VICKI A ROSEN
Affiliation: Harvard University
Rosen V. BMP and BMP inhibitors in bone. Ann N Y Acad Sci. 2006;1068:19-25 pubmed
..Identification of BMP antagonists allows us to investigate their role in diseases that affect skeletal function, such as osteopenia and nonunion fracture, and may provide a novel therapeutic intervention point for treatment. ..
Lyons K, Rosen V. BMPs, TGFβ, and border security at the interzone. Curr Top Dev Biol. 2019;133:153-170 pubmed publisher
..Understanding how BMP antagonists and counteracting TGFβ signals intersect with Gdf5 to sculpt the joint interzone is essential for understanding the origin of osteoarthritis and other diseases of joint tissues. ..
Lowery J, Intini G, Gamer L, Lotinun S, Salazar V, Ote S, et al
. Loss of BMPR2 leads to high bone mass due to increased osteoblast activity. J Cell Sci. 2015;128:1308-15 pubmed publisher
..As BMP and activin pathway modulation are of current therapeutic interest, our findings provide important mechanistic insight into the relationship between these pathways in human health. ..
Rosen V. BMP2 signaling in bone development and repair. Cytokine Growth Factor Rev. 2009;20:475-80 pubmed publisher
..This review summarizes current findings on the specific requirement for BMP2 in bone formation and repair. ..
Salazar V, Ohte S, Capelo L, Gamer L, Rosen V. Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2. Development. 2016;143:4352-4367 pubmed
..The Runx2/Osx1 transition therefore receives crucial regulatory inputs from BMP2 that are not compensated for by cWnt signaling, and this is mediated at least in part by induction and activation of Grhl3. ..