Uwe Schonbeck

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Soluble CD40L and cardiovascular risk in women
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:2266-8. 2001
  2. pmc T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 161:499-506. 2002
  3. ncbi request reprint Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:2888-93. 2002
  4. ncbi request reprint Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells
    Kikuo Isoda
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:611-7. 2006
  5. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
  6. ncbi request reprint Influence of pre-analytical and analytical factors on soluble CD40L measurements
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 741, Boston, MA 02115, USA
    Clin Sci (Lond) 111:341-7. 2006
  7. ncbi request reprint Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study with high-resolution MRI
    Gavin J Blake
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 23:e11-4. 2003
  8. ncbi request reprint TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
  9. pmc Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells
    Alexandra Krettek
    Brigham and Womens Hospital, 77 Avenue Louis Pasteur, NRB 741, Boston, MA 02115, USA
    Am J Pathol 165:1571-81. 2004
  10. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007

Detail Information

Publications19

  1. ncbi request reprint Soluble CD40L and cardiovascular risk in women
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:2266-8. 2001
    ..It is unknown, however, whether elevations of circulating sCD40L precede the onset of acute cardiovascular symptoms...
  2. pmc T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 161:499-506. 2002
    ..These findings suggest that the functional repertoire of T cells differs in stenotic and aneurysmal lesions, and provide a novel framework for understanding the mechanisms of these diametrically opposite expressions of atherosclerosis...
  3. ncbi request reprint Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L expression in human vascular cells
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 106:2888-93. 2002
    ....
  4. ncbi request reprint Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells
    Kikuo Isoda
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Arterioscler Thromb Vasc Biol 26:611-7. 2006
    ..Therefore, this study examined the potential action of metformin as an inhibitor of pro-inflammatory responses in human vascular smooth muscle cells (SMCs), macrophages (Mphis), and endothelial cells (ECs)...
  5. ncbi request reprint CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  6. ncbi request reprint Influence of pre-analytical and analytical factors on soluble CD40L measurements
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 741, Boston, MA 02115, USA
    Clin Sci (Lond) 111:341-7. 2006
    ..Samples with high concentrations of bilirubin, haemoglobin and/or triacylglycerols should be excluded, as these substances interfere with the assay...
  7. ncbi request reprint Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study with high-resolution MRI
    Gavin J Blake
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 23:e11-4. 2003
    ..We tested the hypothesis that plasma levels of soluble CD40 ligand are elevated in patients with evidence of a lipid pool on high-resolution magnetic resonance imaging (MRI) of carotid stenoses...
  8. ncbi request reprint TRAF-1, -2, -3, -5, and -6 are induced in atherosclerotic plaques and differentially mediate proinflammatory functions of CD40L in endothelial cells
    Andreas Zirlik
    Donald W Reynolds Cardiovascular Research Center, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 27:1101-7. 2007
    ..This study investigated the involvement of tumor necrosis factor receptor-associated factors (TRAFs) in CD40 signaling in endothelial cells (ECs) and their expression in atheromata and cells involved in atherogenesis...
  9. pmc Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells
    Alexandra Krettek
    Brigham and Womens Hospital, 77 Avenue Louis Pasteur, NRB 741, Boston, MA 02115, USA
    Am J Pathol 165:1571-81. 2004
    ....
  10. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007
    ..Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population...
  11. ncbi request reprint Soluble CD40L: risk prediction after acute coronary syndromes
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 108:1049-52. 2003
    ..This study tested the hypothesis that plasma sCD40L, alone or in combination with troponin (cTnI) or C-reactive protein (CRP), may identify patients with acute coronary syndromes at heightened risk for recurrent cardiac events...
  12. ncbi request reprint Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products
    Nerea Varo
    Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Diab Vasc Dis Res 2:81-7. 2005
    ....
  13. ncbi request reprint Cytokines in the pathogenesis of atherosclerosis
    James L Young
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, EBRC 309a, Boston, MA, USA
    Thromb Haemost 88:554-67. 2002
    ..This review will focus on members of the interleukin, tumor necrosis factor, and interferon families of cytokines in modulating key processes of atherogenesis...
  14. ncbi request reprint Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?
    Uwe Schonbeck
    Leducq Center for Cardiovascular Research, Division of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 109:II18-26. 2004
    ..This overview addresses the controversy by reviewing in vitro and in vivo evidence regarding statins as antiinflammatory agents...
  15. ncbi request reprint Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones
    Nerea Varo
    Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, Mass 02115, USA
    Circulation 107:2664-9. 2003
    ..This study therefore evaluated the hypothesis that diabetic patients have elevated plasma levels of soluble CD40L (sCD40L) and that treatment with the insulin-sensitizing thiazolidinediones lowers this index of inflammation...
  16. ncbi request reprint Atherogenesis in mice does not require CD40 ligand from bone marrow-derived cells
    Udo Bavendiek
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass02115, USA
    Arterioscler Thromb Vasc Biol 25:1244-9. 2005
    ....
  17. ncbi request reprint Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1
    Udo Bavendiek
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:25032-9. 2002
    ....
  18. pmc Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis
    Norbert Gerdes
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 195:245-57. 2002
    ....
  19. ncbi request reprint Family history of diabetes is a major determinant of endothelial function
    Allison B Goldfine
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 47:2456-61. 2006
    ..We evaluated whether endothelial dysfunction was present in nondiabetic persons with a family history (FH) of diabetes and assessed its relationship with insulin resistance and atherosclerosis risk factors...