Adrian Salic

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A chemical method for fast and sensitive detection of DNA synthesis in vivo
    Adrian Salic
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:2415-20. 2008
  2. ncbi request reprint Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis
    Adrian Salic
    Department of Systems Biology, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 118:567-78. 2004
  3. pmc Evidence for an upper limit to mitotic spindle length
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:1256-61. 2008
  4. pmc The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
    Ethan Lee
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 1:E10. 2003
  5. ncbi request reprint The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly
    Srinath C Sampath
    Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY 10021, USA
    Cell 118:187-202. 2004
  6. pmc Bub1 is essential for assembly of the functional inner centromere
    Yekaterina Boyarchuk
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 176:919-28. 2007
  7. doi request reprint Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies
    Suzanne B Buck
    Invitrogen Corporation, Eugene, OR 97402, USA
    Biotechniques 44:927-9. 2008
  8. ncbi request reprint Lrp6 is required for convergent extension during Xenopus gastrulation
    Emilios Tahinci
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 134:4095-106. 2007
  9. ncbi request reprint Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts
    Adrian Salic
    Methods Enzymol 399:567-85. 2005
  10. ncbi request reprint Anteroposterior patterning in hemichordates and the origins of the chordate nervous system
    Christopher J Lowe
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 113:853-65. 2003

Collaborators

  • Timothy Mitchison
  • Sophie Dumont
  • Martin Wühr
  • Daniel J Needleman
  • Roland Krüger
  • M Dasso
  • Laura A Lee
  • Ryoma Ohi
  • Aaron C Groen
  • Ethan Lee
  • Suzanne B Buck
  • Yekaterina Boyarchuk
  • Emilios Tahinci
  • Srinath C Sampath
  • Christopher J Lowe
  • Marc W Kirschner
  • Sheri L Holmen
  • Jolene Bradford
  • Kyle R Gee
  • Brian J Agnew
  • Scott T Clarke
  • Jeffrey L Franklin
  • Alexei Arnaoutov
  • Robert J Coffey
  • Curtis A Thorne
  • Kelly M Christian
  • Hironori Funabiki
  • Oliver Leismann
  • Andrei Pozniakovski
  • Marc Kirschner
  • Reinhart Heinrich
  • Nicole Stange-Thomann
  • Mike Wu
  • John Gerhart
  • Christian E Gruber
  • J Gerhart
  • Eric Lander
  • Louise Evans
  • Cassandra R Zylstra
  • Bart O Williams

Detail Information

Publications11

  1. pmc A chemical method for fast and sensitive detection of DNA synthesis in vivo
    Adrian Salic
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:2415-20. 2008
    ..In contrast to BrdU, the method does not require sample fixation or DNA denaturation and permits good structural preservation. We demonstrate the use of the method in cultured cells and in the intestine and brain of whole animals...
  2. ncbi request reprint Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis
    Adrian Salic
    Department of Systems Biology, 240 Longwood Avenue, Boston, MA 02115, USA
    Cell 118:567-78. 2004
    ..Sgo is thus critical for mitotic progression and chromosome segregation and provides an unexpected link between sister centromere cohesion and microtubule interactions at kinetochores...
  3. pmc Evidence for an upper limit to mitotic spindle length
    Martin Wühr
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 18:1256-61. 2008
    ..We conclude that early mitotic spindle length in Xenopus laevis is uncoupled from cell length, reaching an upper bound determined by mechanisms that are intrinsic to the spindle...
  4. pmc The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway
    Ethan Lee
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 1:E10. 2003
    ..By applying control analysis to our mathematical model, we demonstrate the modular design, sensitivity, and robustness of the Wnt pathway and derive an explicit expression for tumor suppression and oncogenicity...
  5. ncbi request reprint The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly
    Srinath C Sampath
    Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY 10021, USA
    Cell 118:187-202. 2004
    ..We propose that the chromosomal passenger complex regulates local MCAK activity to permit spindle formation via stabilization of chromatin-associated microtubules...
  6. pmc Bub1 is essential for assembly of the functional inner centromere
    Yekaterina Boyarchuk
    Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 176:919-28. 2007
    ..We further provide evidence that Bub1 kinase activity is pivotal for recruitment of all of these components. Together, our findings demonstrate that Bub1 acts at multiple points to assure the correct kinetochore formation...
  7. doi request reprint Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies
    Suzanne B Buck
    Invitrogen Corporation, Eugene, OR 97402, USA
    Biotechniques 44:927-9. 2008
    ..Elimination of this requirement results in the preservation of helical DNA structure and other cell surface epitopes, decreased assay time, and increased reproducibility...
  8. ncbi request reprint Lrp6 is required for convergent extension during Xenopus gastrulation
    Emilios Tahinci
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 134:4095-106. 2007
    ..We propose a model in which Lrp6 plays a critical role in the switch from Wnt/PCP to Wnt/beta-catenin signaling...
  9. ncbi request reprint Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts
    Adrian Salic
    Methods Enzymol 399:567-85. 2005
    ..Here we describe methods for identifying inhibitors of the proteolytic pathways that regulate cell cycle progression and Wnt signaling in Xenopus extracts...
  10. ncbi request reprint Anteroposterior patterning in hemichordates and the origins of the chordate nervous system
    Christopher J Lowe
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 113:853-65. 2003
    ..We propose that the deuterostome ancestor may have had a diffuse nervous system, which was later centralized during the evolution of the chordate lineage...
  11. ncbi request reprint A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 277:34727-35. 2002
    ..The data suggest that the distinction between the two Wnt classes lies not in intrinsic differences in the molecules but via the Frizzled molecules with which they interact...