P Christian Schulze

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
    P Christian Schulze
    Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:33-40. 2003
  2. ncbi Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure
    P Christian Schulze
    Cardiovascular Research, Partners Research Facility, 65 Landsdowne Street, Room 289, Cambridge, MA 02139, USA
    Basic Res Cardiol 98:267-74. 2003
  3. ncbi Leptin as a new diagnostic tool in chronic heart failure
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Clin Chim Acta 362:1-11. 2005
  4. ncbi Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure
    P Christian Schulze
    University of Leipzig, Heart Center, Department of Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 11:155-61. 2004
  5. ncbi Insulin-like growth factor-1 and muscle wasting in chronic heart failure
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Int J Biochem Cell Biol 37:2023-35. 2005
  6. doi Markers of extracellular matrix turnover and the development of right ventricular failure after ventricular assist device implantation in patients with advanced heart failure
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 31:37-45. 2012
  7. doi Hepatic dysfunction in ambulatory patients with heart failure: application of the MELD scoring system for outcome prediction
    Margaret S Kim
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    J Am Coll Cardiol 61:2253-61. 2013
  8. ncbi Increased levels of retinol binding protein 4 in patients with advanced heart failure correct after hemodynamic improvement through ventricular assist device placement
    Nelson Chavarria
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ J 76:2148-52. 2012
  9. doi Value of peak exercise oxygen consumption combined with B-type natriuretic peptide levels for optimal timing of cardiac transplantation
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 6:6-14. 2013
  10. doi Cardiac transplantation in patients with hypertrophic cardiomyopathy
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    Am J Cardiol 110:568-74. 2012

Detail Information

Publications50

  1. ncbi Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure
    P Christian Schulze
    Department of Cardiology, University of Leipzig, Heart Center, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Heart Fail 5:33-40. 2003
    ..This finding indicates that leptin may participate in the catabolic state leading to the development of cardiac cachexia in the course of CHF...
  2. ncbi Muscular levels of proinflammatory cytokines correlate with a reduced expression of insulinlike growth factor-I in chronic heart failure
    P Christian Schulze
    Cardiovascular Research, Partners Research Facility, 65 Landsdowne Street, Room 289, Cambridge, MA 02139, USA
    Basic Res Cardiol 98:267-74. 2003
    ....
  3. ncbi Leptin as a new diagnostic tool in chronic heart failure
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Clin Chim Acta 362:1-11. 2005
    ..We here review the current knowledge on cardiovascular effects of leptin and discuss its potential as a new therapeutic tool in chronic heart failure...
  4. ncbi Functional and morphological skeletal muscle abnormalities correlate with reduced electromyographic activity in chronic heart failure
    P Christian Schulze
    University of Leipzig, Heart Center, Department of Cardiology, Strumpellstrasse 39, 04289 Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 11:155-61. 2004
    ..The aim of this study was to investigate morphological, functional and electromyographical parameters of the skeletal muscle in CHF...
  5. ncbi Insulin-like growth factor-1 and muscle wasting in chronic heart failure
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02139, USA
    Int J Biochem Cell Biol 37:2023-35. 2005
    ....
  6. doi Markers of extracellular matrix turnover and the development of right ventricular failure after ventricular assist device implantation in patients with advanced heart failure
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 31:37-45. 2012
    ..The association between ECM turnover and right ventricular failure (RVF) development after left ventricular assist device (LVAD) implantation in patients with advanced heart failure (HF) was investigated...
  7. doi Hepatic dysfunction in ambulatory patients with heart failure: application of the MELD scoring system for outcome prediction
    Margaret S Kim
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    J Am Coll Cardiol 61:2253-61. 2013
    ....
  8. ncbi Increased levels of retinol binding protein 4 in patients with advanced heart failure correct after hemodynamic improvement through ventricular assist device placement
    Nelson Chavarria
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ J 76:2148-52. 2012
    ..Retinol binding protein 4 (RBP4) is an adipose tissue-derived protein with pro-diabetogenic effects. The aim of the present study was to investigate the relationship of RBP4 in patients with heart failure...
  9. doi Value of peak exercise oxygen consumption combined with B-type natriuretic peptide levels for optimal timing of cardiac transplantation
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 6:6-14. 2013
    ..B-type natriuretic peptide (BNP) is a useful prognostic marker in patients with heart failure...
