Bruce Rosen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint fMRI at 20: has it changed the world?
    Bruce R Rosen
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA
    Neuroimage 62:1316-24. 2012
  2. pmc Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study
    Shuning Huang
    Harvard MIT HST Athinoula A, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    BMC Med Imaging 8:3. 2008
  3. pmc Characterization of the "deqi" response in acupuncture
    Kathleen K S Hui
    Athinoula A, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 7:33. 2007
  4. ncbi request reprint Functional neuroanatomical investigation of vision-related acupuncture point specificity--a multisession fMRI study
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Hum Brain Mapp 30:38-46. 2009
  5. doi request reprint Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
  6. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
  7. pmc Functional MRI detection of pharmacologically induced memory impairment
    Reisa Sperling
    Massachusetts General Hospital, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 99:455-60. 2002
  8. pmc Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 45:940-9. 2009
  9. pmc An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 47:1066-76. 2009
  10. pmc Enabling collaborative research using the Biomedical Informatics Research Network (BIRN)
    Karl G Helmer
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Med Inform Assoc 18:416-22. 2011

Research Grants

Detail Information

Publications56

  1. doi request reprint fMRI at 20: has it changed the world?
    Bruce R Rosen
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA
    Neuroimage 62:1316-24. 2012
    ..Using five primary areas, i.e. scientific impact, clinical practice, cognitive neuroscience, mental illness, and society-this essay examines the question: Has fMRI changed the world?..
  2. pmc Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study
    Shuning Huang
    Harvard MIT HST Athinoula A, Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    BMC Med Imaging 8:3. 2008
    ..In this case study, we have investigated the feasibility of using a specific form of MRI, i.e. magnetic resonance microscopy or MRM, to study the expansion dynamics of a multicellular tumor spheroid in a collagen type I gel...
  3. pmc Characterization of the "deqi" response in acupuncture
    Kathleen K S Hui
    Athinoula A, Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Complement Altern Med 7:33. 2007
    ....
  4. ncbi request reprint Functional neuroanatomical investigation of vision-related acupuncture point specificity--a multisession fMRI study
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Hum Brain Mapp 30:38-46. 2009
    ..Given the complexity of acupuncture systems and brain activity, additional work is required to determine whether functional neuroanatomical correlates of acupoint specificity can be validated by means of brain imaging tools...
  5. doi request reprint Acupuncture de qi, from qualitative history to quantitative measurement
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Altern Complement Med 13:1059-70. 2007
    ....
  6. ncbi request reprint Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
    ..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
  7. pmc Functional MRI detection of pharmacologically induced memory impairment
    Reisa Sperling
    Massachusetts General Hospital, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 99:455-60. 2002
    ....
  8. pmc Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 45:940-9. 2009
    ..Our results also suggest that the brain network involved in expectancy may vary under different treatment situations (verum and sham acupuncture treatment)...
  9. pmc An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment
    Jian Kong
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuroimage 47:1066-76. 2009
    ..We hypothesize that as a peripheral-central modulation, acupuncture needle stimulation may inhibit incoming noxious stimuli; while as a top-down modulation, expectancy (placebo) may work through the emotional circuit...
  10. pmc Enabling collaborative research using the Biomedical Informatics Research Network (BIRN)
    Karl G Helmer
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Med Inform Assoc 18:416-22. 2011
    ..The goal of the Biomedical Informatics Research Network (BIRN) is to address the challenges inherent in biomedical data sharing...
  11. pmc Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototype
    Ciprian Catana
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Nucl Med 51:1431-8. 2010
    ....
  12. pmc Predicting the location of entorhinal cortex from MRI
    Bruce Fischl
    Athinoula A Martinos Center, Department of Radiology, MGH, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 47:8-17. 2009
    ....
  13. pmc Target-specific contrast agents for magnetic resonance microscopy
    Megan L Blackwell
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129
    Neuroimage 46:382-93. 2009
    ..Our results suggest target-specific contrast agents will enable more detailed MR images with applications in imaging pathological ex vivo samples and constructing better MR atlases from ex vivo brains...
