THOMAS SCAMMELL

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Afferents to the ventrolateral preoptic nucleus
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:977-90. 2002
  2. pmc Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2
    T Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 95:7754-9. 1998
  3. ncbi request reprint Sleep neurobiology for the clinician
    Rodrigo A Espana
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:811-20. 2004
  4. pmc A consensus definition of cataplexy in mouse models of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Sleep 32:111-6. 2009
  5. pmc Orexin receptors: pharmacology and therapeutic opportunities
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Annu Rev Pharmacol Toxicol 51:243-66. 2011
  6. ncbi request reprint Behavioral state instability in orexin knock-out mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 24:6291-300. 2004
  7. pmc Orexin neurons are necessary for the circadian control of REM sleep
    Sandor Kantor
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 32:1127-34. 2009
  8. pmc Abnormal sleep/wake dynamics in orexin knockout mice
    Cecilia G Diniz Behn
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA, USA
    Sleep 33:297-306. 2010
  9. ncbi request reprint Wake-related activity of tuberomammillary neurons in rats
    Emily M Ko
    Department of Psychology, Harvard College, Cambridge, MA 02115, USA
    Brain Res 992:220-6. 2003
  10. pmc Running promotes wakefulness and increases cataplexy in orexin knockout mice
    Rodrigo A Espana
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Sleep 30:1417-25. 2007

Research Grants

  1. Orexin and the Control of Cataplexy
    THOMAS EMERY SCAMMELL; Fiscal Year: 2010
  2. Circadian and Aminergic Regulation of Orexin Neurons
    THOMAS SCAMMELL; Fiscal Year: 2005
  3. ADENOSINE AND THE PREOPTIC REGULATION OF SLEEP
    THOMAS SCAMMELL; Fiscal Year: 2002
  4. Orexin and the Control of Cataplexy
    THOMAS EMERY SCAMMELL; Fiscal Year: 2010