  10. doi Cardiac transplantation in patients with hypertrophic cardiomyopathy
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    Am J Cardiol 110:568-74. 2012
    ..In conclusion, the post-transplant survival of those with HC did not differ from those of the subjects who underwent transplant for other non-HC indications...
  11. ncbi Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 279:30369-74. 2004
    ..These studies implicate reduced thioredoxin activity through interaction with Txnip as an important mechanism for vascular oxidative stress in diabetes mellitus...
  12. doi Risk stratification of ambulatory patients with advanced heart failure undergoing evaluation for heart transplantation
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Center for Advanced Cardiac Care, Columbia University Medical Center, New York, NY 10032, USA
    J Heart Lung Transplant 32:333-40. 2013
    ..We hypothesized that right ventricular stroke work index (RVSWI), pulmonary capillary wedge pressure (PCWP) and the model for end-stage liver disease-albumin score (MELD-A) would be additive prognostic predictors...
  13. doi Outcome of patients with cardiac sarcoidosis undergoing cardiac transplantation--single-center retrospective analysis
    Hirokazu Akashi
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY, USA
    J Cardiol 60:407-10. 2012
    ..Recent data from the United Network for Organ Sharing dataset suggest that the clinical outcome of cardiac sarcoidosis patients is equivalent or even better than that of the general HTx population...
  14. pmc Hepatic dysfunction and survival after orthotopic heart transplantation: application of the MELD scoring system for outcome prediction
    Aalap Chokshi
    Department of Medicine, Division of Cardiology, New York Presbyterian Hospital Columbia University Medical Center, New York, NY 10032, USA
    J Heart Lung Transplant 31:591-600. 2012
    ..Advanced HF is associated with congestive hepatopathy and progressive functional and ultrastructural changes of the liver. We hypothesized that hepatic dysfunction is associated with impaired clinical outcome after heart transplantation...
  15. ncbi Nitric oxide-dependent suppression of thioredoxin-interacting protein expression enhances thioredoxin activity
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 26:2666-72. 2006
    ..We show the NO-dependent transcriptional regulation of the antioxidative thioredoxin system...
  16. ncbi Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction
    P Christian Schulze
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 97:418-26. 2005
    ....
  17. doi Preoperative assessment of high-risk candidates to predict survival after heart transplantation
    P Christian Schulze
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 6:527-34. 2013
    ..Alternate waiting list strategies expand listing criteria for patients awaiting heart transplantation (HTx). We retrospectively analyzed clinical events and outcome of patients listed as high-risk recipients for HTx...
  18. pmc Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance
    Ji Yeon Shin
    Department of Medicine, College of Physicians and Surgeons, Columbia University, 630 West 168 th Street, New York, NY 10032, USA Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, 630 West 168 th Street, New York, NY 10032, USA
    Dev Cell 26:591-603. 2013
    ..They also highlight how dissecting differences between mouse and human phenotypes can provide fundamental insights into disease mechanisms. ..
  19. doi Preoperative serum albumin levels predict 1-year postoperative survival of patients undergoing heart transplantation
    Tomoko S Kato
    Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 6:785-91. 2013
    ..The purpose of this study was to investigate the impact of pretransplant serum albumin concentration on post-transplant outcome in heart transplant recipients...
  20. doi Asymmetric pattern of cerebrovascular lesions in patients after left ventricular assist device implantation
    Tomoko S Kato
    Columbia University Medical Center, Department of Medicine, Division of Cardiology, 622 West 168th St, New York, NY 10032, USA
    Stroke 43:872-4. 2012
    ..Stroke is a major adverse event after left ventricular assist device (LVAD) surgery. The purpose of this study was to describe differences in hemispheric distribution of stroke in LVAD patients...
  21. pmc Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure
    Aalap Chokshi
    Columbia University Medical Center, Center for Advanced Cardiac Care, Department of Medicine, Division of Cardiology, 622 W 168th St, PH 10, Room 203, New York, NY 10032, USA
    Circulation 125:2844-53. 2012
    ..We hypothesized that cardiac accumulation of toxic lipid intermediates inhibits insulin signaling in advanced heart failure and that mechanical unloading of the failing myocardium corrects impaired cardiac metabolism...
