David T Scadden


Affiliation: Harvard University
Country: USA


  1. Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, et al. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nat Commun. 2019;10:617 pubmed publisher
  2. Scadden D. Rethinking stroma: lessons from the blood. Cell Stem Cell. 2012;10:648-649 pubmed publisher
    ..Stroma is a largely understudied component of all organs that contributes to stem cell niches. Studies to define stromal components in the bone marrow have led to some unexpected findings that prompt further research. ..
  3. Scadden D. Nice neighborhood: emerging concepts of the stem cell niche. Cell. 2014;157:41-50 pubmed publisher
    ..It reviews classical and emerging concepts of the niche, particularly considering how niche functions may participate in neoplastic disease. ..
  4. Kfoury Y, Scadden D. Mesenchymal cell contributions to the stem cell niche. Cell Stem Cell. 2015;16:239-53 pubmed publisher
  5. Silberstein L, Goncalves K, Kharchenko P, Turcotte R, Kfoury Y, Mercier F, et al. Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators. Cell Stem Cell. 2016;19:530-543 pubmed publisher
    ..Similar approaches could also be applied to other stem cell/niche pairs to advance the understanding of microenvironmental regulation of stem cell function. ..
  6. Mercier F, Scadden D. Not All Created Equal: Lineage Hard-Wiring in the Production of Blood. Cell. 2015;163:1568-70 pubmed publisher
    ..New data suggest that lineage fate may be determined earlier than thought and that myeloid progenitor populations are aggregates of individual lineage-restricted cells. ..
  7. Yu V, Scadden D. Hematopoietic Stem Cell and Its Bone Marrow Niche. Curr Top Dev Biol. 2016;118:21-44 pubmed publisher
    ..In this chapter, we will review the history of the niche concept, evolving information about its components and how niche dysfunction may contribute to disease. ..
  8. Kalaitzidis D, Scadden D. Tic-TACs: refreshing hair growth. Cell. 2014;157:769-70 pubmed publisher
    ..Using the hair follicle as a model, Hsu at al. demonstrate that the transient-amplifying cells, downstream of stem cells and well-known cell producers, signal back to stem cells to maintain long-term regenerative capacity...
  9. Wang Y, Israelsen W, Lee D, Yu V, Jeanson N, Clish C, et al. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 2014;158:1309-1323 pubmed publisher
    ..This finding suggests that fine-tuning the level of glycolysis may be explored therapeutically for treating leukemia while preserving HSC function. ..

More Information


  1. Goncalves K, Silberstein L, Li S, Severe N, Hu M, Yang H, et al. Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell. 2016;166:894-906 pubmed publisher
    ..These cell-type-specific functions of ANG suggest considerable therapeutic potential. ..
  2. Yu V, Yusuf R, Oki T, Wu J, Saez B, Wang X, et al. Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell. 2016;167:1310-1322.e17 pubmed publisher
    ..This high degree of epigenetically driven cell autonomy among HSCs implies that refinement of the concepts of stem cell plasticity and of the stem cell niche is warranted. ..
  3. Hoggatt J, Singh P, Tate T, Chou B, Datari S, Fukuda S, et al. Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell. 2018;172:191-204.e10 pubmed publisher
    ..Our studies suggest a potential new strategy for the rapid collection of an improved hematopoietic graft. ..
  4. Lee D, Sykes S, Kalaitzidis D, Lane A, Kfoury Y, Raaijmakers M, et al. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem Cell Reports. 2014;3:832-40 pubmed publisher
    ..A transmembrane inhibitor of mTORC2 may provide an attractive target to affect this critical cell regulatory pathway. ..
  5. Yu V, Saez B, Cook C, Lotinun S, Pardo Saganta A, Wang Y, et al. Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. J Exp Med. 2015;212:759-74 pubmed publisher
  6. Yu V, Lymperi S, Oki T, Jones A, Swiatek P, Vasic R, et al. Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow. Stem Cell Reports. 2016;7:220-35 pubmed publisher
  7. Baryawno N, Severe N, Scadden D. Hematopoiesis: Reconciling Historic Controversies about the Niche. Cell Stem Cell. 2017;20:590-592 pubmed publisher
    ..Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate. ..