Clifford B Saper

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The central circadian timing system
    Clifford B Saper
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, United States Electronic address
    Curr Opin Neurobiol 23:747-51. 2013
  2. doi request reprint The neurobiology of sleep
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, 300 Brookline Avenue, Boston, MA 02215, USA
    Continuum (Minneap Minn) 19:19-31. 2013
  3. pmc Neural circuitry engaged by prostaglandins during the sickness syndrome
    Clifford B Saper
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Neurosci 15:1088-95. 2012
  4. pmc The neuroscience peer review consortium
    Clifford B Saper
    Behavioral and Brain Functions, University of Oslo, Oslo, Norway
    Behav Brain Funct 5:4. 2009
  5. ncbi request reprint Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Prog Brain Res 153:243-52. 2006
  6. doi request reprint The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 65:4-6. 2010
  7. ncbi request reprint The hypothalamic integrator for circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 28:152-7. 2005
  8. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
  9. pmc A guide to the perplexed on the specificity of antibodies
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Histochem Cytochem 57:1-5. 2009
  10. ncbi request reprint Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005

Research Grants

  1. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2009
  2. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2009
  3. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2007
  4. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2006
  5. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2005
  6. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2004
  7. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2003
  8. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2002
  9. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2001
  10. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2000

Detail Information

Publications67

  1. pmc The central circadian timing system
    Clifford B Saper
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, United States Electronic address
    Curr Opin Neurobiol 23:747-51. 2013
    ..Finally, we review the evidence that under conditions of restricted food availability, other clocks may be able to take over from the SCN to determine rhythms of behavior and physiology. ..
  2. doi request reprint The neurobiology of sleep
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, 300 Brookline Avenue, Boston, MA 02215, USA
    Continuum (Minneap Minn) 19:19-31. 2013
    ..The basic circuitries that regulate wake-sleep cycles are described, along with how these are affected by different disease states and how those alterations lead to the clinical manifestations of those disorders...
  3. pmc Neural circuitry engaged by prostaglandins during the sickness syndrome
    Clifford B Saper
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Neurosci 15:1088-95. 2012
    ..By examining which prostaglandins are produced at which sites and how they interact with the nervous system, researchers have identified specific neural circuits that underlie the sickness syndrome...
  4. pmc The neuroscience peer review consortium
    Clifford B Saper
    Behavioral and Brain Functions, University of Oslo, Oslo, Norway
    Behav Brain Funct 5:4. 2009
    ..In order to encourage dissemination of the details outlined in this Editorial, it will also be published in other journals in the Neuroscience Peer Review Consortium...
  5. ncbi request reprint Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Prog Brain Res 153:243-52. 2006
    ..We also review the role of the subparaventricular nucleus and the dorsomedial nucleus of the hypothalamus in circadian integration and modulation of both feeding and wake-sleep patterns...
  6. doi request reprint The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 65:4-6. 2010
    ....
  7. ncbi request reprint The hypothalamic integrator for circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 28:152-7. 2005
    ....
  8. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    ..We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy...
  9. pmc A guide to the perplexed on the specificity of antibodies
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Histochem Cytochem 57:1-5. 2009
    ..In this review, I consider the principles of antibody action and how they define a set of rules for what information should be obtained by the investigator before using an antibody in a serious scientific investigation...
  10. ncbi request reprint Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival...
  11. ncbi request reprint Sleep-dependent memory consolidation
    Robert Stickgold
    Department of Psychiatry, Harvard Medical School, and Centre for Sleep and Cognition, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue FD 861, Boston, Massachusetts 02215, USA
    Nature 437:1272-8. 2005
    ..Nevertheless, converging evidence, from the molecular to the phenomenological, leaves little doubt that offline memory reprocessing during sleep is an important component of how our memories are formed and ultimately shaped...
  12. ncbi request reprint Homeostatic, circadian, and emotional regulation of sleep
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 493:92-8. 2005
    ..Understanding the pathways that underlie the regulation of sleep and wakefulness may provide important insights into how the cognitive and emotional systems interact with basic homeostatic and circadian drives for sleep...
  13. ncbi request reprint Biomedicine. Life, the universe, and body temperature
