E S Schernhammer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Consumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and women
    Eva S Schernhammer
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 96:1419-28. 2012
  2. doi request reprint A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 23:609-16. 2012
  3. pmc Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mol Cancer 9:125. 2010
  4. pmc Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer
    Eva S Schernhammer
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Gut 59:794-9. 2010
  5. pmc Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression
    Eva S Schernhammer
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 135:770-80. 2008
  6. pmc Urinary 6-sulfatoxymelatonin levels and risk of breast cancer in postmenopausal women
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 100:898-905. 2008
  7. ncbi request reprint Time trends of the prevalence of asthma and allergic disease in Austrian children
    E S Schernhammer
    Department of Epidemiology, Centre of Public Health, Medical University of Vienna, Vienna, Austria
    Pediatr Allergy Immunol 19:125-31. 2008
  8. ncbi request reprint Body shape throughout life and correlations with IGFs and GH
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 181 Longwood Avenue, Boston 02115, Massachusetts, USA
    Endocr Relat Cancer 14:721-32. 2007
  9. ncbi request reprint Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts
    Eva Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 67:5553-60. 2007
  10. ncbi request reprint Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocr Relat Cancer 13:583-92. 2006

Detail Information

Publications70

  1. pmc Consumption of artificial sweetener- and sugar-containing soda and risk of lymphoma and leukemia in men and women
    Eva S Schernhammer
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 96:1419-28. 2012
    ..Despite safety reports of the artificial sweetener aspartame, health-related concerns remain...
  2. doi request reprint A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 23:609-16. 2012
    ..Effects of longer courses of melatonin among premenopausal women are unknown. Low baseline estradiol levels in our study population may have hindered the ability to detect any further estradiol-lowering effects of melatonin...
  3. pmc Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors
    Yoshifumi Baba
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Mol Cancer 9:125. 2010
    ..Thus, it is of particular interest to examine whether its wide variation can be attributed to clinical, pathologic or molecular features...
  4. pmc Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer
    Eva S Schernhammer
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Gut 59:794-9. 2010
    ..Long interspersed nucleotide element-1 (LINE-1) is an emerging indicator of genome-wide DNA methylation level that has previously been linked to colon cancer survival...
  5. pmc Folate and vitamin B6 intake and risk of colon cancer in relation to p53 expression
    Eva S Schernhammer
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 135:770-80. 2008
    ..In laboratory models, folate deficiency appears to induce p53 mutation...
  6. pmc Urinary 6-sulfatoxymelatonin levels and risk of breast cancer in postmenopausal women
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 100:898-905. 2008
    ..Low urinary melatonin levels have been associated with an increased risk of breast cancer in premenopausal women. However, the association between melatonin levels and breast cancer risk in postmenopausal women remains unclear...
  7. ncbi request reprint Time trends of the prevalence of asthma and allergic disease in Austrian children
    E S Schernhammer
    Department of Epidemiology, Centre of Public Health, Medical University of Vienna, Vienna, Austria
    Pediatr Allergy Immunol 19:125-31. 2008
    ..Additional studies are needed to continue monitoring the dynamics of the prevalence of asthma and allergic disease in Austria and to explore trends in their risk factors...
  8. ncbi request reprint Body shape throughout life and correlations with IGFs and GH
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 181 Longwood Avenue, Boston 02115, Massachusetts, USA
    Endocr Relat Cancer 14:721-32. 2007
    ..Our results suggest that childhood and adult body size may affect premenopausal breast cancer risk differently than birth weight, through associations with IGF and GH levels...
  9. ncbi request reprint Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts
    Eva Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 67:5553-60. 2007
    ..Among participants who obtain these factors exclusively through dietary sources, there may be an inverse relation between circulating folate, B6, and B12 and risk...
