SEWARD RUTKOVE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Foot temperature in diabetic polyneuropathy: innocent bystander or unrecognized accomplice?
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabet Med 22:231-8. 2005
  2. ncbi request reprint Cross-sectional Evaluation of Electrical Impedance Myography and Quantitative Ultrasound for the Assessment of Duchenne Muscular Dystrophy in a Clinical Trial Setting
    Seward B Rutkove
    Division of Neuromuscular Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Electronic address
    Pediatr Neurol 51:88-92. 2014
  3. pmc Cold exposure exacerbates the development of diabetic polyneuropathy in the rat
    Lora J Kasselman
    Division of Neuromuscular Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Exp Diabetes Res 2009:827943. 2009
  4. pmc Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy
    Courtney E McIlduff
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ther Clin Risk Manag 7:377-85. 2011
  5. pmc Electrophysiologic biomarkers for assessing disease progression and the effect of riluzole in SOD1 G93A ALS mice
    Jia Li
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65976. 2013
  6. pmc A technique for performing electrical impedance myography in the mouse hind limb: data in normal and ALS SOD1 G93A animals
    Jia Li
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    PLoS ONE 7:e45004. 2012
  7. pmc Electrical impedance myography as a biomarker to assess ALS progression
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Amyotroph Lateral Scler 13:439-45. 2012
  8. pmc Machine learning algorithms to classify spinal muscular atrophy subtypes
    Tuhin Srivastava
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurology 79:358-64. 2012
  9. doi request reprint Electrical impedance myography in spinal muscular atrophy: a longitudinal study
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 45:642-7. 2012
  10. ncbi request reprint Test-retest reproducibility of 50 kHz linear-electrical impedance myography
    Seward B Rutkove
    Division of Neuromuscular Diseases, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 810, Boston, MA 02215, USA
    Clin Neurophysiol 117:1244-8. 2006

Research Grants

  1. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2003
  2. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2009
  3. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2007
  4. Ambulatory Foot Temperature in Diabetic Neuropathy
    SEWARD RUTKOVE; Fiscal Year: 2006
  5. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2006
  6. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2005
  7. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2004
  8. Electrical Impedance Myography in an Animal Model
    Seward B Rutkove; Fiscal Year: 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Foot temperature in diabetic polyneuropathy: innocent bystander or unrecognized accomplice?
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Diabet Med 22:231-8. 2005
    ..To explore mechanisms by which temperature could influence the pathogenesis and symptoms of diabetic polyneuropathy...
  2. ncbi request reprint Cross-sectional Evaluation of Electrical Impedance Myography and Quantitative Ultrasound for the Assessment of Duchenne Muscular Dystrophy in a Clinical Trial Setting
    Seward B Rutkove
    Division of Neuromuscular Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Electronic address
    Pediatr Neurol 51:88-92. 2014
    ..Both techniques have potential to serve as useful biomarkers in clinical trials in Duchenne muscular dystrophy. However, their comparative sensitivity to disease status and how they relate to one another are unknown...
  3. pmc Cold exposure exacerbates the development of diabetic polyneuropathy in the rat
    Lora J Kasselman
    Division of Neuromuscular Diseases, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Exp Diabetes Res 2009:827943. 2009
    ..047). Cold exposure appears to hasten the development of DPN in the rat STZ model of diabetes. These findings support that further study into the relationship between ambient temperature and DPN is warranted...
  4. pmc Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy
    Courtney E McIlduff
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ther Clin Risk Manag 7:377-85. 2011
    ..Here we review the effectiveness and tolerability of ALA in the treatment of symptomatic DSPN...
  5. pmc Electrophysiologic biomarkers for assessing disease progression and the effect of riluzole in SOD1 G93A ALS mice
    Jia Li
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65976. 2013
    ..To compare electrical impedance myography (EIM) 50 kHz phase to weight, motor score, paw grip endurance (PGE), CMAP amplitude, and MUNE for the identification of disease progression and the effect of riluzole in the SOD1 G93A mouse...
