Barrett Rollins

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint CCL2 (monocyte chemoattractant protein-1) and cancer
    Ilaria Conti
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Semin Cancer Biol 14:149-54. 2004
  2. ncbi request reprint Chemokine-based pathogenetic mechanisms in cancer
    Ilaria Conti
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02116, USA
    Novartis Found Symp 256:29-41; discussion 41-52, 266-9. 2004
  3. ncbi request reprint Inflammatory chemokines in cancer growth and progression
    Barrett J Rollins
    Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Eur J Cancer 42:760-7. 2006
  4. pmc Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
    Laura L Koth
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Respir Res 5:12. 2004
  5. pmc MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma
    Aldo M Roccaro
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Blood 113:6669-80. 2009
  6. pmc RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute, Massachusetts General Hospital, Harvard Medical School, 44 Binney Street, Boston, MA, USA
    Blood 114:619-29. 2009
  7. pmc CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 113:4341-51. 2009
  8. pmc Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?
    Barbara A Degar
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dis Model Mech 2:436-9. 2009
  9. ncbi request reprint Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies
    Christine Daly
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Microcirculation 10:247-57. 2003
  10. ncbi request reprint DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras
    Kenzo Soejima
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 22:4723-33. 2003

Research Grants

Collaborators

  • Aldo M Roccaro
  • Teru Hideshima
  • Karl Munger
  • JAMES RHEINWALD
  • Thomas E Witzig
  • Raina Fichorova
  • D Ribatti
  • Israel Charo
  • Lieping Chen
  • Nikolaos Frangogiannis
  • Richard Ransohoff
  • MEENHARD I HERLYN
  • Abdel Kareem Azab
  • Ilaria Conti
  • Kenneth C Anderson
  • Irene M Ghobrial
  • Molly R Melhem
  • Charles P Lin
  • Barbara A Degar
  • Judith M Runnels
  • Feda Azab
  • Antonio Sacco
  • Hai T Ngo
  • Xiaoying Jia
  • Oliver Dewald
  • Tianqian Zhang
  • Ahalia M Ferreira
  • Laura L Koth
  • Kenzo Soejima
  • Iris Lee
  • William A Kuziel
  • William J H Kim
  • Christine Daly
  • Kerstin Kleine-Lowinski
  • Jayakrishna Ambati
  • DeRen Huang
  • Mena Farag
  • Nicholas Burwick
  • Andrew L Kung
  • Alicia L Carlson
  • Nikhil C Munshi
  • Anne Sophie Moreau
  • Renee Wright
  • Xavier Leleu
  • Costas Pitsillides
  • Beatriz Ospina
  • Simona Blotta
  • Clemens Alt
  • Costas M Pitsillides
  • Brian Thompson
  • Pawel Zymek
  • Tareq Abou-Khamis
  • Guofeng Ren
  • Dorothee Herlyn
  • DuPont Guerry
  • Emma Furth
  • Laura Caputo
  • Klara Berencsi
  • Kim Winkelmann
  • Anna Koerting
  • Phyllis Gimotty
  • Lloyd H Michael
  • Aime L Burns
  • Rolf Swoboda
  • Mark L Entman
  • Mary Putt
  • Pyapalli Rani
  • Xiaofeng Zhu
  • Luisa A DiPietro
  • Rajasekharan Somasundaram
  • Douglas E Faunce
  • Madeleine W Rodriguez
  • Xiaozhu Huang
  • David J Erle
  • Salina Chan
  • Xin Liu Bernstein
  • Christine Dube
  • Igor Chereshnev
  • Akshay Anand
  • Mihaela Gazdoiu
  • Rongxiang Han
  • Christine M Daly
  • Bert C Lynn
  • Qunrui Ye
  • Liqing Wang
  • Martin E Dorf
  • Balamurali K Ambati
  • Eiji Sakurai
  • Wayne W Hancock
  • John Basile

