Aravinthan D T Samuel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Two alternating motor programs drive navigation in Drosophila larva
    Subhaneil Lahiri
    Department of Physics, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e23180. 2011
  2. ncbi request reprint Sensorimotor integration: locating locomotion in neural circuits
    Aravinthan D T Samuel
    Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 15:R341-3. 2005
  3. pmc The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation
    Samuel H Chung
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA
    BMC Neurosci 7:30. 2006
  4. pmc Proprioceptive coupling within motor neurons drives C. elegans forward locomotion
    Quan Wen
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 76:750-61. 2012
  5. pmc Navigational decision making in Drosophila thermotaxis
    Linjiao Luo
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 30:4261-72. 2010
  6. ncbi request reprint Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans
    Cynthia A Chi
    Department of Physics, Harvard University, Cambridge, MA 02138, USA
    J Exp Biol 210:4043-52. 2007
  7. ncbi request reprint Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients
    Damon A Clark
    Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 27:6083-90. 2007
  8. pmc Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans
    Heon Ick Ha
    Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 68:1173-86. 2010
  9. doi request reprint Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans
    Christopher V Gabel
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Development 135:1129-36. 2008
  10. ncbi request reprint Short-term adaptation and temporal processing in the cryophilic response of Caenorhabditis elegans
    Damon A Clark
    Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA
    J Neurophysiol 97:1903-10. 2007