  22. pmc Effects of continuous-flow versus pulsatile-flow left ventricular assist devices on myocardial unloading and remodeling
    Tomoko S Kato
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Circ Heart Fail 4:546-53. 2011
    ..We analyzed the effects of ventricular decompression by continuous-flow versus pulsatile-flow LVADs on myocardial structure and function in this population...
  23. ncbi Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells
    George C Cheng
    Joint Center for Radiation Therapy, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Exp Cell Res 300:297-307. 2004
    ....
  24. ncbi Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload
    Jun Yoshioka
    Cardiovascular Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circ Res 101:1328-38. 2007
    ..These results support the emerging concept that the function of Txnip is not as a simple thioredoxin inhibitor but as a metabolic control protein...
  25. ncbi Proinflammatory cytokines and skeletal muscle
    Ulrike Späte
    The Forsyth Institute, Department of Cytokine Biology, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 7:265-9. 2004
    ..In addition, the underlying molecular signaling pathways, their transcriptional regulation, and the cellular systems contributing to enhanced muscular protein breakdown are discussed...
  26. pmc Cardiac lipotoxicity: molecular pathways and therapeutic implications
    Konstantinos Drosatos
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Curr Heart Fail Rep 10:109-21. 2013
    ....
  27. pmc Dynamics of bone turnover markers in patients with heart failure and following haemodynamic improvement through ventricular assist device implantation
    Christina Wu
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Eur J Heart Fail 14:1356-65. 2012
    ..We hypothesized that mechanical unloading through implantation of a ventricular assist device (VAD) with subsequent haemodynamic improvement would correct abnormal bone metabolism in patients with advanced HF...
  28. doi Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure
    Stewart H Lecker
    Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Circ Heart Fail 5:812-8. 2012
    ....
  29. ncbi Supplementation of glutamine and omega-3 polyunsaturated fatty acids as a novel therapeutic intervention targeting metabolic dysfunction and exercise intolerance in patients with heart failure
    Khurram Shahzad
    Department of Medicine, Division of Cardiology, New York Presbyterian Hospital Columbia University MedicalCenter, USA
    Curr Clin Pharmacol 6:288-94. 2011
    ..These two compounds are of particular interest due to their synergistic role on oxidative metabolism, lipolysis and inflammation...
  30. doi Episodes of acute heart failure syndrome are associated with increased levels of troponin and extracellular matrix markers
    Andreia Biolo
    Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Circ Heart Fail 3:44-50. 2010
    ..We tested the hypothesis that episodes of acute HF syndrome (AHFS) are associated with transient increases in markers of myocyte injury and ECM turnover beyond those observed in chronic stable HF...
  31. ncbi Biomechanically induced gene iex-1 inhibits vascular smooth muscle cell proliferation and neointima formation
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02139, USA
    Circ Res 93:1210-7. 2003
    ..These findings suggest that the induction of iex-1 represents a novel negative biomechanical feedback mechanism limiting the vascular response to injury...
  32. doi Pre-operative echocardiographic features associated with persistent mitral regurgitation after left ventricular assist device implantation
    Shuichi Kitada
    Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 32:897-904. 2013
    ..However, a certain number of patients continue to have significant mitral regurgitation (MR) under LVAD support. We investigated pre-operative echocardiographic features associated with persistent MR after LVAD implantation...
  33. doi PET imaging may provide a novel biomarker and understanding of right ventricular dysfunction in patients with idiopathic pulmonary arterial hypertension
    Sabahat Bokhari
    Division of Cardiology, Department of Medicine, New York Presbyterian Hospital at Columbia University Medical Center, New York, NY 10032, USA
    Circ Cardiovasc Imaging 4:641-7. 2011
    ..The objective is to develop PET metabolic imaging of the RV as a noninvasive tool in patients with PAH...
  34. doi Pre-operative and post-operative risk factors associated with neurologic complications in patients with advanced heart failure supported by a left ventricular assist device
    Tomoko S Kato
    Division of Cardiology, Department of Medicine, Department of Surgery, Columbia University Medical Center, New York, New York, USA
    J Heart Lung Transplant 31:1-8. 2012
    ..Neurologic complications (NCs) are the major adverse events after left ventricular assist device (LVAD) surgery. Pre-operative and post-operative factors associated with NCs in patients with LVADs were investigated...