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Afferents to the ventrolateral preoptic nucleus
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:977-90. 2002
    ..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions...
  2. pmc Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2
    T Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 95:7754-9. 1998
    ..These observations suggest that PGD2 may induce sleep via leptomeningeal PGD2 receptors with subsequent activation of the VLPO...
  3. ncbi request reprint Sleep neurobiology for the clinician
    Rodrigo A Espana
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:811-20. 2004
    ..An up-to-date understanding of these systems should allow clinicians and researchers to better understand the effects of drugs, lesions, and neurologic disease on sleep and wakefulness...
  4. pmc A consensus definition of cataplexy in mouse models of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Sleep 32:111-6. 2009
    ..This working definition provides helpful insights into murine cataplexy and should allow objective and accurate comparisons of cataplexy in future studies using mouse models of narcolepsy...
  5. pmc Orexin receptors: pharmacology and therapeutic opportunities
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Annu Rev Pharmacol Toxicol 51:243-66. 2011
    ..As the orexin system mainly promotes arousal, these new compounds will likely improve insomnia without incurring many of the side effects encountered with current medications...
  6. ncbi request reprint Behavioral state instability in orexin knock-out mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 24:6291-300. 2004
    ..Instead, the fragmented behavior of orexin KO mice may be best described as behavioral state instability, with apparently low thresholds to transition between states...
  7. pmc Orexin neurons are necessary for the circadian control of REM sleep
    Sandor Kantor
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 32:1127-34. 2009
    ....
  8. pmc Abnormal sleep/wake dynamics in orexin knockout mice
    Cecilia G Diniz Behn
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA, USA
    Sleep 33:297-306. 2010
    ..We developed an EEG spectral analysis technique to determine whether the state instability in a mouse model of narcolepsy reflects abnormal sleep or wake states, faster movements between states, or abnormal transitions between states...
  9. ncbi request reprint Wake-related activity of tuberomammillary neurons in rats
    Emily M Ko
    Department of Psychology, Harvard College, Cambridge, MA 02115, USA
    Brain Res 992:220-6. 2003
    ..These results demonstrate that histaminergic neurons throughout the TMN are wake-active, and this activity is largely independent of the time of day...
  10. pmc Running promotes wakefulness and increases cataplexy in orexin knockout mice
    Rodrigo A Espana
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Sleep 30:1417-25. 2007
    ..People with narcolepsy and mice lacking orexin/hypocretin have disrupted sleep/wake behavior and reduced physical activity. Our objective was to identify physiologic mechanisms through which orexin deficiency reduces locomotor activity...
  11. pmc Mathematical model of network dynamics governing mouse sleep-wake behavior
    Cecilia G Diniz Behn
    Department of Mathematics and Center for BioDynamics, Boston University, MA, USA
    J Neurophysiol 97:3828-40. 2007
    ..Because circadian and other factors alter the fine architecture of sleep-wake behavior, this model provides a novel framework to explore dynamical principles that may underlie normal and pathologic sleep-wake physiology...
  12. pmc Do enteric neurons make hypocretin?
    Christian R Baumann
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, USA
    Regul Pept 147:1-3. 2008
    ..These results raise doubts about whether enteric neurons produce hypocretin...
  13. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    ..We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy...
  14. pmc Elevated body temperature during sleep in orexin knockout mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Physiol Regul Integr Comp Physiol 291:R533-40. 2006
    ..In addition, because heat loss is an essential aspect of sleep, the blunted fall in Tb of orexin KO mice may provide an explanation for the fragmented sleep of narcolepsy...
  15. pmc Afferents to the orexin neurons of the rat brain
    Kyoko Yoshida
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 494:845-61. 2006
    ..These observations suggest that the orexin neurons may integrate a variety of interoceptive and homeostatic signals to increase behavioral arousal in response to hunger, stress, circadian signals, and autonomic challenges...
  16. ncbi request reprint Homeostatic, circadian, and emotional regulation of sleep
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 493:92-8. 2005
    ..Understanding the pathways that underlie the regulation of sleep and wakefulness may provide important insights into how the cognitive and emotional systems interact with basic homeostatic and circadian drives for sleep...
  17. ncbi request reprint Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival...
  18. ncbi request reprint The neurobiology, diagnosis, and treatment of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Ann Neurol 53:154-66. 2003
    ..These discoveries have considerably improved our understanding of the neurobiology of sleep and should foster the development of rational treatments for a variety of sleep disorders...
  19. ncbi request reprint Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome")
    David K Simon
    Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Neurology, Boston, Massachusetts 02115, USA
    Mov Disord 19:838-40. 2004
    ..The gait difficulties resolved with venlafaxine. This case demonstrates that status cataplecticus can be misdiagnosed as a psychogenic gait disorder...
  20. ncbi request reprint Orexin/Hypocretin: wired for wakefulness
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Biol 13:R563-4. 2003
    ..Electrophysiological studies have now identified positive and negative feedback signals that allow the orexin neurons to help maintain wakefulness...
  21. ncbi request reprint Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    Thomas C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10691-702. 2003
    ..Through these pathways, the DMH may influence a wide range of behavioral circadian rhythms...
  22. ncbi request reprint Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling
    Achim Kramer
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Novartis Found Symp 253:250-62; discussion 102-9, 263-6, 281-4. 2003
    ..These results implicate EGF receptor signalling in the daily control of locomotor activity, and they identify a neural circuit in the hypothalamus that likely mediates the regulation of behaviour both by the SCN and the retina...
  23. pmc Reward-seeking behavior in human narcolepsy
    Alexandra Dimitrova
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Clin Sleep Med 7:293-300. 2011
    ..Because individuals with narcolepsy with cataplexy have low hypocretin levels, we hypothesized that they may be less prone to risk- and reward-seeking behaviors, including substance abuse...
  24. ncbi request reprint Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:5762-70. 2003
    ..This transduction knock-out technique holds enormous potential for dissecting the functions of different CNS pathways...
  25. pmc Common scale-invariant patterns of sleep-wake transitions across mammalian species
    Chung Chuan Lo
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:17545-8. 2004
    ..Our findings suggest common dynamical features of brief awakenings and sleep durations across species and may provide insights into the dynamics of the neural circuits controlling sleep...

Research Grants12

  1. Orexin and the Control of Cataplexy
    THOMAS EMERY SCAMMELL; Fiscal Year: 2010
    ....
  2. Circadian and Aminergic Regulation of Orexin Neurons
    THOMAS SCAMMELL; Fiscal Year: 2005
    ....
  3. ADENOSINE AND THE PREOPTIC REGULATION OF SLEEP
    THOMAS SCAMMELL; Fiscal Year: 2002
    ..These studies will provide important insights into the pre-optic and basal forebrain sites and mechanisms through which AD induces sleep. ..
  4. Orexin and the Control of Cataplexy
    THOMAS EMERY SCAMMELL; Fiscal Year: 2010
    ....