Rosario Sanchez-Pernaute

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence and Neuroregeneration Laboratories, McLean Hospital, 115 Mill St, Belmont, Massachusetts 02478, USA
    Stem Cells 23:914-22. 2005
  2. ncbi request reprint Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University, Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Toxicol Appl Pharmacol 207:251-6. 2005
  3. pmc Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, Belmont, MA 02478, USA
    Brain 131:2127-39. 2008
  4. pmc Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft
    Daniela Ferrari
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, 115 Mill St, Belmont, MA 02478, USA
    Eur J Neurosci 24:1885-96. 2006
  5. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
  6. pmc Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations
    Jan Pruszak
    Center for Neuroregeneration Research, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 25:2257-68. 2007
  7. pmc Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin
    Kai Christian Sonntag
    Center for Neuroregeneration Research, Udall Parkinson s Disease Center of Excellence, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 25:411-8. 2007
  8. ncbi request reprint Tailoring human embryonic stem cells for neurodegenerative disease therapy
    Kai Christian Sonntag
    Center for Neuroregeneration Research, Udall Parkinson s Disease Center of Excellence, McLean Hospital, Belmont, MA 02478, USA
    Curr Opin Investig Drugs 7:614-8. 2006
  9. pmc In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Neurobiol Dis 27:220-7. 2007

Collaborators

Detail Information

Publications10

  1. pmc Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence and Neuroregeneration Laboratories, McLean Hospital, 115 Mill St, Belmont, Massachusetts 02478, USA
    Stem Cells 23:914-22. 2005
    ..Optimization of differentiation, cell selection, and cell transfer is required for functional studies of ES-derived DA neurons for future therapeutic applications...
  2. ncbi request reprint Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University, Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Toxicol Appl Pharmacol 207:251-6. 2005
    ..Functional imaging techniques are instrumental to our understanding and modeling of disease mechanisms, which should in turn lead to development of new therapies for Parkinson's disease and other neurodegenerative disorders...
  3. pmc Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, Belmont, MA 02478, USA
    Brain 131:2127-39. 2008
    ..These data provide proof for the concept that parthenogenetic stem cells are a suitable source of functional neurons for therapeutic applications...
  4. pmc Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft
    Daniela Ferrari
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, 115 Mill St, Belmont, MA 02478, USA
    Eur J Neurosci 24:1885-96. 2006
    ..Despite the heterogeneity of ES-derived graft cell composition, these results demonstrate normal phenotypic specification, conserved natural axonal target selectivity and functionality of DA neurons derived from primate ES cells...
  5. pmc Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    Lars M Bjorklund
    Udall Parkinson s Disease Research Center of Excellence, Neuroregeneration Laboratories, and Molecular Neurobiology Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 99:2344-9. 2002
    ..These results demonstrate that transplanted ES cells can develop spontaneously into DA neurons. Such DA neurons can restore cerebral function and behavior in an animal model of Parkinson's disease...
  6. pmc Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations
    Jan Pruszak
    Center for Neuroregeneration Research, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 25:2257-68. 2007
    ....
  7. pmc Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin
    Kai Christian Sonntag
    Center for Neuroregeneration Research, Udall Parkinson s Disease Center of Excellence, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Stem Cells 25:411-8. 2007
    ..After transplantation of differentiated hESCs to a rodent model of PD, some grafts contained human midbrain-like DA neurons. This protocol demonstrates hESC derivation and survival of human DA neurons appropriate for cell therapy in PD...
  8. ncbi request reprint Tailoring human embryonic stem cells for neurodegenerative disease therapy
    Kai Christian Sonntag
    Center for Neuroregeneration Research, Udall Parkinson s Disease Center of Excellence, McLean Hospital, Belmont, MA 02478, USA
    Curr Opin Investig Drugs 7:614-8. 2006
    ..This review discusses the current state of research into hES cells, with an emphasis on neurodegenerative diseases...
  9. pmc In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias
    Rosario Sanchez-Pernaute
    McLean Hospital Harvard University Udall Parkinson s Disease Research Center of Excellence, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Neurobiol Dis 27:220-7. 2007
    ....