Evan Rosen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The transcriptional basis of adipocyte development
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Prostaglandins Leukot Essent Fatty Acids 73:31-4. 2005
  2. pmc Adipocytes as regulators of energy balance and glucose homeostasis
    Evan D Rosen
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 444:847-53. 2006
  3. doi request reprint What we talk about when we talk about fat
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA 02215, USA Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA Electronic address
    Cell 156:20-44. 2014
  4. pmc Transcriptional targets in adipocyte biology
    Evan Rosen
    Beth Israel Deaconess Medical Center, Division of Endocrinology CLS743, Boston, MA 02215, USA
    Expert Opin Ther Targets 13:975-86. 2009
  5. ncbi request reprint Adipocyte differentiation from the inside out
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Rev Mol Cell Biol 7:885-96. 2006
  6. pmc Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:7222-9. 2003
  7. pmc Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    Andrew W Norris
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Invest 112:608-18. 2003
  8. pmc Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade
    Maria A Jimenez
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell Biol 27:743-57. 2007
  9. pmc C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway
    Evan D Rosen
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 16:22-6. 2002
  10. pmc Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
    Jianxin Xie
    Hematology Division, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10750-5. 2004

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The transcriptional basis of adipocyte development
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Prostaglandins Leukot Essent Fatty Acids 73:31-4. 2005
    ..These approaches will be discussed, along with the roles of some new transcriptional players in adipogenesis, including the O/E family of proteins...
  2. pmc Adipocytes as regulators of energy balance and glucose homeostasis
    Evan D Rosen
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 444:847-53. 2006
    ..Furthermore, the rational manipulation of adipose physiology is a promising avenue for therapy of these conditions...
  3. doi request reprint What we talk about when we talk about fat
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA 02215, USA Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA Electronic address
    Cell 156:20-44. 2014
    ..Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health. ..
  4. pmc Transcriptional targets in adipocyte biology
    Evan Rosen
    Beth Israel Deaconess Medical Center, Division of Endocrinology CLS743, Boston, MA 02215, USA
    Expert Opin Ther Targets 13:975-86. 2009
    ..In this review, we look at what is known about how adipocytes govern their physiology at the gene expression level, and discuss novel ways that we can accelerate our understanding of this area...
  5. ncbi request reprint Adipocyte differentiation from the inside out
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Nat Rev Mol Cell Biol 7:885-96. 2006
    ....
  6. pmc Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:7222-9. 2003
    ....
  7. pmc Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    Andrew W Norris
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Invest 112:608-18. 2003
    ..The tissue crosstalk mediating these effects is perhaps due to altered lipid metabolism in muscle...
  8. pmc Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade
    Maria A Jimenez
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Mol Cell Biol 27:743-57. 2007
    ..Altogether, these data place Ebf1 within the known transcriptional cascade of adipogenesis and suggest critical roles for Ebf1 and Ebf2...
  9. pmc C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway
    Evan D Rosen
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Genes Dev 16:22-6. 2002
    ..These results indicate that C/EBPalpha and PPARgamma participate in a single pathway of fat cell development with PPARgamma being the proximal effector of adipogenesis...
  10. pmc Absence of a reductase, NCB5OR, causes insulin-deficient diabetes
    Jianxin Xie
    Hematology Division, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10750-5. 2004
    ..Four-week-old Ncb5or-/- mice have enhanced sensitivity to the diabetogenic agent streptozotocin. NCB5OR appears to play a critical role in protecting pancreatic beta cells against oxidant stress...
  11. ncbi request reprint Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms
    Elisabetta Mueller
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:41925-30. 2002
    ..Analyses involving coactivator binding and transcriptional assays indicate that PPARgamma2 has an enhanced ability to bind components of the DRIP/TRAP complex, coactivators required for fat differentiation...
  12. ncbi request reprint The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance
    Qing Wu Yan
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Diabetes 56:2533-40. 2007
    ..The purpose of this study was to determine how expression of Lcn2 is regulated in fat cells and to ascertain whether Lcn2 could be involved in metabolic dysregulation associated with obesity...
  13. ncbi request reprint The molecular control of adipogenesis, with special reference to lymphatic pathology
    Evan D Rosen
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 979:143-58; discussion 188-96. 2002
    ..In particular, the role of the nuclear hormone receptor PPARgamma will be discussed, along with bZip family members C/EBPalpha, C/EBPbeta, and C/EBPdelta. The relationship of adipose depots to the lymphatic system will also be discussed...
  14. pmc Interferon regulatory factors are transcriptional regulators of adipogenesis
    Jun Eguchi
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cell Metab 7:86-94. 2008
    ..This analysis suggests an important role for IRF proteins in adipocyte biology and demonstrates the utility of this approach in identifying cis- and trans-acting factors not previously suspected to participate in adipogenesis...
  15. pmc FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults
    Abir Mukherjee
    Reproductive Endocrine Unit, Division of Cardiology, and Laboratory of Molecular Endocrinology and Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:1348-53. 2007
    ....
  16. ncbi request reprint Energy balance: a new role for PPARalpha
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Research North 330 D, 99 Brookline Avenue, Boston, MA 02214, USA
    Curr Biol 13:R961-3. 2003
  17. pmc The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis
    Zhao Xu
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:2421-6. 2008
    ..Taken together, our data demonstrate that COUP-TFII represents an endogenous suppressor of adipogenesis, linking antiadipogenic extracellular signals to the core transcriptional cascade...
  18. doi request reprint A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance
    Lucy S Jun
    Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 301:E825-35. 2011
    ..We conclude that the global ablation of Lcn2 has a minimal effect on obesity-associated glucose intolerance but does not appear to affect either age- or obesity-mediated insulin resistance in vivo...
  19. ncbi request reprint Reactive oxygen species have a causal role in multiple forms of insulin resistance
    Nicholas Houstis
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Nature 440:944-8. 2006
    ..Together, our findings suggest that increased ROS levels are an important trigger for insulin resistance in numerous settings...
  20. ncbi request reprint Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling
    Kimberlee S Mix
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03756, USA
    Mol Pharmacol 65:309-18. 2004
    ..We conclude that CDDO represses MMP gene expression through a novel PPAR-gamma-independent mechanism that requires Smad signaling...
  21. ncbi request reprint Mutational analysis of PPARG as a candidate tumour suppressor gene in enteropancreatic endocrine tumours
    Jessica Costa-Guda
    Center for Molecular Medicine and Division of Endocrinology and Metabolism, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Clin Endocrinol (Oxf) 62:603-6. 2005
    ..Therefore, we sought to examine PPARG for intragenic inactivating mutations, the evidence needed to rigorously establish it as a tumour suppressor in EPETs...

