James K Rowlett

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, One Pine Hill Road, Box 9102, Southborough, MA 01772, USA
    Proc Natl Acad Sci U S A 102:915-20. 2005
  2. pmc Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Neuropharmacology 58:357-64. 2010
  3. ncbi request reprint Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, Box 9102, One Pine Hill Drive Southborough, MA, 01772 9102, USA
    Psychopharmacology (Berl) 184:201-11. 2006
  4. ncbi request reprint Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys
    Donna M Platt
    New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 322:894-902. 2007
  5. pmc Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine
    Cindy Achat-Mendes
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 204:489-98. 2009
  6. pmc Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 215:311-9. 2011
  7. pmc Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 227:347-54. 2013
  8. pmc Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms
    Daniela Ruedi-Bettschen
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 210:169-77. 2010
  9. ncbi request reprint Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors
    James K Rowlett
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 165:209-15. 2003
  10. ncbi request reprint Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys
    James K Rowlett
    New England Primate Research Center, Harvard Medical School, Box 9102, One Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 321:1135-43. 2007

Collaborators

Detail Information

Publications39

  1. pmc Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, One Pine Hill Road, Box 9102, Southborough, MA 01772, USA
    Proc Natl Acad Sci U S A 102:915-20. 2005
    ..In contrast, stimulation of alpha1GABAA receptors is sufficient, but not necessary, for mediation of the abuse potential of these drugs...
  2. pmc Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Neuropharmacology 58:357-64. 2010
    ..These data suggest that efficacy at alpha2, alpha3, and/or alpha5 subunit-containing GABA(A) receptors likely are sufficient for engendering BZ-like discriminative stimulus effects...
  3. ncbi request reprint Anti-conflict effects of benzodiazepines in rhesus monkeys: relationship with therapeutic doses in humans and role of GABAA receptors
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, Box 9102, One Pine Hill Drive Southborough, MA, 01772 9102, USA
    Psychopharmacology (Berl) 184:201-11. 2006
    ..We established a conflict procedure with rhesus monkeys in order to examine the role of GABAA receptors in the anxiolytic-like effects of BZs...
  4. ncbi request reprint Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys
    Donna M Platt
    New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 322:894-902. 2007
    ..These findings suggest that NE transporter inhibition and alpha2-adrenoceptor mechanisms play a significant role in cocaine-induced reinstatement of drug seeking that is not secondary to activation of brain stress pathways...
  5. pmc Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine
    Cindy Achat-Mendes
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 204:489-98. 2009
    ....
  6. pmc Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 215:311-9. 2011
    ..Experimental evidence suggests that the differential behavioral effects of benzodiazepines depend on their relative actions at γ-aminobutyric acid type A (GABA(A)) receptors that contain either an α1, α2, α3, or α5 subunit...
  7. pmc Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 227:347-54. 2013
    ..Assays of schedule-controlled responding can be used to characterize the pharmacology of benzodiazepines and other GABAA receptor modulators, and are sensitive to changes in drug effects that are related to physical dependence...
  8. pmc Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms
    Daniela Ruedi-Bettschen
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 210:169-77. 2010
    ..The mechanisms underlying this effect have not been characterized fully but may have a serotonergic component as kappa agonists also increase the release of serotonin (5-hydroxytryptamine, 5-HT)...
  9. ncbi request reprint Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABA(A)/alpha1 receptors
    James K Rowlett
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 165:209-15. 2003
    ..0 mg/kg differ from those of conventional benzodiazepines (BZs), but the extent to which these effects reflect the selectivity of zolpidem for GABA(A)/alpha(1) receptors is not known...
  10. ncbi request reprint Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys
    James K Rowlett
    New England Primate Research Center, Harvard Medical School, Box 9102, One Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 321:1135-43. 2007
    ....
  11. ncbi request reprint Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys
    Donna M Platt
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 164:151-9. 2002
    ..OBJECTIVES. The purpose of the present study was to investigate the role of GABAA/alpha1 receptors in the sedative and motor-impairing effects of benzodiazepines...
  12. pmc Reinforcing effects of compounds lacking intrinsic efficacy at α1 subunit-containing GABAA receptor subtypes in midazolam- but not cocaine-experienced rhesus monkeys
