Affiliation: Harvard University
Mahoney C, Cogswell A, Koralnik I, Scammell T. The neurobiological basis of narcolepsy. Nat Rev Neurosci. 2018;: pubmed publisher
..We also summarize the developing evidence that narcolepsy is an autoimmune disorder that may be caused by a T cell-mediated attack on the orexin neurons and explain how these new perspectives can inform better therapeutic approaches. ..
Agostinelli L, Geerling J, Scammell T. Basal forebrain subcortical projections. Brain Struct Funct. 2019;: pubmed publisher
..Considering the intensity of glutamatergic and GABAergic descending projections, the BF likely acts through subcortical targets to promote arousal, motivation, and other behaviors. ..
Scammell T, Winrow C. Orexin receptors: pharmacology and therapeutic opportunities. Annu Rev Pharmacol Toxicol. 2011;51:243-66 pubmed publisher
..As the orexin system mainly promotes arousal, these new compounds will likely improve insomnia without incurring many of the side effects encountered with current medications. ..
Scammell T, Arrigoni E, Lipton J. Neural Circuitry of Wakefulness and Sleep. Neuron. 2017;93:747-765 pubmed publisher
Scammell T, Gerashchenko D, Urade Y, Onoe H, Saper C, Hayaishi O. Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2. Proc Natl Acad Sci U S A. 1998;95:7754-9 pubmed
..These observations suggest that PGD2 may induce sleep via leptomeningeal PGD2 receptors with subsequent activation of the VLPO. ..
Scammell T, Willie J, Guilleminault C, Siegel J. A consensus definition of cataplexy in mouse models of narcolepsy. Sleep. 2009;32:111-6 pubmed
..This working definition provides helpful insights into murine cataplexy and should allow objective and accurate comparisons of cataplexy in future studies using mouse models of narcolepsy...
Kroeger D, Ferrari L, Petit G, Mahoney C, Fuller P, Arrigoni E, et al
. Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice. J Neurosci. 2017;37:1352-1366 pubmed publisher
Mahoney C, Agostinelli L, Brooks J, Lowell B, Scammell T. GABAergic Neurons of the Central Amygdala Promote Cataplexy. J Neurosci. 2017;37:3995-4006 pubmed publisher
..These results demonstrate the importance of the CeA in regulating responses to rewarding stimuli, shedding light on the broader neurobiology of emotions and motor control. ..