Emmett Schmidt

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Genome-wide analysis of YY2 versus YY1 target genes
    Li Chen
    Cancer Research Center at Massachusetts General Hospital, Boston, MA 02114, USA
    Nucleic Acids Res 38:4011-26. 2010
  2. pmc Genes involved in breast cancer progression: analysis of global changes in gene expression or retroviral tagging?
    Emmett V Schmidt
    Massachusetts General Hospital Cancer Center, Building 149, 7th Floor, 13th Street, Charlestown, MA 02129, USA
    Am J Pathol 161:1973-7. 2002
  3. pmc Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway
    Emmett V Schmidt
    Cancer Research Center at Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Cell Cycle 8:1344-51. 2009
  4. ncbi request reprint The role of c-myc in regulation of translation initiation
    Emmett V Schmidt
    Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Oncogene 23:3217-21. 2004
  5. pmc The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2
    Michael Zimmer
    Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Cancer Res 70:3071-9. 2010
  6. pmc Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expression
    Chuanwei Yang
    Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, GRJ 9th floor, Boston, MA 02114, USA
    Mol Cell Biol 30:3111-25. 2010
  7. ncbi request reprint Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth
    Mary Lynch
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    J Biol Chem 279:3327-39. 2004
  8. pmc c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation
    Michael J Ravitz
    Cancer Research Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:11209-17. 2007
  9. ncbi request reprint Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity
    Sally Trent
    Oxford Cancer Centre, Department of Radiotherapy, Churchill Hospital, Oxford, United Kingdom
    Cancer Res 67:10774-81. 2007
  10. ncbi request reprint Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression
    Chuanwei Yang
    Massachusetts General Hospital Cancer Research Center, Massachusetts General Hospital Cancer Center Harvard University, 55 Fruit Street, GRJ 904, Boston, MA 02114, USA
    Cancer Res 66:11649-58. 2006

Research Grants

  1. GENES REGULATED BY C MYC
    Emmett Schmidt; Fiscal Year: 2004
  2. FUNCTIONS OF CYCLIN D1 IN BREAST CANCER
    Emmett Schmidt; Fiscal Year: 2007

Collaborators

  • Li Chen
  • Othon Iliopoulos
  • Justin Lamb
  • Robert Darrell Cardiff
  • Toshihiro Shioda
  • R Nahta
  • Chuanwei Yang
  • Mary Lynch
  • Sally Trent
  • Michael J Ravitz
  • Michael Zimmer
  • Cuiqi Li
  • Eunice L Kwak
  • Dennis Sgroi
  • Viviana Ionescu-Tiba
  • Keiko Miyoshi
  • Mary C Lynch
  • Todd R Golub
  • Benjamin L Ebert
  • Christopher Neil
  • Cathrin Brisken
  • Sang Kim
  • Lan Lan
  • Daniel A Haber
  • Jianmin Zhang
  • Sapna Mehtani
  • Kevin Korenblat
  • Michael J Pazin
  • Chris Fitzgerald
  • Karen Burns
  • David N Louis
  • Shanping Wang
  • Michelle Gadd
  • Lawrence Zukerberg
  • Kelly A Johnston
  • Masahiro Nozawa
  • Christopher Byrd
  • Lothar Hennighausen
  • Gertraud W Robinson
  • Fanta Morgan
  • Makato M Taketo
  • Esther Landesman-Bollag
  • David C Seldin
  • Xin Xu
  • Andrea Rosner