  14. pmc Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI
    Caterina Mainero
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 35:1201-10. 2007
    ..These results indicate that the pain modulatory system is involved to a different extent during primary versus secondary mechanical allodynia...
  15. ncbi request reprint Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm
    David E Sosnovik
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Magn Reson Imaging 26:279-87. 2007
    ..To evaluate the use of a transmit-receive surface (TRS) coil and a cardiac-tailored intensity-correction algorithm for cardiac MRI in mice at 9.4 Tesla (9.4T)...
  16. pmc Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    NMR Biomed 21:453-63. 2008
    ..The optimal performance of ORI will thus likely be seen at low fields, with moderate MION concentrations and with sequences containing very short TEs...
  17. pmc Acupuncture, the limbic system, and the anticorrelated networks of the brain
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Auton Neurosci 157:81-90. 2010
    ....
  18. pmc Inhibition of stimulated dopamine release and hemodynamic response in the brain through electrical stimulation of rat forepaw
    Y Iris Chen
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Room 2301, Charlestown, MA 02129, USA
    Neurosci Lett 431:231-5. 2008
    ..These data provide evidence for physiologic modulation caused by electroacupuncture at points near the median nerve...
  19. pmc In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model
    Christian T Farrar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neuro Oncol 12:341-50. 2010
    ..In addition, preliminary data indicate that the VCI is independent of whether a dynamic susceptibility contrast or SSC measurement method is used...
  20. pmc Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia
    Young R Kim
    Athinoula Martinos Center for Biomedical Imaging Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Stroke 39:439-47. 2008
    ..We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic efficacy of delayed chronic lithium treatment using functional MRI...
  21. pmc Acupuncture mobilizes the brain's default mode and its anti-correlated network in healthy subjects
    Kathleen K S Hui
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Charlestown, MA 02129, USA
    Brain Res 1287:84-103. 2009
    ..Our results suggest that acupuncture mobilizes the anti-correlated functional networks of the brain to mediate its actions, and that the effect is dependent on the psychophysical response...
  22. pmc Parallel input makes the brain run faster
    Tommi Raij
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 40:1792-7. 2008
    ..This arrangement could also allow very early top-down modulation of the bottom-up stream of sensory information...
  23. pmc Stimulus-induced Rotary Saturation (SIRS): a potential method for the detection of neuronal currents with MRI
    Thomas Witzel
    Speech and Hearing Bioscience and Technology Program, Harvard MIT Division of Health Sciences and Technology, USA
    Neuroimage 42:1357-65. 2008
    ..Magn. Reson. Med. 50, 40-49], but is potentially less encumbered by temporal and spatial cancellation effects...
  24. pmc Electrical stimulation modulates the amphetamine-induced hemodynamic changes: an fMRI study to compare the effect of stimulating locations and frequencies on rats
    Y Iris Chen
    Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurosci Lett 444:117-21. 2008
    ..This therefore provided insight into the neurophysiological basis of electroacupuncture effects in cortical and subcortical circuits...
  25. pmc Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex
    Anna Devor
    Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:14347-57. 2008
    ..We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus...
  26. ncbi request reprint Structural and functional plasticity in the somatosensory cortex of chronic stroke patients
    Judith D Schaechter
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging Charlestown, Boston, USA
    Brain 129:2722-33. 2006
    ..These results provide the first evidence of structural plasticity co-localized with areas exhibiting functional plasticity in the human brain after stroke...
  27. ncbi request reprint fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains
    Young R Kim
    Athinoula Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 27:142-53. 2007
    ..Taken together, these data suggest that restoration of fMRI response magnitudes, temporal profiles, and correlations with structure may reveal the extent and specific traits of albumin treatment associated stroke recovery...
  28. ncbi request reprint Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrix
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
    Magn Reson Med 50:164-74. 2003
    ..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics...
  29. ncbi request reprint Basal ganglia activity remains elevated after movement in focal hand dystonia
    Anne J Blood
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Ann Neurol 55:744-8. 2004
    ..We posit that inhibitory control of the basal ganglia may be faulty in focal hand dystonia, and that the increases we observe in "resting" activity may mask basal ganglia abnormalities in standard imaging contrast analyses...
