Thomas E Scammell

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Hypothalamic arousal regions are activated during modafinil-induced wakefulness
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 20:8620-8. 2000
  2. ncbi request reprint The neurobiology, diagnosis, and treatment of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Ann Neurol 53:154-66. 2003
  3. ncbi request reprint An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuroscience 107:653-63. 2001
  4. ncbi request reprint Wakefulness: an eye-opening perspective on orexin neurons
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 11:R769-71. 2001
  5. ncbi request reprint Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neurology 56:1751-3. 2001
  6. pmc Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice
    Takatoshi Mochizuki
    Department of Neurology and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:4471-6. 2011
  7. pmc Orexin neurons are necessary for the circadian control of REM sleep
    Sandor Kantor
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 32:1127-34. 2009
  8. pmc Abnormal sleep/wake dynamics in orexin knockout mice
    Cecilia G Diniz Behn
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA, USA
    Sleep 33:297-306. 2010
  9. ncbi request reprint Homeostatic, circadian, and emotional regulation of sleep
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 493:92-8. 2005
  10. ncbi request reprint Behavioral state instability in orexin knock-out mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 24:6291-300. 2004

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Hypothalamic arousal regions are activated during modafinil-induced wakefulness
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 20:8620-8. 2000
    ..Selective pharmacological activation of these hypothalamic regions may represent a novel approach to inducing wakefulness...
  2. ncbi request reprint The neurobiology, diagnosis, and treatment of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Ann Neurol 53:154-66. 2003
    ..These discoveries have considerably improved our understanding of the neurobiology of sleep and should foster the development of rational treatments for a variety of sleep disorders...
  3. ncbi request reprint An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuroscience 107:653-63. 2001
    ..These ventrolateral preoptic area neurons may then coordinate the inhibition of multiple wake-promoting regions, resulting in sleep...
  4. ncbi request reprint Wakefulness: an eye-opening perspective on orexin neurons
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 11:R769-71. 2001
    ..Orexin-containing neurons regulate wakefulness, and loss of orexin produces narcolepsy. Recent studies of mice lacking orexin neurons have shown that these cells also play essential roles in the control of feeding and energy balance...
  5. ncbi request reprint Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neurology 56:1751-3. 2001
    ..The authors hypothesize that a loss of orexin neurons or their relevant targets may be the specific neuropathology causing this and many other cases of secondary narcolepsy...
  6. pmc Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice
    Takatoshi Mochizuki
    Department of Neurology and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:4471-6. 2011
    ..These observations demonstrate that the tuberomammillary region plays an essential role in the wake-promoting effects of orexins, but orexins must stabilize sleep through other targets...
  7. pmc Orexin neurons are necessary for the circadian control of REM sleep
    Sandor Kantor
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 32:1127-34. 2009
    ....
  8. pmc Abnormal sleep/wake dynamics in orexin knockout mice
    Cecilia G Diniz Behn
    Department of Neurology, Beth Israel Deaconess Medical Center Boston, MA, USA
    Sleep 33:297-306. 2010
    ..We developed an EEG spectral analysis technique to determine whether the state instability in a mouse model of narcolepsy reflects abnormal sleep or wake states, faster movements between states, or abnormal transitions between states...
  9. ncbi request reprint Homeostatic, circadian, and emotional regulation of sleep
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 493:92-8. 2005
    ..Understanding the pathways that underlie the regulation of sleep and wakefulness may provide important insights into how the cognitive and emotional systems interact with basic homeostatic and circadian drives for sleep...
  10. ncbi request reprint Behavioral state instability in orexin knock-out mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 24:6291-300. 2004
    ..Instead, the fragmented behavior of orexin KO mice may be best described as behavioral state instability, with apparently low thresholds to transition between states...
  11. pmc Role of the medial prefrontal cortex in cataplexy
    Yo Oishi
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 33:9743-51. 2013
    ..These observations indicate that the mPFC is a critical site through which positive emotions trigger cataplexy...