Research Grants13

  1. Epigenomics of Human Insulin Resistance
    Evan D Rosen; Fiscal Year: 2010
    ..Understanding the epigenomic basis of insulin resistance will provide novel insights into the mechanisms by which insulin resistance develops, which in turn will lead to new therapeutic strategies. ..
  2. REGULATION OF NUTRIENT HOMEOSTASIS BY IRF4
    Evan D Rosen; Fiscal Year: 2010
    ..Manipulating these factors will allow us to promote beneficial gene expression patterns in fat cells, with potential to alter the course of metabolic diseases like obesity and Type 2 diabetes. ..
  3. Genomic determinants of leptin expression
    Evan Rosen; Fiscal Year: 2007
    ..This proposal uses a variety of innovative technologies to address this deficit, including BAC transgenesis, high-throughput DNase hypersensitivity analysis, and shRNA screening. ..
  4. Novel Transcriptional Pathways in Adipogenesis
    Evan Rosen; Fiscal Year: 2007
    ..Such regulatory motifs will be used to clone and to characterize the cognate transcription factors, and will allow the discovery of novel pathways in adipogenesis. ..
  5. Novel Transcriptional Pathways in Adipogenesis
    Evan Rosen; Fiscal Year: 2006
    ..Such regulatory motifs will be used to clone and to characterize the cognate transcription factors, and will allow the discovery of novel pathways in adipogenesis. ..
  6. EBF Proteins in Adipocyte Differentiation and Metabolism
    Evan D Rosen; Fiscal Year: 2010
    ..Understanding these pathways better will allow us to design rational strategies to combat diseases that involve adipocytes, such as obesity and lipodystrophy. ..
  7. Novel Transcriptional Pathways in Adipogenesis
    Evan Rosen; Fiscal Year: 2003
    ..Such regulatory motifs will be used to clone and to characterize the cognate transcription factors, and will allow the discovery of novel pathways in adipogenesis. ..