R Sackstein

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD
    Mirjana Milinkovic
    Harvard Institutes of Medicine, Rm 671, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 103:740-2. 2004
  2. ncbi request reprint A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA 02115, USA
    Biol Blood Marrow Transplant 12:2-8. 2006
  3. pmc Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm
    Taylor H Schreiber
    Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 109:1381-6. 2007
  4. pmc Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration
    Robert Sackstein
    Departments of Dermatology and of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Biomed Eng 40:766-76. 2012
  5. pmc CD44 is a major E-selectin ligand on human hematopoietic progenitor cells
    C J Dimitroff
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Cell Biol 153:1277-86. 2001
  6. pmc Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1253:193-200. 2012
  7. ncbi request reprint The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing
    Robert Sackstein
    Departments of Dermatology and Medicine, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts, USA
    J Investig Dermatol Symp Proc 9:215-23. 2004
  8. ncbi request reprint In vitro adherence of lymphocytes to dermal endothelium under shear stress: implications in pathobiology and steroid therapy of acute cutaneous GVHD
    Robert Sackstein
    Harvard Skin Disease Research Center, Harvard Medical School, Department of Dermatology, Brigham and Women s Hospital, Boston, MA, USA
    Blood 101:771-8. 2003
  9. doi request reprint Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 14:181-7. 2008
  10. ncbi request reprint The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing
    Robert Sackstein
    Department of Dermatology and Medicine, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 122:1061-9. 2004

Research Grants

Collaborators

Detail Information

Publications49

  1. ncbi request reprint CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD
    Mirjana Milinkovic
    Harvard Institutes of Medicine, Rm 671, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 103:740-2. 2004
    ..HA expressed at dermal endothelium in aGVHD is thus specialized to support lymphocyte adherence under flow conditions, and CD44-HA interactions may contribute to lymphocytotropism to skin in aGVHD...
  2. ncbi request reprint A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host disease
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA 02115, USA
    Biol Blood Marrow Transplant 12:2-8. 2006
    ....
  3. pmc Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm
    Taylor H Schreiber
    Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 109:1381-6. 2007
    ....
  4. pmc Glycoengineering of HCELL, the human bone marrow homing receptor: sweetly programming cell migration
    Robert Sackstein
    Departments of Dermatology and of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Biomed Eng 40:766-76. 2012
    ....
  5. pmc CD44 is a major E-selectin ligand on human hematopoietic progenitor cells
    C J Dimitroff
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Cell Biol 153:1277-86. 2001
    ..These findings offer new insights into the structural biology and physiology of CD44, and into the molecular basis of E-selectin-dependent adhesive interactions that direct homing of human HPC to BM...
  6. pmc Engineering cellular trafficking via glycosyltransferase-programmed stereosubstitution
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1253:193-200. 2012
    ..Without compromising cell viability or native phenotype, this exoglycosylation technology literally "sweetens" CD44, licensing E-selectin-dependent vascular delivery for all cell-based therapeutics...
  7. ncbi request reprint The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing
    Robert Sackstein
    Departments of Dermatology and Medicine, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts, USA
    J Investig Dermatol Symp Proc 9:215-23. 2004
    ....
  8. ncbi request reprint In vitro adherence of lymphocytes to dermal endothelium under shear stress: implications in pathobiology and steroid therapy of acute cutaneous GVHD
    Robert Sackstein
    Harvard Skin Disease Research Center, Harvard Medical School, Department of Dermatology, Brigham and Women s Hospital, Boston, MA, USA
    Blood 101:771-8. 2003
    ....
  9. doi request reprint Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 14:181-7. 2008
    ..These findings establish that the HCELL glycoform of CD44 confers tropism to bone and unveil a readily translatable roadmap for programming cellular trafficking by chemical engineering of glycans on a distinct membrane glycoprotein...
  10. ncbi request reprint The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing
    Robert Sackstein
    Department of Dermatology and Medicine, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 122:1061-9. 2004
    ....
