C B Saper

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The sleep switch: hypothalamic control of sleep and wakefulness
    C B Saper
    Dept of Neurology, Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 24:726-31. 2001
  2. ncbi request reprint The need to feed: homeostatic and hedonic control of eating
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 36:199-211. 2002
  3. ncbi request reprint The central autonomic nervous system: conscious visceral perception and autonomic pattern generation
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 25:433-69. 2002
  4. ncbi request reprint Fos expression in orexin neurons varies with behavioral state
    I V Estabrooke
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 21:1656-62. 2001
  5. ncbi request reprint Differential expression of orexin receptors 1 and 2 in the rat brain
    J N Marcus
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 435:6-25. 2001
  6. ncbi request reprint Orexin (hypocretin) neurons contain dynorphin
    T C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:RC168. 2001
  7. ncbi request reprint Hypothalamic arousal regions are activated during modafinil-induced wakefulness
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 20:8620-8. 2000
  8. ncbi request reprint Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro
    E Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 814, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Neuroscience 140:403-13. 2006
  9. ncbi request reprint An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuroscience 107:653-63. 2001
  10. ncbi request reprint Leptin activates neurons in ventrobasal hypothalamus and brainstem
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Endocrinology 138:839-42. 1997

Collaborators

Detail Information

Publications83

  1. ncbi request reprint The sleep switch: hypothalamic control of sleep and wakefulness
    C B Saper
    Dept of Neurology, Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 24:726-31. 2001
    ..A model is proposed in which wake- and sleep-promoting neurons inhibit each other, which results in stable wakefulness and sleep. Disruption of wake- or sleep-promoting pathways results in behavioral state instability...
  2. ncbi request reprint The need to feed: homeostatic and hedonic control of eating
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 36:199-211. 2002
    ..We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition...
  3. ncbi request reprint The central autonomic nervous system: conscious visceral perception and autonomic pattern generation
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 25:433-69. 2002
    ..These pattern generators are located at multiple levels of the central nervous system, and they can be combined in temporal and spatial patterns to subserve a wide range of behavioral needs...
  4. ncbi request reprint Fos expression in orexin neurons varies with behavioral state
    I V Estabrooke
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 21:1656-62. 2001
    ..Conversely, relative inactivity of orexin neurons may allow the expression of sleep...
  5. ncbi request reprint Differential expression of orexin receptors 1 and 2 in the rat brain
    J N Marcus
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 435:6-25. 2001
    ..The differential distribution of orexin receptors is consistent with the proposed multifaceted roles of orexin in regulating homeostasis and may explain the unique role of the OX(2)R receptor in regulating sleep state stability...
  6. ncbi request reprint Orexin (hypocretin) neurons contain dynorphin
    T C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:RC168. 2001
    ..These findings suggest that dynorphin-A may play an important role in the function of the orexin neurons...
  7. ncbi request reprint Hypothalamic arousal regions are activated during modafinil-induced wakefulness
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 20:8620-8. 2000
    ..Selective pharmacological activation of these hypothalamic regions may represent a novel approach to inducing wakefulness...
  8. ncbi request reprint Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro
    E Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 814, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Neuroscience 140:403-13. 2006
    ..Both of these effects occur via postsynaptic A1 receptors, but are mediated downstream by two separate mechanisms...
  9. ncbi request reprint An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuroscience 107:653-63. 2001
    ..These ventrolateral preoptic area neurons may then coordinate the inhibition of multiple wake-promoting regions, resulting in sleep...
  10. ncbi request reprint Leptin activates neurons in ventrobasal hypothalamus and brainstem
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
    Endocrinology 138:839-42. 1997
    ..These findings indicate that circulating leptin activates specific nuclear groups in the hypothalamus and brainstem known to regulate complex physiological responses during times of substrate availability...
  11. ncbi request reprint Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:4568-76. 2002
    ..The connections and physiological activity of the extended VLPO suggest a specialized role in the regulation of REM sleep...
  12. pmc Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Proc Natl Acad Sci U S A 95:741-6. 1998
    ..Our results demonstrate that a discrete set of hypothalamic pathways may underlie leptin's autonomic, endocrine, and behavioral effects...
