B Rosner

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis
    E K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 157:1770-8. 1998
  2. pmc Risk factors for ductal and lobular breast cancer: results from the nurses' health study
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:R106. 2010
  3. pmc Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:374-81. 2009
  4. pmc Smoking and smoking cessation in relation to mortality in women
    Stacey A Kenfield
    Department of Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    JAMA 299:2037-47. 2008
  5. ncbi request reprint A study of the importance of education and cost incentives on individual food choices at the Harvard School of Public Health cafeteria
    Karin B Michels
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    J Am Coll Nutr 27:6-11. 2008
  6. ncbi request reprint Measurement error correction in nutritional epidemiology based on individual foods, with application to the relation of diet to breast cancer
    B Rosner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 154:827-35. 2001
  7. ncbi request reprint Incorporation of clustering effects for the Wilcoxon rank sum test: a large-sample approach
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts, USA
    Biometrics 59:1089-98. 2003
  8. pmc Power and sample size estimation for the clustered wilcoxon test
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts, 02115 USA
    Biometrics 67:646-53. 2011
  9. ncbi request reprint A nonparametric test for observational non-normally distributed ophthalmic data with eye-specific exposures and outcomes
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ophthalmic Epidemiol 14:243-50. 2007
  10. ncbi request reprint Mathematical models of ovarian cancer incidence
    Bernard A Rosner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Epidemiology 16:508-15. 2005

Research Grants

  1. ANALYSIS OF LONGITUDINAL CARDIOPULMONARY DATA
    Bernard Rosner; Fiscal Year: 2007
  2. STATISTICAL METHODS FOR OPHTHALMOLOGIC AND CLUSTER DATA
    Bernard Rosner; Fiscal Year: 2000
  3. ANALYSIS OF LONGITUDINAL CVD & CANCER DATA
    Bernard Rosner; Fiscal Year: 2002
  4. MEASUREMENT ERRORS IN CANCER EPIDEMIOLOGY
    Bernard Rosner; Fiscal Year: 2002
  5. STATISTICAL METHODS FOR OPHTHALMOLOGIC AND CLUSTER DATA
    Bernard Rosner; Fiscal Year: 2004
  6. STATISTICAL METHODS FOR OPHTHALMOLOGIC AND CLUSTER DATA
    Bernard Rosner; Fiscal Year: 2007
  7. ANALYSIS OF LONGITUDINAL CARDIOPULMONARY DATA
    Bernard Rosner; Fiscal Year: 1990
  8. ANALYSIS OF LONGITUDINAL CARDIOPULMONARY DATA
    Bernard Rosner; Fiscal Year: 1993
  9. MEASUREMENT ERRORS IN CANCER/RESPIRATORY EPIDEMIOLOGY
    Bernard Rosner; Fiscal Year: 1991
  10. MEASUREMENT ERRORS IN CANCER RESPIRATORY EPIDEMIOLOGY
    Bernard Rosner; Fiscal Year: 1993

Collaborators

Detail Information

Publications96

  1. ncbi request reprint Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis
    E K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 157:1770-8. 1998
    ..The increased risk to relatives of early-onset COPD probands for reduced FEV1 and chronic bronchitis, limited to current or ex-smokers, suggests genetic risk factor(s) for COPD that are expressed in response to cigarette smoking...
  2. pmc Risk factors for ductal and lobular breast cancer: results from the nurses' health study
    Joanne Kotsopoulos
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res 12:R106. 2010
    ....
  3. pmc Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Epidemiology 20:374-81. 2009
    ..However, most of these studies have retrospectively collected information on alcohol and caffeine intake, making the results susceptible to biases...
  4. pmc Smoking and smoking cessation in relation to mortality in women
    Stacey A Kenfield
    Department of Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    JAMA 299:2037-47. 2008
    ..There is inadequate or insufficient evidence to infer the presence or absence of a causal relationship between smoking and ovarian cancer and colorectal cancer...
  5. ncbi request reprint A study of the importance of education and cost incentives on individual food choices at the Harvard School of Public Health cafeteria
    Karin B Michels
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    J Am Coll Nutr 27:6-11. 2008
    ..To investigate the importance of cost and awareness of health- or disease-promoting properties of foods and meals for choices by customers of a cafeteria...
