Research Topics
| D H SalatSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Neuroimaging H.M.: a 10-year follow-up examinationD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
Hippocampus 16:936-45. 2006..Most of these alterations were not apparent in his prior scans, suggesting that they are of recent origin. Advanced age and hypertension likely contributed to these new findings...- Imaging of amyloid burden and distribution in cerebral amyloid angiopathyKeith A Johnson
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Ann Neurol 62:229-34. 2007.... 
Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneityH Diana Rosas
Center for Neuro imaging of Aging and Neurodegenerative Diseases, 149 13th Street Room 2275, Charlestown, MA 02129, USA
Brain 131:1057-68. 2008....
The declining infrastructure of the aging brainDavid H Salat
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Brain Connect 1:279-93. 2011....- Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adultsDavid H Salat
Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA
Neuroimage 59:181-92. 2012.... - Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's diseaseD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Charlestown, MA 02129 2060, USA
Neuroimage 54:1795-802. 2011..Such changes are associated with traditional imaging metrics of degeneration and may provide a unique biomarker of the tissue loss that occurs as a result of AD... - Regional white matter volume differences in nondemented aging and Alzheimer's diseaseDavid H Salat
Department of Radiology, Massachusetts General Hospital, Boston MA, USA
Neuroimage 44:1247-58. 2009..Overall, these results demonstrate the utility of automated regional WM measures in revealing the distinct patterns of age and AD associated volume loss that may contribute to cognitive decline... - White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imagingDavid H Salat
Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129 2060, USA
Stroke 37:1759-64. 2006..We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA... - Age-related changes in prefrontal white matter measured by diffusion tensor imagingD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
Ann N Y Acad Sci 1064:37-49. 2005..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures... - White matter pathology isolates the hippocampal formation in Alzheimer's diseaseD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
Neurobiol Aging 31:244-56. 2010..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways... - Age-related alterations in white matter microstructure measured by diffusion tensor imagingD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
Neurobiol Aging 26:1215-27. 2005..These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration... - Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer diseaseD H Salat
Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, OR, USA
Arch Neurol 58:1403-8. 2001..The PFC is vulnerable to neurodegeneration with healthy aging and Alzheimer disease (AD)... - Thinning of the cerebral cortex in agingDavid H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
Cereb Cortex 14:721-30. 2004..These findings demonstrate that cortical thinning occurs by middle age and spans widespread cortical regions that include primary as well as association cortex... - Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrastD H Salat
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
Neuroimage 48:21-8. 2009..These results demonstrate that there are strong regional changes in neural tissue properties with aging and tissue intensity measures may serve as an important biomarker of degeneration... - Greater orbital prefrontal volume selectively predicts worse working memory performance in older adultsDavid H Salat
Department of Behavioral Neuroscience, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201 3098, USA
Cereb Cortex 12:494-505. 2002..These results suggest that working memory is a sensitive measure of cognitive aging and that regional morphology is associated with specific cognitive abilities in older adults... - Regional cortical thinning in preclinical Huntington disease and its relationship to cognitionH D Rosas
Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 65:745-7. 2005..They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD... - Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's diseaseRahul S Desikan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Brain 132:2048-57. 2009.... - Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengthsB C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 39:10-8. 2008.... - Increased hippocampal activation in mild cognitive impairment compared to normal aging and ADB C Dickerson
Department of Neurology, The Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 65:404-11. 2005..CONCLUSIONS: The authors hypothesize that there is a phase of increased medial temporal lobe activation early in the course of prodromal Alzheimer disease followed by a subsequent decrease as the disease progresses... - Prefrontal gray and white matter volumes in healthy aging and Alzheimer diseaseD H Salat
Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland 97201 3098, USA
Arch Neurol 56:338-44. 1999..To quantify the contribution of gray and white matter volumes to total prefrontal volume in healthy aging. To determine if prefrontal tissue volumes distinguish healthy aging from Alzheimer disease (AD)... - Sex differences in prefrontal volume with aging and Alzheimer's diseaseD H Salat
Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland 97201 3098, USA
Neurobiol Aging 20:591-6. 1999..There were no interactions between group and sex for total prefrontal volume. An exploratory analysis of each group suggested that sex differences in both gray and white matter in healthy aging are not sustained in AD... - Regional and progressive thinning of the cortical ribbon in Huntington's diseaseH D Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 02129 4404, USA
Neurology 58:695-701. 2002.... - Predicting the location of entorhinal cortex from MRIBruce Fischl
Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 47:8-17. 2009.... - Medial temporal lobe function and structure in mild cognitive impairmentBradford C Dickerson
Department of Neurology, Gerontology Research Unit, Massachusetts General Hospital, MGH East 149 2691, 149 13th Street, Charlestown, MA 02129, USA
