Jeffrey Saffitz


Affiliation: Harvard University
Country: USA


  1. Asimaki A, Kl├ęber A, Saffitz J. Pathogenesis of Arrhythmogenic Cardiomyopathy. Can J Cardiol. 2015;31:1313-24 pubmed publisher
    ..In this review we summarize the current understanding of the pathogenesis of ACM and highlight future research directions. ..
  2. Saffitz J. Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling. Heart Rhythm. 2009;6:S62-5 pubmed publisher
  3. Saffitz J, Corradi D. The electrical heart: 25 years of discovery in cardiac electrophysiology, arrhythmias and sudden death. Cardiovasc Pathol. 2016;25:149-57 pubmed publisher
  4. Asimaki A, Protonotarios A, James C, Chelko S, Tichnell C, Murray B, et al. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016;9:e003688 pubmed publisher
    ..These cells may prove useful in future studies of disease mechanisms and drug screens for effective therapies in arrhythmogenic cardiomyopathy. ..
  5. Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, et al. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci Transl Med. 2014;6:240ra74 pubmed publisher
    ..These observations pinpoint aberrant trafficking of intercalated disc proteins as a central mechanism in ACM myocyte injury and electrical abnormalities. ..
  6. Saffitz J. Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2017;28:51-58 pubmed publisher
    ..It concludes with acknowledgment of the need for a far more detailed approach as to how we categorize human disease, a task for which pathologists are especially well positioned. ..