Research Topics
Species | S C SchachterSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Quality of life for patients with epilepsy is determined by more than seizure control: the role of psychosocial factorsSteven C Schachter
Harvard Medical School, Boston, MA 02215, USA
Expert Rev Neurother 6:111-8. 2006..Irrespective of their level of seizure control from antiepileptic drugs, patients may also benefit from targeted psychosocial interventions that reduce the negative impact of these factors on their quality of life...
Seizure disordersSteven C Schachter
Department of Neurology, Harvard Medical School, MA, USA
Med Clin North Am 93:343-51, viii. 2009..Special considerations are warranted for women of childbearing potential and elderly patients...
Vagus nerve stimulation: mood and cognitive effectsSteven C Schachter
Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Epilepsy Behav 5:S56-9. 2004..This review evaluates the published evidence for VNS-associated changes in mood and cognition in patients with neuropsychiatric disorders...
Seizure disordersSteven C Schachter
Department of Neurology, Harvard Medical School, Boston, MA, USA
Prim Care 31:85-94. 2004
Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation SummitSteven C Schachter
Center for Integration of Medicine and Innovative Technology, Boston, MA, USA
Epilepsy Behav 16:3-46. 2009..This article summarizes the discussions and demonstrates that cross-disciplinary interactions can catalyze collaborations between physicians and engineers to address and solve many of the pressing unmet needs in epilepsy...
Oxcarbazepine: double-blind, randomized, placebo-control, monotherapy trial for partial seizuresS C Schachter
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Neurology 52:732-7. 1999..To evaluate the efficacy and safety of oxcarbazepine in a placebo-control trial...
The visions of artists with epilepsy: implications for neuroscientistsSteven C Schachter
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Epilepsy Behav 14:12-4. 2009....
What needs to change: goals for clinical and social management and research in the next 60 yearsSteven C Schachter
Departments of Neurology, Beth Israel Deaconess Medical Centre and Harvard Medical School, 330 Brookline Avenue, K 478, Boston, MA 02215, USA
Seizure 19:686-9. 2010....
Complementary and alternative medical therapiesSteven C Schachter
Osher Research Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Curr Opin Neurol 21:184-9. 2008..This review highlights the findings of recently published studies of complementary and alternative medical therapies and epilepsy, and provides an update of the US Food and Drug Administration's role in regulating herbal products...
Flurothyl-induced seizures in rats activate Fos in brainstem catecholaminergic neuronsD C Silveira
Department of Neurology, Beth Israel Deaconess Medical Center, Kirstein 478 and Harvard Medical School, Boston, MA 02115, USA
Epilepsy Res 39:1-12. 2000..Further studies are necessary to determine whether activation of brainstem catecholaminergic neurons contribute to the autonomic manifestations that frequently accompany epileptic seizures...
Comparison of coronal sphenoidal versus standard anteroposterior temporal montage in the EEG recording of temporal lobe seizuresJ R Ives
Department of Neurology, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
Electroencephalogr Clin Neurophysiol 98:417-21. 1996..Indwelling, flexible sphenoidal electrodes assist in ambulatory recording of temporal lobe seizures, both in demonstrating the presence of seizures and in determining the localization and time of seizure onset...
Botanicals and herbs: a traditional approach to treating epilepsySteven C Schachter
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Neurotherapeutics 6:415-20. 2009..S. Food and Drug Administration in regulating herbal products, and presents the author's approach to the scientific assessment of herbal therapies as potential therapies for patients with epilepsy...
Improving quality of life beyond seizure controlSteven C Schachter
Comprehensive Epilepsy Program, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Epileptic Disord 7:S34-8. 2005....
Transcranial magnetic stimulation treatment for epilepsy: can it also improve depression and vice versa?Felipe Fregni
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
Epilepsy Behav 7:182-9. 2005..This article reviews these data and explores further the question of whether depression and epilepsy can be simultaneously treated with TMS for optimal therapeutic impact...
Complementary and alternative medicine use among US adults with common neurological conditionsRebecca Erwin Wells
Division for Research and Education in Complementary and Integrative Medical Therapies, Osher Research Center, Harvard Medical School, Landmark Center, Suite 22A West, Boston, MA 02215, USA
J Neurol 257:1822-31. 2010..CAM is used more frequently among adults with common neurological conditions than those without. More research on the efficacy of CAM use for common neurological conditions is warranted...
Vagus nerve stimulation: where are we?Steven C Schachter
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Curr Opin Neurol 15:201-6. 2002..This review evaluates the role of vagus nerve stimulation in light of recently published research of its mechanism(s) of action, long-term efficacy, safety and tolerability, and application to other disorders besides epilepsy...
Repetitive transcranial magnetic stimulation in the treatment of epilepsia partialis continuaAlexander Rotenberg
Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Epilepsy Behav 14:253-7. 2009..Here, we describe our recent experience with rTMS in the treatment of EPC, as an early step toward evaluating the safety and efficacy of rTMS in the treatment of intractable ongoing focal seizures...
Epilepsy: major advances in treatmentSteven C Schachter
Harvard Medical School, Boston, Massachusetts, USA
Lancet Neurol 3:11. 2004
A patient with a new-onset seizure after a strokeSteven C Schachter
Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Epilepsy Behav 4:S23-6; discussion S27-8. 2003
Current evidence indicates that antiepileptic drugs are anti-ictal, not antiepilepticSteven C Schachter
Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Epilepsy Res 50:67-70. 2002..This paper suggests methods by which drugs could be tested for antiepileptic properties and reviews whether current antiepilectic drugs (AEDs) are antiepileptic in addition to being effective for seizure suppression...
