Jörn E Schmitz

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Immunopathogenesis of simian immunodeficiency virus infection in nonhuman primates
    Joern E Schmitz
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin HIV AIDS 8:273-9. 2013
  2. pmc Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 5:e1000691. 2009
  3. pmc Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 113, 330 Brookline Ave, Boston, Massacusetts 02215, USA
    J Virol 79:8131-41. 2005
  4. ncbi request reprint Effect of complement consumption by cobra venom factor on the the course of primary infection with simian immunodeficiency virus in rhesus monkeys
    J E Schmitz
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    AIDS Res Hum Retroviruses 15:195-202. 1999
  5. ncbi request reprint Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys
    Sampa Santra
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1847-53. 2002
  6. ncbi request reprint Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys
    Paul F McKay
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Immunol 168:332-7. 2002
  7. ncbi request reprint Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes
    Yue Sun
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:4753-60. 2005
  8. ncbi request reprint A simian immunodeficiency virus nef peptide is a dominant cytotoxic T lymphocyte epitope in Indian-origin rhesus monkeys expressing the common MHC class I allele mamu-A*02
    Michael H Newberg
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Virology 301:365-73. 2002
  9. ncbi request reprint Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys
    Paula M Acierno
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
    J Immunol 176:5338-45. 2006
  10. pmc Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection
    Sampa Santra
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 76:6376-81. 2002

Research Grants

  1. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2001
  2. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2002
  3. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2003
  4. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2004
  5. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2006
  6. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2007
  7. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2009

