SEWARD RUTKOVE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Foot temperature in diabetic polyneuropathy: innocent bystander or unrecognized accomplice?
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabet Med 22:231-8. 2005
  2. pmc Electrical impedance myography as a biomarker to assess ALS progression
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Amyotroph Lateral Scler 13:439-45. 2012
  3. pmc Machine learning algorithms to classify spinal muscular atrophy subtypes
    Tuhin Srivastava
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurology 79:358-64. 2012
  4. doi request reprint Electrical impedance myography in spinal muscular atrophy: a longitudinal study
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 45:642-7. 2012
  5. ncbi request reprint Electrode position and size in electrical impedance myography
    Seward B Rutkove
    The Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center and the Department of Physics, Northeastern University, Boston, MA 02215, USA
    Clin Neurophysiol 116:290-9. 2005
  6. ncbi request reprint Test-retest reproducibility of 50 kHz linear-electrical impedance myography
    Seward B Rutkove
    Division of Neuromuscular Diseases, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 810, Boston, MA 02215, USA
    Clin Neurophysiol 117:1244-8. 2006
  7. pmc Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Neurophysiol 118:2413-8. 2007
  8. ncbi request reprint A methodology for the real-time measurement of distal extremity temperature
    Seward B Rutkove
    Department of Neurology, University of Massachusetts, Dartmouth, MA, USA
    Physiol Meas 28:1421-8. 2007
  9. pmc Reference values for 50-kHZ electrical impedance myography
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 810, Boston, Massachusettts 02215, USA
    Muscle Nerve 38:1128-32. 2008
  10. pmc Impaired distal thermoregulation in diabetes and diabetic polyneuropathy
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Diabetes Care 32:671-6. 2009

Research Grants

  1. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2009
  2. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2007
  3. Ambulatory Foot Temperature in Diabetic Neuropathy
    SEWARD RUTKOVE; Fiscal Year: 2006
  4. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2006
  5. Electrical Impedance Myography in an Animal Model
    Seward B Rutkove; Fiscal Year: 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Foot temperature in diabetic polyneuropathy: innocent bystander or unrecognized accomplice?
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabet Med 22:231-8. 2005
    ..To explore mechanisms by which temperature could influence the pathogenesis and symptoms of diabetic polyneuropathy...
  2. pmc Electrical impedance myography as a biomarker to assess ALS progression
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Amyotroph Lateral Scler 13:439-45. 2012
    ..In conclusion, EIM can serve as a useful ALS biomarker that offers the prospect of greatly accelerating phase 2 clinical trials...
  3. pmc Machine learning algorithms to classify spinal muscular atrophy subtypes
    Tuhin Srivastava
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurology 79:358-64. 2012
    ....
  4. doi request reprint Electrical impedance myography in spinal muscular atrophy: a longitudinal study
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 45:642-7. 2012
    ..In this study, we evaluate whether electrical impedance myography (EIM) can detect disease progression in SMA compared with a group of healthy children of similar age...
  5. ncbi request reprint Electrode position and size in electrical impedance myography
    Seward B Rutkove
    The Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center and the Department of Physics, Northeastern University, Boston, MA 02215, USA
    Clin Neurophysiol 116:290-9. 2005
    ..The precise location and size of the electrodes can be critical to the data obtained, and in this study the effects of variation in these factors were evaluated...
  6. ncbi request reprint Test-retest reproducibility of 50 kHz linear-electrical impedance myography
    Seward B Rutkove
    Division of Neuromuscular Diseases, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 810, Boston, MA 02215, USA
    Clin Neurophysiol 117:1244-8. 2006
    ..In this study, the reproducibility for the simplest of these techniques, 50 kHz linear-EIM, was assessed for three muscles...
  7. pmc Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Neurophysiol 118:2413-8. 2007
    ..This study investigates whether EIM could provide a new outcome measure for use in ALS clinical trials work...
  8. ncbi request reprint A methodology for the real-time measurement of distal extremity temperature
    Seward B Rutkove
    Department of Neurology, University of Massachusetts, Dartmouth, MA, USA
    Physiol Meas 28:1421-8. 2007
    ....