  12. pmc Running promotes wakefulness and increases cataplexy in orexin knockout mice
    Rodrigo A Espana
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Sleep 30:1417-25. 2007
    ..People with narcolepsy and mice lacking orexin/hypocretin have disrupted sleep/wake behavior and reduced physical activity. Our objective was to identify physiologic mechanisms through which orexin deficiency reduces locomotor activity...
  13. ncbi request reprint Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    Thomas C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10691-702. 2003
    ..Through these pathways, the DMH may influence a wide range of behavioral circadian rhythms...
  14. pmc Afferents to the orexin neurons of the rat brain
    Kyoko Yoshida
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 494:845-61. 2006
    ..These observations suggest that the orexin neurons may integrate a variety of interoceptive and homeostatic signals to increase behavioral arousal in response to hunger, stress, circadian signals, and autonomic challenges...
  15. pmc Elevated body temperature during sleep in orexin knockout mice
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Physiol Regul Integr Comp Physiol 291:R533-40. 2006
    ..In addition, because heat loss is an essential aspect of sleep, the blunted fall in Tb of orexin KO mice may provide an explanation for the fragmented sleep of narcolepsy...
  16. ncbi request reprint Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival...
  17. ncbi request reprint Sleep neurobiology for the clinician
    Rodrigo A Espana
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Sleep 27:811-20. 2004
    ..An up-to-date understanding of these systems should allow clinicians and researchers to better understand the effects of drugs, lesions, and neurologic disease on sleep and wakefulness...
  18. pmc A consensus definition of cataplexy in mouse models of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Sleep 32:111-6. 2009
    ..This working definition provides helpful insights into murine cataplexy and should allow objective and accurate comparisons of cataplexy in future studies using mouse models of narcolepsy...
  19. ncbi request reprint Wake-related activity of tuberomammillary neurons in rats
    Emily M Ko
    Department of Psychology, Harvard College, Cambridge, MA 02115, USA
    Brain Res 992:220-6. 2003
    ..These results demonstrate that histaminergic neurons throughout the TMN are wake-active, and this activity is largely independent of the time of day...
  20. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    ..We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy...
  21. pmc Amygdala lesions reduce cataplexy in orexin knock-out mice
    Christian R Burgess
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 33:9734-42. 2013
    ....
  22. ncbi request reprint Afferents to the ventrolateral preoptic nucleus
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:977-90. 2002
    ..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions...
  23. ncbi request reprint Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signalling
    Achim Kramer
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Novartis Found Symp 253:250-62; discussion 102-9, 263-6, 281-4. 2003
    ..These results implicate EGF receptor signalling in the daily control of locomotor activity, and they identify a neural circuit in the hypothalamus that likely mediates the regulation of behaviour both by the SCN and the retina...
  24. ncbi request reprint Orexin/Hypocretin: wired for wakefulness
    Takatoshi Mochizuki
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Biol 13:R563-4. 2003
    ..Electrophysiological studies have now identified positive and negative feedback signals that allow the orexin neurons to help maintain wakefulness...
  25. ncbi request reprint Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome")
    David K Simon
    Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Neurology, Boston, Massachusetts 02115, USA
    Mov Disord 19:838-40. 2004
    ..The gait difficulties resolved with venlafaxine. This case demonstrates that status cataplecticus can be misdiagnosed as a psychogenic gait disorder...
  26. pmc Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice
    Sandor Kantor
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 36:1129-38. 2013
    ..We hypothesized that the sleepiness of narcolepsy would substantially improve if orexin signaling were restored in specific brain regions at appropriate times of day...
  27. pmc Orexin receptors: pharmacology and therapeutic opportunities
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Annu Rev Pharmacol Toxicol 51:243-66. 2011
    ..As the orexin system mainly promotes arousal, these new compounds will likely improve insomnia without incurring many of the side effects encountered with current medications...
  28. ncbi request reprint Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:5762-70. 2003
    ..This transduction knock-out technique holds enormous potential for dissecting the functions of different CNS pathways...
  29. pmc Do enteric neurons make hypocretin?
    Christian R Baumann
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, USA
    Regul Pept 147:1-3. 2008
    ..These results raise doubts about whether enteric neurons produce hypocretin...