  13. ncbi request reprint Distributions of leptin receptor mRNA isoforms in the rat brain
    J K Elmquist
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 395:535-47. 1998
    ..Leptin receptors localized in nonneuronal cells in the meninges, choroid plexus, and blood vessels may be involved in transport of leptin into the brain and in the clearance of leptin from the cerebrospinal fluid...
  14. ncbi request reprint Characterization of CART neurons in the rat and human hypothalamus
    C F Elias
    Department of Neurology, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    J Comp Neurol 432:1-19. 2001
    ..The distribution of CART cell bodies and fibers in the human hypothalamus indicates that CART may also play a role in the regulation of energy homeostasis in humans...
  15. pmc Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep-wake cycle and temperature regulation
    J Lu
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 21:4864-74. 2001
    ....
  16. ncbi request reprint Topographic organization of cardiovascular responses to electrical and glutamate microstimulation of the parabrachial nucleus in the rat
    N L Chamberlin
    Dept of Neurology, Beth Israel Hospital, Boston, Massachusetts
    J Comp Neurol 326:245-62. 1992
    ..The locations of the sites giving the most potent responses implicate specific ascending and descending pathways as substrates for the cardiovascular responses...
  17. ncbi request reprint Narcolepsy and low CSF orexin (hypocretin) concentration after a diencephalic stroke
    T E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neurology 56:1751-3. 2001
    ..The authors hypothesize that a loss of orexin neurons or their relevant targets may be the specific neuropathology causing this and many other cases of secondary narcolepsy...
  18. ncbi request reprint Melanopsin in cells of origin of the retinohypothalamic tract
    J J Gooley
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Neurosci 4:1165. 2001
    ..Here we show that most retinal ganglion cells (RGCs) that project to the SCN express the photopigment melanopsin...
  19. pmc Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia
    E Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuroscience 132:575-80. 2005
    ..These findings provide direct evidence that the neuroprotective role of adenosine during hypoxia depends on the rapid inhibition of synaptic transmission by the activation of presynaptic A(1) receptors...
  20. ncbi request reprint Activation of neurons projecting to the paraventricular hypothalamic nucleus by intravenous lipopolysaccharide
    J K Elmquist
    Department of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 374:315-31. 1996
    ..Our results are consistent with the hypothesis that the PVH plays a key role in integrating diverse physiological cues into the varied manifestations that constitute the cerebral component of the acute phase response...
  21. ncbi request reprint Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration
    J K Elmquist
    Department of Neurology, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 371:85-103. 1996
    ....
  22. pmc A neurohistochemical blueprint for pain-induced loss of appetite
    A Malick
    Department of Neurobiology and the Program in Neuroscience, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:9930-5. 2001
    ..Based on these findings, we suggest that at least one of several groups of hypothalamic neurons that normally inhibit appetite in response to metabolic cues is positioned to mediate the suppression of food intake by pain signals...
  23. ncbi request reprint Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    Thomas C Chou
    Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:10691-702. 2003
    ..Through these pathways, the DMH may influence a wide range of behavioral circadian rhythms...
  24. pmc Parallel preoptic pathways for thermoregulation
    Kyoko Yoshida
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 29:11954-64. 2009
    ..Our data suggest that the MnPO and DLPO provide parallel inhibitory pathways that tonically inhibit the DMH/DHA and the RMR at baseline, and that hyperthermia requires the release of this inhibition from both nuclei...
  25. ncbi request reprint Afferents to the ventrolateral preoptic nucleus
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 22:977-90. 2002
    ..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions...
  26. ncbi request reprint Recombinant adeno-associated virus vector: use for transgene expression and anterograde tract tracing in the CNS
    N L Chamberlin
    Departments of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Brain Res 793:169-75. 1998
    ..Not only might it be an ideal vehicle for gene therapy, but also the GFP-containing AAV presents a new strategy for tracing long axonal pathways in the CNS, which is difficult with current tracers (PHAL, biotinylated dextrans)...
  27. pmc Concomitant loss of dynorphin, NARP, and orexin in narcolepsy
    A Crocker
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Neurology 65:1184-8. 2005
    ..Narcolepsy with cataplexy is associated with a loss of orexin/hypocretin. It is speculated that an autoimmune process kills the orexin-producing neurons, but these cells may survive yet fail to produce orexin...
