Research Topics
Species | Aravinthan D T SamuelSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Sensorimotor integration: locating locomotion in neural circuitsAravinthan D T Samuel
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Biol 15:R341-3. 2005..Several recent studies have now functionally mapped the sensorimotor circuits responsible for locomotion behaviors under defined environmental conditions in the nematode Caenorhabditis elegans...
The role of the AFD neuron in C. elegans thermotaxis analyzed using femtosecond laser ablationSamuel H Chung
Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA
BMC Neurosci 7:30. 2006..A current model contends that AFD is part of a thermophilic mechanism for biasing the worm's movement up gradients that counterbalances the cryophilic mechanism for biasing its movement down gradients...- Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegansCynthia A Chi
Department of Physics, Harvard University, Cambridge, MA 02138, USA
J Exp Biol 210:4043-52. 2007..Mutation in the tax-6 calcineurin gene abolishes thermotactic behavior altogether. In summary, we do not find evidence that long-term plasticity requires association between temperature and the presence or absence of bacterial food... 
Two alternating motor programs drive navigation in Drosophila larvaSubhaneil Lahiri
Department of Physics, Center for Brain Science, Harvard University, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e23180. 2011..Thus, reorientation maneuvers during thermotaxis are carried out by two alternating motor programs: (1) peristalsis for driving forward movement and (2) asymmetric contraction of anterior body segments for driving head sweeping movement...- Functional organization of a neural network for aversive olfactory learning in Caenorhabditis elegansHeon Ick Ha
Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 68:1173-86. 2010..Thus, two different neural circuits regulate a behavioral switch between naive and learned olfactory preferences... - Short-term adaptation and temporal processing in the cryophilic response of Caenorhabditis elegansDamon A Clark
Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA
J Neurophysiol 97:1903-10. 2007..Regulating the operating range of the cryophilic response and executing the cryophilic response may have separate neural mechanisms... - Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegansChristopher V Gabel
Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Development 135:1129-36. 2008..Thus, C. elegans may be used as a genetic system to characterize novel cellular and molecular mechanisms underlying adult-stage nervous system regeneration... - A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegansDavid Biron
Department of Physics, Harvard University, 17 Oxford Street, Cambridge, Massachusetts 02138, USA
Nat Neurosci 9:1499-505. 2006..These results provide the first mechanistic insight into the basis of experience-dependent plasticity in this complex behavior... - The AFD sensory neurons encode multiple functions underlying thermotactic behavior in Caenorhabditis elegansDamon A Clark
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 26:7444-51. 2006..Encoding multiple functions in individual sensory neurons may enable C. elegans to perform complex behaviors with simple neuronal circuits... - Olfactory behavior of swimming C. elegans analyzed by measuring motile responses to temporal variations of odorantsLinjiao Luo
Department of Physics, Harvard University, 17 Oxford St, Cambridge, MA 02138, USA
J Neurophysiol 99:2617-25. 2008.... - Neural circuits mediate electrosensory behavior in Caenorhabditis elegansChristopher V Gabel
Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 27:7586-96. 2007..Thus, electrosensory behavior may be used as a model system for understanding how sensory inputs are transformed into motor outputs by the C. elegans nervous system... - Temporal activity patterns in thermosensory neurons of freely moving Caenorhabditis elegans encode spatial thermal gradientsDamon A Clark
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 27:6083-90. 2007..We show that the worm is able, in principle, to evaluate and guide its own thermotactic behaviors with respect to ambient spatial thermal gradients by monitoring the activity of this single thermosensory neuron... - Navigational decision making in Drosophila thermotaxisLinjiao Luo
Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 30:4261-72. 2010.... - Sensorimotor control during isothermal tracking in Caenorhabditis elegansLinjiao Luo
Department of Physics, Harvard University, Cambridge, MA 02138, USA
J Exp Biol 209:4652-62. 2006.... - Mechanosensation and mechanical load modulate the locomotory gait of swimming C. elegansJeremie Korta
Department of Physics, Harvard University, Cambridge, MA 02138, USA
J Exp Biol 210:2383-9. 2007..The adaptability of locomotory gait in C. elegans may be encoded in sensory and motor systems that allow the worm to respond to its own movement in different physical surroundings... - Optogenetic manipulation of neural activity in freely moving Caenorhabditis elegansAndrew M Leifer
Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
Nat Methods 8:147-52. 2011..To test the accuracy, flexibility and utility of our system, we performed optogenetic analyses of the worm motor circuit, egg-laying circuit and mechanosensory circuits that have not been possible with previous methods... - Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegansChristopher Fang-Yen
Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 107:20323-8. 2010..Our results suggest that C. elegans locomotory gait continuously adapts to external mechanical load in order to maintain propulsive thrust... - Temporal analysis of stochastic turning behavior of swimming C. elegansNikhil Srivastava
Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
J Neurophysiol 102:1172-9. 2009.... - Proprioceptive Coupling within Motor Neurons Drives C. elegans Forward LocomotionQuan Wen
Department of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA Electronic address
Neuron 76:750-61. 2012..In C. elegans, a sensorimotor feedback loop operating within a specific type of motor neuron both drives and organizes body movement... - Controlling airborne cues to study small animal navigationMarc Gershow
Department of Physics and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
Nat Methods 9:290-6. 2012.... - Synaptic activity of the AFD neuron in Caenorhabditis elegans correlates with thermotactic memoryAravinthan D T Samuel
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 23:373-6. 2003..This suggests that AFD encodes a direct comparison between T(amb) and T(cult)... - Thermotaxis in Caenorhabditis elegans analyzed by measuring responses to defined Thermal stimuliWilliam S Ryu
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 22:5727-33. 2002..Inactivation of the mechanism for migration down gradients near or below the cultivation temperature requires the neurons AFD and AIY... - Two size-selective mechanisms specifically trap bacteria-sized food particles in Caenorhabditis elegansChristopher Fang-Yen
Department of Physics, Harvard University, 17 Oxford Street, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 106:20093-6. 2009..Experiments with microspheres show that the C. elegans pharynx, in combination with the buccal cavity, is tuned to specifically catch and transport particles of a size range corresponding to most soil bacteria... - An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behaviorDavid Biron
Department of Biology and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA
Proc Natl Acad Sci U S A 105:11002-7. 2008..Our observations suggest that the AFD and AWC neurons encode thermal stimuli via distinct strategies to regulate C. elegans thermotactic behavior... - Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron typesMarc E Colosimo
Department of Biology, Brandeis University, Waltham, MA 02454, USA
Curr Biol 14:2245-51. 2004..Expression profiling of single neuron types provides a rapid, powerful, and unbiased method for identifying neuron-specific genes whose functions can then be investigated in vivo...