  6. ncbi request reprint Measurement error correction in nutritional epidemiology based on individual foods, with application to the relation of diet to breast cancer
    B Rosner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 154:827-35. 2001
    ....
  7. ncbi request reprint Incorporation of clustering effects for the Wilcoxon rank sum test: a large-sample approach
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts, USA
    Biometrics 59:1089-98. 2003
    ..In this article, we present large-sample theory and simulation results for this test procedure and apply it to diabetic retinopathy data from type I diabetics in the Sorbinil Retinopathy Trial...
  8. pmc Power and sample size estimation for the clustered wilcoxon test
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts, 02115 USA
    Biometrics 67:646-53. 2011
    ..These methods are illustrated with examples from randomized trials in ophthalmology. Enhanced power is achieved with use of the subunit as the unit of analysis instead of the cluster using the ordinary Wilcoxon rank sum test...
  9. ncbi request reprint A nonparametric test for observational non-normally distributed ophthalmic data with eye-specific exposures and outcomes
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ophthalmic Epidemiol 14:243-50. 2007
    ....
  10. ncbi request reprint Mathematical models of ovarian cancer incidence
    Bernard A Rosner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Epidemiology 16:508-15. 2005
    ..Pike has proposed "protected time" as one summary method for modeling reproductive risk factors in relation to ovarian cancer incidence. We evaluate this and other approaches to summarizing risk for ovarian cancer...
  11. ncbi request reprint Interval estimation for rank correlation coefficients based on the probit transformation with extension to measurement error correction of correlated ranked data
    Bernard Rosner
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Stat Med 26:633-46. 2007
    ..This extends previous work by Rosner and Willett for obtaining point and interval estimates of measurement error corrected Pearson correlations...
  12. doi request reprint Determination of blood pressure percentiles in normal-weight children: some methodological issues
    B Rosner
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 167:653-66. 2008
    ....
  13. pmc Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976
    J W Rich-Edwards
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    BMJ 315:396-400. 1997
    ..To examine the association between birth weight and non-fatal adult cardiovascular disease while controlling for potential confounders such as socioeconomic group and adult lifestyle...
  14. ncbi request reprint Age at natural menopause and risk of cardiovascular disease
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    Arch Intern Med 159:1061-6. 1999
    ..Early natural menopause has been postulated to increase the risk of cardiovascular disease...
  15. ncbi request reprint Snack food intake does not predict weight change among children and adolescents
    A E Field
    Division of Adolescent Medicine, Department of Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Obes Relat Metab Disord 28:1210-6. 2004
    ..To assess whether intake of snack foods was associated with weight change among children and adolescents...
  16. pmc Cumulative risk of colon cancer up to age 70 years by risk factor status using data from the Nurses' Health Study
    Esther K Wei
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 170:863-72. 2009
    ..For women with a high risk factor profile, adopting a healthier lifestyle could dramatically reduce colon cancer risk...
  17. ncbi request reprint Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men
    Ka He
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Stroke 35:169-74. 2004
    ..However, the effects of intakes of these vitamins on risk of stroke are still uncertain. This study examines intakes of folate, vitamin B6, and B12 in relation to risk of ischemic and hemorrhagic stroke...
  18. pmc Prospective analysis of vitamin D and endometrial cancer risk
    J J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Oncol 24:687-92. 2013
    ..This is the first prospective cohort analysis on the association between vitamin D and endometrial cancer incorporating time-varying predicted plasma 25-hydroxyvitamin D [25(OH)D]...
  19. ncbi request reprint Methods to quantify the relation between disease progression in paired eyes
    R J Glynn
    Brigham and Women s Hospital and Harvard Medical School, and Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 151:965-74. 2000
    ..9 (95% CI: 1.2, 2.9) and 2.7 (95% CI: 1.8, 3.5), respectively. The more complex models for joint survival integrate information on both eyes and provide more stable estimates than do separate analyses of right or left eyes...
  20. ncbi request reprint Two-year changes in blood pressure and subsequent risk of cardiovascular disease in men
    H D Sesso
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215 1204, USA
    Circulation 102:307-12. 2000
    ..Clinicians may need to consider the previous pattern of DBP change when considering the risk associated with the current DBP level. These data require confirmation in other studies in which blood pressure is measured...
