FRANK SCHEER

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Obesity (Silver Spring) 21:421-3. 2013
  2. pmc Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Sleep 35:1395-402. 2012
  3. pmc An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Biol Rhythms 23:353-61. 2008
  4. pmc Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions
    F A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA
    Diabetologia 53:2401-5. 2010
  5. pmc Impact of the human circadian system, exercise, and their interaction on cardiovascular function
    Frank A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:20541-6. 2010
  6. pmc Plasticity of the intrinsic period of the human circadian timing system
    Frank A J L Scheer
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e721. 2007
  7. pmc The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24549. 2011
  8. ncbi request reprint Potential use of melatonin as adjunct antihypertensive therapy
    Frank A J L Scheer
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 18:1619-20. 2005
  9. ncbi request reprint Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature
    F A J L Scheer
    Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroscience 132:465-77. 2005
  10. ncbi request reprint Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock
    Frank A J L Scheer
    Project Group Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Auton Neurosci 110:44-8. 2004

Detail Information

Publications24

  1. pmc The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Obesity (Silver Spring) 21:421-3. 2013
    ..We assessed whether this paradox could be explained by an endogenous circadian influence on appetite with a morning trough, while controlling for sleep/wake and fasting/feeding effects...
  2. pmc Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Sleep 35:1395-402. 2012
    ..Therefore, we tested whether nightly melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers...
  3. pmc An endogenous circadian rhythm in sleep inertia results in greatest cognitive impairment upon awakening during the biological night
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Biol Rhythms 23:353-61. 2008
    ..This robust endogenous circadian rhythm in sleep inertia may have important implications for people who need to be alert soon after awakening...
  4. pmc Day/night variations of high-molecular-weight adiponectin and lipocalin-2 in healthy men studied under fed and fasted conditions
    F A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA
    Diabetologia 53:2401-5. 2010
    ..We also aimed to compare the 24 h rhythms in the levels of these proteins with those of cortisol, leptin, leptin-binding protein and total adiponectin...
  5. pmc Impact of the human circadian system, exercise, and their interaction on cardiovascular function
    Frank A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:20541-6. 2010
    ....
  6. pmc Plasticity of the intrinsic period of the human circadian timing system
    Frank A J L Scheer
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e721. 2007
    ..Both findings have important implications for the treatment of circadian rhythm sleep disorders and human space exploration...
  7. pmc The human endogenous circadian system causes greatest platelet activation during the biological morning independent of behaviors
    Frank A J L Scheer
    Medical Chronobiology Program, Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e24549. 2011
    ....
  8. ncbi request reprint Potential use of melatonin as adjunct antihypertensive therapy
    Frank A J L Scheer
    Harvard Medical School and Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 18:1619-20. 2005
  9. ncbi request reprint Environmental light and suprachiasmatic nucleus interact in the regulation of body temperature
    F A J L Scheer
    Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroscience 132:465-77. 2005
    ..Furthermore, they show that light may have an acute effect on behavior and physiology of the organism via the SCN, which extends beyond the generally acknowledged effect on melatonin secretion...
  10. ncbi request reprint Light and diurnal cycle affect autonomic cardiac balance in human; possible role for the biological clock
    Frank A J L Scheer
    Project Group Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Auton Neurosci 110:44-8. 2004
    ....
  11. ncbi request reprint Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
    Frank A J L Scheer
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Hypertension 43:192-7. 2004
    ..The present study suggests that support of circadian pacemaker function may provide a new strategy in the treatment of essential hypertension...
  12. pmc Adverse metabolic and cardiovascular consequences of circadian misalignment
    Frank A J L Scheer
    Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:4453-8. 2009