Drug-mediated antiepileptogenesis in humansSteven C Schachter
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, K 478, Boston, MA 02215, USA
Neurology 59:S34-5. 2002..e., a cure. Whether any anticonvulsant drugs in current use have antiepileptogenic properties is the subject of this overview...
Management of epilepsy: pharmacologic therapy and quality-of-life issuesS C Schachter
Harvard Medical School, Boston, MA, USA
Postgrad Med 101:133-8, 141-4, 150-3. 1997....
Technical implementation and clinical findings/results of monitoring oxygen saturation in patients referred for long-term EEG monitoringJ R Ives
Department of Neurology, Beth Israel Hospital, Boston, MA 02215, USA
Electroencephalogr Clin Neurophysiol 99:432-9. 1996..From a research aspect, the details of the morphology and timing of the oxygen desaturations and EEG show several interesting relationships with respect to the dynamics of seizure semiology and respiratory physiology...
High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effectsA P Binks
Physiology Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Respir Physiol 127:125-33. 2001....
Therapeutic effects of vagus nerve stimulation in epilepsy and implications for sudden unexpected death in epilepsySteven C Schachter
Harvard Medical School, Dept. of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Room K-478, Boston, MA 02215, USA
Clin Auton Res 16:29-32. 2006..Studies to date of VNS and SUDEP are limited and do not conclusively show an association between VNS and SUDEP rates independent of other epilepsy-specific variables...
Remacemide: current status and clinical applicationsS C Schachter
Departments of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, K 478, Boston, MA 02215, USA
Expert Opin Investig Drugs 9:871-83. 2000..Adverse effects are related to the gastrointestinal and central nervous systems. RMC is a promising drug with numerous potential applications for both acute or chronic conditions associated with glutamate-mediated neurotoxicity...
Pharmacology and clinical experience with tiagabineS C Schachter
Office of Clinical Trials and Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Expert Opin Pharmacother 2:179-87. 2001..Open studies confirm that patients with medically refractory partial epilepsy can be successfully converted to TGB monotherapy and that TGB may be effective for other seizure types, such as infantile spasms...
Vagus nerve stimulation therapy summary: five years after FDA approvalSteven C Schachter
Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 457, Boston, MA 02215, USA
Neurology 59:S15-20. 2002..Additional studies are suggested to further explore the capabilities of VNS therapy...
Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in femalesV L Sheen
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 10:1775-83. 2001..These results demonstrate the sensitivity and specificity of DNA testing for FLN1 mutations and have important functional implications for models of FLN1 protein function in neuronal migration...
Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in ratsD C Silveira
Department of Neurology, Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Enders 320, Boston, MA 02115, USA
Brain Res 878:223-7. 2000..Lesioned rats had significantly shorter latencies to onset of generalized tonic-clonic seizures than controls. Our findings suggest that basal forebrain cholinergic neurons may participate in the modulation of generalized seizures...
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695Y Peng
Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Harvard New Research Building, Room 636F, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Neuroscience 150:386-95. 2007....
Currently available antiepileptic drugsSteven C Schachter
Harvard Medical School, Boston, Massachusetts 02215, USA
Neurotherapeutics 4:4-11. 2007..Consequently, there remains a significant need for further development of new therapies...
Emerging credentialing practices, malpractice liability policies, and guidelines governing complementary and alternative medical practices and dietary supplement recommendations: a descriptive study of 19 integrative health care centers in the United StatMichael H Cohen
Harvard Medical School Osher Institute and the Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, MA 02215, USA
Arch Intern Med 165:289-95. 2005..Consensus policies need to be developed...
The evolving place of vagus nerve stimulation therapySteven C Schachter
Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 457, Boston, MA 02215, USA
Neurology 59:S1-2. 2002..This supplement updates developments with VNS therapy since its approval and suggests future directions for this still-evolving treatment...
Endocrine aspects of epilepsySteven C Schachter
Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Adv Neurol 90:175-84. 2002
Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:410-23. 2004....
Lack of herbal supplement characterization in published randomized controlled trialsPeter M Wolsko
Kaiser Permanente Medical Group, Denver, CO 80020, USA
Am J Med 118:1087-93. 2005..We assessed the extent to which recently published randomized controlled trials of herbal supplements characterized and verified the content of the supplement under study...
Epilepsy surveillance among adults--19 States, Behavioral Risk Factor Surveillance System, 2005Rosemarie Kobau
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, CDC, 4770 Buford Hwy, N E, MS K 51, Atlanta, GA 30347, USA
MMWR Surveill Summ 57:1-20. 2008....
Increasing research capacity at the New England School of Acupuncture through faculty and student research training initiativesPeter M Wayne
New England School of Acupuncture NESA, Watertown, Massachusetts, USA
Altern Ther Health Med 14:52-8. 2008..We discuss successes and challenges encountered in developing and administering these initiatives and the overall impact they have had on research culture and productivity at NESA...
Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:401-9. 2004..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies...
Impact of patient-specificity on seizure onset detection performanceAli Shoeb
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, USA
Conf Proc IEEE Eng Med Biol Soc 2007:4110-4. 2007....