  21. ncbi request reprint Cumulative risk of breast cancer to age 70 years according to risk factor status: data from the Nurses' Health Study
    G A Colditz
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 152:950-64. 2000
    ..Use of unopposed postmenopausal hormones for 10 years significantly increases the risk of breast cancer, and the addition of progestin further increases the risk...
  22. ncbi request reprint Dietary fat intake and ovarian cancer in a cohort of US women
    Elizabeth R Bertone
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Epidemiol 156:22-31. 2002
    ..Overall, results suggest no association between intake of any type of fat and ovarian cancer...
  23. pmc Effects of reproductive and demographic changes on breast cancer incidence in China: a modeling analysis
    Eleni Linos
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Natl Cancer Inst 100:1352-60. 2008
    ..We quantified the expected effect of changes in breast cancer risk factors on future rates of breast cancer in China...
  24. ncbi request reprint Prospective study of smoking, antioxidant intake, and lung cancer in middle-aged women (USA)
    F E Speizer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cancer Causes Control 10:475-82. 1999
    ..We therefore examine prospectively the relation between cigarette smoking and lung cancer incidence among women, and quantify the associations between dietary antioxidants, other nutrients, and lung cancer risk...
  25. doi request reprint Power and sample size estimation for the Wilcoxon rank sum test with application to comparisons of C statistics from alternative prediction models
    B Rosner
    Channing Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biometrics 65:188-97. 2009
    ..These results are based on SAS-callable functions to evaluate the bivariate normal integral and are thus easily implemented with standard software...
  26. ncbi request reprint Sex hormone levels in premenopausal African-American women with upper and lower body fat phenotypes
    J B Barnett
    Nutrition Unit, Department of Family Medicine and Community Health, Tufts University School of Medicine, Boston, MA 02111, USA
    Nutr Cancer 41:47-56. 2001
    ..Obese UBF phenotype AA women, in particular, have a high-risk hormonal profile. Future breast cancer studies might consider controlling for measures of obesity and body fat distribution to minimize confounding...
  27. ncbi request reprint Regression calibration method for correcting measurement-error bias in nutritional epidemiology
    D Spiegelman
    Department of Epidemiology, School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 65:1179S-1186S. 1997
    ..Software implementing these methods uses SAS macros...
  28. ncbi request reprint Dietary fat and risk for advanced age-related macular degeneration
    J M Seddon
    Epidemiology Unit, Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 119:1191-9. 2001
    ..To evaluate the relationship between intake of total and specific types of fat and risk for advanced age-related macular degeneration (AMD), the leading cause of irreversible blindness in adults...
  29. ncbi request reprint Blood pressure differences between blacks and whites in relation to body size among US children and adolescents
    B Rosner
    Channing Laboratory, Harvard University, Boston, MA 02115, USA
    Am J Epidemiol 151:1007-19. 2000
    ....
  30. ncbi request reprint Dietary patterns and the risk of postmenopausal breast cancer
    Teresa T Fung
    Department of Nutrition, Simmons College, Boston, MA 02115, USA
    Int J Cancer 116:116-21. 2005
    ..However, a Western-type diet may elevate risk of breast cancer among smokers, and a prudent diet may protect against estrogen receptive-negative tumors...
  31. pmc Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease
    Xuefen Su
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 21:1033-46. 2010
    ..We examined the association between adolescent fiber intake and proliferative BBD, a marker of increased breast cancer risk, in the Nurses' Health Study II...
  32. ncbi request reprint Effect on blood pressure of potassium, calcium, and magnesium in women with low habitual intake
    F M Sacks
    Department of Nutrition, Harvard School of Public Health, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Hypertension 31:131-8. 1998
    ..This study strengthens evidence for the importance of potassium for blood pressure regulation in the general population...
  33. ncbi request reprint Association between fruit and vegetable intake and change in body mass index among a large sample of children and adolescents in the United States
    A E Field
    Children s Hospital Boston, Division of Adolescent Medicine, 300 Longwood Avenue, Boston, MA 02115, USA
    Int J Obes Relat Metab Disord 27:821-6. 2003
    ..To assess whether intake of fruits and vegetables was associated with change in body mass index (BMI) among a large sample of children and adolescents in the United States...