  30. ncbi request reprint Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model
    Rick M Dijkhuizen
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass, USA
    Stroke 33:2100-4. 2002
    ..Our aim was to characterize acute effects of rtPA administration on the integrity of microvascular barriers...
  31. ncbi request reprint Effects of tracer arrival time on flow estimates in MR perfusion-weighted imaging
    Ona Wu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology Harvard Medical School, Boston, 02129, USA
    Magn Reson Med 50:856-64. 2003
    ..These conditions may occur in practice due to the application of a user-selected AIF that is not the "true AIF" and therefore caution must be taken in interpreting CBF and MTT estimates...
  32. pmc Mapping cognitive function
    Steven M Stufflebeam
    Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuroimaging Clin N Am 17:469-84, viii-ix. 2007
    ..A unifying theme of this article is the concept that a more complete understanding of cognition only comes through integration of multimodal structural and functional imaging technologies...
  33. ncbi request reprint Functional imaging of working memory in obstructive sleep-disordered breathing
    Robert J Thomas
    Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, CC 866, Sleep Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol 98:2226-34. 2005
    ..There may be dissociations between respiratory vs. cortical recovery and objective vs. subjective recovery. Hypofrontality may provide a plausible biological mechanism for a clinical overlap with disorders of mood and attention...
  34. ncbi request reprint Human cerebellum: surface-assisted cortical parcellation and volumetry with magnetic resonance imaging
    Nikos Makris
    Massachusetts General Hospital, USA
    J Cogn Neurosci 15:584-99. 2003
    ..The SAP technique makes it possible to represent multimodal structural and functional imaging data on the flattened surface of the cerebellar cortex as illustrated in one functional MRI experiment...
  35. ncbi request reprint Stereopsis activates V3A and caudal intraparietal areas in macaques and humans
    Doris Y Tsao
    Massachusetts General Hospital, NMR Center, Athinoula A Martinos Center, Charlestown, Massachusetts 02129, USA
    Neuron 39:555-68. 2003
    ..Thus, in both primate species a small cluster of areas at the parieto-occipital junction appears to be specialized for stereopsis...
  36. ncbi request reprint Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats
    Young R Kim
    NMR Center MGH, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 25:820-9. 2005
    ..These results suggest that stroke affects not only local hemodynamics and coupling but also other factors including neural connectivity...
  37. pmc Dorsal anterior cingulate cortex: a role in reward-based decision making
    George Bush
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:523-8. 2002
    ..These findings should be of interest to those studying reward, cognition, emotion, motivation, and motor control...
  38. ncbi request reprint Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study
    Judith D Schaechter
    Massachusetts General Hospital NMR Center, Department of Radiology, Charlestown, MA 02129, USA
    Neurorehabil Neural Repair 16:326-38. 2002
    ..These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere...
  39. ncbi request reprint Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study
    Rick M Dijkhuizen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 23:510-7. 2003
    ....
  40. ncbi request reprint Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging
    Yin Ching I Chen
    Athinoula A Martinos Center for Biomedical Imaging and MGH NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychopharmacology (Berl) 180:705-15. 2005
    ..We wished to show that pharmacological magnetic resonance imaging (phMRI) may prove useful for this purpose...
  41. ncbi request reprint Iron-induced susceptibility effect at the globus pallidus causes underestimation of flow and volume on dynamic susceptibility contrast-enhanced MR perfusion images
    Kei Yamada
    Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto City, Japan
    AJNR Am J Neuroradiol 23:1022-9. 2002
    ..The purpose of this study was to assess the effect of iron-induced susceptibility on the calculated perfusion parameters. The difference of this effect between gradient-echo and spin-echo sequences was also assessed...
