Genomes and Genes
Affiliation: Harvard University
- Polymerization of Ftsz, a bacterial homolog of tubulin. is assembly cooperative?L Romberg
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 276:11743-53. 2001..It predicts that unlike microtubules, FtsZ protofilaments consist of GTP-bound FtsZ subunits that hydrolyze their nucleotide only slowly and are connected by high affinity longitudinal bonds with a nanomolar K(D)...
- Assembly dynamics of the bacterial cell division protein FTSZ: poised at the edge of stabilityLaura Romberg
Institute for Cellular and Chemical Biology, Harvard Medical School, SGM 604, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
Annu Rev Microbiol 57:125-54. 2003..Thus, regulatory proteins that modulate FtsZ's assembly dynamics can cause the ring to rapidly remodel in response to developmental and environmental cues...
- Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethalityDanielle N Margalit
Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:11821-6. 2004..Our results illustrate the utility of small-molecule chemical probes to study FtsZ polymerization dynamics and the feasibility of FtsZ as a novel therapeutic target...
- Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell divisionLaura Romberg
Department of Cell Biology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA
Biochemistry 43:282-8. 2004..These results clarify previously conflicting results in the literature and suggest that pure FtsZ polymers, unlike microtubules, may not be able to undergo dynamic instability or to store energy in the polymer for force production...