Research Topics
| HERMINIA DIANA ROSASSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Alterations in brain transition metals in Huntington disease: an evolving and intricate storyH Diana Rosas
Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, 02129, USA
Arch Neurol 69:887-93. 2012..Aberrant accumulation of transition metals in the brain may have an early and important role in the pathogenesis of several neurodegenerative disorders, including Huntington disease (HD)...- Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measuresH Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Mov Disord 21:1317-25. 2006.... 
Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?H Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Ann N Y Acad Sci 1147:196-205. 2008..Understanding changes in brain morphometry and their relationship to clinical symptoms may provide important and new insights into basic pathophysiological mechanisms at play in the disease...- Regional cortical thinning in preclinical Huntington disease and its relationship to cognitionH D Rosas
Department of Neurology, Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 65:745-7. 2005..They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD... 
Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"H Diana Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 49:2995-3004. 2010..Our findings provide evidence for early degeneration of commissural pyramidal neurons in the neocortex, loss of cortico-cortical connectivity, and functional compromise of associative cortical processing...- Using advances in neuroimaging to detect, understand, and monitor disease progression in Huntington's diseaseH D Rosas
Center for Neuroimaging of Aging and Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
NeuroRx 1:263-72. 2004..Following is a review of the literature, which highlights the studies that have been published to date... - Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysisH D Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Neurology 60:1615-20. 2003.... - Regional and progressive thinning of the cortical ribbon in Huntington's diseaseH D Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 02129 4404, USA
Neurology 58:695-701. 2002.... - Striatal volume loss in HD as measured by MRI and the influence of CAG repeatH D Rosas
Department of Neurology, Massachusetts General Hospital and Harvard Medical School 02114, USA
Neurology 57:1025-8. 2001..Progressive degeneration of the striatum is the pathologic hallmark of the disease. Little is known about the regional selectivity of the neurodegeneration and its relationship to the genetic expansion... - A tale of two factors: what determines the rate of progression in Huntington's disease? A longitudinal MRI studyH Diana Rosas
Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Mov Disord 26:1691-7. 2011..These findings suggest that other genetic, epigenetic, and environmental factors play important roles in neurodegeneration in Huntington's disease... - Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneityH Diana Rosas
Center for Neuro imaging of Aging and Neurodegenerative Diseases, 149 13th Street Room 2275, Charlestown, MA 02129, USA
Brain 131:1057-68. 2008.... - Age-associated alterations in cortical gray and white matter signal intensity and gray to white matter contrastD H Salat
Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
Neuroimage 48:21-8. 2009..These results demonstrate that there are strong regional changes in neural tissue properties with aging and tissue intensity measures may serve as an important biomarker of degeneration... - White matter pathology isolates the hippocampal formation in Alzheimer's diseaseD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
Neurobiol Aging 31:244-56. 2010..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways... - Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dGS M Hersch
Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
Neurology 66:250-2. 2006..Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment... - Age-related changes in prefrontal white matter measured by diffusion tensor imagingD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
Ann N Y Acad Sci 1064:37-49. 2005..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures... - An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniquesB G Jenkins
Department of Radiology, Massachusetts General Hospital NMR Center, Charlestown, USA
Ann N Y Acad Sci 893:214-42. 1999..The consequences of oxidative stress and/or mitochondrial dysfunction are explored in the context of the various parameters that can be measured using the integrated MR exam... - Neurocognitive effects of chronic lead intoxication in Andean childrenS A Counter
Department of Neurology Biological Laboratories, Harvard University, Cambridge, MA 02138, USA
J Neurol Sci 160:47-53. 1998..The results demonstrate a range of neurological responses in children with chronically elevated PbB levels from apparent exceptional neuro-physiological tolerance of PbB intoxication, to some fine motor and cognitive deficits... - Hippocampal degeneration is associated with temporal and limbic gray matter/white matter tissue contrast in Alzheimer's diseaseD H Salat
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Charlestown, MA 02129 2060, USA
Neuroimage 54:1795-802. 2011..Such changes are associated with traditional imaging metrics of degeneration and may provide a unique biomarker of the tissue loss that occurs as a result of AD... - Genome-wide expression profiling of human blood reveals biomarkers for Huntington's diseaseF Borovecki
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Center for Interdisciplinary Informatics, MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:11023-8. 2005..These alterations in mRNA expression correlate with disease progression and response to experimental treatment. Such markers may provide clues to the state of HD and may be of predictive value in clinical trials...
Research Grants
- Huntington's Disease:Morphometry, Chemistry & CognitionHERMINIA ROSAS; Fiscal Year: 2002..This work will advance our understanding of the functional consequences of the genetic mutation in HD and may lead to improvements in monitoring and treating the disease. ..
- Prospective Neuroimaging in Huntington's DiseaseHERMINIA ROSAS; Fiscal Year: 2007..abstract_text> ..
- Prospective Neuroimaging in Huntington's DiseaseHERMINIA ROSAS; Fiscal Year: 2009..Even without efficacy, we will learn how regional brain involvement underlies the complex symptomatology and course of HD. ..
- Prospective Neuroimaging in Huntington's DiseaseHERMINIA DIANA ROSAS; Fiscal Year: 2010..Even without efficacy, we will learn how regional brain involvement underlies the complex symptomatology and course of HD. ..