Detail Information

Publications18

  1. ncbi request reprint CCL2 (monocyte chemoattractant protein-1) and cancer
    Ilaria Conti
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Semin Cancer Biol 14:149-54. 2004
    ..These have been documented in animal models and clinical epidemiological studies. If CCL2's protumorigenic activities can be validated, then CCL2 and its receptor CCR2 may be therapeutic targets in cancer...
  2. ncbi request reprint Chemokine-based pathogenetic mechanisms in cancer
    Ilaria Conti
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02116, USA
    Novartis Found Symp 256:29-41; discussion 41-52, 266-9. 2004
    ..Together, these observations suggest that therapies directed against chemokine ligands or receptors may be beneficial in cancer...
  3. ncbi request reprint Inflammatory chemokines in cancer growth and progression
    Barrett J Rollins
    Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Eur J Cancer 42:760-7. 2006
    ..By either mechanism, tumour cells that secrete and/or respond to chemokines would have a selective advantage. This provides another example of cancer's ability to co-opt host systems in order to promote tumour progression...
  4. pmc Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2
    Laura L Koth
    Lung Biology Center, Department of Medicine, University of California, San Francisco, California, USA
    Respir Res 5:12. 2004
    ..Furthermore, MCP-1-deficient mice have not previously been studied in models of experimental allergic asthma...
  5. pmc MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma
    Aldo M Roccaro
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Blood 113:6669-80. 2009
    ..These data indicate that microRNAs play a pivotal role in the biology of MM and represent important targets for novel therapies in MM...
  6. pmc RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute, Massachusetts General Hospital, Harvard Medical School, 44 Binney Street, Boston, MA, USA
    Blood 114:619-29. 2009
    ..In conclusion, we characterized the role of RhoA and Rac1 GTPases in SDF1-induced adhesion, chemotaxis, and homing of MM cells to the BM, providing the framework for targeting RhoA and Rac1 GTPases as novel MM therapy...
  7. pmc CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    Abdel Kareem Azab
    Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 113:4341-51. 2009
    ..These experiments provide a proof of concept for the use of agents that disrupt interaction with the microenvironment for enhancement of efficacy of cytotoxic agents in cancer therapy...
  8. pmc Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one?
    Barbara A Degar
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dis Model Mech 2:436-9. 2009
    ..Still, some of the phenotypic abnormalities in adhesion molecule or chemokine receptor expression might be modeled with sufficient precision to allow the testing of novel therapies...
  9. ncbi request reprint Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies
    Christine Daly
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Microcirculation 10:247-57. 2003
    ..This presents both a challenge and an opportunity for targeting the MCP-1/CCL2/CCR2 axis in disease...
  10. ncbi request reprint DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras
    Kenzo Soejima
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 22:4723-33. 2003
    ..Regardless of mechanism, our data indicate that DNMT3b plays an important role in transformation...
  11. ncbi request reprint Selective suppression of monocyte chemoattractant protein-1 expression by human papillomavirus E6 and E7 oncoproteins in human cervical epithelial and epidermal cells
    Kerstin Kleine-Lowinski
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Int J Cancer 107:407-15. 2003
    ..These observations are consistent with a model in which MCP-1 expression by infected keratinocytes, which would stimulate an immune attack on HPV-transformed cells, is suppressed for invasive cervical cancer to appear...
  12. ncbi request reprint Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism
    Iris Lee
    Department of Pathology and Laboratory Medicine, Joseph Stokes, Jr, Research Institute and Biesecker Pediatric Liver Center, Children s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 171:6929-35. 2003
    ....
  13. ncbi request reprint MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injury
    William J H Kim
    The Zena and Michael A Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA
    Biochem Biophys Res Commun 310:936-42. 2003
    ..These data suggest that MCP-1 and CCR2 deficiencies have distinct effects on arterial injury. The effects of MCP-1 on intimal hyperplasia may be mediated largely through SMC migration...
  14. ncbi request reprint CXC chemokine ligand 12 (stromal cell-derived factor 1 alpha) and CXCR4-dependent migration of CTLs toward melanoma cells in organotypic culture
    Tianqian Zhang
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 174:5856-63. 2005
    ....
  15. ncbi request reprint The effect of MCP-1 depletion on chemokine and chemokine-related gene expression: evidence for a complex network in acute inflammation
    Ahalia M Ferreira
    Burn and Shock Trauma Institute, Department of Surgery, Loyola Medical Center, Maywood, IL 60153, USA
    Cytokine 30:64-71. 2005
    ..The data suggest that loss of a single chemokine perturbs the chemokine network not only in the setting of acute inflammation but even in an isolated inflammatory cell, the macrophage...
  16. ncbi request reprint CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts
    Oliver Dewald
    Section of Cardiovascular Sciences, DeBakey Heart Center, Baylor College of Medicine, and The Methodist Hospital, Houston, Tex 77030, USA
    Circ Res 96:881-9. 2005
    ..Absence of MCP-1 results in attenuated post-infarction left ventricular remodeling, at the expense of a prolonged inflammatory phase and delayed replacement of injured cardiomyocytes with granulation tissue...
  17. ncbi request reprint An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
    Jayakrishna Ambati
    Department of Ophthalmology, University of Kentucky, 740 South Limestone Street, Lexington, Kentucky 40536 0284, USA
    Nat Med 9:1390-7. 2003
    ..These models implicate macrophage dysfunction in AMD pathogenesis and may be useful as a platform for validating therapies...
  18. ncbi request reprint Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice
    DeRen Huang
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 22:10633-42. 2002
    ..These studies characterize a novel model of reversible inflammatory encephalopathy that is dependent on both genetic and environmental factors...