  11. ncbi request reprint The lymphocyte homing receptors: gatekeepers of the multistep paradigm
    Robert Sackstein
    Department of Dermatology and Medicine, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Hematol 12:444-50. 2005
    ..This review focuses on the current and emerging perspectives of the biology of these 'homing receptors.'..
  12. doi request reprint Glycosyltransferase-programmed stereosubstitution (GPS) to create HCELL: engineering a roadmap for cell migration
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Immunol Rev 230:51-74. 2009
    ....
  13. ncbi request reprint A hematopoietic cell L-selectin ligand that is distinct from PSGL-1 and displays N-glycan-dependent binding activity
    R Sackstein
    Bone Marrow Transplant Service, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Blood 96:2765-74. 2000
    ..This novel ligand may help mediate L-selectin-dependent cell-cell adhesive interactions within the cytoarchitecture of the bone marrow microenvironment. (Blood. 2000;96:2765-2774)..
  14. pmc The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway' and other emerging perspectives
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital, Harvard Skin Disease Research Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Hematol 18:239-48. 2011
    ..This review focuses on recent advances in our understanding of the biology of CD44 and HCELL in hematopoiesis...
  15. doi request reprint Western blot analysis of adhesive interactions under fluid shear conditions: the blot rolling assay
    Robert Sackstein
    Department of Dermatology and Medicine, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Mailstop HIM, Room 671, Boston, MA, 02115, USA
    Methods Mol Biol 536:343-54. 2009
    ..This method thus allows for the identification, within a complex mixture and without prior isolation or purification, of both known and previously uncharacterized adhesion molecules operational under dynamic conditions...
  16. ncbi request reprint differential L-selectin binding activities of human hematopoietic cell L-selectin ligands, HCELL and PSGL-1
    C J Dimitroff
    Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women's Hospital, Harvard Medical School, 77 Ave. Louis Pasteur, Boston, MA 02115, USA
    J Biol Chem 276:47623-31. 2001
    ..Taken together, these data indicate that HCELL is a more avid L-selectin ligand than PSGL-1 and may be the preferential mediator of L-selectin-dependent adhesive interactions among human HCs in the bone marrow...
  17. ncbi request reprint Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation
    I P Alwayn
    The Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
    Transplantation 71:1601-9. 2001
    ..Eptifibatide can fully abrogate platelet aggregation induced by porcine PBPC in vitro. Purification of the progenitor cells from porcine PBPC and/or treatment of baboons with eptifibatide may be beneficial...
  18. pmc A distinct glycoform of CD44 is an L-selectin ligand on human hematopoietic cells
    C J Dimitroff
    Department of Medicine and Dermatology, Brigham and Women s Hospital and Harvard Skin Disease Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:13841-6. 2000
    ..These data provide important insights on the structural biology of CD44 and reveal a role for this protein as an L-selectin ligand on human hematopoietic cells...
  19. ncbi request reprint Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin
    Charles J Dimitroff
    Department of Dermatology and the Harvard Skin Disease Research Center at Brigham and Women s Hospital, Boston, MA, USA
    Blood 101:602-10. 2003
    ....
  20. ncbi request reprint Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy
    L Buhler
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, USA
    Bone Marrow Transplant 27:1227-36. 2001
    ....
  21. ncbi request reprint Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation
    B R Dey
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Blood Marrow Transplant 7:604-12. 2001
    ..Further follow-up and evaluation of additional patients are required to conclusively establish the role of this strategy in the treatment of hematologic malignancies after an autologous transplantation...
  22. ncbi request reprint HCELL is the major E- and L-selectin ligand expressed on LS174T colon carcinoma cells
    Monica M Burdick
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 281:13899-905. 2006
    ....
  23. ncbi request reprint Direct real-time observation of E- and P-selectin-mediated rolling on cutaneous lymphocyte-associated antigen immobilized on Western blots
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 168:5645-51. 2002
    ....