  10. ncbi request reprint Insulin-like growth factor-I, its binding proteins (IGFBP-1 and IGFBP-3), and growth hormone and breast cancer risk in The Nurses Health Study II
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocr Relat Cancer 13:583-92. 2006
    ..In conclusion, circulating IGF-I, IGFBP-1, IGFBP-3, and GH levels appear to have no important association with breast cancer risk in a large cohort of premenopausal women...
  11. ncbi request reprint Circulating melatonin levels: possible link between Parkinson's disease and cancer risk?
    Eva Schernhammer
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Causes Control 17:577-82. 2006
    ..We therefore hypothesize that elevated circulating melatonin levels in PD patients may contribute to their lower cancer rates...
  12. pmc Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 94:928-34. 2006
    ..Moreover, the A870G genotype may enhance the protective effect of postmenopausal oestrogen use on the development of colorectal neoplasia...
  13. pmc A prospective study of dietary folate and vitamin B and colon cancer according to microsatellite instability and KRAS mutational status
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 17:2895-8. 2008
    ..In conclusion, the influence of dietary one-carbon nutrient intake on colon cancer risk does not seem to differ according to MSI or KRAS mutational status...
  14. pmc Urinary melatonin levels and postmenopausal breast cancer risk in the Nurses' Health Study cohort
    Eva S Schernhammer
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 18:74-9. 2009
    ..Melatonin seems to play a role in breast cancer etiology, but data addressing the association between melatonin levels and breast cancer risk in postmenopausal women is sparse...
  15. pmc Dietary correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses' Health Study cohorts
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 90:975-85. 2009
    ..Although melatonin is a direct derivative of the essential amino acid tryptophan, little is known about the relation of diet with melatonin concentrations...
  16. pmc Rotating nightshift work and the risk of endometriosis in premenopausal women
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 205:476.e1-8. 2011
    ..The purpose of this prospective study was to study the association between rotating nightshift work and endometriosis risk within the Nurses' Health Study II...
  17. pmc B vitamins, methionine and alcohol intake and risk of colon cancer in relation to BRAF mutation and CpG island methylator phenotype (CIMP)
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21102. 2011
    ..How one-carbon nutrients affect the CpG island methylator phenotype (CIMP) or BRAF mutation status in colon cancer remains uncertain...
  18. pmc Diabetes and the risk of developing Parkinson's disease in Denmark
    Eva Schernhammer
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 34:1102-8. 2011
    ..Using Danish population registers, we investigated whether a history of diabetes or the use of antidiabetes drugs was associated with Parkinson's disease...
  19. pmc Rotating night shifts and risk of skin cancer in the nurses' health study
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, MA 02115, USA
    J Natl Cancer Inst 103:602-6. 2011
    ..005). Hair color, a surrogate for an individual's susceptibility to skin cancer, was a statistically significant effect modifier for the observed associations; darker-haired women had the lowest risk (P(interaction) = .02)...
  20. ncbi request reprint Harvard launches a workshop series targeting the control of obesity in the US
    Eva S Schernhammer
    Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Causes Control 14:1009-12. 2003
    ..Future workshops will help refine these messages with the ultimate goal of providing policy makers and communities with a tool for obesity control...
  21. ncbi request reprint A study of trends in beliefs and attitudes toward cancer
    Eva Schernhammer
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Cancer Educ 25:211-6. 2010
    ..Differences in other subgroups, although existent, were only modest. Prevention education strategies should consider targeted approaches that aim to reduce disparities in cancer perception among those with less formal education...
  22. pmc Urinary 6-Sulphatoxymelatonin levels and risk of breast cancer in premenopausal women: the ORDET cohort
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:729-37. 2010
    ..Lower urinary melatonin levels are associated with a higher risk of breast cancer in postmenopausal women. Literature for premenopausal women is scant and inconsistent...
  23. ncbi request reprint Attitudes about the use of complementary and alternative medicine in cancer treatment
    Eva S Schernhammer
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Altern Complement Med 15:1115-20. 2009
    ..The aim of this study was to achieve an understanding what determines the attitude of people toward complementary and alternative medicine (CAM) is essential in decisions about costly therapies in cancer treatment...