    ..These findings demonstrate the adverse cardiometabolic implications of circadian misalignment, as occurs acutely with jet lag and chronically with shift work...
  13. doi request reprint Is there a circadian variation of epileptiform abnormalities in idiopathic generalized epilepsy?
    Milena K Pavlova
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Epilepsy Behav 16:461-7. 2009
    ..001). In both patients who had NREM at all circadian phases, there was apparent circadian variation in IEDs but with different phases relative to peak melatonin...
  14. pmc The human circadian system adapts to prior photic history
    Anne Marie Chang
    Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 221 Longwood Avenue, Suite 438, Boston, MA 02115, USA
    J Physiol 589:1095-102. 2011
    ..This plasticity has important implications for the optimization of light therapy for the treatment of circadian rhythm sleep disorders...
  15. pmc Effects of circadian disruption on the cardiometabolic system
    Melanie Rüger
    Division of Sleep Medicine, Harvard Medical School, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Rev Endocr Metab Disord 10:245-60. 2009
    ..We will review the evidence for circadian control of cardiometabolic functioning, as well its sensitivity to light and melatonin, and discuss potential implication for therapy...
  16. pmc Existence of an endogenous circadian blood pressure rhythm in humans that peaks in the evening
    Steven A Shea
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 108:980-4. 2011
    ..Whether the endogenous circadian control system contributes to this daily BP variation has not been determined under appropriately controlled conditions...
  17. pmc The circadian pacemaker generates similar circadian rhythms in the fractal structure of heart rate in humans and rats
    Kun Hu
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Cardiovasc Res 80:62-8. 2008
    ....
  18. pmc The endogenous circadian pacemaker imparts a scale-invariant pattern of heart rate fluctuations across time scales spanning minutes to 24 hours
    Kun Hu
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Rhythms 23:265-73. 2008
    ..These results demonstrate that experimental manipulations (e.g., SCN lesion) can be used to begin to model and understand the origin of scale-invariant behavior in a neurophysiological system...
  19. ncbi request reprint Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans
    Steven W Lockley
    Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Sleep 29:161-8. 2006
    ..To assess the wavelength-dependent sensitivity of the acute effects of ocular light exposure on alertness, performance, waking electroencephalogram (EEG), and cortisol...
  20. pmc Endogenous circadian rhythm in vasovagal response to head-up tilt
    Kun Hu
    Division of Sleep Medicine, Harvard Medical School, 221 Longwood Ave, 044 BLI, Boston, MA 02115, USA
    Circulation 123:961-70. 2011
    ..This study tested the hypothesis that the circadian system modulates cardiovascular responses to postural stress, leading to increased susceptibility to syncope at specific times of day...
  21. ncbi request reprint Human basal cortisol levels are increased in hospital compared to home setting
    Frank A J L Scheer
    Department of Hypothalamic Integration Mechanisms, Netherlands Institute for Brain Research, 1105 AZ, The, Amsterdam, Netherlands
    Neurosci Lett 333:79-82. 2002
    ....
  22. pmc Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker
    Kun Hu
    Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:2490-4. 2009
    ..Thus, aging and AD significantly attenuate the scale invariance of activity fluctuations over multiple time scales. This attenuation may reflect functional changes of the SCN...
  23. ncbi request reprint Melatonin, sleep, and circadian rhythms
    Frank A J L Scheer
    Sleep Med Rev 9:5-9. 2005
  24. ncbi request reprint Decreased sleep in heart failure: are medications to blame?
    Frank A J L Scheer
    Arch Intern Med 167:1098-9; author reply 1099-100. 2007

Research Grants3

  1. Melatonin Supplementation in Hypertensive Patients
    FRANK SCHEER; Fiscal Year: 2007
    ..Furthermore, supplementation of suppressed nighttime melatonin levels may lead to a novel strategy in the treatment of essential hypertension. ..
  2. Mechanisms underlying adverse health consequences of shift work
    FRANK SCHEER; Fiscal Year: 2009
    ..This research will provide a possible mechanistic explanation for the increased risk for diabetes, obesity, and cardiovascular disease in shift workers. ..
  3. Mechanisms underlying adverse health consequences of shift work
    Frank A Scheer; Fiscal Year: 2010
    ..This research will provide a possible mechanistic explanation for the increased risk for diabetes, obesity, and cardiovascular disease in shift workers. ..