  24. ncbi request reprint Directing stem cell trafficking via GPS
    Robert Sackstein
    Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Methods Enzymol 479:93-105. 2010
    ..Ex vivo glycan engineering of HCELL via GPS licenses trafficking of infused cells to endothelial beds that express E-selectin, thereby enabling efficient vascular delivery of stem/progenitor cells to sites where they are needed...
  25. ncbi request reprint Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation
    M Sykes
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Lancet 353:1755-9. 1999
    ..We tested a new approach to find out whether lymphohaemopoietic graft-versus-host reactions could occur without excessive GVHD in mixed haemopoietic chimeras produced across HLA barriers with non-myeloablative conditioning...
  26. pmc Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    Kalindi Parmar
    Department of Radiation Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:5431-6. 2007
    ....
  27. ncbi request reprint G-CSF induces E-selectin ligand expression on human myeloid cells
    Nilesh M Dagia
    Department of Dermatology, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Room 671, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Med 12:1185-90. 2006
    ..These findings provide direct evidence for a role of G-CSF in the induction of E-selectin ligands on myeloid cells, thus providing mechanistic insight into the pathobiology of G-CSF complications...
  28. pmc Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen
    Charles J Dimitroff
    Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 112:1008-18. 2003
    ..These data indicate that 4-F-GlcNAc prevents CHS by inhibiting selectin ligand activity and the capacity of effector T cells to enter antigen-challenged skin without affecting the afferent phase of CHS...
  29. pmc CD43 is a ligand for E-selectin on CLA+ human T cells
    Robert C Fuhlbrigge
    Department of Dermatology, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Blood 107:1421-6. 2006
    ..The identification and characterization of CD43 as a T-cell E-selectin ligand distinct from PSGL-1 expands the role of CD43 in the regulation of T-cell trafficking and provides new targets for the modulation of immune functions in skin...
  30. pmc SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia
    Hai T Ngo
    Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 112:150-8. 2008
    ..Together, these studies demonstrate that the CXCR4/SDF-1 axis interacts with VLA-4 in regulating migration and adhesion of WM cells in the bone marrow microenvironment...
  31. ncbi request reprint Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation
    Bimalangshu R Dey
    Bone Marrow Transplantation Program Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Biol Blood Marrow Transplant 9:320-9. 2003
    ....
  32. ncbi request reprint The blot rolling assay: a method for identifying adhesion molecules mediating binding under shear conditions
    Robert Sackstein
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 341:217-26. 2006
    ..Thus, this method allows for the identification, within a complex mixture and without previous isolation or purification, of both known and novel adhesion molecules capable of binding under shear conditions...
  33. ncbi request reprint Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade
    L Buhler
    Transplantation Biology Research Center, Massachusetts General Hospital, MGH East, Building 149 9019, 13th Street, Boston, MA 02129, USA
    Transplantation 73:12-22. 2002
    ....
  34. ncbi request reprint A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses
    M A Exley
    Cancer Biology Program, Hematology Oncology, Beth Israel Deaconess Medical Center, Bone Marrow Transplant Program, Harvard Skin Disease Research Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 167:5531-4. 2001
    ..Distinct CD1d-reactive T cell populations have the potential to suppress graft-vs-host disease and stimulate antitumor responses...
  35. ncbi request reprint The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha
    R Salgia
    Department of Medical Oncology, Division of Hematologic Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 94:4233-46. 1999
    ....
  36. pmc Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions
    Jack Y Lee
    Harvard Skin Disease Research Center and Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Leukoc Biol 86:1285-94. 2009
    ..These findings broaden our understanding of chemokine biology and support a novel paradigm by which temporospatial modulations in subendothelial chemokine display drive cell migration from interstitial compartments into the bloodstream...
  37. ncbi request reprint Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation
    Pierre R Theodore
    Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Xenotransplantation 9:277-89. 2002
    ....
  38. pmc CD15 expression in human myeloid cell differentiation is regulated by sialidase activity
    Samah Zeineb Gadhoum
    Department of Dermatology, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    Nat Chem Biol 4:751-7. 2008
    ..Our results unveil a new paradigm by demonstrating a critical role for post-Golgi membrane glycosidase activity in the 'biosynthesis' of a key glycan determinant...