  34. ncbi request reprint The effect of fruit and vegetable intake on risk for coronary heart disease
    K J Joshipura
    Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Ann Intern Med 134:1106-14. 2001
    ..CONCLUSIONS: Consumption of fruits and vegetables, particularly green leafy vegetables and vitamin C-rich fruits and vegetables, appears to have a protective effect against coronary heart disease...
  35. ncbi request reprint A population-based case-control study of carotenoid and vitamin A intake and ovarian cancer (United States)
    E R Bertone
    Department of Boistatistics and Epidemiology, University of Massachusetts, Amherst 01003 9304, USA
    Cancer Causes Control 12:83-90. 2001
    ..To evaluate the association between dietary intake of carotenoids and vitamin A and the incidence of ovarian cancer...
  36. ncbi request reprint Seven-year changes in alcohol consumption and subsequent risk of cardiovascular disease in men
    H D Sesso
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215 1204
    Arch Intern Med 160:2605-12. 2000
    ..Few studies have examined whether changes in alcohol consumption influence future cardiovascular risk...
  37. pmc Validity of adolescent diet recall 48 years later
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 170:1563-70. 2009
    ..However, this food frequency questionnaire did not validly measure overall adolescent diet when completed by middle-aged and older adults on average 48 years after adolescence...
  38. ncbi request reprint Iron intake and risk of ovulatory infertility
    Jorge E Chavarro
    Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Obstet Gynecol 108:1145-52. 2006
    ..To evaluate whether iron supplement use or greater intake of total, heme and nonheme iron is associated with lower risk of ovulatory infertility...
  39. pmc Cigarette smoking and the incidence of breast cancer
    Fei Xue
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 171:125-33. 2011
    ..Conversely, cigarette smoking also has antiestrogenic effects, which may reduce the risk of BC. The association between smoking and BC remains controversial...
  40. ncbi request reprint Preschool diet and adult risk of breast cancer
    Karin B Michels
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 118:749-54. 2006
    ..Further studies are needed to evaluate whether the association between preschool diet and breast cancer is reproducible in prospective data not subject to recall bias...
  41. ncbi request reprint Parental age at delivery and incidence of breast cancer: a prospective cohort study
    Fei Xue
    Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Breast Cancer Res Treat 104:331-40. 2007
    ..Studies on parental age at delivery in relation to breast cancer risk have had mixed results, but prospective data are limited. No study has explored the associations with subtypes of breast cancer defined by hormonal receptor status...
  42. pmc Caffeine consumption and the risk of primary open-angle glaucoma: a prospective cohort study
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Invest Ophthalmol Vis Sci 49:1924-31. 2008
    ..To investigate whether caffeine, which transiently increases intraocular pressure (IOP) is associated with the risk of primary open-angle glaucoma (POAG)...
  43. pmc Use of nonsteroidal antiinflammatory agents and incidence of ovarian cancer in 2 large prospective cohorts
    Simone P Pinheiro
    Department of Medicine, Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 169:1378-87. 2009
    ..In this large prospective study, the authors found no compelling evidence to support an association between regular use of aspirin, nonaspirin NSAIDs, or acetaminophen and ovarian cancer incidence...
  44. pmc Relation of food cost to healthfulness of diet among US women
    Adam M Bernstein
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 92:1197-203. 2010
    ..Few studies have evaluated the cost of a diet that may prevent cardiovascular disease. High scores on the Alternative Healthy Eating Index (AHEI) have been associated with lower rates of cardiovascular disease...
  45. pmc Risk factors for epithelial ovarian cancer by histologic subtype
    Margaret A Gates
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 171:45-53. 2010
    ..03). Results suggest that associations with several ovarian cancer risk factors vary by subtype, and these differences are consistent with known similarities between each major histologic subtype and its normal tissue counterpart...
  46. pmc Protein intake and ovulatory infertility
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Obstet Gynecol 198:210.e1-7. 2008
    ..The objective of the study was to evaluate whether intake of protein from animal and vegetable origin is associated with ovulatory infertility...
  47. pmc The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal women
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int J Cancer 126:199-207. 2010
    ..Future studies are needed to clarify further which lifestyle factors modulate androgen levels...
