Research Topics
Genomes and Genes
| David H RowitchSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factorD H Rowitch
Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
Teratology 60:22-8. 1999..These observations raise the possibility that abnormal regulation of Engrailed genes, or targets of Engrailed, may be involved in the pathogenesis of cystic central nervous system malformations of the posterior fossa in humans...- An 'oligarchy' rules neural developmentDavid H Rowitch
Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Trends Neurosci 25:417-22. 2002..These findings alter our views of how the oligodendrocyte lineage is generated and raise further questions about the underlying developmental relationships between neurons and glia... - Glial specification in the vertebrate neural tubeDavid H Rowitch
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nat Rev Neurosci 5:409-19. 2004 - Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellumD H Rowitch
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Brain Res Dev Brain Res 117:99-108. 1999..Successful misexpression of Sonic hedgehog demonstrates that Pax-2 regulatory sequences should prove generally useful for transgenic gain-of-function approaches in mice... - Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tubeTao Sun
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Dev Biol 292:152-64. 2006..Our findings indicate complex regulation of Olig2 by stage- and lineage-specific regulatory elements. They further suggest that transcriptional regulation of Olig2 is involved in segregation of pMN neuroblasts... 
Development of NG2 neural progenitor cells requires Olig gene functionKeith L Ligon
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:7853-8. 2006..These findings show a general requirement for Olig function in NG2 cell development and highlight further roles for Olig transcription factors in neural progenitor cells...- Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant gliomaKeith L Ligon
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Neuron 53:503-17. 2007..Our findings identify an Olig2-regulated lineage-restricted pathway critical for proliferation of normal and tumorigenic CNS stem cells... - Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastomaUlrich Schüller
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 14:123-34. 2008..Thus, oncogenic Hh signaling promotes medulloblastoma from lineage-restricted granule cell progenitors... - Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesisUlrich Schüller
Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Mol Cell Neurosci 33:247-59. 2006..We propose that this atlas of the cerebellar transcriptome and the panel of 24 validated markers will be generally useful in analyses of mutations affecting postnatal cerebellar development and neoplasia... - Expression and function of Nkx6.3 in vertebrate hindbrainBrian P Hafler
Department of Pediatric Oncology, Dana Farber Cancer Institute, USA
Brain Res 1222:42-50. 2008..These findings indicate Nkx6.3 function is dispensable for CNS development and lead to the proposal that absence of overt defects is due to functional compensation from a related homeodomain transcription factor... - Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tubeYuko Muroyama
Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
Nature 438:360-3. 2005..They further indicate that acquisition of embryonic glial subtype identity might be regulated by genetic interactions between SCL and the transcription factor Olig2 in the ventral neural tube... - Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursorsAnna Marie Kenney
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Development 130:15-28. 2003..Together, these findings identify Nmyc as a direct target of the Shh pathway that functions to regulate cell cycle progression in cerebellar granule neuron precursors... - The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant gliomaShwetal Mehta
Department of Cancer Biology, 44 Binney Street, Boston, MA 02115, USA
Cancer Cell 19:359-71. 2011..In the absence of Olig2 function, even attenuated levels of p53 are adequate for biological responses to genotoxic damage... - Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cordMasaaki Kitada
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Glia 54:35-46. 2006..Our findings suggest that TF co-expression patterns identify and might regulate distinct functional classes of grey and white matter oligodendroglia... - bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNSHeather A Arnett
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Science 306:2111-5. 2004..Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis... - Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasiaKeith L Ligon
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 0215, USA
Development 130:2275-87. 2003..They further suggest that EMX2-Wnt1 interactions are essential for normal development of preplate derivatives in the mammalian cerebral cortex... - Olig gene function in CNS development and diseaseKeith L Ligon
Department of Pathology, Division of Neuropathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
Glia 54:1-10. 2006..Studies of Olig expression in human brain tumors and repair of demyelinating lesions suggest the possibility of additional functions in a variety of neurological diseases... - Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connectionQ Richard Lu
Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cell 109:75-86. 2002..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons... - Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous miceJohn Y H Kim
Department of Neurology, Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 263:50-66. 2003..These results indicate that Ptc heterozygosity contributes to tumorigenesis by predisposing a subset of granule cell precursors to the formation of proliferative rests and subsequent dysregulation of developmental gene expression... - Mouse brain organization revealed through direct genome-scale TF expression analysisPaul A Gray
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Science 306:2255-7. 2004..We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database... - Phosphorylation state of Olig2 regulates proliferation of neural progenitorsYu Sun
Department of Cancer Biology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 02115, USA
