF in ALC and VIC patients was more reduced than in patients with PBC. This may be due to saturation of enzymes in ALC and ongoing inflammation in VIC...
  46. ncbi request reprint Hepatic fibrosis: from bench to bedside
    Detlef Schuppan
    Department of Medicine I, Division of Gastroenterology, Hepatology and Infectiology, University of Erlangen Nuernberg, Germany
    J Gastroenterol Hepatol 17:S300-5. 2002
    ..Combined with the evolving validation of serological markers of fibrogenesis and fibrolysis an effective and individualized treatment of liver fibrosis can be anticipated...
  47. ncbi request reprint Autoimmunity and HCV infection in porphyria cutanea tarda: a controlled study
    Ulrich Stölzel
    Department of Gastroenterology, Medizinische Klinik II, Klinikum Chernitz GmbH, Teaching Hospital of the University of Leipzig, Germany
    Cell Mol Biol (Noisy-le-grand) 48:43-7. 2002
    ..However, a higher prevalence of HCV infection and systemic lupus erythematosus in patients with porphyria cutanea tarda was confirmed...
  48. ncbi request reprint Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases
    Johannes Hansler
    Department of Medicine, Friedrich Alexander University, Erlangen Nuremberg, Germany
    World J Gastroenterol 12:3716-21. 2006
    ..To assess if a specific cytotoxic T cell response can be induced in patients with malignant liver tumors treated with radio-frequency ablation (RFA)...
  49. ncbi request reprint Human intestinal fibroblasts prevent apoptosis in human intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4, and nerve growth factor
    Gernot Sellge
    Department of Gastroenterology, Hepatology, and Endocrinology, Medical School of Hannover, Hannover, Germany
    J Immunol 172:260-7. 2004
    ..Such interactions between MCs and FBs may explain why MCs accumulate at sites of inflammatory bowel disease and intestinal fibrosis...
  50. ncbi request reprint Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha
    Dariusz Marek Lebensztejn
    IIIrd Department of Pediatrics, Medical University of Bialystok, Poland
    World J Gastroenterol 12:3338-43. 2006
    ..To evaluate prospectively 4 selected serum fibrosis markers (tenascin, hyaluronan, collagen VI, TIMP-1) before, during and 12 mo after IFN treatment of children with chronic hepatitis B...
  51. ncbi request reprint Serum fibrosis markers as predictors of an antifibrotic effect of interferon alfa in children with chronic hepatitis B
    Dariusz M Lebensztejn
    IIIrd Dept of Pediatrics, Medical University, Bialystok, Poland
    Eur J Gastroenterol Hepatol 17:843-8. 2005
    ..We evaluated prospectively four selected serum fibrosis markers before, immediately after and 12 months after IFN treatment of children with chronic hepatitis B (CHB)...
  52. ncbi request reprint Potentiated anticancer effects on hepatoma cells by the retinoid adapalene
    Matthias Ocker
    Department of Internal Medicine I, University Erlangen Nuernberg, Ulmenweg 18, D 91054 Erlangen, Germany
    Cancer Lett 208:51-8. 2004
    ..3 in hepatoma cells. ADA inhibits hepatoma cell growth in vitro and is a powerful inducer of hepatoma cell apoptosis...
  53. ncbi request reprint The combination of tamoxifen and 9cis retinoic acid exerts overadditive anti-tumoral efficacy in rat hepatocellular carcinoma
    Marion Ganslmayer
    Department of Internal Medicine I, University Erlangen Nuernberg, Ulmenweg 18, D 91054 Erlangen, Germany
    J Hepatol 40:952-6. 2004
    ..While an acyclic retinoid improved tumor-free survival after hepatoma resection, tamoxifen finally proved ineffective. Combination therapy of both agents has not been investigated in vitro and in vivo...
  54. ncbi request reprint TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Medical University of Vienna, Austria
    Cytokine 31:142-8. 2005
    ..8 (95% CI 1.4-5.7, p = 0.004). In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg...
  55. ncbi request reprint Pathomechanisms in celiac disease
    Frits Koning
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, P O Box 9600, 2300 RC Leiden, The Netherlands
    Best Pract Res Clin Gastroenterol 19:373-87. 2005
    ..Together, these observations provide a unique explanation for the disease inducing capacity of gluten...
  56. ncbi request reprint Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Hepatol 42:914-9. 2005
    ..This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC...
  57. ncbi request reprint The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells
    Matthias Ocker
    Department of Medicine I, University of Erlangen Nuernberg, Ulmenweg 18, 91054, Erlangen, Germany
    J Cancer Res Clin Oncol 131:385-94. 2005
    ..The use of the triple combination could optimize treatment results in vivo and needs further evaluation...
  58. ncbi request reprint Hepatocyte growth factor and c-Met expression in rat and human liver fibrosis
    Thorsten Cramer
    Institute of Pathology, University of Muenster, Germany
    Liver Int 24:335-44. 2004
    ..Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes in vitro...
  59. ncbi request reprint Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
    Michael Hopfner
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Hindenburgdamm 30, 12200 Berlin, Germany
    J Hepatol 41:1008-16. 2004
    ..We therefore studied the antineoplastic potency of gefitinib in human HCC cells...
  60. ncbi request reprint Enhancement of the immune response to residual intrahepatic tumor tissue by laser-induced thermotherapy (LITT) compared to hepatic resection
    Christoph Isbert
    Depatment of Surgery, Klinikum Nuernberg Nord, Prof Ernst Nathan Strasse 1, D 90419 Nuernberg, Germany
    Lasers Surg Med 35:284-92. 2004
    ..The aim of the study was to evaluate the effect of LITT and hepatic resection on the immune response to residual intrahepatic tumor tissue and the growth of untreated liver metastases...