  48. ncbi request reprint Prospective study of cigarette smoking and the risk of primary open-angle glaucoma
    Jae H Kang
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arch Ophthalmol 121:1762-8. 2003
    ..To examine the association between cigarette smoking and incident primary open-angle glaucoma (POAG)...
  49. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:971-9. 2010
    ..To evaluate the association between the nitric oxide synthase gene (NOS3) variants and primary open-angle glaucoma (POAG)...
  50. ncbi request reprint Risk factors for breast cancer according to estrogen and progesterone receptor status
    Graham A Colditz
    Cancer Epidemiology Program, Dana Farber Harvard Cancer Center, and Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115 5899, USA
    J Natl Cancer Inst 96:218-28. 2004
    ..To address this issue, we conducted a prospective evaluation of risk factors for breast cancer classified according to receptor status...
  51. pmc A randomized trial on folic acid supplementation and risk of recurrent colorectal adenoma
    Kana Wu
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 90:1623-31. 2009
    ..Evidence from observational studies suggests that inadequate folate status enhances colorectal carcinogenesis, but results from some randomized trials do not support this hypothesis...
  52. ncbi request reprint Dietary fat consumption and primary open-angle glaucoma
    Jae H Kang
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 79:755-64. 2004
    ..Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure...
  53. ncbi request reprint Prospective study of alcohol consumption and the risk of primary open-angle glaucoma
    Jae H Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Ophthalmic Epidemiol 14:141-7. 2007
    ..Alcohol intake reduces intraocular pressure, a risk factor for primary open-angle glaucoma (POAG). We investigated whether alcohol consumption is associated with a reduced risk of POAG...
  54. ncbi request reprint Breastfeeding and risk of ovarian cancer in two prospective cohorts
    Kim N Danforth
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
    Cancer Causes Control 18:517-23. 2007
    ..To describe the association between breastfeeding and ovarian cancer risk in two prospective cohorts...
  55. ncbi request reprint Parental characteristics as predictors of birthweight
    Fei Xue
    Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Hum Reprod 23:168-77. 2008
    ..Previous studies provided conflicting results on the relevance of parental characteristics for offspring's size at birth. The objective of this study was to investigate parental predictors of birthweight...
  56. ncbi request reprint Diet and lifestyle in the prevention of ovulatory disorder infertility
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston MA 02115, USA
    Obstet Gynecol 110:1050-8. 2007
    ..To evaluate the relation of a dietary pattern and other lifestyle practices to risk of ovulatory disorder infertility...
  57. pmc A prospective study on dietary acrylamide intake and the risk for breast, endometrial, and ovarian cancers
    Kathryn M Wilson
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 19:2503-15. 2010
    ..We studied acrylamide intake and risk for breast, endometrial, and ovarian cancers in a prospective cohort study...
  58. pmc Burden of smoking on cause-specific mortality: application to the Nurses' Health Study
    Stacey A Kenfield
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Tob Control 19:248-54. 2010
    ..The burden of smoking on six causes of death in women was evaluated using various novel modelling approaches...
  59. pmc Validity of maternal recall of preschool diet after 43 years
    Jorge E Chavarro
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 169:1148-57. 2009
    ..27; range, -0.14 to 0.85). Correlations for nutrient intakes were consistently low (median, 0.06; range, -0.35 to 0.27). Overall, the FFQ did not validly reflect overall preschool diet when completed by mothers 4 decades later...
  60. pmc Mammographic screening and risk factors for breast cancer
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Am J Epidemiol 170:1422-32. 2009
    ..Adjustment for screening had some impact on breast cancer prediction in this cohort, especially for hormone therapy and smoking...
  61. pmc Anthropometric measures and their relation to incident primary open-angle glaucoma
    Louis R Pasquale
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 117:1521-9. 2010
    ..To assess the relation between anthropometric measures and incident primary open-angle glaucoma (POAG)...
  62. ncbi request reprint Attributes of female reproductive aging and their relation to primary open-angle glaucoma: a prospective study
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    J Glaucoma 16:598-605. 2007
    ..We investigated the relation between age at menopause, postmenopausal hormone (PMH) use, and incident primary open-angle glaucoma (POAG)...