  6. pmc A technique for performing electrical impedance myography in the mouse hind limb: data in normal and ALS SOD1 G93A animals
    Jia Li
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    PLoS ONE 7:e45004. 2012
    ..To test a method for performing electrical impedance myography (EIM) in the mouse hind limb for the assessment of disease status in neuromuscular disease models...
  7. pmc Electrical impedance myography as a biomarker to assess ALS progression
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Amyotroph Lateral Scler 13:439-45. 2012
    ..In conclusion, EIM can serve as a useful ALS biomarker that offers the prospect of greatly accelerating phase 2 clinical trials...
  8. pmc Machine learning algorithms to classify spinal muscular atrophy subtypes
    Tuhin Srivastava
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurology 79:358-64. 2012
    ....
  9. doi request reprint Electrical impedance myography in spinal muscular atrophy: a longitudinal study
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 45:642-7. 2012
    ..In this study, we evaluate whether electrical impedance myography (EIM) can detect disease progression in SMA compared with a group of healthy children of similar age...
  10. ncbi request reprint Test-retest reproducibility of 50 kHz linear-electrical impedance myography
    Seward B Rutkove
    Division of Neuromuscular Diseases, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 810, Boston, MA 02215, USA
    Clin Neurophysiol 117:1244-8. 2006
    ..In this study, the reproducibility for the simplest of these techniques, 50 kHz linear-EIM, was assessed for three muscles...
  11. ncbi request reprint A methodology for the real-time measurement of distal extremity temperature
    Seward B Rutkove
    Department of Neurology, University of Massachusetts, Dartmouth, MA, USA
    Physiol Meas 28:1421-8. 2007
    ....
  12. pmc Reference values for 50-kHZ electrical impedance myography
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 810, Boston, Massachusettts 02215, USA
    Muscle Nerve 38:1128-32. 2008
    ..By using commercially available bioimpedance devices, these values will allow other investigators to explore the application of 50-kHZ EIM in clinical neuromuscular disease research...
  13. ncbi request reprint Electrical impedance myography in the detection of radiculopathy
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Muscle Nerve 32:335-41. 2005
    ..3%; there was a tendency for muscles with more prominent chronic neurogenic change to show greater relative reductions in theta(avg). These findings support the potential utility of EIM in assessment of localized neuromuscular disease...
  14. ncbi request reprint Electrode position and size in electrical impedance myography
    Seward B Rutkove
    The Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center and the Department of Physics, Northeastern University, Boston, MA 02215, USA
    Clin Neurophysiol 116:290-9. 2005
    ..The precise location and size of the electrodes can be critical to the data obtained, and in this study the effects of variation in these factors were evaluated...
  15. pmc Impaired distal thermoregulation in diabetes and diabetic polyneuropathy
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Diabetes Care 32:671-6. 2009
    ..To determine how thermoregulation of the feet is affected by diabetes and diabetic polyneuropathy in both wakefulness and sleep...
  16. doi request reprint A 52-year-old woman with disabling peripheral neuropathy: review of diabetic polyneuropathy
    Seward B Rutkove
    Harvard Medical School, and Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, TCC 810, Boston, MA 02215, USA
    JAMA 302:1451-8. 2009
    ..Alpha-lipoic acid appears to be effective as well...
  17. pmc Electrical impedance myography: Background, current state, and future directions
    Seward B Rutkove
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 40:936-46. 2009
    ..Ongoing efforts have been focused on obtaining a deeper understanding of the basic mechanisms of impedance change, studying EIM in a variety of clinical contexts, and further refining the methods of EIM data acquisition and analysis...
  18. doi request reprint Characterizing spinal muscular atrophy with electrical impedance myography
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Shapiro 810, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 42:915-21. 2010
    ..These results confirm that EIM can accurately categorize patients with SMA. Because EIM requires no patient effort and is rapid to apply, it may serve a useful role in future SMA clinical trials...