Collaborators

Detail Information

Publications34

  1. pmc Immunopathogenesis of simian immunodeficiency virus infection in nonhuman primates
    Joern E Schmitz
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin HIV AIDS 8:273-9. 2013
    ..Even after 3 decades, this animal model remains an invaluable tool to provide a greater insight into HIV immunopathogenesis. In this review, recent progress in deciphering pathways of immunopathogenesis in SIV-infected NHP is discussed...
  2. pmc Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 5:e1000691. 2009
    ..However, the maintenance of a disease-free course of SIV infection in AGM likely depends on a number of mechanisms including non-adaptive immune mechanisms...
  3. pmc Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 113, 330 Brookline Ave, Boston, Massacusetts 02215, USA
    J Virol 79:8131-41. 2005
    ....
  4. ncbi request reprint Effect of complement consumption by cobra venom factor on the the course of primary infection with simian immunodeficiency virus in rhesus monkeys
    J E Schmitz
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    AIDS Res Hum Retroviruses 15:195-202. 1999
    ..However, we cannot rule out that the observed increased virus replication was induced by immune activation resulting from the administration of a foreign antigen to these monkeys...
  5. ncbi request reprint Recombinant canarypox vaccine-elicited CTL specific for dominant and subdominant simian immunodeficiency virus epitopes in rhesus monkeys
    Sampa Santra
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 168:1847-53. 2002
    ..The later emerging CTL response specific for the subdominant epitope may contribute to the control of viral replication in the setting of chronic infection...
  6. ncbi request reprint Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys
    Paul F McKay
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Immunol 168:332-7. 2002
    ..Moreover, an AIDS vaccine that confers protection against clinical disease evolution in this experimental model also preserves the functional capacity of these CTL to produce both IL-2 and TNF-alpha...
  7. ncbi request reprint Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes
    Yue Sun
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:4753-60. 2005
    ..Persisting clinical protection in vaccinated and challenged monkeys is thus correlated with a preserved capacity of the peripheral blood central memory CD4+ T cells to express this important immunomodulatory cytokine...
  8. ncbi request reprint A simian immunodeficiency virus nef peptide is a dominant cytotoxic T lymphocyte epitope in Indian-origin rhesus monkeys expressing the common MHC class I allele mamu-A*02
    Michael H Newberg
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Virology 301:365-73. 2002
    ..Knowledge of this dominant CTL epitope should prove valuable in the evaluation of HIV vaccine strategies using this animal model...
  9. ncbi request reprint Preservation of functional virus-specific memory CD8+ T lymphocytes in vaccinated, simian human immunodeficiency virus-infected rhesus monkeys
    Paula M Acierno
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02115, USA
    J Immunol 176:5338-45. 2006
    ....
  10. pmc Prior vaccination increases the epitopic breadth of the cytotoxic T-lymphocyte response that evolves in rhesus monkeys following a simian-human immunodeficiency virus infection
    Sampa Santra
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 76:6376-81. 2002
    ..These data indicate that prior vaccination can increase the breadth of the CTL response that evolves after an AIDS virus infection...
  11. pmc Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease
    Roland C Zahn
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 115:3070-8. 2010
    ..Thus, adaptive immune responses in natural hosts appear to be less critical for viral containment than in HIV infection...
  12. pmc Magnitude and diversity of cytotoxic-T-lymphocyte responses elicited by multiepitope DNA vaccination in rhesus monkeys
    Ramu A Subbramanian
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Research East RE 113, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 77:10113-8. 2003
    ..These studies suggest that multiepitope plasmid DNA vaccine-based prime-boost regimens can efficiently prime for CTL responses of increased breadth and magnitude, although they do not overcome predicted hierarchies of immunodominance...
  13. pmc Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:4396-400. 2003
    ..These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies...
  14. pmc Global dysfunction of CD4 T-lymphocyte cytokine expression in simian-human immunodeficiency virus/SIV-infected monkeys is prevented by vaccination
    Paul F McKay
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:4695-702. 2003
    ....
  15. pmc Recombinant poxvirus boosting of DNA-primed rhesus monkeys augments peak but not memory T lymphocyte responses
    Sampa Santra
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:11088-93. 2004
    ..This study, therefore, indicates that the steady-state memory, rather than the peak effector vaccine-elicited T lymphocyte responses, may be the critical immune correlate of protection for a CTL-based HIV vaccine...
  16. pmc Evaluation of CD62L expression as a marker for vaccine-elicited memory cytotoxic T lymphocytes
    Shawn S Jackson
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Immunology 116:443-53. 2005
    ..Therefore, the definition of memory CD8(+) T-cell subpopulations on the basis of CD62L expression in mice does not allow the delineation of functionally distinct CTL subpopulations...
  17. ncbi request reprint Immunodomination in the evolution of dominant epitope-specific CD8+ T lymphocyte responses in simian immunodeficiency virus-infected rhesus monkeys
    Michael H Newberg
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 176:319-28. 2006
    ....
  18. pmc Subsets of memory cytotoxic T lymphocytes elicited by vaccination influence the efficiency of secondary expansion in vivo
    Michael S Seaman
    Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 78:206-15. 2004
    ..These observations suggest that CTL-based vaccines should elicit central memory rather than effector memory T cells and illustrate the importance of monitoring the phenotype and functionality of vaccine-induced, antigen-specific CTL...
  19. pmc Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm
    Roland C Zahn
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Virol 82:11577-88. 2008
    ..These observations demonstrate that natural hosts like SIV-infected vervet AGM develop SIV-specific T-cell responses, but the disease-free course of infection does not depend on the generation of robust CD8(+) T-cell responses...
  20. pmc Virus-specific cellular immune correlates of survival in vaccinated monkeys after simian immunodeficiency virus challenge
    Yue Sun
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RE113, Boston, MA 02215, USA
    J Virol 80:10950-6. 2006
    ..These findings underscore the contribution of virus-specific central memory T lymphocytes to controlling clinical progression in vaccinated individuals following a primate immunodeficiency virus infection...
  21. ncbi request reprint Expansion after epitope peptide exposure in vitro predicts cytotoxic T lymphocyte epitope dominance hierarchy in lymphocytes of vaccinated mamu-a*01+ rhesus monkeys
    Ramu A Subbramanian
    Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    AIDS Res Hum Retroviruses 22:445-52. 2006
    ..This finding underscores the enormous challenge associated with increasing the breadth of CTL recognition through vaccination...
  22. pmc Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus
    Jörn E Schmitz
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:2165-73. 2003
    ..However, the inverse correlation between neutralizing antibodies and plasma virus level during the postacute phases of infection suggests that humoral immune responses may contribute to the control of SIV replication...
  23. ncbi request reprint Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 190:998-1005. 2004
    ....
  24. pmc Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys
    Dan H Barouch
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:7367-75. 2003
    ..These data suggest that CTL exert selective pressure on viral replication and that viral escape from CTL may be a limitation of CTL-based AIDS vaccine strategies...
  25. pmc Magnitude and quality of vaccine-elicited T-cell responses in the control of immunodeficiency virus replication in rhesus monkeys
    Yue Sun
    Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 82:8812-9. 2008
    ..These observations highlight the contributions of both the quality and the magnitude of vaccine-elicited cellular immune responses in the control of immunodeficiency virus replication...
  26. ncbi request reprint Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity
    Ramu A Subbramanian
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Biotechnol 22:1429-34. 2004
    ..TCR tetramers should facilitate analysis of the MHC-peptide interface and, more generally, the design of immunotherapeutics and vaccines...
  27. pmc KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques
    Ina Hellmann
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 87:5305-10. 2013
    ..These findings underscore the crucial role of activating killer-cell immunoglobulin-like receptors (KIRs) in NK cell-mediated SIV responses during early SIV infection...
  28. ncbi request reprint Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
    Dan H Barouch
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Research East Room 113, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 415:335-9. 2002
    ..These data indicate that viral escape from CTL recognition may be a major limitation of the CTL-based AIDS vaccines that are likely to be administered to large human populations over the next several years...
  29. pmc Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses
    Edwin R Manuel
    Beth Israel Deaconess Medical Center, 41 Ave Louis Pasteur, Boston, MA 02115, USA
    J Virol 80:12032-40. 2006
    ....
  30. pmc Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeys
    Ina Hellmann
    Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 86:13103-7. 2012
    ....
  31. pmc Anti-gamma interferon antibodies enhance the immunogenicity of recombinant adenovirus vectors
    Shawn S Jackson
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Clin Vaccine Immunol 18:1969-78. 2011
    ..These observations illustrate the utility of an anti-IFN-γ Ab for potentiating rAd immunizations to effect quantitative and qualitative changes in the effector and memory CTL populations...
  32. pmc Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys
    Norman L Letvin
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 312:1530-3. 2006
    ..These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans...
  33. ncbi request reprint Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy patients with a CTL response specific for a commonly recognized JC virus epitope
    Igor J Koralnik
    Neurology Department, Beth Israel Deaconess Medical Center, RE 213B, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215
    J Immunol 168:499-504. 2002
    ..These data suggest that the JCV-specific cellular immune response may be important in the containment of PML, and the tetramer-staining assay may provide a useful prognostic tool in the clinical management of these patients...
  34. ncbi request reprint Clonotype tracking of TCR repertoires during chronic virus infections
    George B Cohen
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Virology 304:474-84. 2002
    ....

Research Grants8

  1. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2001
    ..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
  2. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2002
    ..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
  3. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2003
    ..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
  4. CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESIS
    JOERN SCHMITZ; Fiscal Year: 2004
    ..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
  5. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2006
    ..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. ..
  6. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2007
    ..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. ..
  7. Immune control of SIVagm replication in vivo
    JOERN SCHMITZ; Fiscal Year: 2009
    ..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. ..