David H Rowitch

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factor
    D H Rowitch
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Teratology 60:22-8. 1999
  2. ncbi An 'oligarchy' rules neural development
    David H Rowitch
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Trends Neurosci 25:417-22. 2002
  3. ncbi Glial specification in the vertebrate neural tube
    David H Rowitch
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 5:409-19. 2004
  4. ncbi Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum
    D H Rowitch
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Brain Res Dev Brain Res 117:99-108. 1999
  5. ncbi Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube
    Tao Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:152-64. 2006
  6. pmc Development of NG2 neural progenitor cells requires Olig gene function
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7853-8. 2006
  7. pmc Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 14:123-34. 2008
  8. pmc Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Neuron 53:503-17. 2007
  9. ncbi Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Neurosci 33:247-59. 2006
  10. pmc Expression and function of Nkx6.3 in vertebrate hindbrain
    Brian P Hafler
    Department of Pediatric Oncology, Dana Farber Cancer Institute, USA
    Brain Res 1222:42-50. 2008

Detail Information

Publications63

  1. ncbi Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factor
    D H Rowitch
    Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Teratology 60:22-8. 1999
    ..These observations raise the possibility that abnormal regulation of Engrailed genes, or targets of Engrailed, may be involved in the pathogenesis of cystic central nervous system malformations of the posterior fossa in humans...
  2. ncbi An 'oligarchy' rules neural development
    David H Rowitch
    Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Trends Neurosci 25:417-22. 2002
    ..These findings alter our views of how the oligodendrocyte lineage is generated and raise further questions about the underlying developmental relationships between neurons and glia...
  3. ncbi Glial specification in the vertebrate neural tube
    David H Rowitch
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 5:409-19. 2004
  4. ncbi Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum
    D H Rowitch
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Brain Res Dev Brain Res 117:99-108. 1999
    ..Successful misexpression of Sonic hedgehog demonstrates that Pax-2 regulatory sequences should prove generally useful for transgenic gain-of-function approaches in mice...
  5. ncbi Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube
    Tao Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:152-64. 2006
    ..Our findings indicate complex regulation of Olig2 by stage- and lineage-specific regulatory elements. They further suggest that transcriptional regulation of Olig2 is involved in segregation of pMN neuroblasts...
  6. pmc Development of NG2 neural progenitor cells requires Olig gene function
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:7853-8. 2006
    ..These findings show a general requirement for Olig function in NG2 cell development and highlight further roles for Olig transcription factors in neural progenitor cells...
  7. pmc Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Cancer Cell 14:123-34. 2008
    ..Thus, oncogenic Hh signaling promotes medulloblastoma from lineage-restricted granule cell progenitors...
  8. pmc Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Neuron 53:503-17. 2007
    ..Our findings identify an Olig2-regulated lineage-restricted pathway critical for proliferation of normal and tumorigenic CNS stem cells...
  9. ncbi Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Mol Cell Neurosci 33:247-59. 2006
    ..We propose that this atlas of the cerebellar transcriptome and the panel of 24 validated markers will be generally useful in analyses of mutations affecting postnatal cerebellar development and neoplasia...
  10. pmc Expression and function of Nkx6.3 in vertebrate hindbrain
    Brian P Hafler
    Department of Pediatric Oncology, Dana Farber Cancer Institute, USA
    Brain Res 1222:42-50. 2008
    ..These findings indicate Nkx6.3 function is dispensable for CNS development and lead to the proposal that absence of overt defects is due to functional compensation from a related homeodomain transcription factor...
  11. ncbi Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
    Anna Marie Kenney
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Development 130:15-28. 2003
    ..Together, these findings identify Nmyc as a direct target of the Shh pathway that functions to regulate cell cycle progression in cerebellar granule neuron precursors...
  12. ncbi Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube
    Yuko Muroyama
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Nature 438:360-3. 2005
    ..They further indicate that acquisition of embryonic glial subtype identity might be regulated by genetic interactions between SCL and the transcription factor Olig2 in the ventral neural tube...
  13. ncbi Transcription factor co-expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord
    Masaaki Kitada
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Glia 54:35-46. 2006
    ..Our findings suggest that TF co-expression patterns identify and might regulate distinct functional classes of grey and white matter oligodendroglia...