  19. pmc Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Clin Neurophysiol 118:2413-8. 2007
    ..This study investigates whether EIM could provide a new outcome measure for use in ALS clinical trials work...
  20. ncbi request reprint Pseudofacilitation: A temperature-sensitive phenomenon
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 23:115-8. 2000
    ..Although providing only indirect evidence, these findings are consistent with the hypothesis that increased activity of muscle Na(+),K(+)-pump plays a role in producing pseudofacilitation...
  21. ncbi request reprint Heat-sensitive conduction block in ulnar neuropathy at the elbow
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, MA, Boston 02215, USA
    Clin Neurophysiol 112:280-5. 2001
    ..To study the effects of elbow heating on conduction block (CB) and across-elbow conduction velocity (CV) in patients with ulnar neuropathy at the elbow (UNE)...
  22. ncbi request reprint Focal cooling improves neuronal conduction in peroneal neuropathy at the fibular neck
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 24:1622-6. 2001
    ..Both the electrophysiologic and clinical changes readily reversed upon rewarming. These data support the belief that, in compressive neuropathies, cooling relieves conduction block in selected motor neurons, improving strength...
  23. ncbi request reprint A pilot randomized trial of oxandrolone in inclusion body myositis
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Neurology 58:1081-7. 2002
    ..Inclusion body myositis (IBM) remains without effective therapy. As anabolic steroids have myotrophic properties, the authors studied whether a synthetic androgen, oxandrolone, would have efficacy in IBM...
  24. doi request reprint Neuroprotective effects of Kv7 channel agonist, retigabine, for cisplatin-induced peripheral neuropathy
    Hiroyuki Nodera
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurosci Lett 505:223-7. 2011
    ..These results support the general concept that chemotherapy-induced neuropathy can be partially inhibited via Kv7 channel activation...
  25. ncbi request reprint Effects of temperature on neuromuscular electrophysiology
    S B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC-810, Boston, MA 02215, USA
    Muscle Nerve 24:867-82. 2001
    ..Finally, extremes of temperature have long been known to produce permanent neuronal dysfunction; recent investigations are beginning to elucidate the mechanisms of such injury...
  26. ncbi request reprint Electrical impedance myography in the bedside assessment of inflammatory myopathy
    A Tarulli
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Neurology 65:451-2. 2005
    ..The major EIM parameter, the spatially averaged phase, was 35% lower in the myositis patients and correlated with whole-body (r = 0.765, p = 0.01) and quadriceps (r = 0.673, p = 0.03) strength...
  27. ncbi request reprint Diagnostic accuracy of electrodiagnostic testing in the evaluation of weakness
    Rachel A Nardin
    Department of Neurology, Beth Israel Deaconess Medical Center, Shapiro Clinical Center 810, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 26:201-5. 2002
    ....
  28. ncbi request reprint Effects of age on muscle as measured by electrical impedance myography
    Ronald Aaron
    Department of Physics, Northeastern University, Boston, MA 02215, USA
    Physiol Meas 27:953-9. 2006
    ..The findings of this study support the potential use of EIM as a simple and effort-independent test of muscle health in the elderly...
  29. ncbi request reprint Localized bioimpedance analysis in the evaluation of neuromuscular disease
    Seward B Rutkove
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 25:390-7. 2002
    ..These findings suggest that localized bioimpedance analysis has the potential of playing a substantial role in the diagnostic and therapeutic evaluation of neuromuscular disease...
  30. ncbi request reprint Electrical impedance of muscle during isometric contraction
    Carl A Shiffman
    Physics Department, Northeastern University, Boston, MA 02115, USA
    Physiol Meas 24:213-34. 2003
    ..We propose the name 'dynamic electrical impedance myography' for this new technique...
  31. ncbi request reprint Ambulatory foot temperature measurement: a new technique in polyneuropathy evaluation
    Peter B Kang
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts, USA
    Muscle Nerve 27:737-42. 2003
    ..This technique shows promise in studying temperature regulation in the feet and may provide new insights into neuropathy-associated pain and the pathogenesis of polyneuropathy...