  61. ncbi request reprint A quadruple therapy synergistically blocks proliferation and promotes apoptosis of hepatoma cells
    Marion Ganslmayer
    Medical Department I, University of Erlangen Nuernberg, D 91054 Erlangen, Germany
    Oncol Rep 11:943-50. 2004
    ..While the single substances were not effective on hepatoma cells in tolerable doses, their combination significantly increases anti-tumoral efficacy. Combination therapy with biomodulators is a promising treatment option for HCC...
  62. ncbi request reprint The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells
    Christoph Herold
    Department of Medicine I, University of Erlangen Nuernberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    J Hepatol 36:233-40. 2002
    ..The histone-deacetylase inhibitor Trichostatin A (TSA) was shown to induce apoptosis in non-hepatic cells at submicromolar concentrations. However, the effect of TSA on hepatoma cells is unknown...
  63. ncbi request reprint Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
    Karine Hellemans
    Lab Molecular Liver Cell Biology, Free University Brussels, Brussels, Belgium
    Hepatology 39:97-108. 2004
    ..Our observations may explain prior divergent results obtained following retinoid administration to cultured stellate cells or to animals subjected to fibrogenic stimuli...
  64. ncbi request reprint Matrix metalloproteinase pattern in celiac duodenal mucosa
    Rachele Ciccocioppo
    Gastroenterology Unit, IRCCS Policlinico San Matteo, University of Pavia, Italy
    Lab Invest 85:397-407. 2005
    ..In conclusion, our results show the presence of a peculiar MMP pattern in active CD strongly dominated by MMP-12, correlating either with IFN-gamma or the degree of mucosal damage...
  65. ncbi request reprint Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells
    Michael Hopfner
    Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, 12200 Berlin, Germany
    Biochem Pharmacol 71:1435-48. 2006
    ..Here we studied the antineoplastic effects of inhibiting IGF-1R signaling in HCC cells by the novel IGF-1R tyrosine kinase inhibitor NVP-AEW541...
  66. ncbi request reprint Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB
    Yury Popov
    Department of Medicine I, University of Erlangen Nuernberg, 91054 Erlangen, Germany
    J Biol Chem 281:15090-8. 2006
    ..The remarkable induction of MMP-3 and -13 makes HAL a promising agent for antifibrotic combination therapies...
  67. ncbi request reprint Efficacy and tolerability of pegylated IFN-alpha in patients with neuroendocrine gastroenteropancreatic carcinomas
    Marianne E Pavel
    Department of Medicine I, University Hospital Erlangen Nuremberg, 91054 Erlangen, Germany
    J Interferon Cytokine Res 26:8-13. 2006
    ..Better tolerability of PEG-IFN-alpha2b improved patients' compliance, justifying its use in patients who do not tolerate conventional IFN-alpha treatment...
  68. ncbi request reprint EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer
    Alexander Huether
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Gastroenterology Infectious Diseases Rheumatology, Hindenburgdamm 30, 12200 Berlin, Germany
    Biochem Pharmacol 70:1568-78. 2005
    ..To conclude, our study may provide a rationale for future clinical investigations of cetuximab combination therapy for growth control of hepatocellular cancer...
  69. ncbi request reprint Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes
    Yury Popov
    Laboratory of Liver Research, Department of Medicine I, University of Erlangen Nuremberg, Germany Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Hepatol 43:1045-54. 2005
    ..Mdr2 (Abcb4)-/- mice develop hepatic lesions resembling primary sclerosing cholangitis. Our aim was to characterize the evolution of fibrosis in Mdr2-/- mice...
  70. ncbi request reprint Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis
    Felix Stickel
    Department of Medicine I, University of Erlangen Nurnberg, Erlangen, Germany
    Arch Intern Med 165:1835-40. 2005
    ..Our objective was to establish the role of the functional polymorphisms of GSTP1 (codon 105 Ile-->Val) and MnSOD (codon 16 of precursor protein Ala-->Val) on the evolution of cirrhosis in patients with HHC and CHC...
  71. ncbi request reprint Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor
    Andreas P Sutter
    Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Medical Clinic I, Berlin, Germany
    J Hepatol 43:808-16. 2005
    ..We additionally investigated the potential benefit of a combination of peripheral benzodiazepine receptor (PBR) ligands and statins...
  72. ncbi request reprint Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics
    Alexander Huether
    Gastroenterology Infectious Diseases Rheumatology, Medical Clinic I, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany
    J Hepatol 43:661-9. 2005
    ..Several reports indicate that EGFRs are expressed frequently in HCC, most likely contributing to the aggressive growth characteristics of these tumors...
  73. ncbi request reprint Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1
    Andreas P Sutter
    Medical Clinic I, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Hepatol 41:799-807. 2004
    ..Thus, novel therapies are urgently needed. A promising approach is the use of peripheral benzodiazepine receptor (PBR) ligands which inhibit the proliferation of various tumors...

Research Grants5

  1. Mouse Models for Celiac Disease
    Detlef Schuppan; Fiscal Year: 2007
    ..g. by immunomodulatory cytokines or by cytokine antagonists. It is anticipated that the results will improve our understanding and management of cd and related autoimmune diseases. ..
  2. Identification of Serum Markers of Liver Fibrogenesis/ Fibrolysis by Proteomics
    Detlef Schuppan; Fiscal Year: 2007
    ..Adaptation to the human proteome and prospective validation shall allow noninvasive monitoring of fibrosis progression and regression in patients with liver diseases. ..