  63. ncbi request reprint Association of oral contraceptive use, other contraceptive methods, and infertility with ovarian cancer risk
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 166:894-901. 2007
    ..Furthermore, tubal ligation, intrauterine device use, and infertility were associated with ovarian cancer risk...
  64. ncbi request reprint Fish consumption and risk of stroke in men
    Ka He
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA
    JAMA 288:3130-6. 2002
    ..The effect of fish consumption or long-chain omega-3 polyunsaturated fatty acid (PUFA) intake on risk of stroke remains uncertain...
  65. ncbi request reprint Using the area under the curve to reduce measurement error in predicting young adult blood pressure from childhood measures
    Nancy R Cook
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Stat Med 23:3421-35. 2004
    ....
  66. ncbi request reprint Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinoma
    Wendy Y Chen
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer 101:1490-500. 2004
    ....
  67. doi request reprint Exposure to cigarette smoke in utero: comparison of reports from mother and daughter
    Julia F Simard
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 19:628-33. 2008
    ..To study the role of in utero smoking exposure in offsprings' adult health outcomes, it may be necessary to rely upon reports by the offspring themselves...
  68. ncbi request reprint Active and passive smoking in breast cancer: prospective results from the Nurses' Health Study
    Kathleen M Egan
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 13:138-45. 2002
    ..The role of active and passive smoking in breast cancer remains controversial...
  69. ncbi request reprint Joint association of alcohol and folate intake with risk of major chronic disease in women
    Rui Jiang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 158:760-71. 2003
    ..Adequate folate intake may be important in the primary prevention of overall major chronic disease in women, especially among younger women consuming more than two alcoholic drinks per day...
  70. ncbi request reprint Obesity, weight gain, and ovarian cancer
    Kathleen M Fairfield
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Obstet Gynecol 100:288-96. 2002
    ..To investigate how adipose tissue alters endogenous hormone levels and may affect events at the ovarian tissue level...
  71. pmc Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study
    Ka He
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    BMJ 327:777-82. 2003
    ..To examine the association between intake of total fat, specific types of fat, and cholesterol and risk of stroke in men. Design and setting Health professional follow up study with 14 year follow up...
  72. ncbi request reprint Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study
    Karin B Michels
    Obstetrics and Gynecology Epidemiology Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes Care 26:1752-8. 2003
    ..We prospectively evaluated the association between type 2 diabetes and invasive breast cancer incidence in the Nurses' Health Study...
  73. ncbi request reprint Dietary evaluation and attenuation of relative risk: multiple comparisons between blood and urinary biomarkers, food frequency, and 24-hour recall questionnaires: the DEARR study
    Iris Shai
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
    J Nutr 135:573-9. 2005
    ..The DEARR study showed that the newly developed FFQ is a valid and reproducible instrument for assessing dietary intake. The VCs obtained can be used for future adjustment of diet-disease RR estimates in this population...
  74. ncbi request reprint Risk factors and individual probabilities of melanoma for whites
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 23:2669-75. 2005
    ....
  75. ncbi request reprint Area of residence, birthplace, and asthma in Puerto Rican children
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Chest 131:1331-8. 2007
    ..There have been no studies that directly compare the burden of asthma between Puerto Ricans living in Puerto Rico and those living in the mainland United States...
  76. ncbi request reprint Dietary fatty acid intakes and the risk of ovulatory infertility
    Jorge E Chavarro
    Department of Nutrition, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Clin Nutr 85:231-7. 2007
    ..Pharmacologic activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) improves ovulatory function in women with polycystic ovary syndrome, and specific dietary fatty acids can affect PPAR-gamma activity...
  77. pmc What can be learnt from models of incidence rates?
    Graham A Colditz
    Cancer Epidemiology Program, Dana Farber Harvard Cancer Center, Boston, MA, USA
    Breast Cancer Res 8:208. 2006
    ..Models that both inform and reflect the emerging understanding of the molecular and cell biology of carcinogenesis are still a long way off...
  78. ncbi request reprint Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women
    Louis R Pasquale
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 113:1081-6. 2006
    ..To study the relation between type 2 diabetes mellitus (T2DM) and incident primary open-angle glaucoma (POAG) in women...