    Clifford B Saper
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Science 314:773-4. 2006
  14. pmc Standards of evidence in chronobiology: A response
    Patrick M Fuller
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
    J Circadian Rhythms 7:9. 2009
    ....
  15. pmc Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment
    Heinrich S Gompf
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 30:14543-51. 2010
    ..Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention...
  16. pmc Parallel preoptic pathways for thermoregulation
    Kyoko Yoshida
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 29:11954-64. 2009
    ..Our data suggest that the MnPO and DLPO provide parallel inhibitory pathways that tonically inhibit the DMH/DHA and the RMR at baseline, and that hyperthermia requires the release of this inhibition from both nuclei...
  17. ncbi request reprint Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    Thomas C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10691-702. 2003
    ..Through these pathways, the DMH may influence a wide range of behavioral circadian rhythms...
  18. pmc Reassessment of the structural basis of the ascending arousal system
    Patrick M Fuller
    Division of Sleep Medicine, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 519:933-56. 2011
    ....
  19. pmc Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal
    Satvinder Kaur
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 33:7627-40. 2013
    ..Our results suggest that glutamatergic neurons in the lateral PB are necessary for arousals from sleep in response to CO2, while medial PB glutamatergic neurons play an important role in promoting spontaneous waking...
  20. pmc Differential rescue of light- and food-entrainable circadian rhythms
    Patrick M Fuller
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 320:1074-7. 2008
    ..These results demonstrate that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food entrainment of circadian rhythms...
  21. ncbi request reprint EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
    Michael Lazarus
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:1131-3. 2007
    ..These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses...
  22. pmc Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus
    Elda Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Eur J Neurosci 30:2112-20. 2009
    ..LTP in VLPO-lesioned animals was partially restored by adenosine antagonists, suggesting that adenosine accumulation in VLPO-lesioned animals could account for some of the observed synaptic plasticity deficits...
  23. pmc Role of the medial prefrontal cortex in cataplexy
    Yo Oishi
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 33:9743-51. 2013
    ..These observations indicate that the mPFC is a critical site through which positive emotions trigger cataplexy...
  24. pmc Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats
    Eveline Bruinstroop
    Department of Neurology, Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Comp Neurol 520:1985-2001. 2012
    ..The pattern of spinal projections observed suggests that the locus coeruleus might have the greatest effect on somatosensory transmission, the A7 group on motor function, and the A5 group on sympathetic function...
  25. pmc Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals
    Andrew S P Lim
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Sleep 35:633-40B. 2012
    ....
  26. ncbi request reprint The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms
    Joshua J Gooley
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Neurosci 9:398-407. 2006
    ..These results establish that the neurons of the DMH have a critical role in the expression of food-entrainable circadian rhythms...
  27. ncbi request reprint A putative flip-flop switch for control of REM sleep
    Jun Lu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 441:589-94. 2006
    ..The mutually inhibitory interactions of the REM-on and REM-off areas may form a flip-flop switch that sharpens state transitions and makes them vulnerable to sudden, unwanted transitions-for example, in narcolepsy...
  28. ncbi request reprint Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurosci Lett 370:123-6. 2004
    ..Furthermore, most orexin neurons and MCH neurons appear to contain AChE. AChE immunoreactivity appears to be a key feature of nearly all of the diffusely-projecting cortical systems...
  29. ncbi request reprint A broad role for melanopsin in nonvisual photoreception
    Joshua J Gooley
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:7093-106. 2003
    ....
  30. ncbi request reprint Afferents to the ventrolateral preoptic nucleus
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:977-90. 2002
    ..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions...
  31. pmc Neural circuitry of stress-induced insomnia in rats
    Georgina Cano
    Department of Neurology, Beth Israel Deaconess Medical Center, Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 28:10167-84. 2008
    ..These results suggest that shutting down the residual activity of the limbic-arousal system might be a better approach to treat stress-induced insomnia, rather than potentiation of the sleep system, which remains fully active...
  32. ncbi request reprint Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:4568-76. 2002
    ..The connections and physiological activity of the extended VLPO suggest a specialized role in the regulation of REM sleep...
  33. pmc Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors
    Takakazu Oka
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience and Harvard Medical School, Boston, MA 02115, USA