  24. ncbi request reprint Night work and risk of breast cancer
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Epidemiology 17:108-11. 2006
    ..Melatonin shows potential oncostatic activity and is acutely suppressed by light exposure. Some evidence suggests an association between night work and breast cancer risk, possibly through the melatonin pathway...
  25. ncbi request reprint Sugar-sweetened soft drink consumption and risk of pancreatic cancer in two prospective cohorts
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:2098-105. 2005
    ..We investigated whether higher consumption of sugar-sweetened soft drinks increases the risk of pancreatic cancer...
  26. ncbi request reprint A prospective study of aspirin use and the risk of pancreatic cancer in women
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:22-8. 2004
    ....
  27. ncbi request reprint Rotating night shifts and risk of breast cancer in women participating in the nurses' health study
    E S Schernhammer
    E S Schernhammer, Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 93:1563-8. 2001
    ..There is little information, however, about the direct effect of night work on the risk of cancer. We investigated the effect of night work in breast cancer...
  28. ncbi request reprint Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:699-704. 2005
    ..Few studies have assessed IGF binding protein-1 (IGFBP-1) or free IGF and breast cancer risk...
  29. ncbi request reprint Suicide rates among physicians: a quantitative and gender assessment (meta-analysis)
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Am J Psychiatry 161:2295-302. 2004
    ..In this study, physicians' suicide rate ratios were estimated with a meta-analysis and systematic quality assessment of recent studies...
  30. ncbi request reprint Job stress and breast cancer risk: the nurses' health study
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 160:1079-86. 2004
    ..87 (95% CI: 0.73, 1.04) for women in high-strain jobs, and 0.90 (95% CI: 0.76, 1.06) for women in passive jobs. Findings from this study indicate that job stress is not related to any increase in breast cancer risk...
  31. pmc Melatonin and cancer risk: does light at night compromise physiologic cancer protection by lowering serum melatonin levels?
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 90:941-3. 2004
    ..We hypothesise that the potential primary culprit for this observed association is the lack of melatonin, a cancer-protective agent whose production is severely diminished in people exposed to light at night...
  32. ncbi request reprint Epidemiology of urinary melatonin in women and its relation to other hormones and night work
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 13:936-43. 2004
    ..There is little information, however, about the interrelationships of night work, urinary melatonin levels, and levels of plasma steroid hormones in women...
  33. ncbi request reprint Light at night and cancer risk
    Eva Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Photochem Photobiol 79:316-8. 2004
    ..There is also fairly consistent indirect evidence from observational studies for an association between melatonin suppression, using night work as a surrogate, and breast cancer risk...
  34. ncbi request reprint Urinary melatonin levels and breast cancer risk
    Eva S Schernhammer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Natl Cancer Inst 97:1084-7. 2005
    ..These prospective data support the hypothesis that higher melatonin levels, as measured in first morning urine, are associated with a lower risk of breast cancer...
  35. ncbi request reprint Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 107:60-4. 2003
    ..Our data do not demonstrate a significant influence of this locus on breast cancer risk, but we cannot exclude a minor influence or an influence confined to subgroups...
  36. pmc Gallstones, cholecystectomy, and the risk for developing pancreatic cancer
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Br J Cancer 86:1081-4. 2002
    ..11, 95% CI, 0.78-1.56); this risk did not increase with increasing time following cholecystectomy or gallstones. Gallstones or cholecystectomy do not appear to be significant risk factors for pancreatic cancer...
  37. pmc Cholecystectomy and the risk for developing colorectal cancer and distal colorectal adenomas
    E S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Br J Cancer 88:79-83. 2003
    ..In this large prospective cohort study, a history of cholecystectomy appears to increase modestly the risk of colorectal cancer, even after adjustment for other colorectal cancer risk factors...
  38. ncbi request reprint [Epidemiological studies for evaluating the role of cyclooxygenase in chemoprevention of malignant tumors]
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Wien Med Wochenschr 153:104-15. 2003
    ....