  39. ncbi request reprint Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation
    Bimalangshu R Dey
    Department of Medicine Harvard Medical School Boston, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Br J Haematol 128:351-9. 2005
    ..Immunological mechanisms that correlated with rejection of the graft may have a role in anti-tumour responses via a cell or cytokine-mediated pathway...
  40. ncbi request reprint Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease
    Leo H Buhler
    Department of Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    Transplantation 74:1405-9. 2002
    ....
  41. ncbi request reprint Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant
    Han C Toh
    Bone Marrow Transplant Program, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Cytokines Cell Mol Ther 7:43-7. 2002
    ..Eventual lymphoma relapse temporally correlated with a generalised immunosuppressed state...
  42. pmc Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival
    Angela Shaulov
    Department of Hematology Oncology Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Exp Hematol 36:464-72. 2008
    ..Recent data suggests that NKT might contribute to clinical benefits of PBPC...
  43. ncbi request reprint Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation
    Annette B Kraus
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Mass, USA
    Exp Hematol 31:609-21. 2003
    ..To assess the role of immunologic rejection in graft loss, we compared T-cell recovery and in vitro alloresponses in six patients who lost their marrow graft to that in 16 concurrent patients with sustained donor chimerism...
  44. ncbi request reprint Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants
    Andrew Daly
    Allogeneic Bone Marrow Transplant Program, Princess Margaret Hospital University Health Network, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Biol Blood Marrow Transplant 9:373-82. 2003
    ..We conclude that a quantitative T-cell deficiency in these extensively T-cell depleted patients may be a risk factor for infection, even in the absence of graft-versus-host disease...
  45. ncbi request reprint Variant isoforms of CD44 are P- and L-selectin ligands on colon carcinoma cells
    William D Hanley
    Department of The Johns Hopkins University, Baltimore, Maryland, USA
    FASEB J 20:337-9. 2006
    ..The novel finding that CD44v are selectin ligands offers a unifying perspective on the apparent enhanced metastatic potential associated with tumor cell CD44v overexpression and the critical role of selectins in metastasis...
  46. ncbi request reprint CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity
    William D Hanley
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cancer Res 65:5812-7. 2005
    ..Our finding that tumor-associated CD44 splice variant(s) express E-selectin ligand activity provides novel perspectives on the biology of CD44 in cancer metastasis...
  47. pmc L-selectin-mediated lymphocyte-cancer cell interactions under low fluid shear conditions
    Vicente A Resto
    Department of Otolaryngology and the Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 283:15816-24. 2008
    ..g. HCELL). These data define a novel class of L-selectin ligands and expand the scope of function for L-selectin within circulatory systems to now include a novel activity within shear stresses characteristic of lymphatic flow...
  48. ncbi request reprint Primed marrow for autologous and allogeneic transplantation: a review comparing primed marrow to mobilized blood and steady-state marrow
    Gerald J Elfenbein
    Blood and Marrow Transplant Program, Roger Williams Medical Center, Providence, RI 02908, USA
    Exp Hematol 32:327-39. 2004
    ....
  49. ncbi request reprint Do G-CSF mobilized, peripheral blood-derived stem cells from healthy, HLA-identical donors really engraft more rapidly than do G-CSF primed, bone marrow-derived stem cells? No!
    Gerald J Elfenbein
    Blood and Marrow Transplant Program, Roger Williams Medical Center, Providence, RI 02908, USA
    Blood Cells Mol Dis 32:106-11. 2004
    ..We propose the concept that the level of activation of the stem cells (induced by G-CSF) determines engraftment kinetics and not the anatomical site of derivation...

Research Grants26

  1. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2000
    ....
  2. MOLECULAR ANALYSIS OF HEMATOPOIETIC L SELECTIN LIGAND
    Robert Sackstein; Fiscal Year: 1999
    ....
