Elizabeth M Sajdel-Sulkowska

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Sex-dependent changes in cerebellar thyroid hormone-dependent gene expression following perinatal exposure to thimerosal in rats
    A Khan
    Department of Psychiatry, Harvard Medical School BWH, Boston, MA 02115, USA
    J Physiol Pharmacol 63:277-83. 2012
  2. ncbi Brain region-specific changes in oxidative stress and neurotrophin levels in autism spectrum disorders (ASD)
    Elizabeth M Sajdel-Sulkowska
    Department of Psychiatry Harvard Medical School, Boston, MA, USA
    Cerebellum 10:43-8. 2011
  3. ncbi Cerebellar brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 expression in male and female rats is differentially affected by hypergravity exposure during discrete developmental periods
    Elizabeth M Sajdel-Sulkowska
    Department of Psychiatry, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Cerebellum 8:454-62. 2009
  4. ncbi Increase in cerebellar neurotrophin-3 and oxidative stress markers in autism
    Elizabeth M Sajdel-Sulkowska
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Cerebellum 8:366-72. 2009
  5. ncbi Brain development, environment and sex: what can we learn from studying graviperception, gravitransduction and the gravireaction of the developing CNS to altered gravity?
    Elizabeth M Sajdel-Sulkowska
    Harvard Medical School BWH, Psychiatry, Boston, Massachusetts 02115, USA
    Cerebellum 7:223-39. 2008
  6. ncbi Purkinje cell loss accompanies motor impairment in rats developing at altered gravity
    Elizabeth M Sajdel-Sulkowska
    Deparment of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 021115, USA
    Neuroreport 16:2037-40. 2005
  7. ncbi Effects of hypergravity exposure on the developing central nervous system: possible involvement of thyroid hormone
    E M Sajdel-Sulkowska
    Department of Psychiatry, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Exp Biol Med (Maywood) 226:790-8. 2001
  8. ncbi Impact of thyroid hormone deficiency on the developing CNS: cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil
    Gui-Hua Li
    Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Cerebellum 3:100-6. 2004
  9. ncbi Maternal thimerosal exposure results in aberrant cerebellar oxidative stress, thyroid hormone metabolism, and motor behavior in rat pups; sex- and strain-dependent effects
    Z L Sulkowski
    Department of Psychiatry, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Cerebellum 11:575-86. 2012
  10. ncbi Environmental impacts on the developing CNS: CD15, NCAM-L1, and GFAP expression in rat neonates exposed to hypergravity
    G M Sulkowski
    Harvard Med Sch, Boston, MA
    Adv Space Res 33:1423-30. 2004

Research Grants

  1. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004

Collaborators

Detail Information

Publications10

  1. ncbi Sex-dependent changes in cerebellar thyroid hormone-dependent gene expression following perinatal exposure to thimerosal in rats
    A Khan
    Department of Psychiatry, Harvard Medical School BWH, Boston, MA 02115, USA
    J Physiol Pharmacol 63:277-83. 2012
    ..Interestingly, the genes that were activated by TM are negatively regulated by TH, supporting our hypothesis of local brain hypothyroidism being induced by TM and suggesting a novel mechanism of action TM in the developing brain...
  2. ncbi Brain region-specific changes in oxidative stress and neurotrophin levels in autism spectrum disorders (ASD)
    Elizabeth M Sajdel-Sulkowska
    Department of Psychiatry Harvard Medical School, Boston, MA, USA
    Cerebellum 10:43-8. 2011
    ..These preliminary results reveal, for the first time, brain region-specific changes in oxidative stress marker 3-NT and neurotrophin-3 levels in ASD...
  3. ncbi Cerebellar brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 expression in male and female rats is differentially affected by hypergravity exposure during discrete developmental periods
    Elizabeth M Sajdel-Sulkowska
    Department of Psychiatry, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Cerebellum 8:454-62. 2009
    ....
  4. ncbi Increase in cerebellar neurotrophin-3 and oxidative stress markers in autism
    Elizabeth M Sajdel-Sulkowska
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Cerebellum 8:366-72. 2009
    ....
  5. ncbi Brain development, environment and sex: what can we learn from studying graviperception, gravitransduction and the gravireaction of the developing CNS to altered gravity?
    Elizabeth M Sajdel-Sulkowska
    Harvard Medical School BWH, Psychiatry, Boston, Massachusetts 02115, USA
    Cerebellum 7:223-39. 2008
    ..Some of these findings transcend gravitational research and are relevant to our understanding of the impact of environmental factors on CNS development on Earth...
  6. ncbi Purkinje cell loss accompanies motor impairment in rats developing at altered gravity
    Elizabeth M Sajdel-Sulkowska
    Deparment of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 021115, USA
    Neuroreport 16:2037-40. 2005
    ..7-25.3%. These results imply that exposure to altered gravity during Purkinje cell birth may affect their proliferation, resulting in a decrease in Purkinje cell number, which, in turn, leads to motor impairment...
  7. ncbi Effects of hypergravity exposure on the developing central nervous system: possible involvement of thyroid hormone
    E M Sajdel-Sulkowska
    Department of Psychiatry, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Exp Biol Med (Maywood) 226:790-8. 2001
    ....
  8. ncbi Impact of thyroid hormone deficiency on the developing CNS: cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil
    Gui-Hua Li
    Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Cerebellum 3:100-6. 2004
    ..Altered expression of cerebellar proteins is likely to affect cell-cell interactions and consequently cell proliferation and migration and contribute to structural and functional alterations seen in the hypothyroid rat neonates...
  9. ncbi Maternal thimerosal exposure results in aberrant cerebellar oxidative stress, thyroid hormone metabolism, and motor behavior in rat pups; sex- and strain-dependent effects
    Z L Sulkowski
    Department of Psychiatry, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Cerebellum 11:575-86. 2012
    ..Our data thus demonstrate a negative neurodevelopmental impact of perinatal TM exposure which appears to be both strain- and sex-dependent...
  10. ncbi Environmental impacts on the developing CNS: CD15, NCAM-L1, and GFAP expression in rat neonates exposed to hypergravity
    G M Sulkowski
    Harvard Med Sch, Boston, MA
    Adv Space Res 33:1423-30. 2004
    ..Our data suggest that both cerebellar development and its response to gravitational manipulations differ in males and females...

Research Grants3

  1. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004
    ..These studies will aid in developing an understanding of how altered gravity affects CNS development, what role the thyroid hormone plays in that response, and whether this response can be modulated by hormonal therapy. ..