Derrick J Rossi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Hematopoietic stem cell aging: mechanism and consequence
    Derrick J Rossi
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Exp Gerontol 42:385-90. 2007
  2. ncbi request reprint Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    Derrick J Rossi
    Department of Pathology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 447:725-9. 2007
  3. doi request reprint Stems cells and the pathways to aging and cancer
    Derrick J Rossi
    Immune Disease Institute, Harvard Stem Cell Institute, and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 132:681-96. 2008
  4. doi request reprint Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    Isabel Beerman
    Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 12:413-25. 2013
  5. doi request reprint Stem cells and the aging hematopoietic system
    Isabel Beerman
    Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Curr Opin Immunol 22:500-6. 2010
  6. doi request reprint DNA-damage-induced differentiation in hematopoietic stem cells
    Pankaj K Mandal
    Department of Stem Cell and Regenerative Biology, Harvard University, Immune Disease Institute, Children s Hospital Boston, Boston, MA 02116, USA
    Cell 148:847-8. 2012
  7. pmc Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
    Isabel Beerman
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5465-70. 2010
  8. pmc Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
    Lior Zangi
    1 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA 2 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA 4 Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, USA 5 Boston and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA 6
    Nat Biotechnol 31:898-907. 2013
  9. doi request reprint DNA damage response in adult stem cells: pathways and consequences
    Pankaj K Mandal
    Immune Disease Institute, the Program in Cellular and Molecular Medicine, Childrens Hospital Boston, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 12:198-202. 2011
  10. doi request reprint Hematopoietic stem cells and the aging hematopoietic system
    Roi Gazit
    Immune Disease Institute, Harvard Stem Cell Institute, and Department of Pathology, Harvard Medical School, Boston, MA
    Semin Hematol 45:218-24. 2008

Collaborators

Detail Information

Publications19

  1. pmc Hematopoietic stem cell aging: mechanism and consequence
    Derrick J Rossi
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Exp Gerontol 42:385-90. 2007
    ....
  2. ncbi request reprint Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
    Derrick J Rossi
    Department of Pathology, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 447:725-9. 2007
    ..These data are consistent with DNA damage accrual being a physiological mechanism of stem cell ageing that may contribute to the diminished capacity of aged tissues to return to homeostasis after exposure to acute stress or injury...
  3. doi request reprint Stems cells and the pathways to aging and cancer
    Derrick J Rossi
    Immune Disease Institute, Harvard Stem Cell Institute, and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 132:681-96. 2008
    ..Here, we examine evidence linking stem cell dysfunction to the pathophysiological conditions accompanying aging, focusing on the mechanisms underlying stem cell decline and their contribution to disease pathogenesis...
  4. doi request reprint Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    Isabel Beerman
    Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 12:413-25. 2013
    ..Our results provide evidence that epigenomic alterations of the DNA methylation landscape contribute to the functional decline of HSCs during aging...
  5. doi request reprint Stem cells and the aging hematopoietic system
    Isabel Beerman
    Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Curr Opin Immunol 22:500-6. 2010
    ..Recent developments have shed light on how aging of the hematopoietic stem cell compartment contributes to hematopoietic decline through diverse mechanisms...
  6. doi request reprint DNA-damage-induced differentiation in hematopoietic stem cells
    Pankaj K Mandal
    Department of Stem Cell and Regenerative Biology, Harvard University, Immune Disease Institute, Children s Hospital Boston, Boston, MA 02116, USA
    Cell 148:847-8. 2012
    ..Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage...
  7. pmc Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
    Isabel Beerman
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5465-70. 2010
    ..Finally, we present data supporting a model in which clonal expansion of a class of intrinsically myeloid-biased HSCs with robust self-renewal potential is a central component of hematopoietic aging...
  8. pmc Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
    Lior Zangi
    1 Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA 2 Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA 4 Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, Massachusetts, USA 5 Boston and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA 6
    Nat Biotechnol 31:898-907. 2013
    ..Our results suggest that modRNA is a versatile approach for expressing paracrine factors as cell fate switches to control progenitor cell fate and thereby enhance long-term organ repair. ..
  9. doi request reprint DNA damage response in adult stem cells: pathways and consequences
    Pankaj K Mandal
    Immune Disease Institute, the Program in Cellular and Molecular Medicine, Childrens Hospital Boston, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 12:198-202. 2011
    ..Indeed, evidence suggests that stem cell compartments possess unique properties that combine to either limit or, in some instances, accelerate DNA damage accrual...
  10. doi request reprint Hematopoietic stem cells and the aging hematopoietic system
    Roi Gazit
    Immune Disease Institute, Harvard Stem Cell Institute, and Department of Pathology, Harvard Medical School, Boston, MA
    Semin Hematol 45:218-24. 2008
    ..In this review, we examine evidence implicating a role for stem cells in the aging of the hematopoietic system, and focus on the mechanisms suggested to contribute to stem cell aging...
  11. pmc Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle
    Isabel Beerman
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 15:37-50. 2014
    ..These results provide a potential mechanism through which premalignant mutations accrue in HSCs. ..
  12. pmc The transcriptional landscape of αβ T cell differentiation
    Michael Mingueneau
    Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:619-32. 2013
    ..The transcripts newly identified as encoding candidate mediators of key transitions help define the 'known unknowns' of thymocyte differentiation...
  13. pmc Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML
    Thanh Trang Vo
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 151:344-55. 2012
    ..BH3 profiling refines predictive information provided by conventional biomarkers currently in use and thus may itself have utility as a clinical predictive biomarker. PAPERCLIP:..
  14. pmc Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
    Nadia R Cohen
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:90-9. 2013
    ..Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes...
  15. pmc Stem cells and aging in the hematopoietic system
    Luigi A Warren
    Department of Pathology, Harvard Medical School, Harvard University, Boston, MA 02115, USA
    Mech Ageing Dev 130:46-53. 2009
    ..Challenges for the future include assessing the significance of 'lineage skewing' to immune dysfunction, and investigating the role of epigenetic dysregulation in HSC aging...
  16. ncbi request reprint Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging
    Derrick J Rossi
    Department of Pathology, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Cell Cycle 6:2371-6. 2007
    ..Moreover, the cytoprotection afforded by stem cell quiescence in stress-free, steady-state conditions suggests a mechanism through which potentially dangerous lesions can accumulate in the stem cell pool with age...
  17. ncbi request reprint Transcriptional instability is not a universal attribute of aging
    Luigi A Warren
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Aging Cell 6:775-82. 2007
    ..We conclude that large-scale regulatory destabilization is not a universal concomitant of aging, and may be of significance as an aging mechanism primarily in nonrenewing tissues...
  18. pmc Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning
    Deepta Bhattacharya
    Department of Pathology, Institute of Cancer and Stem Cell Biology and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 203:73-85. 2006
    ..These experiments provide a general mechanism by which transplanted HSCs can correct hematopoietic deficiencies without any host conditioning or with only highly specific and transient lymphoablation...
  19. pmc Cell intrinsic alterations underlie hematopoietic stem cell aging
    Derrick J Rossi
    Department of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 102:9194-9. 2005
    ....