    Nina M Shinday
    Department of Psychiatry, Division of Neuroscience, New England Primate Research Center, Beth Israel Deaconess Medical Center and Harvard Medical School, MA 01772, USA
    Neuropsychopharmacology 38:1006-14. 2013
    ....
  13. pmc Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, One Pine Hill Dr, Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 332:985-95. 2010
    ....
  14. pmc Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine
    Donna M Platt
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 200:167-76. 2008
    ..Cocaine addicts use varied amounts of cocaine over long periods of time, and an effective pharmacotherapy would almost certainly require more chronic treatment...
  15. ncbi request reprint Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes
    Angela N Duke
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 187:321-30. 2006
    ..Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely...
  16. ncbi request reprint Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 313:658-67. 2005
    ..These findings suggest a key role for alpha(5)GABA(A), but not alpha(1)GABA(A), receptor mechanisms in the DS effects of ethanol and the ethanol-like DS effects of benzodiazepine agonists...
  17. ncbi request reprint Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys
    Donna M Platt
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, PO Box 9102, MA 01772 9102, Southborough, USA
    Psychopharmacology (Berl) 166:298-305. 2003
    ..The D2-like receptor partial agonist terguride has a profile of behavioral effects in rats that suggests potential benefit as a pharmacotherapy for cocaine addiction...
  18. ncbi request reprint Self-Administration of cocaine-opioid combinations by rhesus monkeys: evaluation of the role of mu receptor efficacy using labor supply analysis
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, Box 9102, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 312:1289-97. 2005
    ....
  19. ncbi request reprint Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 313:1118-25. 2005
    ..Moreover, a compound with reduced efficacy at alpha(1) GABA(A) and/or alpha(5) GABA(A) receptors may lack some of the motor and subjective effects associated with conventional BZs...
  20. ncbi request reprint Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms
    Glenn R Valdez
    Division of Behavioral Biology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
    J Pharmacol Exp Ther 323:525-33. 2007
    ..The results point to interactions between a subpopulation of kappa opioid receptors and central corticotropin-releasing factor and noradrenergic stress systems in the reinstatement of cocaine seeking induced by kappa agonists...
  21. pmc Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys
    Daniela Ruedi-Bettschen
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    Alcohol Clin Exp Res 37:624-34. 2013
    ..This study evaluated the capacity of α5GABAA receptor ligands to alter selectively the reinforcing effects of alcohol...
  22. pmc Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys
    Leah Makaron
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Box 9102, 1 Pine Hill Drive, Southborough, MA 01772, USA
    Pharmacol Biochem Behav 104:62-8. 2013
    ..While these findings suggest a role for both α1GABAA and α5GABAA receptor mechanisms, α1GABAA receptor mechanisms appear to be sufficient for impairments in executive function induced by BZ-type drugs...
  23. ncbi request reprint Comparison of zolpidem and midazolam self-administration under progressive-ratio schedules: consumer demand and labor supply analyses
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    Exp Clin Psychopharmacol 15:328-37. 2007
    ..Differences in price effects may play a key role in determining the relative reinforcing effectiveness of selective versus nonselective benzodiazepine agonists...
  24. ncbi request reprint Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine
    Buyean Lee
    Harvard Medical School, New England Primate Research Center, P O Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 312:1232-40. 2005
    ..The contrasting interactions of MPEP and dizocilpine with cocaine imply that glutamate acting through different metabotropic and ionotropic receptors may modulate the behavioral effects of cocaine in qualitatively different ways...
  25. ncbi request reprint Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 308:1030-9. 2004
    ..The results suggest that 3-MNTX functions primarily as a partial agonist at micro-receptors in monkeys and do not support a singular role for M6G receptors in the abuse-related effects of heroin...
  26. ncbi request reprint Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    J Pharmacol Exp Ther 310:342-8. 2004
    ..Unlike the DS effects of cocaine itself, however, the cocaine-like DS effects of heroin do not appear to involve either noradrenergic or serotonergic mechanisms...
  27. pmc Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, Massachusetts 01772 9102, USA
    Neuropharmacology 59:612-8. 2010
    ..These behavioral effects suggest that the anxiolytic and rate-reducing effects of GABA(A) receptor positive modulators are dependent on their relative efficacy and affinity at different GABA(A) receptor subtypes...
