Clemens Scherzer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Molecular markers of early Parkinson's disease based on gene expression in blood
    Clemens R Scherzer
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:955-60. 2007
  2. pmc GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein
    Clemens R Scherzer
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:10907-12. 2008
  3. pmc Chipping away at diagnostics for neurodegenerative diseases
    Clemens R Scherzer
    Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA
    Neurobiol Dis 35:148-56. 2009
  4. ncbi request reprint Interview - Searching for biomarkers in Parkinson's disease
    Clemens Scherzer
    Brigham and Women s Hospital and Harvard Medical School, Center for Neurologic Diseases, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Biomark Med 3:113-4. 2009
  5. ncbi request reprint Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
    Clemens R Scherzer
    Center for Neurologic Diseases, Harvard Medical School, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Hum Mol Genet 12:2457-66. 2003
  6. ncbi request reprint Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
  7. ncbi request reprint Yeast genetics targets lipids in Parkinson's disease
    Clemens R Scherzer
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Genet 20:273-7. 2004
  8. ncbi request reprint Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism
    Michael A Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Arch Neurol 62:917-21. 2005
  9. ncbi request reprint Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease
    Pu Ting Xu
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Dis 21:256-75. 2006

Detail Information

Publications9

  1. pmc Molecular markers of early Parkinson's disease based on gene expression in blood
    Clemens R Scherzer
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:955-60. 2007
    ..59 +/- 0.05) than in controls (0.96 +/- 0.09) (P = 0.002) in two independent populations. Thus, gene expression signals measured in blood can facilitate the development of biomarkers for PD...
  2. pmc GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein
    Clemens R Scherzer
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:10907-12. 2008
    ..This critical link between GATA factors and SNCA may enable therapies designed to lower alpha-synuclein production...
  3. pmc Chipping away at diagnostics for neurodegenerative diseases
    Clemens R Scherzer
    Laboratory for Neurogenomics, Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, 65 Landsdowne Street, Suite 307A, Cambridge, MA 02139, USA
    Neurobiol Dis 35:148-56. 2009
    ..Advances in pre-analytical and analytical methods are improving search efficiency and reproducibility and may lead to a pipeline of biomarker candidates suitable for development into future neurologic diagnostics...
  4. ncbi request reprint Interview - Searching for biomarkers in Parkinson's disease
    Clemens Scherzer
    Brigham and Women s Hospital and Harvard Medical School, Center for Neurologic Diseases, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Biomark Med 3:113-4. 2009
    ..In his clinical practice he serves as a movement disorders specialist at Brigham and Women's Hospital...
  5. ncbi request reprint Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
    Clemens R Scherzer
    Center for Neurologic Diseases, Harvard Medical School, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    Hum Mol Genet 12:2457-66. 2003
    ....
  6. ncbi request reprint Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
    ..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
  7. ncbi request reprint Yeast genetics targets lipids in Parkinson's disease
    Clemens R Scherzer
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Genet 20:273-7. 2004
  8. ncbi request reprint Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism
    Michael A Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Arch Neurol 62:917-21. 2005
    ..Genes contributing to rare mendelian forms of PD have been identified, but the genes involved in the more common idiopathic PD are not well understood...
  9. ncbi request reprint Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease
    Pu Ting Xu
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Dis 21:256-75. 2006
    ..These mechanisms may contribute increased risk for AD and for cognitive dysfunction in AD patients who carry the APOE4 allele(s)...