Research Topics
| Jörn E SchmitzSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Effect of complement consumption by cobra venom factor on the the course of primary infection with simian immunodeficiency virus in rhesus monkeysJ E Schmitz
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
AIDS Res Hum Retroviruses 15:195-202. 1999..However, we cannot rule out that the observed increased virus replication was induced by immune activation resulting from the administration of a foreign antigen to these monkeys...
Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeysJörn E Schmitz
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
PLoS Pathog 5:e1000691. 2009..However, the maintenance of a disease-free course of SIV infection in AGM likely depends on a number of mechanisms including non-adaptive immune mechanisms...- Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaquesJörn E Schmitz
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 113, 330 Brookline Ave, Boston, Massacusetts 02215, USA
J Virol 79:8131-41. 2005.... - Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce diseaseRoland C Zahn
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Blood 115:3070-8. 2010..Thus, adaptive immune responses in natural hosts appear to be less critical for viral containment than in HIV infection... - Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virusJörn E Schmitz
Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 77:2165-73. 2003..However, the inverse correlation between neutralizing antibodies and plasma virus level during the postacute phases of infection suggests that humoral immune responses may contribute to the control of SIV replication... - Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagmRoland C Zahn
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Virol 82:11577-88. 2008..These observations demonstrate that natural hosts like SIV-infected vervet AGM develop SIV-specific T-cell responses, but the disease-free course of infection does not depend on the generation of robust CD8(+) T-cell responses... - Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeysDan H Barouch
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 77:7367-75. 2003..These data suggest that CTL exert selective pressure on viral replication and that viral escape from CTL may be a limitation of CTL-based AIDS vaccine strategies... - Magnitude and quality of vaccine-elicited T-cell responses in the control of immunodeficiency virus replication in rhesus monkeysYue Sun
Department of Medicine, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Virol 82:8812-9. 2008..These observations highlight the contributions of both the quality and the magnitude of vaccine-elicited cellular immune responses in the control of immunodeficiency virus replication... - Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytesDan H Barouch
Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Research East Room 113, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nature 415:335-9. 2002..These data indicate that viral escape from CTL recognition may be a major limitation of the CTL-based AIDS vaccines that are likely to be administered to large human populations over the next several years... - Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responsesEdwin R Manuel
Beth Israel Deaconess Medical Center, 41 Ave Louis Pasteur, Boston, MA 02115, USA
J Virol 80:12032-40. 2006.... - Activating KIR copy number variation is associated with granzyme B release by NK cells during primary simian immunodeficiency virus infection in rhesus monkeysIna Hellmann
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
J Virol 86:13103-7. 2012.... - Anti-gamma interferon antibodies enhance the immunogenicity of recombinant adenovirus vectorsShawn S Jackson
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Clin Vaccine Immunol 18:1969-78. 2011..These observations illustrate the utility of an anti-IFN-γ Ab for potentiating rAd immunizations to effect quantitative and qualitative changes in the effector and memory CTL populations... - Clonotype tracking of TCR repertoires during chronic virus infectionsGeorge B Cohen
Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
Virology 304:474-84. 2002.... - Association of prolonged survival in HLA-A2+ progressive multifocal leukoencephalopathy patients with a CTL response specific for a commonly recognized JC virus epitopeIgor J Koralnik
Neurology Department, Beth Israel Deaconess Medical Center, RE 213B, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215
J Immunol 168:499-504. 2002..These data suggest that the JCV-specific cellular immune response may be important in the containment of PML, and the tetramer-staining assay may provide a useful prognostic tool in the clinical management of these patients... - Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeysNorman L Letvin
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Science 312:1530-3. 2006..These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans...
Research Grants
- CD8 LYMPHOCYTE RESPONSES IN SIV PATHOGENESISJOERN SCHMITZ; Fiscal Year: 2004..Determine the contribution of CD8+ lymphocytes to the loss of CD4+ Tcells following infection by SIVmac or the rapidly CD4+T cell-depleting virus SHIV-KB9. ..
- Immune control of SIVagm replication in vivoJOERN SCHMITZ; Fiscal Year: 2007..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. ..
- Immune control of SIVagm replication in vivoJOERN SCHMITZ; Fiscal Year: 2009..3. Assess whether abolishing both cellular and humoral adaptive immune responses will affect the course of SIVagm infection of African green monkeys. ..