  42. ncbi request reprint Repeated fMRI using iron oxide contrast agent in awake, behaving macaques at 3 Tesla
    Francisca P Leite
    Massachusetts Institute of Technology, Department of Nuclear Engineering, Cambridge, Massachusetts 02139, USA
    Neuroimage 16:283-94. 2002
    ..Overall, the contrast agent produced a dramatic improvement in functional brain imaging results in the awake, behaving primate at this field strength. (c) 2002 Elsevier Science (USA)...
  43. ncbi request reprint Magnetic resonance perfusion-weighted imaging of acute cerebral infarction: effect of the calculation methods and underlying vasculopathy
    Kei Yamada
    Massachusetts General Hospital NMR Center, Harvard Medical School, Boston, USA
    Stroke 33:87-94. 2002
    ..Steno-occlusive disease in the parent vessels is another factor that may affect the results of the PWI. The purpose of this study was to elucidate the effect of the calculation methods and underlying vasculopathy on PWI...
  44. ncbi request reprint Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models
    Ona Wu
    Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cereb Blood Flow Metab 27:196-204. 2007
    ..Our study shows that predictive algorithms are promising metrics for diagnosis, prognosis and therapeutic evaluation after acute stroke that can translate readily from preclinical to clinical settings...
  45. pmc Functional response of tumor vasculature to PaCO2: determination of total and microvascular blood volume by MRI
    Scott D Packard
    MGH NMR Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neoplasia 5:330-8. 2003
    ..Furthermore, reduced reactivity of tumor vessels to a single physiological perturbation, such as hypercarbia, should not be construed as a generalized reduction of functional activity of the tumor vascular bed...
  46. ncbi request reprint Role of matrix metalloproteinases in delayed cortical responses after stroke
    Bing Qiao Zhao
    Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, MGH East 149 2401, Charlestown, Massachusetts 02129, USA
    Nat Med 12:441-5. 2006
    ..These data suggest that, contrary to MMP inhibitor therapies for acute stroke, strategies that modulate MMPs may be needed for promoting stroke recovery...
  47. pmc MR contrast probes that trace gene transcripts for cerebral ischemia in live animals
    Christina H Liu
    AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    FASEB J 21:3004-15. 2007
    ..This study should enable MR detection of mRNA alteration in disease models of the central nervous system...
  48. pmc Forebrain ischemia-reperfusion simulating cardiac arrest in mice induces edema and DNA fragmentation in the brain
    Christina H Liu
    A A Martinos Center for Biomedical Imaging Charlestown, MA, USA
    Mol Imaging 6:156-70. 2007
    ..These findings suggest that brain injury induced by cardiac arrest can be detected in live animals...
  49. doi request reprint Spatio-temporal characteristics of low-frequency BOLD signal fluctuations in isoflurane-anesthetized rat brain
    Sridhar S Kannurpatti
    Department of Radiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Neuroimage 40:1738-47. 2008
    ..Also, a high inter-hemispheric synchrony combined with different phase characteristics of the low-frequency BOLD fluctuations particularly in the hippocampus relative to the cortex emphasizes distinct functional networks...
  50. ncbi request reprint Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]
    Michael H Lev
    Departments of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 25:214-21. 2004
    ..We compared the specificity of SE rCBV mapping with that of conventional, contrast material-enhanced MR imaging in differentiating high- from low-grade glial tumors and in predicting survival of patients with these lesions...
  51. ncbi request reprint Motor cortex activation is related to force of squeezing
    Steven C Cramer
    MGH NMR Center, Department of Radiology, Charlestown, Massachusetts, USA
    Hum Brain Mapp 16:197-205. 2002
    ..This relationship was found across the full spectrum of forces that the human hand is capable of generating. Use of a valid, reliable method for assessing motor behavior during functional MRI may be important to clinical applications...
  52. pmc Imaging cerebral gene transcripts in live animals
    Christina H Liu
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 27:713-22. 2007
    ..These results demonstrated that SPION-sODN conjugates can detect active transcriptions of specific mRNA species in living animals with MRI...
  53. ncbi request reprint Correlation of FDG-PET interpretation with survival in a cohort of glioma patients
    Francisco S Pardo
    Department of Radiation Oncology Massachusetts General Hospital and Harvard Medical School Boston, MA, USA
    Anticancer Res 24:2359-65. 2004
    ....
