Leileata M Russo

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Impaired tubular uptake explains albuminuria in early diabetic nephropathy
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital Harvard Medical School, Simches Research Center, Boston, MA 02114, USA
    J Am Soc Nephrol 20:489-94. 2009
  2. ncbi request reprint Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital Harvard Medical School, Simches Research Center, 185 Cambridge St, Rm 8100, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 291:F246-53. 2006
  3. ncbi request reprint Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital Harvard Medical School, Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    Diabetes 56:380-8. 2007
  4. doi request reprint The soluble transforming growth factor-beta receptor: advantages and applications
    Leileata M Russo
    Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Biochem Cell Biol 41:472-6. 2009
  5. ncbi request reprint Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
    Teodor G Paunescu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 294:F130-8. 2008
  6. pmc cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells
    Teodor G Paunescu
    MGH Center for Systems Biology, Program in Membrane Biology, and Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 298:F643-54. 2010
  7. pmc Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells
    Teodor G Paunescu
    Program in Membrane Biology Division of Nephrology, Massachusetts General Hospital, Simches Research Center, 185 Cambridge St, CPZN8150, Boston, MA 02114
    Am J Physiol Renal Physiol 305:F1783-95. 2013
  8. doi request reprint Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
    Kevin C Miranda
    Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 78:191-9. 2010
  9. ncbi request reprint Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA
    Kevin C Miranda
    Program in Membrane Biology, Division of Nephrology and Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 9:e96094. 2014
  10. ncbi request reprint Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice
    Teodor G Paunescu
    Div of Nephrology, Massachusetts General Hospital, 185 Cambridge St, CPZN 8150, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 293:F1915-26. 2007

Detail Information

Publications20

  1. pmc Impaired tubular uptake explains albuminuria in early diabetic nephropathy
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital Harvard Medical School, Simches Research Center, Boston, MA 02114, USA
    J Am Soc Nephrol 20:489-94. 2009
    ..In conclusion, in the early stages of diabetic nephropathy, the PT plays a major role in the development of albuminuria, which may be preceded by peptideuria...
  2. ncbi request reprint Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital Harvard Medical School, Simches Research Center, 185 Cambridge St, Rm 8100, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 291:F246-53. 2006
    ....
  3. ncbi request reprint Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor
    Leileata M Russo
    Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital Harvard Medical School, Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    Diabetes 56:380-8. 2007
    ..Fc is a potential new agent for the treatment of fibrosis and albuminuria in diabetic nephropathy and may reduce albuminuria by reducing TGF-beta1-induced disruptions of renal proximal tubule cell uptake of albumin...
  4. doi request reprint The soluble transforming growth factor-beta receptor: advantages and applications
    Leileata M Russo
    Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Biochem Cell Biol 41:472-6. 2009
    ..Here we discuss the design, use and advantages of the highly specific TGF-beta binding molecule, the soluble human TGF-beta receptor (sTbetaR.Fc) as a TGF-beta sequestering agent...
  5. ncbi request reprint Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
    Teodor G Paunescu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 294:F130-8. 2008
    ..This suggests that these enzymes have a close association and could be part of a protein complex that is involved in regulating renal distal proton secretion...
  6. pmc cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells
    Teodor G Paunescu
    MGH Center for Systems Biology, Program in Membrane Biology, and Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 298:F643-54. 2010
    ....
  7. pmc Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells
    Teodor G Paunescu
    Program in Membrane Biology Division of Nephrology, Massachusetts General Hospital, Simches Research Center, 185 Cambridge St, CPZN8150, Boston, MA 02114
    Am J Physiol Renal Physiol 305:F1783-95. 2013
    ..Importantly, the absence of apical caveolae indicates that while Cavs may have an as yet undetermined role in vasopressin-regulated signaling processes, this is probably unrelated to AQP2 internalization by caveolae. ..
  8. doi request reprint Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
    Kevin C Miranda
    Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 78:191-9. 2010
    ..Our study provides an experimental strategy for the routine isolation and use of urinary microvesicles as a novel and non-invasive source of nucleic acids to further renal disease biomarker discovery...
  9. ncbi request reprint Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA
    Kevin C Miranda
    Program in Membrane Biology, Division of Nephrology and Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 9:e96094. 2014
    ....
  10. ncbi request reprint Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice
    Teodor G Paunescu
    Div of Nephrology, Massachusetts General Hospital, 185 Cambridge St, CPZN 8150, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 293:F1915-26. 2007
    ..However, our results show no increase in cell surface V-ATPase activity in response to metabolic acidosis in ICs from these animals, consistent with their inability to appropriately acidify their urine under these conditions...
  11. ncbi request reprint Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment
    Richard Bouley
    Program in Membrane Biology and Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biol Cell 98:215-32. 2006
    ..In the present study, we further investigated AQP2 accumulation at the cell surface, and compared it with V2R (VP type 2 receptor) trafficking using cells that express epitope-tagged AQP2 and V2R...
  12. ncbi request reprint Renal processing of albumin in diabetes and hypertension in rats: possible role of TGF-beta1
    Leileata M Russo
    Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, Clayton, Victoria 3800, Australia
    Am J Nephrol 23:61-70. 2003
    ..Recent studies show that albuminuria may be the result of changes in post-glomerular cellular uptake and processing of albumin. This study aims to determine whether this processing is disrupted in diabetes and/or hypertension...
  13. ncbi request reprint Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade
    Fabrice Bonnet
    Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg West, Victoria 3081, Australia
    J Hypertens 20:1615-24. 2002
    ....
  14. ncbi request reprint Modulation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria
    Josephine M Forbes
    Department of Medicine and Endocrinology, University of Melbourne, Austin, Australia
    J Hypertens 20:985-92. 2002
    ..This study examines the possible relationship between nephrin expression and albuminuria in normotensive and hypertensive diabetic rats...
  15. ncbi request reprint Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2
    Tanya M Osicka
    Endocrine Unit, Department of Medicine, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia
    J Hypertens 21:2399-407. 2003
    ..Corresponding changes in renal microtubules were also assessed...
  16. ncbi request reprint Reduced tubular cation transport in diabetes: prevented by ACE inhibition
    Merlin C Thomas
    Division of Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia
    Kidney Int 63:2152-61. 2003
    ..Alterations of cation transport may occur in diabetes, although the role of the OCTs has not been previously assessed...
  17. ncbi request reprint The effect of ramipril on albumin excretion in diabetes and hypertension: the role of increased lysosomal activity and decreased transforming growth factor-beta expression
    Leileata M Russo
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    J Hypertens 21:419-28. 2003
    ....
  18. ncbi request reprint Nephrotic-like proteinuria in experimental diabetes
    Kerryn A Greive
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic, Australia
    Am J Nephrol 23:38-46. 2003
    ..To test this we have measured the excretion rates and fractional clearances of [(14)C]albumin, [(3)H]immunoglobulin G and [(3)H]transferrin in diabetic rats...
  19. ncbi request reprint Renal handling of albumin: a critical review of basic concepts and perspective
    Leileata M Russo
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Am J Kidney Dis 39:899-919. 2002
    ..We conclude with a discussion of topical and controversial issues associated with the proposed new understanding of renal handling of albumin...
  20. ncbi request reprint Albuminuria in hypertension is linked to altered lysosomal activity and TGF-beta1 expression
    Leileata M Russo
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    Hypertension 39:281-6. 2002
    ..These changes may be correlated with increased renal transforming growth factor-beta(1) expression...