  39. pmc Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
    B M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Br J Cancer 97:98-104. 2007
    ..In four prospective cohorts, we found no association between the risk of pancreatic cancer and prediagnostic plasma levels of IGF-I, IGF-II, or IGFBP-3...
  40. pmc Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    JAMA 294:914-23. 2005
    ..However, data on long-term risk of colorectal cancer according to dose, timing, or duration of therapy with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) remain limited...
  41. ncbi request reprint Prostate cancer and prostate-specific antigen (PSA) screening in Austria
    Christian Vutuc
    Division of Epidemiology, Centre of Public Health, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 117:457-61. 2005
    ..However, given the long lead-time for prostate cancer, even longer follow-up may still be needed to detect any important trends...
  42. pmc Aspirin dose and duration of use and risk of colorectal cancer in men
    Andrew T Chan
    Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Gastroenterology 134:21-8. 2008
    ..Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited...
  43. ncbi request reprint Work characteristics and incidence of type 2 diabetes in women
    Candyce H Kroenke
    Robert Wood Johnson Health and Society Scholars Program, University of California, San Francisco, CA 94118, USA
    Am J Epidemiol 165:175-83. 2007
    ..Job strain was unrelated to risk of type 2 diabetes. In conclusion, working overtime predicted a slightly elevated risk of type 2 diabetes in young and middle-aged female nurses...
  44. pmc Nightshift work and fracture risk: the Nurses' Health Study
    D Feskanich
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Osteoporos Int 20:537-42. 2009
    ..Our study, to our knowledge, the first to address this question, supports the hypothesis that nightshift work may negatively affect bone health, adding to the growing list of ailments that have been associated with shift work...
  45. ncbi request reprint Effect of light perception on menarche in blind women
    Erin E Flynn-Evans
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Ophthalmic Epidemiol 16:243-8. 2009
    ..The present study was conducted to determine whether differences exist in reproductive measures among blind women with at least light perception (LP) compared to women with no perception of light (NPL)...
  46. pmc Rotating night shift work and risk of ovarian cancer
    Elizabeth M Poole
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 20:934-8. 2011
    ..Night shift work has been associated with higher risks of breast and endometrial cancer, but few studies have evaluated associations with other reproductive cancers...
  47. doi request reprint Parkinson's disease and cancer risk: a systematic review and meta-analysis
    Archna Bajaj
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Causes Control 21:697-707. 2010
    ....
  48. ncbi request reprint Night-shift work and risk of colorectal cancer in the nurses' health study
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 95:825-8. 2003
    ..84 to 1.19) and 1.35 (95% CI = 1.03 to 1.77), respectively (P(trend) =.04). These data suggest that working a rotating night shift at least three nights per month for 15 or more years may increase the risk of colorectal cancer in women...
  49. ncbi request reprint Total visual blindness is protective against breast cancer
    Erin E Flynn-Evans
    Division of Sleep Medicine, Brigham and Women s Hospital, 221 Longwood Avenue BLI 438, Boston, MA 02115, USA
    Cancer Causes Control 20:1753-6. 2009
    ..Mechanisms influenced by ocular light perception, such as melatonin or circadian synchronization, are thought to account for this lower risk...
  50. pmc Circulating melatonin and the risk of breast and endometrial cancer in women
    Akila N Viswanathan
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cancer Lett 281:1-7. 2009
    ..Additional studies are needed to delineate further the potential of melatonin in cancer prevention...
  51. ncbi request reprint A prospective study on habitual duration of sleep and incidence of breast cancer in a large cohort of women
    Simone P Pinheiro
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Res 66:5521-5. 2006
    ..05). In this prospective study, we found no convincing evidence for an association between sleep duration and the incidence of breast cancer...
  52. ncbi request reprint The association of self-reported sleep duration, difficulty sleeping, and snoring with cognitive function in older women
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Alzheimer Dis Assoc Disord 20:41-8. 2006
    ..However, the lack of an association with prospective cognitive decline warrants further investigation...
