HERMINIA DIANA ROSAS

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Alterations in brain transition metals in Huntington disease: an evolving and intricate story
    H Diana Rosas
    Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
    Arch Neurol 69:887-93. 2012
  2. ncbi request reprint Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 21:1317-25. 2006
  3. pmc Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Ann N Y Acad Sci 1147:196-205. 2008
  4. ncbi request reprint Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
    H D Rosas
    Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:745-7. 2005
  5. pmc Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 49:2995-3004. 2010
  6. pmc Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease
    H D Rosas
    Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    NeuroRx 1:263-72. 2004
  7. ncbi request reprint Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Neurology 60:1615-20. 2003
  8. ncbi request reprint Regional and progressive thinning of the cortical ribbon in Huntington's disease
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 02129 4404, USA
    Neurology 58:695-701. 2002
  9. ncbi request reprint Striatal volume loss in HD as measured by MRI and the influence of CAG repeat
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School 02114, USA
    Neurology 57:1025-8. 2001
  10. pmc A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI study
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Mov Disord 26:1691-7. 2011

Research Grants

  1. Huntington's Disease:Morphometry, Chemistry & Cognition
    HERMINIA ROSAS; Fiscal Year: 2002
  2. Prospective Neuroimaging in Huntington's Disease
    HERMINIA ROSAS; Fiscal Year: 2007
  3. Prospective Neuroimaging in Huntington's Disease
    HERMINIA ROSAS; Fiscal Year: 2009
  4. Prospective Neuroimaging in Huntington's Disease
    HERMINIA DIANA ROSAS; Fiscal Year: 2010

Detail Information

Publications19

  1. pmc Alterations in brain transition metals in Huntington disease: an evolving and intricate story
    H Diana Rosas
    Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
    Arch Neurol 69:887-93. 2012
    ..Aberrant accumulation of transition metals in the brain may have an early and important role in the pathogenesis of several neurodegenerative disorders, including Huntington disease (HD)...
  2. ncbi request reprint Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 21:1317-25. 2006
    ....
  3. pmc Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Ann N Y Acad Sci 1147:196-205. 2008
    ..Understanding changes in brain morphometry and their relationship to clinical symptoms may provide important and new insights into basic pathophysiological mechanisms at play in the disease...
  4. ncbi request reprint Regional cortical thinning in preclinical Huntington disease and its relationship to cognition
    H D Rosas
    Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:745-7. 2005
    ..They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD...
  5. pmc Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 49:2995-3004. 2010
    ..Our findings provide evidence for early degeneration of commissural pyramidal neurons in the neocortex, loss of cortico-cortical connectivity, and functional compromise of associative cortical processing...
  6. pmc Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's disease
    H D Rosas
    Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    NeuroRx 1:263-72. 2004
    ..Following is a review of the literature, which highlights the studies that have been published to date...
  7. ncbi request reprint Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Neurology 60:1615-20. 2003
    ....
  8. ncbi request reprint Regional and progressive thinning of the cortical ribbon in Huntington's disease
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 02129 4404, USA
    Neurology 58:695-701. 2002
    ....
  9. ncbi request reprint Striatal volume loss in HD as measured by MRI and the influence of CAG repeat
    H D Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School 02114, USA
    Neurology 57:1025-8. 2001
    ..Progressive degeneration of the striatum is the pathologic hallmark of the disease. Little is known about the regional selectivity of the neurodegeneration and its relationship to the genetic expansion...
  10. pmc A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI study
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Mov Disord 26:1691-7. 2011
    ..These findings suggest that other genetic, epigenetic, and environmental factors play important roles in neurodegeneration in Huntington's disease...
  11. pmc Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity
    H Diana Rosas
    Center for Neuro imaging of Aging and Neurodegenerative Diseases, 149 13th Street Room 2275, Charlestown, MA 02129, USA
    Brain 131:1057-68. 2008
    ....
  12. pmc Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrast
    D H Salat
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
    Neuroimage 48:21-8. 2009
    ..These results demonstrate that there are strong regional changes in neural tissue properties with aging and tissue intensity measures may serve as an important biomarker of degeneration...
  13. pmc White matter pathology isolates the hippocampal formation in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
    Neurobiol Aging 31:244-56. 2010
    ..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways...
  14. ncbi request reprint Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG
    S M Hersch
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neurology 66:250-2. 2006
    ..Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment...
  15. ncbi request reprint Age-related changes in prefrontal white matter measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
    Ann N Y Acad Sci 1064:37-49. 2005
    ..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures...
  16. ncbi request reprint An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques
    B G Jenkins
    Department of Radiology, Massachusetts General Hospital NMR Center, Charlestown, USA
    Ann N Y Acad Sci 893:214-42. 1999
    ..The consequences of oxidative stress and/or mitochondrial dysfunction are explored in the context of the various parameters that can be measured using the integrated MR exam...
  17. ncbi request reprint Neurocognitive effects of chronic lead intoxication in Andean children
    S A Counter
    Department of Neurology Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
    J Neurol Sci 160:47-53. 1998
    ..The results demonstrate a range of neurological responses in children with chronically elevated PbB levels from apparent exceptional neuro-physiological tolerance of PbB intoxication, to some fine motor and cognitive deficits...
  18. pmc Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Charlestown, MA 02129 2060, USA
    Neuroimage 54:1795-802. 2011
    ..Such changes are associated with traditional imaging metrics of degeneration and may provide a unique biomarker of the tissue loss that occurs as a result of AD...
  19. pmc Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease
    F Borovecki
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Center for Interdisciplinary Informatics, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:11023-8. 2005
    ..These alterations in mRNA expression correlate with disease progression and response to experimental treatment. Such markers may provide clues to the state of HD and may be of predictive value in clinical trials...

Research Grants8

  1. Huntington's Disease:Morphometry, Chemistry & Cognition
    HERMINIA ROSAS; Fiscal Year: 2002
    ..This work will advance our understanding of the functional consequences of the genetic mutation in HD and may lead to improvements in monitoring and treating the disease. ..
  2. Prospective Neuroimaging in Huntington's Disease
    HERMINIA ROSAS; Fiscal Year: 2007
    ..abstract_text> ..
  3. Prospective Neuroimaging in Huntington's Disease
    HERMINIA ROSAS; Fiscal Year: 2009
    ..Even without efficacy, we will learn how regional brain involvement underlies the complex symptomatology and course of HD. ..
  4. Prospective Neuroimaging in Huntington's Disease
    HERMINIA DIANA ROSAS; Fiscal Year: 2010
    ..Even without efficacy, we will learn how regional brain involvement underlies the complex symptomatology and course of HD. ..