Research Grants28

  1. CYCLIN C ASSOCIATED PROTEINS IN LUNG CANCER
    Barrett Rollins; Fiscal Year: 2001
    ..To test these hypotheses, it is proposed to: (a) identify cyclin C associated proteins; (b) examine cyclin C's association with p130; and (c) test activities of cyclin C associated proteins. ..
  2. Human Subjects Research Protections Outreach Project
    Barrett Rollins; Fiscal Year: 2003
    ..We expect that this approach will provide a model whereby other Comprehensive Cancer Centers can extend their systems and expertise to smaller affiliated institutions. ..
  3. 2004 Gordon Research Conference on Chemotactic Cytokines
    Barrett Rollins; Fiscal Year: 2004
    ..The conference is also intended to expose students, postdoctoral fellows, and other trainees to leading scientists. Support is requested to help cover the travel and registration costs at the European venue. ..
  4. FUNCTIONAL ANALYSIS OF A PDGF INDUCIBLE CYTOKINE
    Barrett Rollins; Fiscal Year: 2005
    ..Other receptors will be tested for their ability to effect Th2 polarization by MCP- 1, and another CCR2 ligand, MCP-3, will be knocked into the MCP-1 locus to test whether MCP-1 is specifically required. ..
  5. Molecular Pathobiology of Langerhans Cell Histiocytosis
    Barrett Rollins; Fiscal Year: 2007
    ..Attempts will be made to immortalize LCs and PLCs by genetic manipulation so that the genes discovered in Specific Aims 1, 2, and 3 can be tested for their relevance to disease. ..
  6. FUNCTIONAL ANALYSIS OF A PDGF-INDUCIBLE CYTOKINE
    Barrett Rollins; Fiscal Year: 1993
    ..In addition to the potential for revealing new activities for JE, this model will also provide in vivo confirmation of JE's effects on monocute physiology. ..
  7. FUNCTIONAL ANALYSIS OF A PDGF-INDUCIBLE CYTOKINE
    Barrett Rollins; Fiscal Year: 2000
    ..Instead, transgenic mice expressing dominant suppressor chemokine variants will be constructed. Their mating will produce mice multiple simultaneous disruption of several chemokines. ..
  8. Fortieth Annual Meeting of the Society for Leukocyte Biology
    Barrett Rollins; Fiscal Year: 2007
    ..To provide opportunities for women, underrepresented minorities, and persons with disabilities to participate in a meeting that showcases their results and facilitates interactions with other scientists in their fields. ..