  53. ncbi request reprint Night shift work and the risk of endometrial cancer
    Akila N Viswanathan
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Res 67:10618-22. 2007
    ..Our results add to growing literature that suggests women who work at night may benefit from cancer prevention strategies...
  54. pmc Aspirin, NSAID, and acetaminophen use and the risk of endometrial cancer
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    Cancer Res 68:2507-13. 2008
    ..However, risk was significantly lower for current aspirin users who were obese or who were postmenopausal and had never used PMHs; these subgroup findings require further confirmation...
  55. ncbi request reprint Caregiving stress, endogenous sex steroid hormone levels, and breast cancer incidence
    Candyce H Kroenke
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 159:1019-27. 2004
    ..7.46 pg/ml (95% confidence interval: 6.36, 8.76)) and bioavailable estradiol (geometric mean, 1.86 pg/ml vs. 1.35 pg/ml (95% confidence interval: 1.00, 1.82)). Stress from caregiving did not appear to increase breast cancer risk...
  56. ncbi request reprint Urinary 6-sulfatoxymelatonin levels and their correlations with lifestyle factors and steroid hormone levels
    Eva S Schernhammer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Pineal Res 40:116-24. 2006
    ..Melatonin levels may be one mechanism through which these factors influence the development of cancer, but more studies are needed to elucidate these mechanisms definitively...
  57. pmc A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer
    Shuji Ogino
    Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 100:1734-8. 2008
    ..In conclusion, tumoral LINE-1 hypomethylation is independently associated with shorter survival among colon cancer patients...
  58. ncbi request reprint Insulin-like growth factors and neoplasia
    Michael N Pollak
    Department of Oncology, McGill University and Lady Davis Research Institute, 3999 Rue Côte Sainte Catherine, Montreal, Quebec H3T 1E2, Canada
    Nat Rev Cancer 4:505-18. 2004
  59. ncbi request reprint Social networks, social support, and survival after breast cancer diagnosis
    Candyce H Kroenke
    Robert Wood Johnson Health and Society Scholars, University of California, San Francisco, Center for Health and Community, San Francisco, CA 94118, USA
    J Clin Oncol 24:1105-11. 2006
    ..We prospectively examined social ties and survival after breast cancer diagnosis...
  60. ncbi request reprint A prospective study of aspirin use and the risk for colorectal adenoma
    Andrew T Chan
    Massachusetts General Hospital, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts 02114, USA
    Ann Intern Med 140:157-66. 2004
    ..However, the effect of dose and duration of use, particularly in an average-risk population, is not well understood...
  61. ncbi request reprint Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer
    Brian M Wolpin
    Department of Medical Oncology, Dana Farber Cancer Institute, MA 02115, USA
    Cancer Res 67:7923-8. 2007
    ..30; 95% CI, 1.48-7.35). Among participants in four U.S. prospective cohort studies, low plasma IGFBP-1 levels significantly predicted an increased risk of pancreatic cancer...
  62. pmc Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells
    Natsumi Irahara
    Molecular Oncologic Pathology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, 44 Binney St, Room JF 215C, Boston, MA 02115, USA
    J Mol Diagn 12:177-83. 2010
    ..9) in leukocyte DNA. In conclusion, bisulfite conversion and PCR-pyrosequencing assay can measure LINE-1 methylation in macrodissected colon cancer, normal colon, and blood DNA, and may be useful in clinical and research settings...
  63. pmc Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample
    Katsuhiko Nosho
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    PLoS ONE 3:e3698. 2008
    ..In stratified analyses, the relations of CIMP-high with poor differentiation, KRAS mutation and LINE-1 hypomethylation significantly differed according to MSI status...
  64. ncbi request reprint Nutritional and lifestyle correlates of the cancer-protective hormone melatonin
    Regina P Dopfel
    Harvard University, A L M Program, Biological Sciences, 51 Brattle Street, Cambridge, MA 02138, USA
    Cancer Detect Prev 31:140-8. 2007
    ....