  9. pmc Reference values for 50-kHZ electrical impedance myography
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 810, Boston, Massachusettts 02215, USA
    Muscle Nerve 38:1128-32. 2008
    ..By using commercially available bioimpedance devices, these values will allow other investigators to explore the application of 50-kHZ EIM in clinical neuromuscular disease research...
  10. pmc Impaired distal thermoregulation in diabetes and diabetic polyneuropathy
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Diabetes Care 32:671-6. 2009
    ..To determine how thermoregulation of the feet is affected by diabetes and diabetic polyneuropathy in both wakefulness and sleep...
  11. doi request reprint A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy
    Seward B Rutkove
    Harvard Medical School, and Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 810, Boston, MA 02215, USA
    JAMA 302:1451-8. 2009
    ..Alpha-lipoic acid appears to be effective as well...
  12. pmc Electrical impedance myography: Background, current state, and future directions
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 40:936-46. 2009
    ..Ongoing efforts have been focused on obtaining a deeper understanding of the basic mechanisms of impedance change, studying EIM in a variety of clinical contexts, and further refining the methods of EIM data acquisition and analysis...
  13. doi request reprint Characterizing spinal muscular atrophy with electrical impedance myography
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Shapiro 810, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 42:915-21. 2010
    ..These results confirm that EIM can accurately categorize patients with SMA. Because EIM requires no patient effort and is rapid to apply, it may serve a useful role in future SMA clinical trials...
  14. ncbi request reprint Electrical impedance myography in the detection of radiculopathy
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Muscle Nerve 32:335-41. 2005
    ..3%; there was a tendency for muscles with more prominent chronic neurogenic change to show greater relative reductions in theta(avg). These findings support the potential utility of EIM in assessment of localized neuromuscular disease...
  15. ncbi request reprint Pseudofacilitation: A temperature-sensitive phenomenon
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 23:115-8. 2000
    ..Although providing only indirect evidence, these findings are consistent with the hypothesis that increased activity of muscle Na(+),K(+)-pump plays a role in producing pseudofacilitation...
  16. ncbi request reprint Heat-sensitive conduction block in ulnar neuropathy at the elbow
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, MA, Boston 02215, USA
    Clin Neurophysiol 112:280-5. 2001
    ..To study the effects of elbow heating on conduction block (CB) and across-elbow conduction velocity (CV) in patients with ulnar neuropathy at the elbow (UNE)...
  17. ncbi request reprint Focal cooling improves neuronal conduction in peroneal neuropathy at the fibular neck
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 24:1622-6. 2001
    ..Both the electrophysiologic and clinical changes readily reversed upon rewarming. These data support the belief that, in compressive neuropathies, cooling relieves conduction block in selected motor neurons, improving strength...
  18. ncbi request reprint A pilot randomized trial of oxandrolone in inclusion body myositis
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 58:1081-7. 2002
    ..Inclusion body myositis (IBM) remains without effective therapy. As anabolic steroids have myotrophic properties, the authors studied whether a synthetic androgen, oxandrolone, would have efficacy in IBM...
  19. ncbi request reprint Effects of temperature on neuromuscular electrophysiology
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC-810, Boston, MA 02215, USA
    Muscle Nerve 24:867-82. 2001
    ..Finally, extremes of temperature have long been known to produce permanent neuronal dysfunction; recent investigations are beginning to elucidate the mechanisms of such injury...
  20. ncbi request reprint Electrical impedance myography in the bedside assessment of inflammatory myopathy
    A Tarulli
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurology 65:451-2. 2005
    ..The major EIM parameter, the spatially averaged phase, was 35% lower in the myositis patients and correlated with whole-body (r = 0.765, p = 0.01) and quadriceps (r = 0.673, p = 0.03) strength...
  21. ncbi request reprint Localized bioimpedance analysis in the evaluation of neuromuscular disease
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 25:390-7. 2002
    ..These findings suggest that localized bioimpedance analysis has the potential of playing a substantial role in the diagnostic and therapeutic evaluation of neuromuscular disease...
  22. ncbi request reprint Diagnostic accuracy of electrodiagnostic testing in the evaluation of weakness
    Rachel A Nardin
    Department of Neurology, Beth Israel Deaconess Medical Center, Shapiro Clinical Center 810, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 26:201-5. 2002
    ....