  28. ncbi request reprint Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs
    James K Rowlett
    Department of Psychiatry and Division of Behavioral Biology, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA
    CNS Spectr 10:40-8. 2005
    ..Altogether, these results indicate that subtype-selective antagonists represent a useful approach to studying receptor mechanisms underlying the behavioral effects of BZ-type drugs...
  29. pmc Anticonflict and reinforcing effects of triazolam + pregnanolone combinations in rhesus monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 337:805-11. 2011
    ..These results suggest that combinations of triazolam and pregnanolone may have enhanced anxiolytic effects with reduced behavioral disruption and abuse potential compared with either drug alone...
  30. ncbi request reprint Self-administration of cocaine, alfentanil, and nalbuphine under progressive-ratio schedules: consumer demand and labor supply analyses of relative reinforcing effectiveness
    James K Rowlett
    Department of Psychiatry, Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    Exp Clin Psychopharmacol 10:367-75. 2002
    ..These results suggest that PR schedules with varying IRRs can provide meaningful estimates of the relative reinforcing effectiveness of abused drugs...
  31. pmc Abuse and dependence liability of benzodiazepine-type drugs: GABA(A) receptor modulation and beyond
    Stephanie C Licata
    McLean Hospital Harvard Medical School, Behavioral Psychopharmacology Research Laboratory, 115 Mill Street, Belmont, MA 02478, United States
    Pharmacol Biochem Behav 90:74-89. 2008
    ..This review examines the behavioral determinants of the abuse and dependence liability of benzodiazepine-type drugs. Moreover, the pharmacological and putative biochemical basis of the abuse-related behavior is discussed...
  32. ncbi request reprint Getting back to basics: commentary on McSweeney, Murphy, and Kowal (2005)
    James K Rowlett
    New England Primate Research Center, Harvard Medical School, PO Box 9102, Southborough, MA 01772, USA
    Exp Clin Psychopharmacol 13:187-9; discussion 194-9. 2005
    ..In addition, a multidisciplinary approach might broaden this model and increase its power. Other approaches include, but are not limited to, pharmacokinetic-pharmacodynamic modeling and in vivo measures of brain activity...
  33. ncbi request reprint Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95
    Jingping Zhang
    New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
    J Neurogenet 28:98-111. 2014
    ..Understanding PSD-95-dependent neuroprotective mechanisms may help elucidate processes underlying neurodegeneration in HD and other neurological disorders...
  34. pmc Emergence of anti-conflict effects of zolpidem in rhesus monkeys following extended post-injection intervals
    James K Rowlett
    New England Primate Research Center, Harvard Medical School, P O Box 9102, Pine Hill Drive, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 214:855-62. 2011
    ..Zolpidem is a hypnotic drug that binds to γ-aminobutyric acid type A receptors but lacks consistently demonstrable anxiolytic efficacy...
  35. ncbi request reprint The efficacy of diazepam treatment for the management of acute wounding episodes in captive rhesus macaques
    Stefan Tiefenbacher
    New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 017721, USA
    Comp Med 55:387-92. 2005
    ..Our findings suggest that SIB is not a homogeneous disorder in rhesus monkeys; rather, distinct subtypes exist that require different treatment approaches...
  36. ncbi request reprint Role of GABAA/benzodiazepine receptors containing alpha 1 and alpha 5 subunits in the discriminative stimulus effects of triazolam in squirrel monkeys
    Snjezana Lelas
    Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 161:180-8. 2002
    ..The role of these different GABA(A) receptor subtypes in mediating the subjective effects of BZs remains largely unknown...
  37. ncbi request reprint Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development
    Donna M Platt
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, PO Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 163:265-82. 2002
    ..The functional analysis of behavior in laboratory animals has allowed for the development of strategies identifying candidate medications to treat cocaine addiction...
  38. ncbi request reprint GABAA/alpha1 receptor agonists and antagonists: effects on species-typical and heightened aggressive behavior after alcohol self-administration in mice
    Rosa M M de Almeida
    Department of Psychology, Tufts University, Bacon Hall, 530 Boston Avenue, Medford, MA 02155, USA
    Psychopharmacology (Berl) 172:255-63. 2004
    ..However, the degree to which GABAA subunit composition plays a role in heightened aggressive behavior induced by self-administration of a moderate alcohol dose remains unresolved...
  39. ncbi request reprint Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates
    Taline V Khroyan
    SRI International, Center for Health Sciences, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Psychopharmacology (Berl) 168:124-31. 2003
    ..The mechanisms by which these different classes of D(1) receptor drugs produce these similar effects on cocaine seeking are unknown...