Ann Neurol 56:27-35. 2004..We hypothesize that increased activation in MTL regions reflects a compensatory response to accumulating AD pathology and may serve as a marker for impending clinical decline... - Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"H Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 49:2995-3004. 2010..Our findings provide evidence for early degeneration of commissural pyramidal neurons in the neocortex, loss of cortico-cortical connectivity, and functional compromise of associative cortical processing... - Variation in blood pressure is associated with white matter microstructure but not cognition in African AmericansElizabeth C Leritz
VA Boston Healthcare System and Brigham, and Women s Hospital
Neuropsychology 24:199-208. 2010..These data provide important evidence that variation in BP may contribute to significant alterations in specific neural regions of white matter in nonmedicated individuals without symptoms of overt CVD... - Automated MRI measures predict progression to Alzheimer's diseaseRahul S Desikan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neurobiol Aging 31:1364-74. 2010.... - Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adultsElizabeth C Leritz
Geriatric Research, Education and Clinical Center GRECC, VA Boston Healthcare System, Boston, MA 02130, USA
Neuroimage 54:2659-71. 2011.... - Age-associated reductions in cerebral blood flow are independent from regional atrophyJ Jean Chen
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 55:468-78. 2011..These findings demonstrate the dissociation between regional CBF and structural alterations specific to normal aging, and augment our understanding of mechanisms of pathology in older adults... - Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?H Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Ann N Y Acad Sci 1147:196-205. 2008..Understanding changes in brain morphometry and their relationship to clinical symptoms may provide important and new insights into basic pathophysiological mechanisms at play in the disease... - Selective disruption of the cerebral neocortex in Alzheimer's diseaseRahul S Desikan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
PLoS ONE 5:e12853. 2010..However, the precise relationship between pathologic changes in neocortical regions and hippocampal atrophy is largely unknown... - Sequence-independent segmentation of magnetic resonance imagesBruce Fischl
Department of Radiology, MGH, Athinoula A Martinos Center, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 23:S69-84. 2004..This sequence has the added benefit of allowing the explicit estimation of T2* and of reducing test-retest intensity variability... - Detection of entorhinal layer II using 7Tesla [corrected] magnetic resonance imagingJean C Augustinack
Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA
Ann Neurol 57:489-94. 2005..Our ex vivo results could break ground for high-resolution in vivo scanning that could ultimately benefit early diagnosis and treatment of neurodegenerative disease... - On-line automatic slice positioning for brain MR imagingAndre J W van der Kouwe
Department of Radiology, MGH, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 27:222-30. 2005..Translations and rotations relative to the atlas can be set so that planning can be done in anatomical space, rather than scanner coordinates, and stored as part of the protocol allowing standardization of slice orientations... - Automatically parcellating the human cerebral cortexBruce Fischl
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
Cereb Cortex 14:11-22. 2004..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling... - Regionally localized thinning of the cerebral cortex in schizophreniaGina R Kuperberg
Department of Psychiatry, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Charlestown, 02129, USA
Arch Gen Psychiatry 60:878-88. 2003.... - Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measuresH Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Mov Disord 21:1317-25. 2006.... - Brain morphometry with multiecho MPRAGEAndre J W van der Kouwe
Department of Radiology, Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 40:559-69. 2008..Since acquisition time is the same for MEMPR as for MPRAGE, and it has better distortion properties and additional T2* information, MEMPR is recommended for morphometry studies... - Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attentionDavid S Tuch
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:12212-7. 2005.... - The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 19:497-510. 2009.... - Spatial relation between microbleeds and amyloid deposits in amyloid angiopathyGregory A Dierksen
Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Neurol 68:545-8. 2010..0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition... - Whole brain segmentation: automated labeling of neuroanatomical structures in the human brainBruce Fischl
Massachusetts General Hospital, Nuclear Magnetic Resonance Center, Rm. 2328, Building 149, 13th Street, Charlestown, MA 02129, USA
Neuron 33:341-55. 2002..The technique is shown to be comparable in accuracy to manual labeling, and of sufficient sensitivity to robustly detect changes in the volume of noncortical structures that presage the onset of probable Alzheimer's disease... - Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer typeBrian T Gold
Department of Anatomy and Neurobiology, University of Kentucky, MN214 Chandler Medical Center, Lexington, KY 40536 0298, USA
Neuropsychologia 43:833-46. 2005....
Research Grants
- Cerebrovascular Contributions to Brain Aging and DementiaDavid Salat; Fiscal Year: 2007..Knowledge from the proposed studies would be useful in the differential therapeutic intervention of AD and CVD related brain degeneration. ..
- Diffusion Tensor Imaging of White Matter Change in ADDavid Salat; Fiscal Year: 2007..Thus, the proposed integrated training and research program could lead to novel insights about the unique contribution of WM degeneration to the clinical sequel of AD. ..
- Cerebrovascular Contributions to Brain Aging and DementiaDavid H Salat; Fiscal Year: 2010..Knowledge from the proposed studies would be useful in the differential therapeutic intervention of AD and CVD related brain degeneration. ..
- Cerebrovascular Contributions to Brain Aging and DementiaDavid H Salat; Fiscal Year: 2010..Knowledge from the proposed studies would be useful in the differential therapeutic intervention of AD and CVD related brain degeneration. ..