David T Scadden
Affiliation: Harvard University
- Goncalves K, Silberstein L, Li S, Severe N, Hu M, Yang H, et al. Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell. 2016;166:894-906 pubmed publisher..These cell-type-specific functions of ANG suggest considerable therapeutic potential. ..
- Yu V, Yusuf R, Oki T, Wu J, Saez B, Wang X, et al. Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell. 2016;167:1310-1322.e17 pubmed publisher..This high degree of epigenetically driven cell autonomy among HSCs implies that refinement of the concepts of stem cell plasticity and of the stem cell niche is warranted. ..
- Hoggatt J, Singh P, Tate T, Chou B, Datari S, Fukuda S, et al. Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell. 2018;172:191-204.e10 pubmed publisher..Our studies suggest a potential new strategy for the rapid collection of an improved hematopoietic graft. ..
- Lee D, Sykes S, Kalaitzidis D, Lane A, Kfoury Y, Raaijmakers M, et al. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem Cell Reports. 2014;3:832-40 pubmed publisher..A transmembrane inhibitor of mTORC2 may provide an attractive target to affect this critical cell regulatory pathway. ..
- Baryawno N, Severe N, Scadden D. Hematopoiesis: Reconciling Historic Controversies about the Niche. Cell Stem Cell. 2017;20:590-592 pubmed publisher..Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate. ..