    J Physiol 551:945-54. 2003
    ....
  34. ncbi request reprint Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain
    Joseph F Kelly
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 53:911-20. 2004
    ..Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin...
  35. ncbi request reprint Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback
    Patrick M Fuller
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 814, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    J Biol Rhythms 21:482-93. 2006
    ....
  36. pmc Metabolic effects of chronic sleep restriction in rats
    Ramalingam Vetrivelan
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 35:1511-20. 2012
    ..We used rats with lesions in the ventrolateral preoptic area (VLPO), which spontaneously sleep about 30% less than intact rats, as an animal model to study the consequences of chronic partial sleep loss on energy metabolism...
  37. pmc A neural mechanism for exacerbation of headache by light
    Rodrigo Noseda
    Department of Anesthesia, Boston, Massachusetts, USA
    Nat Neurosci 13:239-45. 2010
    ..We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons...
  38. pmc A consensus definition of cataplexy in mouse models of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Sleep 32:111-6. 2009
    ..This working definition provides helpful insights into murine cataplexy and should allow objective and accurate comparisons of cataplexy in future studies using mouse models of narcolepsy...
  39. pmc COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice
    Daniel Vardeh
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 119:287-94. 2009
    ..Mechanical pain is a major symptom of most inflammatory conditions, such as postoperative pain and arthritis, and induction of COX2 in neural cells in the CNS seems to contribute to this...
  40. pmc The ventrolateral preoptic nucleus is not required for isoflurane general anesthesia
    Matthias Eikermann
    Department of Anesthesia, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Brain Res 1426:30-7. 2011
    ..We conclude that the sleep loss caused by ablation of VLPO neurons sensitizes animals to the general anesthetic effects of isoflurane, but that the sedation produced by VLPO neurons themselves is not required for isoflurane anesthesia...
  41. ncbi request reprint Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:5762-70. 2003
    ..This transduction knock-out technique holds enormous potential for dissecting the functions of different CNS pathways...
  42. doi request reprint Role of endogenous sleep-wake and analgesic systems in anesthesia
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:648-62. 2008
    ....
  43. ncbi request reprint Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 457:213-35. 2003
    ..The distribution of MC4-R mRNA is consistent with the proposed roles of central melanocortin systems in feeding and autonomic regulation...
  44. ncbi request reprint Expression of ghrelin receptor mRNA in the rat and the mouse brain
    Jeffrey M Zigman
    Department of Medicine and Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 494:528-48. 2006
    ....
  45. ncbi request reprint Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain
    Yi Hong Zhang
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 463:3-12. 2003
    ..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J...
  46. ncbi request reprint Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 26:193-202. 2006
    ....
  47. ncbi request reprint Is food-directed behavior an appropriate measure of circadian entrainment to restricted daytime feeding?
    Joshua J Gooley
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Biol Rhythms 22:479-83. 2007
  48. pmc The pontine REM switch: past and present
    Patrick M Fuller
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Physiol 584:735-41. 2007
    ..Our findings demonstrating independent pathways mediating atonia and the EEG components of REM provide a basis for their occasional dissociation in pathological states, e.g. REM sleep behaviour disorder...
  49. ncbi request reprint Central neurogenic hyperventilation: a case report and discussion of pathophysiology
    Andrew W Tarulli
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Neurol 62:1632-4. 2005
    ..Central neurogenic hyperventilation is a rare condition with poorly understood pathophysiology...
  50. pmc Perspectives on the rapid eye movement sleep switch in rapid eye movement sleep behavior disorder
    Vetrivelan Ramaligam
    Department of Neurology and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Sleep Med 14:707-13. 2013
    ..Animal research has lead to the hypothesis that complex behaviors in RBD are due to SLD pathology, while simple behaviors of RBD may be due to less severe SLD pathology or dysfunction of the VMM, ventral pons, or spinal cord. ..
  51. doi request reprint Emerging therapeutics in sleep
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA
    Ann Neurol 74:435-40. 2013
    ....
  52. ncbi request reprint The need to feed: homeostatic and hedonic control of eating
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 36:199-211. 2002
    ..We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition...
  53. pmc Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    Hiroshi Yamamoto
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    J Clin Invest 110:43-52. 2002
    ..These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo...
  54. ncbi request reprint Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital East, Room 2625, 149 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 58:408-16. 2005