  28. ncbi request reprint Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species
    S E Gaus
    Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Neuroscience 115:285-94. 2002
    ..The VLPO appears to be a critical component of sleep circuitry across multiple species, and we hypothesize that shrinkage of the VLPO with advancing age may explain sleep deficits in elderly humans...
  29. ncbi request reprint The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms
    Joshua J Gooley
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Neurosci 9:398-407. 2006
    ..These results establish that the neurons of the DMH have a critical role in the expression of food-entrainable circadian rhythms...
  30. ncbi request reprint Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages
    J K Elmquist
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02115, USA
    J Comp Neurol 381:119-29. 1997
    ....
  31. ncbi request reprint Unraveling the central nervous system pathways underlying responses to leptin
    J K Elmquist
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Neurosci 1:445-50. 1998
    ..We describe neural circuits that are downstream of leptin receptors and propose a model linking populations of leptin-responsive neurons with effector neurons underlying leptin's endocrine, autonomic and behavioral effects...
  32. ncbi request reprint Localization of mu-opioid receptors on amygdaloid projection neurons in the parabrachial nucleus of the rat
    N L Chamberlin
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, Boston, MA 02215, USA
    Brain Res 827:198-204. 1999
    ....
  33. ncbi request reprint Homeostatic, circadian, and emotional regulation of sleep
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 493:92-8. 2005
    ..Understanding the pathways that underlie the regulation of sleep and wakefulness may provide important insights into how the cognitive and emotional systems interact with basic homeostatic and circadian drives for sleep...
  34. ncbi request reprint Central neurogenic hyperventilation: a case report and discussion of pathophysiology
    Andrew W Tarulli
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Neurol 62:1632-4. 2005
    ..Central neurogenic hyperventilation is a rare condition with poorly understood pathophysiology...
  35. pmc Reassessment of the structural basis of the ascending arousal system
    Patrick M Fuller
    Division of Sleep Medicine, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Comp Neurol 519:933-56. 2011
    ....
  36. ncbi request reprint A putative flip-flop switch for control of REM sleep
    Jun Lu
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nature 441:589-94. 2006
    ..The mutually inhibitory interactions of the REM-on and REM-off areas may form a flip-flop switch that sharpens state transitions and makes them vulnerable to sudden, unwanted transitions-for example, in narcolepsy...
  37. ncbi request reprint Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Prog Brain Res 153:243-52. 2006
    ..We also review the role of the subparaventricular nucleus and the dorsomedial nucleus of the hypothalamus in circadian integration and modulation of both feeding and wake-sleep patterns...
  38. pmc Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment
    Heinrich S Gompf
    Department of Neurology, Program in Neuroscience and Division of Sleep Medicine Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 30:14543-51. 2010
    ..Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention...
  39. ncbi request reprint The hypothalamic integrator for circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Trends Neurosci 28:152-7. 2005
    ....
  40. ncbi request reprint Biomedicine. Life, the universe, and body temperature
    Clifford B Saper
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Science 314:773-4. 2006
  41. ncbi request reprint Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback
    Patrick M Fuller
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 814, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    J Biol Rhythms 21:482-93. 2006
    ....
  42. ncbi request reprint Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 26:193-202. 2006
    ....
  43. doi request reprint Role of endogenous sleep-wake and analgesic systems in anesthesia
    Jun Lu
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Comp Neurol 508:648-62. 2008
    ....
  44. doi request reprint The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neuron 65:4-6. 2010
    ....
  45. pmc Sleep state switching
    Clifford B Saper
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neuron 68:1023-42. 2010
    ..We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy...
  46. pmc A guide to the perplexed on the specificity of antibodies
    Clifford B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    J Histochem Cytochem 57:1-5. 2009
    ..In this review, I consider the principles of antibody action and how they define a set of rules for what information should be obtained by the investigator before using an antibody in a serious scientific investigation...
  47. pmc A consensus definition of cataplexy in mouse models of narcolepsy
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Sleep 32:111-6. 2009
    ..This working definition provides helpful insights into murine cataplexy and should allow objective and accurate comparisons of cataplexy in future studies using mouse models of narcolepsy...
  48. pmc Standards of evidence in chronobiology: A response
    Patrick M Fuller
    Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
    J Circadian Rhythms 7:9. 2009
    ....