  54. ncbi request reprint Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke
    Aneesh B Singhal
    Neuroprotection Research Laboratory, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurology 58:945-52. 2002
    ..Hyperbaric oxygen therapy is considered an important stroke treatment strategy...
  55. ncbi request reprint Tonotopic organization in human auditory cortex revealed by progressions of frequency sensitivity
    Thomas M Talavage
    Speech and Hearing Sciences Program, Massachusetts Institute of Technology Harvard Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA
    J Neurophysiol 91:1282-96. 2004
    ....
  56. ncbi request reprint Dynamic magnetic resonance perfusion imaging of brain tumors
    Diego J Covarrubias
    Department of Radiology, Neuroradiology Division, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02144, USA
    Oncologist 9:528-37. 2004
    ..Finally, the future potential applications of this technology in the setting of novel antiangiogenic therapies for brain tumors will be addressed...

Research Grants36

  1. 500 MHz NMR Spectrometer for Molecular Imaging Applications
    Bruce Rosen; Fiscal Year: 2007
    ..Projects requiring HR-MAS NMR spectroscopy include identifying biomarkers for (1) breast cancer, (2) inflammatory response in burn tissue (3) HIV injured brain tissue, and (4) ostereoporosis. ..
  2. MEMP Neuroimaging Training Program
    Bruce Rosen; Fiscal Year: 2007
    ..The program we envision will create an environment of enhanced mentorship and formal didactic training that will attract exceptional individuals to the pursuit of clinical neuroimaging research. ..
  3. Morphometry Biomedical Informatics Research Network
    Bruce Rosen; Fiscal Year: 2007
    ....
  4. CENTER FOR FUNCTIONAL IMAGING TECHNOLOGIES
    Bruce Rosen; Fiscal Year: 2007
    ..abstract_text> ..
  5. Advanced Multimodal Neuroimaging Training Grant
    Bruce Rosen; Fiscal Year: 2007
    ..Central to the research education component will be paired mentorship with a senior neuroimaging researcher, and opportunities for extended stays to engage in hands-on research experiences. ..
  6. Advanced Multimodal Neuroimaging Training Grant
    Bruce Rosen; Fiscal Year: 2007
    ..Central to the research education component will be paired mentorship with a senior neuroimaging researcher, and opportunities for extended stays to engage in hands-on research experiences. ..
  7. PERFUSION IMAGING WITH MAGNETIC RESONANCE
    Bruce Rosen; Fiscal Year: 2009
    ....
  8. PERFUSION IMAGING WITH MAGNETIC RESONANCE
    Bruce Rosen; Fiscal Year: 2009
    ....
  9. PERFUSION IMAGING WITH MAGNETIC RESONANCE
    Bruce Rosen; Fiscal Year: 2002
    ..abstract_text> ..
  10. Cholinergic Enhancement of Human Cortical Plasticity
    Bruce Rosen; Fiscal Year: 2003
    ..If the novel method of enhancing plasticity that is proposed here should turn out to be successful, then there could be a wide range of potential clinical and practical applications. ..
  11. CENTER FOR FUNCTIONAL IMAGING TECHNOLOGIES
    Bruce Rosen; Fiscal Year: 2003
    ..The Regional Resource will provide training for students, fellows and staff scientists, and will advance the field of functional imaging through active dissemination of new technologies and results. ..
  12. Cyclotron and Radiochemistry
    Bruce Rosen; Fiscal Year: 2004
    ....
  13. A Siemens MAGNETOTOM Trio 3 Tesla MRI System
    Bruce Rosen; Fiscal Year: 2006
    ..This badly needed shared instrument will enhance the imaging activities of the many PHS supported research programs at the Martinos Center. ..
  14. CENTER FOR FUNCTIONAL IMAGING TECHNOLOGIES
    Bruce R Rosen; Fiscal Year: 2010
    ..Ultimately, this work may thus facilitate the development of new therapeutic advances for an astounding array of neurological and psychiatric diseases. ..