  14. ncbi bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS
    Heather A Arnett
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 306:2111-5. 2004
    ..Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis...
  15. pmc The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma
    Shwetal Mehta
    Department of Cancer Biology, 44 Binney Street, Boston, MA 02115, USA
    Cancer Cell 19:359-71. 2011
    ..In the absence of Olig2 function, even attenuated levels of p53 are adequate for biological responses to genotoxic damage...
  16. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
  17. ncbi Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 0215, USA
    Development 130:2275-87. 2003
    ..They further suggest that EMX2-Wnt1 interactions are essential for normal development of preplate derivatives in the mammalian cerebral cortex...
  18. ncbi Olig gene function in CNS development and disease
    Keith L Ligon
    Department of Pathology, Division of Neuropathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Glia 54:1-10. 2006
    ..Studies of Olig expression in human brain tumors and repair of demyelinating lesions suggest the possibility of additional functions in a variety of neurological diseases...
  19. ncbi Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice
    John Y H Kim
    Department of Neurology, Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 263:50-66. 2003
    ..These results indicate that Ptc heterozygosity contributes to tumorigenesis by predisposing a subset of granule cell precursors to the formation of proliferative rests and subsequent dysregulation of developmental gene expression...
  20. pmc A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development
    Hui Fu
    Department of Cancer Biology, Dana Farber Cancer Institute, and Departments of Neurobiology and Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:11399-408. 2009
    ..Another transcription factor, Tcf4, plays an important role in maturation of oligodendrocyte progenitors...
  21. pmc Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2
    Dimphna H Meijer
    Department of Neurobiology, Harvard Medical School, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Rev Neurosci 13:819-31. 2012
    ..We discuss how the unique functions of OLIG1 and OLIG2 may reflect their distinct genetic targets, co-regulator proteins and/or post-translational modifications...
  22. pmc Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:8259-70. 2007
    ....
  23. pmc Phosphorylation state of Olig2 regulates proliferation of neural progenitors
    Yu Sun
    Department of Cancer Biology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neuron 69:906-17. 2011
    ..In the phosphorylated state, Olig2 maintains antineural (i.e., promitotic) functions that are reflected in human glioma cells and in a genetically defined murine model of primary glioma...
  24. ncbi The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas
    Keith L Ligon
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Neuropathol Exp Neurol 63:499-509. 2004
    ..Overall, OLIG2 is a useful marker of diffuse gliomas as a class. However, expression heterogeneity of OLIG2 in astrocytomas precludes immunohistochemical classification of individual gliomas by OLIG2 alone...
  25. pmc Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination
    Emily P Harrington
    Department of Pediatrics, University of California at San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 68:703-16. 2010
    ....
  26. ncbi Mouse brain organization revealed through direct genome-scale TF expression analysis
    Paul A Gray
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 306:2255-7. 2004
    ..We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database...
  27. doi Overcoming remyelination failure in multiple sclerosis and other myelin disorders
    Stephen P J Fancy
    Department of Pediatrics, Eli and Edyth Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Exp Neurol 225:18-23. 2010
    ....
  28. ncbi Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors
    Anna Marie Kenney
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Development 131:217-28. 2004
    ..These findings indicate that Shh and PI3K signaling pathways converge on N-Myc to regulate neuronal precursor cell cycle progression. Furthermore, they provide a rationale for therapeutic targeting of PI3K signaling in medulloblastoma...
  29. pmc Development of mice expressing a single D-type cyclin
    Maria A Ciemerych
    Department of Cancer Biology, Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:3277-89. 2002
    ..Hence, the requirement for a particular cyclin in a given tissue is likely caused by specific transcription factors, rather than by unique properties of cyclins...
  30. pmc Histology-based expression profiling yields novel prognostic markers in human glioblastoma
    Shumin Dong
    Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA
    J Neuropathol Exp Neurol 64:948-55. 2005
    ....
  31. pmc Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers
    Alvin T Kho
    Children s Hospital Informatics Program, Children s Hospital Boston, MA 02115, USA
    Genes Dev 18:629-40. 2004
    ....