  49. pmc Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus
    Elda Arrigoni
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Eur J Neurosci 30:2112-20. 2009
    ..LTP in VLPO-lesioned animals was partially restored by adenosine antagonists, suggesting that adenosine accumulation in VLPO-lesioned animals could account for some of the observed synaptic plasticity deficits...
  50. ncbi request reprint Hypothalamic regulation of sleep and circadian rhythms
    Clifford B Saper
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
    Nature 437:1257-63. 2005
    ..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival...
  51. doi request reprint Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord
    F J Weng
    Department of Neurology, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, Center for Life Science Room 713, Boston, MA 02215, USA
    J Physiol 592:1601-17. 2014
    ..These observations suggest that acetylcholine produces synergistic, excitatory pre- and postsynaptic responses on SLDsp neurons that, in turn, probably serve to promote muscle atonia during REM sleep. ..
  52. ncbi request reprint Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats
    F Torrealba
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Neuroscience 119:1033-44. 2003
    ..Orexinergic afferents to the tuberomammillary neurons contain separate populations of orexinergic and glutamatergic vesicles, suggesting that the release of these neurotransmitters may be differentially regulated...
  53. pmc Neural circuitry of stress-induced insomnia in rats
    Georgina Cano
    Department of Neurology, Beth Israel Deaconess Medical Center, Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 28:10167-84. 2008
    ..These results suggest that shutting down the residual activity of the limbic-arousal system might be a better approach to treat stress-induced insomnia, rather than potentiation of the sleep system, which remains fully active...
  54. ncbi request reprint Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormone
    Thomas C Chou
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurosci Lett 370:123-6. 2004
    ..Furthermore, most orexin neurons and MCH neurons appear to contain AChE. AChE immunoreactivity appears to be a key feature of nearly all of the diffusely-projecting cortical systems...
  55. pmc Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons
    Hiroshi Yamamoto
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    J Clin Invest 110:43-52. 2002
    ..These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo...
  56. ncbi request reprint Inducible clocks: living in an unpredictable world
    C B Saper
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cold Spring Harb Symp Quant Biol 72:543-50. 2007
    ..We discuss here new data on the location of the FEO and suggest that it may involve an oscillator mechanism that is "induced" by starvation and refeeding...
  57. ncbi request reprint Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons
    N L Chamberlin
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institute of Medicine, Room 820, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuroscience 119:913-8. 2003
    ..We conclude that AD-mediated disinhibition increases the excitability of VLPO neurons thus contributing to the somnogenic properties of AD...
  58. ncbi request reprint EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
    Michael Lazarus
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:1131-3. 2007
    ..These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses...
  59. pmc A neural mechanism for exacerbation of headache by light
    Rodrigo Noseda
    Department of Anesthesia, Boston, Massachusetts, USA
    Nat Neurosci 13:239-45. 2010
    ..We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons...
  60. pmc In the flicker of an eye
    N P Pedersen
    Beth Israel Deaconess Medical Center, Department of Neurology, 330 Brookline Avenue, Boston, MA 02482, USA
    J Physiol 586:3305-6. 2008
  61. ncbi request reprint Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
    B F Boeve
    Department of Neurology, 6Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Brain 130:2770-88. 2007
    ..Furthermore, longitudinal studies in patients with idiopathic RBD are warranted to characterize the natural history of such patients and prepare for future therapeutic trials...
  62. ncbi request reprint Molecular evolution of tau protein: implications for Alzheimer's disease
    P T Nelson
    Department of Neurology, Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurochem 67:1622-32. 1996
    ..We propose that differences in the expression of tau and tau-related protein sequences may underlie the predilection of human but not monkey brains to develop neurofibrillary degeneration...
  63. pmc Differential rescue of light- and food-entrainable circadian rhythms
    Patrick M Fuller
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 320:1074-7. 2008
    ..These results demonstrate that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food entrainment of circadian rhythms...
  64. ncbi request reprint A broad role for melanopsin in nonvisual photoreception
    Joshua J Gooley
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:7093-106. 2003
    ....
  65. ncbi request reprint Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector
    Thomas E Scammell
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 23:5762-70. 2003
    ..This transduction knock-out technique holds enormous potential for dissecting the functions of different CNS pathways...