  79. ncbi request reprint Prospective study of alcohol consumption and risk of oral premalignant lesions in men
    Nancy Nairi Maserejian
    Department of Epidemiology, Harvard School of Dental Medicine, Boston, USA
    Cancer Epidemiol Biomarkers Prev 15:774-81. 2006
    ..Alcohol is an independent risk factor for OPL, regardless of beverage type or drinking pattern. Recommendations to reduce alcohol intake have the potential to reduce incidence of OPL in nonsmokers and smokers alike...
  80. pmc Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility
    Jorge E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Fertil Steril 89:668-76. 2008
    ..To examine whether use of multivitamins and intake of specific nutrients in multivitamins is associated with ovulatory infertility...
  81. ncbi request reprint Risk factors for melanoma by body site
    Eunyoung Cho
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:1241-4. 2005
    ..04). Age, family history of melanoma, and hair color did not statistically differ by anatomic site of the cancer. These data support divergent etiologic pathways of melanoma development by anatomic sites...
  82. pmc One-carbon metabolism factors and endometrial cancer risk
    J J Liu
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Br J Cancer 108:183-7. 2013
    ..This is the largest prospective cohort analysis to assess how dietary factors involved in one-carbon metabolism are associated with endometrial cancer incidence, using 26 years of follow-up data from the Nurses' Health Study...
  83. ncbi request reprint Use of the Mann-Whitney U-test for clustered data
    B Rosner
    Channing Laboratory, Harvard Medical School, Boston, MA 02115, USA
    Stat Med 18:1387-400. 1999
    ..We illustrate the methods with an example comparing the baseline Humphrey visual field between two treatment groups in a randomized clinical trial of patients with retinitis pigmentosa (RP)...
  84. pmc In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
    J Allergy Clin Immunol 126:491-7. 2010
    ..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma...
  85. ncbi request reprint Tooth loss and dietary intake
    Hsin Chia Hung
    Department of Epidemiology, Harvard School of Public Health, Boston, USA
    J Am Dent Assoc 134:1185-92. 2003
    ..Several studies have reported that impaired dentition status is associated with poor nutritional intake. However, most of these studies are cross-sectional and thus are unable to clarify the temporal sequence...
  86. ncbi request reprint Effects of nicotine gum dose by level of nicotine dependence
    A J Garvey
    Harvard School of Dental Medicine, Boston, MA, USA
    Nicotine Tob Res 2:53-63. 2000
    ..The 4-mg dose provided a non-significant increase in cessation rates for high-dependence smokers. Smoking history and demographic variables also have a significant impact on the outcome of a quit-smoking attempt...
  87. ncbi request reprint A prospective study of dairy foods intake and anovulatory infertility
    J E Chavarro
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Hum Reprod 22:1340-7. 2007
    ..Yet, few studies have been conducted in humans and their results are inconsistent. We evaluated whether intake of dairy foods was associated with anovulatory infertility and whether this association differed according to fat content...
  88. pmc Anti-MUC1 antibodies and ovarian cancer risk: prospective data from the Nurses' Health Studies
    Simone P Pinheiro
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 19:1595-601. 2010
    ..Antibodies developed against tumor-like MUC1 in response to such events could be one way through which ovarian cancer risk factors operate...
  89. pmc Deletion of repeats in the alpha C protein enhances the pathogenicity of group B streptococci in immune mice
    C Gravekamp
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Infect Immun 66:4347-54. 1998
    ....
  90. pmc Effect of vitamin A supplementation on rhodopsin mutants threonine-17 --> methionine and proline-347 --> serine in transgenic mice and in cell cultures
    T Li
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 95:11933-8. 1998
    ..Vitamin A supplementation may confer therapeutic benefit by stabilizing mutant opsins through increased availability of the chromophore...
  91. ncbi request reprint Thrombin generation in non-cardioembolic stroke subtypes: the Hemostatic System Activation Study
    K L Furie
    V B K 802, Stroke Service, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Neurology 63:777-84. 2004
    ..The Hemostatic System Activation Study (HAS) investigators measured serial levels of prothrombin fragment F1.2, a marker of thrombin generation, in patients enrolled in the Warfarin Aspirin Recurrent Stroke Study (WARSS)...