  32. ncbi Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex
    Tao Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:9547-56. 2003
    ..2 that helps to establish the pMN-p3 boundary in the developing spinal cord...
  33. pmc Molecular diversity of astrocytes with implications for neurological disorders
    Robert M Bachoo
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:8384-9. 2004
    ....
  34. pmc Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism
    Vivi M Heine
    Department of Pediatrics, Howard Hughes Medical Institute and Institute for Regeneration Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 119:267-77. 2009
    ..Furthermore, they led us to propose that 11betaHSD2-sensitive GCs (e.g., hydrocortisone) should be used in preference to dexamethasone in neonatal human infants because of the potential for reduced neurotoxicity...
  35. pmc Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord
    An Chi Tien
    Department of Pediatrics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research and Howard Hughes Medical Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Development 139:2477-87. 2012
    ....
  36. pmc Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy
    Emmanuelle Huillard
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:8710-5. 2012
    ..Our findings indicate a rational therapeutic strategy for treating a subset of pediatric astrocytomas with BRAF(V600E) mutation and CDKN2A deficiency...
  37. pmc Myelin abnormalities without oligodendrocyte loss in periventricular leukomalacia
    Saraid S Billiards
    Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Brain Pathol 18:153-63. 2008
    ..OL migration toward the "core" of injury may occur to replenish OL cell number. This study provides new insight into the cellular basis of the myelin deficits observed in survivors of PVL...
  38. doi Myelin restoration: progress and prospects for human cell replacement therapies
    Gregory B Potter
    Department of Pediatrics, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143 0525, USA
    Arch Immunol Ther Exp (Warsz) 59:179-93. 2011
    ..We summarize studies in which different types of myelin-forming cells have been transplanted into the CNS and highlight the continuing challenges regarding the use of cell-based therapies for human white matter disorders...
  39. ncbi Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes
    Tiffany A Heanue
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mech Dev 111:75-87. 2002
    ..Our results indicate that Pax6, Pax2, and Eya1 do not regulate Dach1 expression through a simple linear hierarchy...
  40. ncbi The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors
    Sarah K Sjostrom
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 9:327-38. 2005
    ..These findings provide a mechanism for promoting growth arrest in the final cycle of neural precursor proliferation competency, or for resetting the cell cycle in the G1 phase, by destabilizing N-myc in mitosis...
  41. pmc Astrocytes and disease: a neurodevelopmental perspective
    Anna V Molofsky
    Department of Pediatrics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 26:891-907. 2012
    ..We propose here that a precise understanding of astrocyte development is critical to defining heterogeneity and could lead advances in understanding and treating a variety of neuropsychiatric diseases...
  42. doi Glioma stem cells: a midterm exam
    Charles D Stiles
    Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Neuron 58:832-46. 2008
    ..Do glioma stem cells arise from developmentally stalled neural progenitors or from dedifferentiated astrocytes? Five separate predictions of a neural progenitor cell of origin are put to the test...
  43. ncbi Beta-catenin function is required for cerebellar morphogenesis
    Ulrich Schüller
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Dana 640D, Boston, MA 02115, USA
    Brain Res 1140:161-9. 2007
    ..We discuss our results with respect to genetic pathways that regulate formation of derivatives of the embryonic midbrain-hindbrain region...
  44. ncbi Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1
    D H Rowitch
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mech Dev 52:3-8. 1995
    ..Pax-5 expression commences later, at the 3-somite stage. Thus, the spatial and temporal expression of Pax-2 is consistent with a possible regulatory role in the activation of Wnt-1 and En-1...
  45. ncbi Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    Robert M Bachoo
    Center for Neuro Oncology, Boston, Massachusetts 02115, USA
    Cancer Cell 1:269-77. 2002
    ..These data support the view that dysregulation of specific genetic pathways, rather than cell-of-origin, dictates the emergence and phenotype of high-grade gliomas...
  46. pmc A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury
    Vivi M Heine
    Division of Neonatology, Department of Pediatrics, University of California, San Francisco UCSF, San Francisco, CA 94143, USA
    Sci Transl Med 3:105ra104. 2011
    ..These findings suggest that a small-molecule agonist of Smo has potential as a neuroprotective agent in neonates at risk for glucocorticoid-induced neonatal cerebellar injury...