  32. ncbi request reprint Ulnar neuropathy in the forearm: A possible complication of diabetes mellitus
    Juan A Acosta
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 28:40-5. 2003
    ..Whether this lesion is due to an increased propensity to focal compression of the ulnar nerve within the humero-ulnar arcade or whether it represents a localized manifestation of the generalized polyneuropathy remains to be determined...
  33. ncbi request reprint Pattern recognition
    Seward B Rutkove
    Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC 810, Boston, MA 02215, USA
    Neurology 61:585-6. 2003
  34. ncbi request reprint Repetitive nerve stimulation for the evaluation of peripheral nerve hyperexcitability
    Michael Benatar
    Department of Neurology, Emory University, 1365A Clifton Road N E, Atlanta, GA 30322, USA
    J Neurol Sci 221:47-52. 2004
    ..To examine the utility of repetitive nerve stimulation (RNS) in the evaluation of peripheral nerve hyperexcitability (PNH)...
  35. pmc Optimizing measurement of the electrical anisotropy of muscle
    Anne B Chin
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 37:560-5. 2008
    ..These results support the belief that, with the appropriate measurement technique, non-invasive assessment of electrical anisotropy of muscle may have useful clinical application...
  36. ncbi request reprint Electrical impedance myography: transitioning from human to animal studies
    Rui Nie
    Department of Neurology, Division of Neuromuscular Diseases, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, TCC 810, Boston, MA 02215, USA
    Clin Neurophysiol 117:1844-9. 2006
    ..To determine the feasibility of performing electrical impedance myography (EIM) in rats...
  37. ncbi request reprint Assessing neuromuscular disease with multifrequency electrical impedance myography
    Gregory J Esper
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, TCC 810, Boston, Massachusetts 02215, USA
    Muscle Nerve 34:595-602. 2006
    ..Multifrequency EIM may be well-suited to serve as an easily applied technique to assess disease severity in a variety of neuromuscular conditions...
  38. ncbi request reprint Psoriatic arthritis-associated polyneuropathy: a report of three cases
    Pushpa Narayanaswami
    Beth Israel Deaconess Medical Center Department of Neurology, Boston, Massachusetts, USA
    J Clin Neuromuscul Dis 9:248-51. 2007
    ..PA-associated neuropathy should be considered in the differential diagnosis of chronic length-dependent axonal polyneuropathies...
  39. ncbi request reprint Electrodiagnostic automation: principles and practice
    Shai N Gozani
    NeuroMetrix, Inc, 62 Fourth Ave Waltham, MA 02451, USA
    Phys Med Rehabil Clin N Am 16:1015-32, x. 2005

Research Grants10

  1. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2003
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  2. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2009
    ..to prepare the way for the use of EIM in screening of drugs and therapies in animals models of neuromuscular disease. ..
  3. Electrical Impedance Myography in an Animal Model
    SEWARD RUTKOVE; Fiscal Year: 2007
    ..to prepare the way for the use of EIM in screening of drugs and therapies in animals models of neuromuscular disease. ..
  4. Ambulatory Foot Temperature in Diabetic Neuropathy
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..Ultimately, the results obtained in this work may justify the use of ambulatory foot temperature monitoring in DN clinical trials, both as a screening tool for early disease and as an outcome measure. ..
  5. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2006
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  6. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2005
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  7. Localized Bioimpedance in Neuromuscular Disease
    SEWARD RUTKOVE; Fiscal Year: 2004
    ..As part of this aim, a prototype device for easy use will be developed and tested in the clinical setting. ..
  8. Electrical Impedance Myography in an Animal Model
    Seward B Rutkove; Fiscal Year: 2010
    ..to prepare the way for the use of EIM in screening of drugs and therapies in animals models of neuromuscular disease. ..