Detail Information

Publications16

  1. pmc Genome-wide analysis of YY2 versus YY1 target genes
    Li Chen
    Cancer Research Center at Massachusetts General Hospital, Boston, MA 02114, USA
    Nucleic Acids Res 38:4011-26. 2010
    ..Our studies show that human YY2 is not redundant to YY1, and YY2 is a significant regulator of genes previously identified as uniquely responding to YY1...
  2. pmc Genes involved in breast cancer progression: analysis of global changes in gene expression or retroviral tagging?
    Emmett V Schmidt
    Massachusetts General Hospital Cancer Center, Building 149, 7th Floor, 13th Street, Charlestown, MA 02129, USA
    Am J Pathol 161:1973-7. 2002
  3. pmc Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway
    Emmett V Schmidt
    Cancer Research Center at Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Cell Cycle 8:1344-51. 2009
    ..Further experiments will be needed to clarify the mechanisms underlying this important connection, and evaluate its overall contribution to cancers caused by TSC loss or Myc gain...
  4. ncbi request reprint The role of c-myc in regulation of translation initiation
    Emmett V Schmidt
    Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Oncogene 23:3217-21. 2004
    ..The ability of translation initiation factors to affect both cell division control and cell growth control coincides with myc's remarkable effects on both cell growth and cell division...
  5. pmc The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2
    Michael Zimmer
    Center for Cancer Research, Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Cancer Res 70:3071-9. 2010
    ....
  6. pmc Cyclin D1 enhances the response to estrogen and progesterone by regulating progesterone receptor expression
    Chuanwei Yang
    Cancer Research Center at Massachusetts General Hospital, 55 Fruit Street, GRJ 9th floor, Boston, MA 02114, USA
    Mol Cell Biol 30:3111-25. 2010
    ..Additionally, its regulation of the progesterone receptor identifies a novel role for cyclin D1 in ovarian hormone control of breast development and breast carcinogenesis...
  7. ncbi request reprint Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth
    Mary Lynch
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    J Biol Chem 279:3327-39. 2004
    ..It further identifies G(1) control by translation initiation factors as an essential genetic target of c-myc that is necessary for its ability to transform cells...
  8. pmc c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation
    Michael J Ravitz
    Cancer Research Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 67:11209-17. 2007
    ..Together, these findings show that regulation of TSC2 can contribute to the effects of Myc on cell proliferation and neoplastic growth...
  9. ncbi request reprint Heat shock protein B8, a cyclin-dependent kinase-independent cyclin D1 target gene, contributes to its effects on radiation sensitivity
    Sally Trent
    Oxford Cancer Centre, Department of Radiotherapy, Churchill Hospital, Oxford, United Kingdom
    Cancer Res 67:10774-81. 2007
    ..Taken together, our results show that some of cyclin D1's effects on radiation sensitivity are CDK and p21 independent and identify HSPB8 as a candidate CDK-independent cyclin D1 target that can mediate its effects...
  10. ncbi request reprint Identification of cyclin D1- and estrogen-regulated genes contributing to breast carcinogenesis and progression
    Chuanwei Yang
    Massachusetts General Hospital Cancer Research Center, Massachusetts General Hospital Cancer Center Harvard University, 55 Fruit Street, GRJ 904, Boston, MA 02114, USA
    Cancer Res 66:11649-58. 2006
    ....
  11. pmc Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant
    Eunice L Kwak
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Cancer Res 66:1923-8. 2006
    ..The increased rate of tumor formation in MMTV-CHK2-D347A mice, compared with the relatively low incidence in chk2-null mice, provides a model to study modifiers of CHK2-dependent transformation...
  12. pmc hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation
    Mary Lynch
    Cancer Research Center at Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Mol Cell Biol 25:6436-53. 2005
    ..hnRNP K is an unusually diverse regulator of multiple steps in growth regulation because it also directly regulates c-myc transcription, mRNA export, splicing, and translation initiation...
  13. pmc The role of the cyclin D1-dependent kinases in ErbB2-mediated breast cancer
    Chuanwei Yang
    Massachusetts General Hospital MGH Cancer Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Pathol 164:1031-8. 2004
    ....
  14. ncbi request reprint Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer
    Rita Nahta
    Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA
    Cancer Res 63:3626-31. 2003
    ..Taken together, our results suggest that synergy between flavopiridol and trastuzumab can result from enhanced apoptosis, and that combination effects on EGFR expression are involved in the interaction...
  15. ncbi request reprint Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors
    Keiko Miyoshi
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:5548-56. 2002
    ....
  16. ncbi request reprint Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol
    Rita Nahta
    Laboratory of Tumor Biology, Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA
    Cancer Res 62:2267-71. 2002
    ..Addition of flavopiridol to Herceptin synergistically lowered erbB2 levels in these cells. Our data suggest the potential use of combinations of cyclin-dependent kinase inhibitors and Herceptin in breast cancer...

Research Grants2

  1. GENES REGULATED BY C MYC
    Emmett Schmidt; Fiscal Year: 2004
    ..Biological functions of the 4ERFs in growth regulation will be analyzed and their potential regulation by c-myc tested. ..
  2. FUNCTIONS OF CYCLIN D1 IN BREAST CANCER
    Emmett Schmidt; Fiscal Year: 2007
    ..These candidate genes involved in neoplastic progression will be validated by analysis of human cancers, in functional assays, and by assessment of their regulatory controls. ..