Research Topics
Species | Evan RosenSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Publications
The transcriptional basis of adipocyte developmentEvan D Rosen
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Prostaglandins Leukot Essent Fatty Acids 73:31-4. 2005..These approaches will be discussed, along with the roles of some new transcriptional players in adipogenesis, including the O/E family of proteins...
Adipocytes as regulators of energy balance and glucose homeostasisEvan D Rosen
Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nature 444:847-53. 2006..Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions...- Adipocyte differentiation from the inside outEvan D Rosen
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Nat Rev Mol Cell Biol 7:885-96. 2006.... - Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasisEvan D Rosen
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Mol Cell Biol 23:7222-9. 2003.... - Transcriptional targets in adipocyte biologyEvan Rosen
Beth Israel Deaconess Medical Center, Division of Endocrinology CLS743, Boston, MA 02215, USA
Expert Opin Ther Targets 13:975-86. 2009..In this review, we look at what is known about how adipocytes govern their physiology at the gene expression level, and discuss novel ways that we can accelerate our understanding of this area... - Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinedionesAndrew W Norris
Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
J Clin Invest 112:608-18. 2003..The tissue crosstalk mediating these effects is perhaps due to altered lipid metabolism in muscle... - Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascadeMaria A Jimenez
Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Mol Cell Biol 27:743-57. 2007..Altogether, these data place Ebf1 within the known transcriptional cascade of adipogenesis and suggest critical roles for Ebf1 and Ebf2... - C/EBPalpha induces adipogenesis through PPARgamma: a unified pathwayEvan D Rosen
Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Genes Dev 16:22-6. 2002..These results indicate that C/EBPalpha and PPARgamma participate in a single pathway of fat cell development with PPARgamma being the proximal effector of adipogenesis... - Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoformsElisabetta Mueller
Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:41925-30. 2002..Analyses involving coactivator binding and transcriptional assays indicate that PPARgamma2 has an enhanced ability to bind components of the DRIP/TRAP complex, coactivators required for fat differentiation... - Absence of a reductase, NCB5OR, causes insulin-deficient diabetesJianxin Xie
Hematology Division, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:10750-5. 2004..Four-week-old Ncb5or-/- mice have enhanced sensitivity to the diabetogenic agent streptozotocin. NCB5OR appears to play a critical role in protecting pancreatic beta cells against oxidant stress... - The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistanceQing Wu Yan
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Diabetes 56:2533-40. 2007..The purpose of this study was to determine how expression of Lcn2 is regulated in fat cells and to ascertain whether Lcn2 could be involved in metabolic dysregulation associated with obesity... - The molecular control of adipogenesis, with special reference to lymphatic pathologyEvan D Rosen
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 979:143-58; discussion 188-96. 2002..In particular, the role of the nuclear hormone receptor PPARgamma will be discussed, along with bZip family members C/EBPalpha, C/EBPbeta, and C/EBPdelta. The relationship of adipose depots to the lymphatic system will also be discussed... - Interferon regulatory factors are transcriptional regulators of adipogenesisJun Eguchi
Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Cell Metab 7:86-94. 2008..This analysis suggests an important role for IRF proteins in adipocyte biology and demonstrates the utility of this approach in identifying cis- and trans-acting factors not previously suspected to participate in adipogenesis... - FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adultsAbir Mukherjee
Reproductive Endocrine Unit, Division of Cardiology, and Laboratory of Molecular Endocrinology and Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 104:1348-53. 2007.... - Energy balance: a new role for PPARalphaEvan D Rosen
Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Research North 330-D, 99 Brookline Avenue, Boston, MA 02214, USA
Curr Biol 13:R961-3. 2003 - The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesisZhao Xu
Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:2421-6. 2008..Taken together, our data demonstrate that COUP-TFII represents an endogenous suppressor of adipogenesis, linking antiadipogenic extracellular signals to the core transcriptional cascade... 
A minor role for lipocalin 2 in high-fat diet-induced glucose intoleranceLucy S Jun
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Am J Physiol Endocrinol Metab 301:E825-35. 2011..We conclude that the global ablation of Lcn2 has a minimal effect on obesity-associated glucose intolerance but does not appear to affect either age- or obesity-mediated insulin resistance in vivo...- Reactive oxygen species have a causal role in multiple forms of insulin resistanceNicholas Houstis
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
Nature 440:944-8. 2006..Together, our findings suggest that increased ROS levels are an important trigger for insulin resistance in numerous settings... - Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumoursJessica Costa-Guda
Center for Molecular Medicine and Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, CT 06030, USA
Clin Endocrinol (Oxf) 62:603-6. 2005..CONCLUSION: These findings strongly suggest that PPARG does not commonly function as a classical tumour suppressor gene in the pathogenesis of EPETs... - Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signalingKimberlee S Mix
Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
Mol Pharmacol 65:309-18. 2004..We conclude that CDDO represses MMP gene expression through a novel PPAR-gamma-independent mechanism that requires Smad signaling...
Research Grants
- Novel Transcriptional Pathways in AdipogenesisEvan Rosen; Fiscal Year: 2003..Such regulatory motifs will be used to clone and to characterize the cognate transcription factors, and will allow the discovery of novel pathways in adipogenesis. ..
- EBF Proteins in Adipocyte Differentiation and MetabolismEvan D Rosen; Fiscal Year: 2010..Understanding these pathways better will allow us to design rational strategies to combat diseases that involve adipocytes, such as obesity and lipodystrophy. ..
- REGULATION OF NUTRIENT HOMEOSTASIS BY IRF4Evan D Rosen; Fiscal Year: 2010..Manipulating these factors will allow us to promote beneficial gene expression patterns in fat cells, with potential to alter the course of metabolic diseases like obesity and Type 2 diabetes. ..
- Genomic determinants of leptin expressionEvan Rosen; Fiscal Year: 2007..This proposal uses a variety of innovative technologies to address this deficit, including BAC transgenesis, high-throughput DNase hypersensitivity analysis, and shRNA screening. ..
- Novel Transcriptional Pathways in AdipogenesisEvan Rosen; Fiscal Year: 2007..Such regulatory motifs will be used to clone and to characterize the cognate transcription factors, and will allow the discovery of novel pathways in adipogenesis. ..
- Novel Transcriptional Pathways in AdipogenesisEvan Rosen; Fiscal Year: 2006..Such regulatory motifs will be used to clone and to characterize the cognate transcription factors, and will allow the discovery of novel pathways in adipogenesis. ..
- Epigenomics of Human Insulin ResistanceEvan D Rosen; Fiscal Year: 2010..Understanding the epigenomic basis of insulin resistance will provide novel insights into the mechanisms by which insulin resistance develops, which in turn will lead to new therapeutic strategies. ..