  3. Analysis of Homing Receptors on Human Adult Stem Cells
    Robert Sackstein; Fiscal Year: 2004
    ....
  4. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2001
    ....
  5. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2002
    ....
  6. Analysis of Homing Receptors on Human Adult Stem Cells
    Robert Sackstein; Fiscal Year: 2006
    ....
  7. Structure & Biology of Hematopoietic E-/L-Selectin
    Robert Sackstein; Fiscal Year: 2002
    ..This information will contribute greatly to our understanding of the adhesive systems that regulate steady-state and pathologic hematopoiesis, as well as hematopoietic recovery following stem cell transplantation. ..
  8. Structure & Biology of Hematopoietic E-/L-Selectin
    Robert Sackstein; Fiscal Year: 2006
    ..This information will contribute greatly to our understanding of the adhesive systems that regulate steady-state and pathologic hematopoiesis, as well as hematopoietic recovery following stem cell transplantation. ..
  9. Molecular Analysis of CD44 on Colon Cancer Cells
    Robert Sackstein; Fiscal Year: 2010
    ..It is anticipated that information gathered from these studies will form the basis for development of therapeutics targeting CD44 in colon cancer. ..
  10. Analysis of Homing Receptors on Human Adult Stem Cells
    Robert Sackstein; Fiscal Year: 2005
    ....
  11. Optimizing Osteotropism of Human Mesenchymal Stem Cells
    Robert Sackstein; Fiscal Year: 2007
    ....
  12. Molecular Analysis of CD44 on Colon Cancer Cells
    Robert Sackstein; Fiscal Year: 2009
    ..It is anticipated that information gathered from these studies will form the basis for development of therapeutics targeting CD44 in colon cancer. ..
  13. Optimizing Osteotropism of Human Mesenchymal Stem Cells
    Robert Sackstein; Fiscal Year: 2009
    ....
  14. Characterization of A Novel 65kDa E-selectin Ligand on G-CSF Mobilized Leukocytes
    Robert Sackstein; Fiscal Year: 2007
    ..It is anticipated that the results obtained will lead to new approaches for preventing or alleviating G-CSF-induced vascular and inflammatory complications ..
  15. Molecular Analysis of CD44 on Colon Cancer Cells
    Robert Sackstein; Fiscal Year: 2007
    ..It is anticipated that information gathered from these studies will form the basis for development of therapeutics targeting CD44 in colon cancer. ..
  16. Structure & Biology of Hematopoietic E-/L-Selectin
    Robert Sackstein; Fiscal Year: 2005
    ..This information will contribute greatly to our understanding of the adhesive systems that regulate steady-state and pathologic hematopoiesis, as well as hematopoietic recovery following stem cell transplantation. ..
  17. Structure & Biology of Hematopoietic E-/L-Selectin
    Robert Sackstein; Fiscal Year: 2004
    ..This information will contribute greatly to our understanding of the adhesive systems that regulate steady-state and pathologic hematopoiesis, as well as hematopoietic recovery following stem cell transplantation. ..
  18. Analysis of Homing Receptors on Human Adult Stem Cells
    Robert Sackstein; Fiscal Year: 2003
    ....
  19. Structure & Biology of Hematopoietic E-/L-Selectin
    Robert Sackstein; Fiscal Year: 2003
    ..This information will contribute greatly to our understanding of the adhesive systems that regulate steady-state and pathologic hematopoiesis, as well as hematopoietic recovery following stem cell transplantation. ..
  20. ADHESION MOLECULES MEDIATING SKIN TROPISM IN ACUTE GVHD
    Robert Sackstein; Fiscal Year: 2003
    ....
  21. MOLECULAR ANALYSIS OF HEMATOPOIETIC L SELECTIN LIGAND
    Robert Sackstein; Fiscal Year: 2000
    ....
  22. Optimizing Osteotropism of Human Mesenchymal Stem Cells
    Robert Sackstein; Fiscal Year: 2010
    ....