  23. ncbi request reprint Electrical impedance of muscle during isometric contraction
    Carl A Shiffman
    Physics Department, Northeastern University, Boston, MA 02115, USA
    Physiol Meas 24:213-34. 2003
    ..We propose the name 'dynamic electrical impedance myography' for this new technique...
  24. pmc Optimizing measurement of the electrical anisotropy of muscle
    Anne B Chin
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 37:560-5. 2008
    ..These results support the belief that, with the appropriate measurement technique, non-invasive assessment of electrical anisotropy of muscle may have useful clinical application...
  25. ncbi request reprint Ambulatory foot temperature measurement: a new technique in polyneuropathy evaluation
    Peter B Kang
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts, USA
    Muscle Nerve 27:737-42. 2003
    ..This technique shows promise in studying temperature regulation in the feet and may provide new insights into neuropathy-associated pain and the pathogenesis of polyneuropathy...
  26. ncbi request reprint Ulnar neuropathy in the forearm: A possible complication of diabetes mellitus
    Juan A Acosta
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 28:40-5. 2003
    ..Whether this lesion is due to an increased propensity to focal compression of the ulnar nerve within the humero-ulnar arcade or whether it represents a localized manifestation of the generalized polyneuropathy remains to be determined...
  27. ncbi request reprint Effects of age on muscle as measured by electrical impedance myography
    Ronald Aaron
    Department of Physics, Northeastern University, Boston, MA 02215, USA
    Physiol Meas 27:953-9. 2006
    ..The findings of this study support the potential use of EIM as a simple and effort-independent test of muscle health in the elderly...
  28. ncbi request reprint Assessing neuromuscular disease with multifrequency electrical impedance myography
    Gregory J Esper
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 34:595-602. 2006
    ..Multifrequency EIM may be well-suited to serve as an easily applied technique to assess disease severity in a variety of neuromuscular conditions...
  29. ncbi request reprint Electrical impedance myography: transitioning from human to animal studies
    Rui Nie
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC 810, Boston, MA 02215, USA
    Clin Neurophysiol 117:1844-9. 2006
    ..To determine the feasibility of performing electrical impedance myography (EIM) in rats...
  30. ncbi request reprint Pattern recognition
    Seward B Rutkove
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC 810, Boston, MA 02215, USA
    Neurology 61:585-6. 2003
  31. ncbi request reprint Repetitive nerve stimulation for the evaluation of peripheral nerve hyperexcitability
    Michael Benatar
    Department of Neurology, Emory University, 1365A Clifton Road N E, Atlanta, GA 30322, USA
    J Neurol Sci 221:47-52. 2004
    ..To examine the utility of repetitive nerve stimulation (RNS) in the evaluation of peripheral nerve hyperexcitability (PNH)...
  32. ncbi request reprint Psoriatic arthritis-associated polyneuropathy: a report of three cases
    Pushpa Narayanaswami
    Beth Israel Deaconess Medical Center Department of Neurology, Boston, Massachusetts, USA
    J Clin Neuromuscul Dis 9:248-51. 2007
    ..PA-associated neuropathy should be considered in the differential diagnosis of chronic length-dependent axonal polyneuropathies...
  33. ncbi request reprint Electrodiagnostic automation: principles and practice
    Shai N Gozani
    NeuroMetrix, Inc, 62 Fourth Ave Waltham, MA 02451, USA
    Phys Med Rehabil Clin N Am 16:1015-32, x. 2005

Research Grants10

  1. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2009
    ..to prepare the way for the use of EIM in screening of drugs and therapies in animals models of neuromuscular disease. ..
  2. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2007
    ..to prepare the way for the use of EIM in screening of drugs and therapies in animals models of neuromuscular disease. ..
  3. Ambulatory Foot Temperature in Diabetic Neuropathy
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..Ultimately, the results obtained in this work may justify the use of ambulatory foot temperature monitoring in DN clinical trials, both as a screening tool for early disease and as an outcome measure. ..
  4. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  5. Electrical Impedance Myography in an Animal Model
    Seward B Rutkove; Fiscal Year: 2010
    ..to prepare the way for the use of EIM in screening of drugs and therapies in animals models of neuromuscular disease. ..