J P SanGiovanni


Affiliation: Harvard University
Country: USA


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    SanGiovanni J, Rosen R, Kaushal S. Application and interpretation of genome-wide association (GWA) studies for informing pharmacogenomic research - examples from the field of age-related macular degeneration. Curr Mol Med. 2014;14:814-32 pubmed
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    SanGiovanni J, Berkey C, Dwyer J, Colditz G. Dietary essential fatty acids, long-chain polyunsaturated fatty acids, and visual resolution acuity in healthy fullterm infants: a systematic review. Early Hum Dev. 2000;57:165-88 pubmed
    ..Whether n-3 intake confers lasting advantage in the development of visually based processes is still in question. ..
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    SanGiovanni J, Parra Cabrera S, Colditz G, Berkey C, Dwyer J. Meta-analysis of dietary essential fatty acids and long-chain polyunsaturated fatty acids as they relate to visual resolution acuity in healthy preterm infants. Pediatrics. 2000;105:1292-8 pubmed
    ..Whether n-3 intake confers lasting advantage in visually based process development across the life-span is still to be determined. ..
  4. SanGiovanni J, Agrón E, Meleth A, Reed G, Sperduto R, Clemons T, et al. {omega}-3 Long-chain polyunsaturated fatty acid intake and 12-y incidence of neovascular age-related macular degeneration and central geographic atrophy: AREDS report 30, a prospective cohort study from the Age-Related Eye Disease Study. Am J Clin Nutr. 2009;90:1601-7 pubmed publisher
    ..If these results are generalizable, they may guide the development of low-cost and easily implemented preventive interventions for progression to advanced AMD. This trial was registered at clinicaltrials.gov as NCT00594672. ..
  5. SanGiovanni J, Neuringer M. The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration: promise of molecular genetics for guiding mechanistic and translational research in the field. Am J Clin Nutr. 2012;96:1223S-33S pubmed publisher
    ..We then use this context to discuss emerging research opportunities that offer promise for meaningful investigation and inference in the field...
  6. SanGiovanni J, Chen J, Sapieha P, Aderman C, Stahl A, Clemons T, et al. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS ONE. 2013;8:e53155 pubmed publisher
    ..We have linked the co-activator of a lipid-sensing transcription factor (PPARG co-activator 1 alpha, PPARGC1A) to age-related macular degeneration (AMD) and AMD-associated genes. ..