  66. pmc Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors
    Takakazu Oka
    Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience and Harvard Medical School, Boston, MA 02115, USA
    J Physiol 551:945-54. 2003
    ....
  67. pmc COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice
    Daniel Vardeh
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 119:287-94. 2009
    ..Mechanical pain is a major symptom of most inflammatory conditions, such as postoperative pain and arthritis, and induction of COX2 in neural cells in the CNS seems to contribute to this...
  68. ncbi request reprint Is food-directed behavior an appropriate measure of circadian entrainment to restricted daytime feeding?
    Joshua J Gooley
    Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    J Biol Rhythms 22:479-83. 2007
  69. pmc The pontine REM switch: past and present
    Patrick M Fuller
    Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Physiol 584:735-41. 2007
    ..Our findings demonstrating independent pathways mediating atonia and the EEG components of REM provide a basis for their occasional dissociation in pathological states, e.g. REM sleep behaviour disorder...
  70. ncbi request reprint Expression of ghrelin receptor mRNA in the rat and the mouse brain
    Jeffrey M Zigman
    Department of Medicine and Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 494:528-48. 2006
    ....
  71. ncbi request reprint Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat
    Toshiro Kishi
    Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 457:213-35. 2003
    ..The distribution of MC4-R mRNA is consistent with the proposed roles of central melanocortin systems in feeding and autonomic regulation...
  72. ncbi request reprint Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain
    Joseph F Kelly
    Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 53:911-20. 2004
    ..Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin...
  73. ncbi request reprint Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain
    Yi Hong Zhang
    Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Comp Neurol 463:3-12. 2003
    ..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J...
  74. ncbi request reprint Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats
    Takakazu Oka
    Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    Brain Res 968:256-62. 2003
    ..In contrast, ONO-AE1-329, an EP4 receptor agonist, decreased the T(c). These findings suggest that the EP1, EP3, and EP4 receptors all may contribute to the thermoregulatory response to PGE2, but each may have a different role...
  75. ncbi request reprint Orexin, drugs and motivated behaviors
    Thomas E Scammell
    Nat Neurosci 8:1286-8. 2005
  76. pmc Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats
    Dmitry Gerashchenko
    West Roxbury Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
    Sleep 27:1275-81. 2004
    ..Hence, we placed cell-specific lesions in the TMN to determine its role in spontaneous wakefulness...
  77. ncbi request reprint The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects
    Laura E Nelson
    Department of Anaesthetics, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Anesthesiology 98:428-36. 2003
    ..The authors investigated whether the sedative, or hypnotic, action of the general anesthetic dexmedetomidine (a selective alpha -adrenoceptor agonist) activates endogenous nonrapid eye movement (NREM) sleep-promoting pathways...
  78. pmc Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome
    Paul S A Kalanithi
    Child Study Center and Department of Neurobiology, Yale University, New Haven, CT 06520
    Proc Natl Acad Sci U S A 102:13307-12. 2005
    ..The imbalance in striatal and GPi inhibitory neuron distribution suggests that the functional dynamics of cortico-striato-thalamic circuitry are fundamentally altered in severe, persistent TS...
  79. ncbi request reprint Movement suppression during anesthesia: neural projections from the mesopontine tegmentum to areas involved in motor control
    Inna Sukhotinsky
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Comp Neurol 489:425-48. 2005
    ..Analysis of MPTA connectivity has the potential for furthering our understanding of the neural circuitry responsible for the various functional components of general anesthesia...
  80. pmc Orexins: looking forward to sleep, back at addiction
    Thomas E Scammell
    Nat Med 13:126-8. 2007
  81. ncbi request reprint REM sleep behavior disorder: a dopaminergic deficiency disorder?
    Jean K Matheson
    Neurology 61:1328-9. 2003
  82. doi request reprint Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors
    Hiroyoshi Tsuchiya
    Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences and Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Biol Chem 283:11064-71. 2008
    ..These results indicate that PGE(2)-EP3 signaling elicits G(i/o) activation in preoptic thermocenter neurons, and we propose the possibility that a rapid decrease in preoptic GABA(A) expression may be involved in PGE(2)-induced fever...
  83. ncbi request reprint Modafinil: a drug in search of a mechanism
    Clifford B Saper
    Sleep 27:11-2. 2004