  65. ncbi request reprint Correlates for poor sleepers in a Los Angeles high school
    Sarah P Megdal
    Yale College, Yale University, New Haven, CT, USA
    Sleep Med 9:60-3. 2007
    ..We explored sleep patterns including morning-evening preference and their associations with other lifestyle determinants among high school students...
  66. pmc Urinary melatonin and risk of incident hypertension among young women
    John P Forman
    Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Hypertens 28:446-51. 2010
    ..However, whether lower physiologic levels of melatonin are an independent risk factor for the development of hypertension has never been reported...
  67. ncbi request reprint Night work and breast cancer risk: a systematic review and meta-analysis
    Sarah P Megdal
    Milken Community High School, Los Angeles, CA, USA
    Eur J Cancer 41:2023-32. 2005
    ..05). Studies on night shift work and breast cancer risk collectively show an increased breast cancer risk among women. Publication bias is unlikely to have influenced the results...
  68. ncbi request reprint In-utero exposures and breast cancer risk: joint effect of estrogens and insulin-like growth factor?
    Eva S Schernhammer
    Cancer Causes Control 13:505-8. 2002
    ..More research is needed to elucidate this potential mechanism...
  69. ncbi request reprint A prospective study of sleep duration and mortality risk in women
    Sanjay R Patel
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Sleep 27:440-4. 2004
    ..However, recent studies suggest the risk of death is lower in those sleeping 7 hours. We prospectively examined the association between sleep duration and mortality in women to better understand the effect of sleep duration on health...
  70. pmc Validation of a light questionnaire with real-life photopic illuminance measurements: the Harvard Light Exposure Assessment questionnaire
    Archna Bajaj
    Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 20:1341-9. 2011
    ..To study the effects of light on chronic diseases like cancer, methods to measure light exposure in large observational studies are needed. We aimed to investigate the validity of self-reported current light exposure...

Research Grants14

  1. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2007
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
  2. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2005
    ....
  3. The Interplay Between Sleep, Melatonin, and Mortality in Older Men
    Eva S Schernhammer; Fiscal Year: 2010
    ..We will use existing resources from 2,846 participants of the ongoing MrOS Sleep Study. If successful, our study could lay the groundwork for a melatonin trial for healthy aging in the elderly. ..
  4. The Interplay Between Sleep, Melatonin, and Mortality in Older Men
    Eva Schernhammer; Fiscal Year: 2009
    ..We will use existing resources from 2,846 participants of the ongoing MrOS Sleep Study. If successful, our study could lay the groundwork for a melatonin trial for healthy aging in the elderly. ..
  5. The Interplay Between Sleep, Melatonin, and Mortality in Older Men
    Eva Schernhammer; Fiscal Year: 2008
    ..We will use existing resources from 2,846 participants of the ongoing MrOS Sleep Study. If successful, our study could lay the groundwork for a melatonin trial for healthy aging in the elderly. ..
  6. Aspartame Intake and the Risk of Cancer
    Eva Schernhammer; Fiscal Year: 2008
    ..Our results may help decision-makers formulate guidelines and direct future aspartame studies. Even a null finding would be important in this context. [unreadable] [unreadable] [unreadable]..
  7. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2008
    ..abstract_text> ..
  8. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2008
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. ..
  9. A Pilot Trial of Oral Melatonin Supplementation in Breast Cancer Survivors
    Eva Schernhammer; Fiscal Year: 2007
    ..This pilot data could lay the groundwork for a large scale trial to assess the chemopreventive potential of melatonin in women, both with and without a personal history of breast cancer. [unreadable] [unreadable] [unreadable]..
  10. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2007
    ..abstract_text> ..
  11. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2007
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. [unreadable] [unreadable]..
  12. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2006
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. [unreadable] [unreadable]..
  13. Minimizing Cancer Risk in Shift Workers
    Eva S Schernhammer; Fiscal Year: 2010
    ....