  47. pmc Identification of genes expressed with temporal-spatial restriction to developing cerebellar neuron precursors by a functional genomic approach
    Qing Zhao
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:5704-9. 2002
    ..They further show that genome-wide methods are an effective means to identify stage-specific gene expression in the developing granule cell lineage...
  48. ncbi Medulloblastoma: a problem of developmental biology
    Joshua B Rubin
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 2:7-8. 2002
    ..The identification of SUFU mutations in desmoplastic medulloblastoma provides new insights into vertebrate Hedgehog signaling and brain tumor formation...
  49. ncbi Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    Q R Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Neuron 25:317-29. 2000
    ..Gain- and loss-of-function analyses in transgenic mice demonstrate that Shh is both necessary and sufficient for Olg gene expression in vivo...
  50. ncbi GDNF induces branching and increased cell proliferation in the ureter of the mouse
    C V Pepicelli
    Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Dev Biol 192:193-8. 1997
    ..These results support a model in which GDNF supplied by the mesenchyme regulates growth and branching in the metanephric kidney through the local regulation of ureter tip-specific factors...
  51. pmc Identification of molecular compartments and genetic circuitry in the developing mammalian kidney
    Jing Yu
    Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
    Development 139:1863-73. 2012
    ..The annotated informational resource (www.gudmap.org) will facilitate functional analysis of the mammalian kidney and provides useful information for the generation of novel genetic tools to manipulate emerging cell populations...
  52. ncbi Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells
    D H Rowitch
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 19:8954-65. 1999
    ..Thus, Hedgehog signaling may contribute to CNS tumorigenesis by directly enhancing proliferation and preventing neural differentiation in selected precursor cells...
  53. ncbi Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube
    T Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Curr Biol 11:1413-20. 2001
    ..One of these, Nkx2.2, is necessary and sufficient for the development of V3 interneurons...
  54. pmc Towards improved animal models of neonatal white matter injury associated with cerebral palsy
    John C Silbereis
    Department of Pediatrics, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Dis Model Mech 3:678-88. 2010
    ....
  55. ncbi Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain
    J A Alberta
    Department of Cancer Biology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA
    Mol Cell Neurosci 18:434-41. 2001
    ..Our results demonstrate essential functions for Shh during early phases of oligodendrocyte development in the mammalian central nervous system. They further suggest that a key role of Shh signaling is activation of Olig genes...
  56. pmc Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
    Q R Lu
    Department of Cancer Biology, the Program in Neuro oncology, Dana Farber Harvard Cancer Center, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:10851-6. 2001
    ..They further suggest the diagnostic potential of OLIG markers to augment identification of oligodendroglial tumors...
  57. ncbi Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
    A Kispert
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 122:3627-37. 1996
    ..We suggest that Wnt-11 acts as an autocrine factor within the ureter epithelium and that its expression is regulated at least in part by proteoglycans...
  58. pmc Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain
    Magdalena A Petryniak
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2611, USA
    Neuron 55:417-33. 2007
    ..Our results identify another role for Dlx genes as modulators of neuron versus oligodendrocyte development in the ventral embryonic forebrain...
  59. pmc Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
    Yuko Mori-Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9360-5. 2003
    ..We hypothesize that these cells change their cell fate and acquire the ability to differentiate into osteoblasts. We conclude that Sox9 is required for the determination of the chondrogenic lineage in CNC cells...
  60. ncbi Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2
    Audrey Rousseau
    Molecular Pathology Unit, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Neuropathol Exp Neurol 65:1149-56. 2006
    ..In addition to GFAP, therefore, YKL-40, ApoE, ASCL1, and NKX2-2 represent promising tumor cell markers to distinguish oligodendrogliomas from astrocytomas...
  61. pmc Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
    Zeng Jie Yang
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 14:135-45. 2008
    ..These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment...
  62. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
    ..We propose that loss of Sox9 inhibits epithelial-mesenchymal transformation after delamination and initial migration, but before definitive mesenchymal transformation...
  63. ncbi N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth
    Beryl A Hatton
    Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA
    Cancer Res 66:8655-61. 2006
    ....