Collaborators

Detail Information

Publications29

  1. pmc Two alternating motor programs drive navigation in Drosophila larva
    Subhaneil Lahiri
    Department of Physics, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e23180. 2011
    ..Thus, reorientation maneuvers during thermotaxis are carried out by two alternating motor programs: (1) peristalsis for driving forward movement and (2) asymmetric contraction of anterior body segments for driving head sweeping movement...
  2. ncbi request reprint Sensorimotor integration: locating locomotion in neural circuits
    Aravinthan D T Samuel
    Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 15:R341-3. 2005
    ..Several recent studies have now functionally mapped the sensorimotor circuits responsible for locomotion behaviors under defined environmental conditions in the nematode Caenorhabditis elegans...
  3. pmc The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablation
    Samuel H Chung
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA
    BMC Neurosci 7:30. 2006
    ..A current model contends that AFD is part of a thermophilic mechanism for biasing the worm's movement up gradients that counterbalances the cryophilic mechanism for biasing its movement down gradients...
  4. pmc Proprioceptive coupling within motor neurons drives C. elegans forward locomotion
    Quan Wen
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 76:750-61. 2012
    ..In C. elegans, a sensorimotor feedback loop operating within a specific type of motor neuron both drives and organizes body movement...
  5. pmc Navigational decision making in Drosophila thermotaxis
    Linjiao Luo
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 30:4261-72. 2010
    ....
  6. ncbi request reprint Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans
    Cynthia A Chi
    Department of Physics, Harvard University, Cambridge, MA 02138, USA
    J Exp Biol 210:4043-52. 2007
    ..Mutation in the tax-6 calcineurin gene abolishes thermotactic behavior altogether. In summary, we do not find evidence that long-term plasticity requires association between temperature and the presence or absence of bacterial food...
  7. ncbi request reprint Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradients
    Damon A Clark
    Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 27:6083-90. 2007
    ..We show that the worm is able, in principle, to evaluate and guide its own thermotactic behaviors with respect to ambient spatial thermal gradients by monitoring the activity of this single thermosensory neuron...
  8. pmc Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegans
    Heon Ick Ha
    Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 68:1173-86. 2010
    ..Thus, two different neural circuits regulate a behavioral switch between naive and learned olfactory preferences...
  9. doi request reprint Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans
    Christopher V Gabel
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Development 135:1129-36. 2008
    ..Thus, C. elegans may be used as a genetic system to characterize novel cellular and molecular mechanisms underlying adult-stage nervous system regeneration...
  10. ncbi request reprint Short-term adaptation and temporal processing in the cryophilic response of Caenorhabditis elegans
    Damon A Clark
    Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA
    J Neurophysiol 97:1903-10. 2007
    ..Regulating the operating range of the cryophilic response and executing the cryophilic response may have separate neural mechanisms...
  11. ncbi request reprint A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans
    David Biron
    Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA
    Nat Neurosci 9:1499-505. 2006
    ..These results provide the first mechanistic insight into the basis of experience-dependent plasticity in this complex behavior...
  12. ncbi request reprint The AFD sensory neurons encode multiple functions underlying thermotactic behavior in Caenorhabditis elegans
    Damon A Clark
    Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 26:7444-51. 2006
    ..Encoding multiple functions in individual sensory neurons may enable C. elegans to perform complex behaviors with simple neuronal circuits...
  13. pmc Monoaminergic orchestration of motor programs in a complex C. elegans behavior
    Jamie L Donnelly
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Biol 11:e1001529. 2013
    ..Our studies show, at the level of single cells, how a sensory input recruits the action of a monoamine to change neural circuit properties and orchestrate a compound motor sequence...
  14. ncbi request reprint Neural circuits mediate electrosensory behavior in Caenorhabditis elegans
    Christopher V Gabel
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 27:7586-96. 2007
    ..Thus, electrosensory behavior may be used as a model system for understanding how sensory inputs are transformed into motor outputs by the C. elegans nervous system...
  15. doi request reprint Olfactory behavior of swimming C. elegans analyzed by measuring motile responses to temporal variations of odorants
    Linjiao Luo
    Department of Physics, Harvard University, 17 Oxford St, Cambridge, MA 02138, USA
    J Neurophysiol 99:2617-25. 2008
    ....
  16. ncbi request reprint Sensorimotor control during isothermal tracking in Caenorhabditis elegans
    Linjiao Luo
    Department of Physics, Harvard University, Cambridge, MA 02138, USA
    J Exp Biol 209:4652-62. 2006
    ....
  17. pmc Dynamic Encoding of Perception, Memory, and Movement in a C. elegans Chemotaxis Circuit
    Linjiao Luo
    Key Laboratory of Modern Acoustics, Ministry of Education, Department of Physics, Nanjing University, China Center for Brain Science, Harvard University, Cambridge, MA 02138, USA Department of Physics, Harvard University, Cambridge, MA 02138, USA
    Neuron 82:1115-28. 2014
    ..Our study reveals compact encoding of perception, memory, and locomotion in an experience-dependent navigational behavior in C. elegans. ..
  18. pmc Temporal analysis of stochastic turning behavior of swimming C. elegans
    Nikhil Srivastava
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    J Neurophysiol 102:1172-9. 2009
    ....
  19. ncbi request reprint Mechanosensation and mechanical load modulate the locomotory gait of swimming C. elegans
    Jeremie Korta
    Department of Physics, Harvard University, Cambridge, MA 02138, USA
    J Exp Biol 210:2383-9. 2007
    ..The adaptability of locomotory gait in C. elegans may be encoded in sensory and motor systems that allow the worm to respond to its own movement in different physical surroundings...
  20. pmc Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegans
    Andrew M Leifer
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    Nat Methods 8:147-52. 2011
    ..To test the accuracy, flexibility and utility of our system, we performed optogenetic analyses of the worm motor circuit, egg-laying circuit and mechanosensory circuits that have not been possible with previous methods...
  21. pmc Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans
    Christopher Fang-Yen
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 107:20323-8. 2010
    ..Our results suggest that C. elegans locomotory gait continuously adapts to external mechanical load in order to maintain propulsive thrust...
  22. pmc Shifts in the distribution of mass densities is a signature of caloric restriction in Caenorhabditis elegans
    Alfonso Reina
    Department of Chemistry and Chemical Biology, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS ONE 8:e69651. 2013
    ..Thus, measurements of changes in density could be used to conduct screens on the effects of drugs on several populations of worms cultured on single plates. ..
  23. pmc Dopamine signaling is essential for precise rates of locomotion by C. elegans
    Daniel T Omura
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e38649. 2012
    ..We suggest that C. elegans and other animals, including humans, might share mechanisms by which dopamine restricts motor activity levels and coordinates movement...
  24. ncbi request reprint Synaptic activity of the AFD neuron in Caenorhabditis elegans correlates with thermotactic memory
    Aravinthan D T Samuel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 23:373-6. 2003
    ..This suggests that AFD encodes a direct comparison between T(amb) and T(cult)...
  25. pmc Controlling airborne cues to study small animal navigation
    Marc Gershow
    Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    Nat Methods 9:290-6. 2012
    ....
  26. ncbi request reprint Thermotaxis in Caenorhabditis elegans analyzed by measuring responses to defined Thermal stimuli
    William S Ryu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 22:5727-33. 2002
    ..Inactivation of the mechanism for migration down gradients near or below the cultivation temperature requires the neurons AFD and AIY...
  27. pmc Two size-selective mechanisms specifically trap bacteria-sized food particles in Caenorhabditis elegans
    Christopher Fang-Yen
    Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 106:20093-6. 2009
    ..Experiments with microspheres show that the C. elegans pharynx, in combination with the buccal cavity, is tuned to specifically catch and transport particles of a size range corresponding to most soil bacteria...
  28. pmc An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior
    David Biron
    Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
    Proc Natl Acad Sci U S A 105:11002-7. 2008
    ..Our observations suggest that the AFD and AWC neurons encode thermal stimuli via distinct strategies to regulate C. elegans thermotactic behavior...
  29. ncbi request reprint Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types
    Marc E Colosimo
    Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Curr Biol 14:2245-51. 2004
    ..Expression profiling of single neuron types provides a rapid, powerful, and unbiased method for identifying neuron-specific genes whose functions can then be investigated in vivo...