  30. pmc Mathematical model of network dynamics governing mouse sleep-wake behavior
    Cecilia G Diniz Behn
    Department of Mathematics and Center for BioDynamics, Boston University, MA, USA
    J Neurophysiol 97:3828-40. 2007
    ..Because circadian and other factors alter the fine architecture of sleep-wake behavior, this model provides a novel framework to explore dynamical principles that may underlie normal and pathologic sleep-wake physiology...
  31. doi request reprint Emerging therapeutics in sleep
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA
    Ann Neurol 74:435-40. 2013
    ....
  32. pmc Common scale-invariant patterns of sleep-wake transitions across mammalian species
    Chung Chuan Lo
    Center for Polymer Studies and Department of Physics, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:17545-8. 2004
    ..Our findings suggest common dynamical features of brief awakenings and sleep durations across species and may provide insights into the dynamics of the neural circuits controlling sleep...
  33. doi request reprint Increase of histaminergic tuberomammillary neurons in narcolepsy
    Philipp O Valko
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA Department of Neurology, University Hospital of Zurich, Zurich, Switzerland
    Ann Neurol 74:794-804. 2013
    ..As cerebrospinal fluid histamine levels may be low in patients with narcolepsy, we examined histaminergic neurons in patients with narcolepsy and in 2 mouse models of narcolepsy...
  34. pmc Neural circuitry engaged by prostaglandins during the sickness syndrome
    Clifford B Saper
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Neurosci 15:1088-95. 2012
    ..By examining which prostaglandins are produced at which sites and how they interact with the nervous system, researchers have identified specific neural circuits that underlie the sickness syndrome...
  35. ncbi request reprint Diurnal variation in CSF orexin-A in healthy male subjects
    Scott P Grady
    Portland Diabetes and Endocrinology Center, Portland, OR, USA
    Sleep 29:295-7. 2006
    ..Orexin-A is hypothesized to promote wakefulness, and we examined whether cerebrospinal fluid (CSF) orexin-A levels are higher during the waking period in man...
  36. ncbi request reprint Hypocretin/orexin and sleep: implications for the pathophysiology and diagnosis of narcolepsy
    Sebastiaan Overeem
    Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Neurol 15:739-45. 2002
    ..Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness and cataplexy. The discovery that the majority of human patients lack the hypothalamic neuropeptide hypocretin-1 has initiated a large body of new research...
  37. ncbi request reprint Narcolepsy caused by acute disseminated encephalomyelitis
    Richard F Gledhill
    Department of Neurology, Medical University of Southern Africa, Ga Rankuwa Hospital, Pretoria, Republic of South Africa
    Arch Neurol 61:758-60. 2004
    ..Narcolepsy with cataplexy is caused by a selective loss of hypocretin-producing neurons, but narcolepsy can also result from hypothalamic and rostral brainstem lesions...
  38. ncbi request reprint The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy
    Thomas E Scammell
    Sleep 29:601-2. 2006
  39. ncbi request reprint Orexin, drugs and motivated behaviors
    Thomas E Scammell
    Nat Neurosci 8:1286-8. 2005
  40. ncbi request reprint Pharmacotherapy for cataplexy
    William C Houghton
    Orphan Medical, Inc, Medical Affairs, 13911 Ridgedale Drive, Suite 250, Minnetonka, MN 55305, USA
    Sleep Med Rev 8:355-66. 2004
    ..This review is intended to familiarize readers with the safety and efficacy of these medications, thus enabling clinicians to optimize their management of cataplexy...
  41. pmc Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep
    Matthew P Anderson
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 102:1743-8. 2005
    ..1 was deleted from cortical pyramidal neurons. These findings support the hypothesis that thalamic T-type Ca2+ channels are required to block transmission of arousal signals through the thalamus and to stabilize sleep...
  42. ncbi request reprint Modafinil: a drug in search of a mechanism
    Clifford B Saper
    Sleep 27:11-2. 2004
  43. pmc Orexins: looking forward to sleep, back at addiction
    Thomas E Scammell
    Nat Med 13:126-8. 2007
  44. ncbi request reprint Parkinson's disease, sleepiness and hypocretin/orexin
    Christian R Baumann
    Brain 131:e91. 2008