  35. pmc Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
    Jan Lammerding
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Clin Invest 113:370-8. 2004
    ..These findings suggest that the tissue-specific effects of lamin A/C mutations observed in the laminopathies may arise from varying degrees of impaired nuclear mechanics and transcriptional activation...
  36. pmc Metabolism of the right ventricle and the response to hypertrophy and failure
    S Elissa Altin
    Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York 10032, USA
    Prog Cardiovasc Dis 55:229-33. 2012
    ....
  37. doi Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes
    Raju V S R K Gottumukkala
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Transl Med 4:138ra80. 2012
    ..Our findings suggest that PIA may contribute to worsened post-MI outcomes in T1D and highlight a role for antigen-specific immunointervention to selectively block this pathway...
  38. pmc Lipid metabolism and toxicity in the heart
    Ira J Goldberg
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 15:805-12. 2012
    ..Finally, the known relationships between heart lipid metabolism and dysfunction in humans will be summarized...
  39. ncbi Oxidative stress and atherosclerosis
    P Christian Schulze
    Cardiovascular Research, Partners Research Facility, 65 Landsdowne Street, Room 279, Cambridge, MA 02139, USA
    Curr Atheroscler Rep 7:242-8. 2005
    ..Further, it contributes to mechanisms of disease progression such as lipid oxidation and vascular remodeling. This article reviews the role of reactive oxygen species and oxidative stress in atherosclerosis...
  40. pmc Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells
    Jan Lammerding
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 170:781-91. 2005
    ....
  41. doi Epicardial fat volume in patients with left ventricular systolic dysfunction
    Tuba Khawaja
    Division of Cardiology, Department of Medicine, New York Presbyterian Hospital Columbia University Medical Center, New York, USA
    Am J Cardiol 108:397-401. 2011
    ..In conclusion, our data demonstrate a stepwise decrease in EFV in patients with impaired cardiac function...
  42. pmc Exercise as a nonpharmacologic intervention in patients with heart failure
    Christine J Chung
    Department of Medicine, Columbia University Medical Center, New York, NY, USA
    Phys Sportsmed 39:37-43. 2011
    ....
  43. ncbi Thioredoxin-interacting protein controls cardiac hypertrophy through regulation of thioredoxin activity
    Jun Yoshioka
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 109:2581-6. 2004
    ..Because thioredoxin is a major intracellular antioxidant and can also regulate redox-dependent transcription, we explored the role of thioredoxin activity in mechanically overloaded cardiomyocytes in vitro and in vivo...
  44. ncbi Proatherogenic pathways leading to vascular calcification
    Michael J Mazzini
    Department of Cardiology, Boston University Medical Center, Boston, MA 02118 2526, USA
    Eur J Radiol 57:384-9. 2006
    ..We here review the current knowledge on molecular pathways of vascular calcification and their relevance for the progression of cardiovascular disease...
  45. ncbi Vitamin D3-upregulated protein-1 (VDUP-1) regulates redox-dependent vascular smooth muscle cell proliferation through interaction with thioredoxin
    P Christian Schulze
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circ Res 91:689-95. 2002
    ..These data also demonstrate that activation of the reductase TRX plays a pivotal role in the redox-dependent proliferation of SMCs...
  46. ncbi Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes
    Tomosaburo Takahashi
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 107:1912-6. 2003
    ..In appropriate culture conditions, ES cells can differentiate into specialized cells, including cardiac myocytes, but the efficiency is typically low and the process is incompletely understood...
  47. ncbi Macrophage-mediated cardiac fibrosis
    P Christian Schulze
    Circ Res 95:552-3. 2004
  48. ncbi Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training
    Brian D Duscha
    Duke University Medical Center, Box 3022, Durham, NC 27710, USA
    Heart Fail Rev 13:21-37. 2008
    ..We also identify gaps in the literature that may constitute priorities for further investigation...
  49. pmc TXNIP regulates peripheral glucose metabolism in humans
    Hemang Parikh
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    PLoS Med 4:e158. 2007
    ..Impaired glucose uptake in skeletal muscle is believed to be one of the earliest features in the natural history of T2DM, although underlying mechanisms remain obscure...
  50. ncbi Periprocedural kinetics in serum levels of cytokines and adhesion molecules in elective PTCA and stent implantation: impact on restenosis
    P Christian Schulze
    Arterioscler Thromb Vasc Biol 22:2105-7. 2002