    ..In a previous postmortem study, we found a reduction in the density of striatal interneurons that stain immunohistochemically for choline acetyltransferase (ChAT) in schizophrenia...
  55. pmc Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis
    Andrew S P Lim
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Sleep 34:1569-81. 2011
    ..We then applied this to the study of the temporal dynamics of rest-activity patterns in older individuals...
  56. ncbi request reprint The central autonomic nervous system: conscious visceral perception and autonomic pattern generation
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 25:433-69. 2002
    ..These pattern generators are located at multiple levels of the central nervous system, and they can be combined in temporal and spatial patterns to subserve a wide range of behavioral needs...
  57. ncbi request reprint Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats
    Takakazu Oka
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Brain Res 968:256-62. 2003
    ..In contrast, ONO-AE1-329, an EP4 receptor agonist, decreased the T(c). These findings suggest that the EP1, EP3, and EP4 receptors all may contribute to the thermoregulatory response to PGE2, but each may have a different role...
  58. ncbi request reprint The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects
    Laura E Nelson
    Department of Anaesthetics, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Anesthesiology 98:428-36. 2003
    ..The authors investigated whether the sedative, or hypnotic, action of the general anesthetic dexmedetomidine (a selective alpha -adrenoceptor agonist) activates endogenous nonrapid eye movement (NREM) sleep-promoting pathways...
  59. ncbi request reprint Orexin, drugs and motivated behaviors
    Thomas E Scammell
    Nat Neurosci 8:1286-8. 2005
  60. pmc Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats
    Dmitry Gerashchenko
    West Roxbury Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
    Sleep 27:1275-81. 2004
    ..Hence, we placed cell-specific lesions in the TMN to determine its role in spontaneous wakefulness...
  61. doi request reprint Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors
    Hiroyoshi Tsuchiya
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences and Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 283:11064-71. 2008
    ..These results indicate that PGE(2)-EP3 signaling elicits G(i/o) activation in preoptic thermocenter neurons, and we propose the possibility that a rapid decrease in preoptic GABA(A) expression may be involved in PGE(2)-induced fever...
  62. ncbi request reprint REM sleep behavior disorder: a dopaminergic deficiency disorder?
    Jean K Matheson
    Neurology 61:1328-9. 2003
  63. ncbi request reprint Modafinil: a drug in search of a mechanism
    Clifford B Saper
    Sleep 27:11-2. 2004
  64. pmc Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
    Paul S A Kalanithi
    Child Study Center and Department of Neurobiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 102:13307-12. 2005
    ..The imbalance in striatal and GPi inhibitory neuron distribution suggests that the functional dynamics of cortico-striato-thalamic circuitry are fundamentally altered in severe, persistent TS...
  65. pmc Orexins: looking forward to sleep, back at addiction
    Thomas E Scammell
    Nat Med 13:126-8. 2007
  66. ncbi request reprint Movement suppression during anesthesia: neural projections from the mesopontine tegmentum to areas involved in motor control
    Inna Sukhotinsky
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Comp Neurol 489:425-48. 2005
    ..Analysis of MPTA connectivity has the potential for furthering our understanding of the neural circuitry responsible for the various functional components of general anesthesia...

Research Grants15

  1. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2009
    ....
  2. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2009
    ....
  3. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2007
    ....
  4. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2006
    ....
  5. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2005
    ....
  6. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2004
    ..These studies should advance our understanding of the molecular and cellular mechanisms that underlie the autonomic, endocrine, and behaviora1 responses associated with fever ..
  7. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2003
    ..These studies should advance our understanding of the molecular and cellular mechanisms that underlie the autonomic, endocrine, and behaviora1 responses associated with fever ..
  8. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2002
    ..These studies should advance our understanding of the molecular and cellular mechanisms that underlie the autonomic, endocrine, and behaviora1 responses associated with fever ..
  9. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2001
    ..These studies should advance our understanding of the molecular and cellular mechanisms that underlie the autonomic, endocrine, and behaviora1 responses associated with fever ..
  10. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2000
    ..These studies should advance our understanding of the molecular and cellular mechanisms that underlie the autonomic, endocrine, and behaviora1 responses associated with fever ..
  11. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2000
    ..These studies should advance our understanding of the molecular and cellular mechanisms that underlie the autonomic, endocrine, and behaviora1 responses associated with fever ..
  12. Circuitry for circadian rhythms
    Clifford B Saper; Fiscal Year: 2010
    ....