  92. ncbi request reprint A double-blind study of cysteine photoprotection in erythropoietic protoporphyria
    M M Mathews Roth
    Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Photodermatol Photoimmunol Photomed 10:244-8. 1994
    ..We conclude that cysteine ingestion may be an effective therapy in the prevention of photosensitivity associated with EPP...
  93. ncbi request reprint A prospective study of the relationship between body mass index and cataract extraction among US women and men
    J M Weintraub
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Obes Relat Metab Disord 26:1588-95. 2002
    ..Obesity may influence several physiologic processes involved in cataract formation such as oxidative stress, glycosylation and osmotic stress...
  94. ncbi request reprint The association between fruit and vegetable consumption and peripheral arterial disease
    Hsin Chia Hung
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 14:659-65. 2003
    ..In this study, we evaluated the association of consumption of fruits and vegetables with peripheral arterial disease...
  95. ncbi request reprint Lung cancer rates in men and women with comparable histories of smoking
    Chris Bain
    School of Population Health, University of Queensland, Brisbane, Queensland, Australia
    J Natl Cancer Inst 96:826-34. 2004
    ..Despite prospective data that conflict with this hypothesis, mechanistic studies to find a biologic basis for a sex difference continue...
  96. ncbi request reprint Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
    JAMA 294:2455-64. 2005
    ..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...

Research Grants35

  1. ANALYSIS OF LONGITUDINAL CARDIOPULMONARY DATA
    Bernard Rosner; Fiscal Year: 2007
    ....
  2. STATISTICAL METHODS FOR OPHTHALMOLOGIC AND CLUSTER DATA
    Bernard Rosner; Fiscal Year: 2000
    ..This will allow estimation of the rates of decline of the ERG and visual field over a long period of time as well as provide estimates for an individual patient of the number of years of useful vision they can expect to have. ..
  3. ANALYSIS OF LONGITUDINAL CVD & CANCER DATA
    Bernard Rosner; Fiscal Year: 2002
    ....
  4. MEASUREMENT ERRORS IN CANCER EPIDEMIOLOGY
    Bernard Rosner; Fiscal Year: 2002
    ..g., pancreatic cancer). We propose to investigate the impact of this misclassification on estimated racial differences in survival for persons with pancreatic cancer. ..
  5. STATISTICAL METHODS FOR OPHTHALMOLOGIC AND CLUSTER DATA
    Bernard Rosner; Fiscal Year: 2004
    ..We propose to extend traditional ROC curve methods (Hanley and McNeil, 1982) to the clustered data situation where outcome on fellow eyes may be either concordant (bilateral cases) or discordant (unilateral cases). ..
  6. STATISTICAL METHODS FOR OPHTHALMOLOGIC AND CLUSTER DATA
    Bernard Rosner; Fiscal Year: 2007
    ..The methods developed in this proposal as well as in the previous cycle will be available in the form of SAS macros which can be accessed at the following web site URL:(http://www.qeocities.com/bernardrosner/channina.html). ..
  7. ANALYSIS OF LONGITUDINAL CARDIOPULMONARY DATA
    Bernard Rosner; Fiscal Year: 1990
    ..Furthermore, it is often only through the modelling of longitudinal data that processes pertaining to change can be understood...
  8. ANALYSIS OF LONGITUDINAL CARDIOPULMONARY DATA
    Bernard Rosner; Fiscal Year: 1993
    ....
  9. MEASUREMENT ERRORS IN CANCER/RESPIRATORY EPIDEMIOLOGY
    Bernard Rosner; Fiscal Year: 1991
    ..However, issues from cancer and respiratory epidemiology are emphasized. The primary goal of this grant is to develop methods suitable for the types of studies and data most frequently encountered by investigators in these fields...
  10. MEASUREMENT ERRORS IN CANCER RESPIRATORY EPIDEMIOLOGY
    Bernard Rosner; Fiscal Year: 1993
    ..We believe that methods developed for these diverse studies will be of use in many epidemiologic settings...
  11. ANALYSIS OF LONGITUDINAL CARDIOPULMONARY DATA
    Bernard A Rosner; Fiscal Year: 2010
    ..These methods should be applicable to other long-term longitudinal bp datasets as well as longitudinal analyses of pulmonary function data and other cardiopulmonary measures. ..