Lee L Rubin

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Stem cells and drug discovery: the beginning of a new era?
    Lee L Rubin
    Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge MA 02138, USA
    Cell 132:549-52. 2008
  2. ncbi request reprint Targeting the Hedgehog pathway in cancer
    Lee L Rubin
    Harvard Stem Cell Institute, Biolabs, Room 150, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Rev Drug Discov 5:1026-33. 2006
  3. pmc Stem cell biology and drug discovery
    Lee L Rubin
    Dept of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
    BMC Biol 9:42. 2011
  4. pmc Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity
    Yu Wang
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Chem Biol 19:972-82. 2012
  5. pmc Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation
    Yu Wang
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    ACS Chem Biol 7:1040-8. 2012
  6. pmc Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions
    Juliet A Williams
    Curis Incorporated, 61 Moulton Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:4616-21. 2003
  7. ncbi request reprint Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway
    Rudolph D Paladini
    Curis Inc, Cambridge, Massachusetts, USA
    J Invest Dermatol 125:638-46. 2005
  8. ncbi request reprint A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons
    Leu Fen H Lin
    Curis Inc, 61 Moulton Street, Cambridge, MA 02138, USA
    J Neurochem 89:1387-95. 2004
  9. ncbi request reprint The hedgehog pathway and neurological disorders
    Tammy Dellovade
    Curis, Inc, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:539-63. 2006
  10. pmc A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog
    Justin K Ichida
    Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Cell Stem Cell 5:491-503. 2009

Collaborators

Detail Information

Publications18

  1. doi request reprint Stem cells and drug discovery: the beginning of a new era?
    Lee L Rubin
    Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge MA 02138, USA
    Cell 132:549-52. 2008
    ..Much of the attention focused on stem cells relates to their use in cell replacement therapy; however, stem cells may also transform the way in which therapeutics are discovered and validated...
  2. ncbi request reprint Targeting the Hedgehog pathway in cancer
    Lee L Rubin
    Harvard Stem Cell Institute, Biolabs, Room 150, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Rev Drug Discov 5:1026-33. 2006
    ..We will focus here on the Hedgehog pathway, which is abnormally activated in most basal cell carcinomas, and discuss potential therapeutic opportunities offered by the progress made in understanding this signalling pathway...
  3. pmc Stem cell biology and drug discovery
    Lee L Rubin
    Dept of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
    BMC Biol 9:42. 2011
    ..Remaining difficulties are highlighted, as are new therapeutic insights that have emerged...
  4. pmc Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity
    Yu Wang
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Chem Biol 19:972-82. 2012
    ..They also raise a concern about potential crosstalk of glucocorticoid drugs in the Hedgehog pathway, if therapeutic administration exceeds levels associated with on-target transcriptional mechanisms of glucocorticoid action...
  5. pmc Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation
    Yu Wang
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    ACS Chem Biol 7:1040-8. 2012
    ..Our observations identify important differences among Hh antagonists and the potential for development of novel therapeutic approaches against mutant forms of Smo that are resistant to current therapeutic strategies...
  6. pmc Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions
    Juliet A Williams
    Curis Incorporated, 61 Moulton Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 100:4616-21. 2003
    ..These findings directly demonstrate that the use of Hh inhibitors could be a valid therapeutic approach for treating BCC...
  7. ncbi request reprint Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway
    Rudolph D Paladini
    Curis Inc, Cambridge, Massachusetts, USA
    J Invest Dermatol 125:638-46. 2005
    ..These results suggest that the topical application of Hh-agonist could be effective in treating conditions of decreased proliferation and aberrant follicular cycling in the scalp including androgenetic alopecia (pattern hair loss)...
  8. ncbi request reprint A non-peptidyl neurotrophic small molecule for midbrain dopaminergic neurons
    Leu Fen H Lin
    Curis Inc, 61 Moulton Street, Cambridge, MA 02138, USA
    J Neurochem 89:1387-95. 2004
    ..CUR-162590 thus represents a new class of neurotrophic small molecules that may have utility in the treatment of Parkinson's disease, which is marked by degeneration of midbrain dopaminergic neurons...
  9. ncbi request reprint The hedgehog pathway and neurological disorders
    Tammy Dellovade
    Curis, Inc, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:539-63. 2006
    ..We also describe the discovery and utility of small molecule agonists and antagonists of this pathway and their potential as novel types of therapeutics...
  10. pmc A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog
    Justin K Ichida
    Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Cell Stem Cell 5:491-503. 2009
    ..We find that this inhibition promotes the completion of reprogramming through induction of the transcription factor Nanog...
  11. doi request reprint A small molecule that directs differentiation of human ESCs into the pancreatic lineage
    Shuibing Chen
    Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, Massachusetts, USA
    Nat Chem Biol 5:258-65. 2009
    ..This study describes a chemical screening platform to investigate human ESC differentiation and demonstrates the generation of a cell population that is a key milepost on the path to making beta cells...
  12. pmc Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication
    Justin P Annes
    Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:3915-20. 2012
    ..Short-term in vivo treatment with an ADK-I also increases β-cell replication but not exocrine cell or hepatocyte replication. Therefore, we propose ADK inhibition as a strategy for the treatment of diabetes...
  13. pmc Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    Jason Rihel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 327:348-51. 2010
    ..These results demonstrate the power of high-throughput behavioral profiling in zebrafish to discover and characterize psychotropic drugs and to dissect the pharmacology of complex behaviors...
  14. pmc Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
    Maria Frank-Kamenetsky
    Curis, Inc, 61 Moulton Street, Cambridge, MA 02138, USA
    J Biol 1:10. 2002
    ....
  15. ncbi request reprint Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro
    Limor Gabay
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 40:485-99. 2003
    ....
  16. ncbi request reprint Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons
    Prabakaran Soundararajan
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    J Neurosci 26:3256-68. 2006
    ..These results indicate that ES cells can be directed to form subtypes of neurons with specific phenotypic properties...
  17. ncbi request reprint Temporal gene expression during differentiation of human embryonic stem cells and embryoid bodies
    Tamar Dvash
    Department of Genetics, The Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel
    Hum Reprod 19:2875-83. 2004
    ..The aim of this study was to characterize human embryonic stem (ES) cells at the molecular level by performing large-scale complementary DNA (cDNA) analysis using DNA micro-arrays...
  18. doi request reprint A paracrine requirement for hedgehog signalling in cancer
    Robert L Yauch
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 455:406-10. 2008
    ..Taken together, these studies demonstrate a paracrine requirement for Hh ligand signalling in the tumorigenesis of Hh-expressing cancers and have important implications for the development of Hh pathway antagonists in cancer...