Neuron 69:906-17. 2011..In the phosphorylated state, Olig2 maintains antineural (i.e., promitotic) functions that are reflected in human glioma cells and in a genetically defined murine model of primary glioma... - Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursorsUlrich Schüller
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
Mol Cell Biol 27:8259-70. 2007.... - The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomasKeith L Ligon
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Neuropathol Exp Neurol 63:499-509. 2004..Overall, OLIG2 is a useful marker of diffuse gliomas as a class. However, expression heterogeneity of OLIG2 in astrocytomas precludes immunohistochemical classification of individual gliomas by OLIG2 alone... - Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelinationEmily P Harrington
Department of Pediatrics, University of California at San Francisco, San Francisco, CA 94143, USA
Ann Neurol 68:703-16. 2010.... - A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial developmentHui Fu
Department of Cancer Biology, Dana Farber Cancer Institute, and Departments of Neurobiology and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 29:11399-408. 2009..Another transcription factor, Tcf4, plays an important role in maturation of oligodendrocyte progenitors... - Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursorsAnna Marie Kenney
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Development 131:217-28. 2004..These findings indicate that Shh and PI3K signaling pathways converge on N-Myc to regulate neuronal precursor cell cycle progression. Furthermore, they provide a rationale for therapeutic targeting of PI3K signaling in medulloblastoma... - Development of mice expressing a single D-type cyclinMaria A Ciemerych
Department of Cancer Biology, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 16:3277-89. 2002..Hence, the requirement for a particular cyclin in a given tissue is likely caused by specific transcription factors, rather than by unique properties of cyclins... - Molecular diversity of astrocytes with implications for neurological disordersRobert M Bachoo
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:8384-9. 2004.... - Histology-based expression profiling yields novel prognostic markers in human glioblastomaShumin Dong
Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA
J Neuropathol Exp Neurol 64:948-55. 2005.... - Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancersAlvin T Kho
Children's Hospital Informatics Program, Children's Hospital Boston, MA 02115, USA
Genes Dev 18:629-40. 2004.... - Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complexTao Sun
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 23:9547-56. 2003..2 that helps to establish the pMN-p3 boundary in the developing spinal cord... 
Overcoming remyelination failure in multiple sclerosis and other myelin disordersStephen P J Fancy
Department of Pediatrics, Eli and Edyth Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Exp Neurol 225:18-23. 2010....- Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanismVivi M Heine
Department of Pediatrics, Howard Hughes Medical Institute and Institute for Regeneration Medicine, UCSF, San Francisco, California, USA
J Clin Invest 119:267-77. 2009..Furthermore, they led us to propose that 11betaHSD2-sensitive GCs (e.g., hydrocortisone) should be used in preference to dexamethasone in neonatal human infants because of the potential for reduced neurotoxicity... - Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cordAn Chi Tien
Department of Pediatrics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Development 139:2477-87. 2012.... - Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapyEmmanuelle Huillard
Department of Pediatrics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 109:8710-5. 2012..Our findings indicate a rational therapeutic strategy for treating a subset of pediatric astrocytomas with BRAF(V600E) mutation and CDKN2A deficiency... - Myelin abnormalities without oligodendrocyte loss in periventricular leukomalaciaSaraid S Billiards
Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Brain Pathol 18:153-63. 2008..OL migration toward the "core" of injury may occur to replenish OL cell number. This study provides new insight into the cellular basis of the myelin deficits observed in survivors of PVL... - Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genesTiffany A Heanue
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
Mech Dev 111:75-87. 2002..Our results indicate that Pax6, Pax2, and Eya1 do not regulate Dach1 expression through a simple linear hierarchy... - Myelin restoration: progress and prospects for human cell replacement therapiesGregory B Potter
Department of Pediatrics, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143 0525, USA
Arch Immunol Ther Exp (Warsz) 59:179-93. 2011..We summarize studies in which different types of myelin-forming cells have been transplanted into the CNS and highlight the continuing challenges regarding the use of cell-based therapies for human white matter disorders... - The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursorsSarah K Sjostrom
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Dev Cell 9:327-38. 2005..These findings provide a mechanism for promoting growth arrest in the final cycle of neural precursor proliferation competency, or for resetting the cell cycle in the G1 phase, by destabilizing N-myc in mitosis... - Astrocytes and disease: a neurodevelopmental perspectiveAnna V Molofsky
Department of Pediatrics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, California 94143, USA
Genes Dev 26:891-907. 2012..We propose here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases... - Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2Dimphna H Meijer
Departments of Neurobiology, Harvard Medical School and Cancer Biology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
Nat Rev Neurosci 13:819-31. 2012..We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications... - Beta-catenin function is required for cerebellar morphogenesisUlrich Schüller
Department of Pediatric Oncology, Dana Farber Cancer Institute, Dana 640D, Boston, MA 02115, USA
Brain Res 1140:161-9. 2007..We discuss our results with respect to genetic pathways that regulate formation of derivatives of the embryonic midbrain-hindbrain region... - Glioma stem cells: a midterm examCharles D Stiles
Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Neuron 58:832-46. 2008..Do glioma stem cells arise from developmentally stalled neural progenitors or from dedifferentiated astrocytes? Five separate predictions of a neural progenitor cell of origin are put to the test... - Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axisRobert M Bachoo
Center for Neuro-Oncology, Boston, Massachusetts 02115, USA
Cancer Cell 1:269-77. 2002..These data support the view that dysregulation of specific genetic pathways, rather than cell-of-origin, dictates the emergence and phenotype of high-grade gliomas... - Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1D H Rowitch
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Mech Dev 52:3-8. 1995..Pax-5 expression commences later, at the 3-somite stage. Thus, the spatial and temporal expression of Pax-2 is consistent with a possible regulatory role in the activation of Wnt-1 and En-1... - A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injuryVivi M Heine
Division of Neonatology, Department of Pediatrics, University of California, San Francisco UCSF, San Francisco, CA 94143, USA
Sci Transl Med 3:105ra104. 2011..These findings suggest that a small-molecule agonist of Smo has potential as a neuroprotective agent in neonates at risk for glucocorticoid-induced neonatal cerebellar injury... - Medulloblastoma: a problem of developmental biologyJoshua B Rubin
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
Cancer Cell 2:7-8. 2002..The identification of SUFU mutations in desmoplastic medulloblastoma provides new insights into vertebrate Hedgehog signaling and brain tumor formation... - Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approachQing Zhao
Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:5704-9. 2002..They further show that genome-wide methods are an effective means to identify stage-specific gene expression in the developing granule cell lineage... - Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous systemQ R Lu
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Neuron 25:317-29. 2000..Gain- and loss-of-function analyses in transgenic mice demonstrate that Shh is both necessary and sufficient for Olg gene expression in vivo... - GDNF induces branching and increased cell proliferation in the ureter of the mouseC V Pepicelli
Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Dev Biol 192:193-8. 1997..These results support a model in which GDNF supplied by the mesenchyme regulates growth and branching in the metanephric kidney through the local regulation of ureter tip-specific factors... - Identification of molecular compartments and genetic circuitry in the developing mammalian kidneyJing Yu
Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
Development 139:1863-73. 2012..The annotated informational resource (www.gudmap.org) will facilitate functional analysis of the mammalian kidney and provides useful information for the generation of novel genetic tools to manipulate emerging cell populations... - Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cellsD H Rowitch
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 19:8954-65. 1999..Thus, Hedgehog signaling may contribute to CNS tumorigenesis by directly enhancing proliferation and preventing neural differentiation in selected precursor cells... - Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tubeT Sun
Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Curr Biol 11:1413-20. 2001..One of these, Nkx2.2, is necessary and sufficient for the development of V3 interneurons... - Towards improved animal models of neonatal white matter injury associated with cerebral palsyJohn C Silbereis
Department of Pediatrics, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Dis Model Mech 3:678-88. 2010.... - Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brainJ A Alberta
Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
Mol Cell Neurosci 18:434-41. 2001..Our results demonstrate essential functions for Shh during early phases of oligodendrocyte development in the mammalian central nervous system. They further suggest that a key role of Shh signaling is activation of Olig genes... - Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tipsA Kispert
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Development 122:3627-37. 1996..We suggest that Wnt-11 acts as an autocrine factor within the ureter epithelium and that its expression is regulated at least in part by proteoglycans... - Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumorsQ R Lu
Department of Cancer Biology, the Program in Neuro oncology, Dana Farber Harvard Cancer Center, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:10851-6. 2001..They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors... - Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrainMagdalena A Petryniak
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2611, USA
Neuron 55:417-33. 2007..Our results identify another role for Dlx genes as modulators of neuron versus oligodendrocyte development in the ventral embryonic forebrain... - Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crestYuko Mori-Akiyama
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 100:9360-5. 2003..We hypothesize that these cells change their cell fate and acquire the ability to differentiate into osteoblasts. We conclude that Sox9 is required for the determination of the chondrogenic lineage in CNC cells... - Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2Audrey Rousseau
Molecular Pathology Unit, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
J Neuropathol Exp Neurol 65:1149-56. 2006..In addition to GFAP, therefore, YKL-40, ApoE, ASCL1, and NKX2-2 represent promising tumor cell markers to distinguish oligodendrogliomas from astrocytomas... - Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cellsZeng Jie Yang
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Cancer Cell 14:135-45. 2008..These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment... - Essential role of Sox9 in the pathway that controls formation of cardiac valves and septaHaruhiko Akiyama
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 101:6502-7. 2004..We propose that loss of Sox9 inhibits epithelial-mesenchymal transformation after delamination and initial migration, but before definitive mesenchymal transformation... - N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growthBeryl A Hatton
Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
Cancer Res 66:8655-61. 2006....