Research Topics
Species | Simon RobsonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
CD39 and control of cellular immune responsesKaren M Dwyer
Immunology Research Centre, St Vincent s Health, Melbourne, Australia
Purinergic Signal 3:171-80. 2007..Our findings also suggest novel therapeutic strategies for immune-mediated diseases...
Factors in xenograft rejectionS C Robson
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Ann N Y Acad Sci 875:261-76. 1999....- Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantationSimon C Robson
Vascular Biology and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Research North, 99 Brookline Avenue, Boston, MA 02215, USA
Semin Thromb Hemost 31:217-33. 2005..Administration of soluble CD39 or targeted expression may have future therapeutic application in transplantation-associated and other vascular diseases... - Hepatic colorectal cancer metastases: imaging initial steps of formation in miceJonathan B Kruskal
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, West Clinical Center CC302B, 1 Deaconess Rd, Boston, MA 02215, USA
Radiology 243:703-11. 2007..To prospectively use optical imaging to study the cell-specific mechanisms of entrapment and subsequent growth of two human colon cancer cell lines differing in their propensity to form hepatic metastases... - ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell functionHolger K Eltzschig
Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Germany
Circ Res 99:1100-8. 2006..01). Taken together, our results identify a previously unappreciated role for Cx43 in activated PMN ATP release, therein contributing to the innate metabolic control of the inflammatory milieu... - Upregulation of CD39/NTPDases and P2 receptors in human pancreatic diseaseBeat M Künzli
Liver and Transplantation Centers, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, 02215, USA
Am J Physiol Gastrointest Liver Physiol 292:G223-30. 2007..Our data suggest distinct roles for CD39 and P2-purinergic signaling in both tissue remodeling and fibrogenesis with respect to human pancreatic diseases... - Reconstitution of CD39 in liposomes amplifies nucleoside triphosphate diphosphohydrolase activity and restores thromboregulatory propertiesCarolyn A Haller
Department of Surgery, Emory University, Atlanta, GA 30322, USA
J Vasc Surg 43:816-23. 2006..Treatment with CD39 in liposomal formulations decreased mortality in a murine model of thromboplastin-induced thromboembolism by limiting intravascular platelet aggregation and thrombosis... - Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targetsBen Atkinson
Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Blood Cells Mol Dis 36:217-22. 2006..Future clinical applications will involve the development of new therapeutic strategies to various inflammatory vascular diseases and in transplantation... - Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferationSantosh K Mishra
Biocenter, J.W. Goethe-University, AK Neurochemistry, Frankfurt am Main, Germany
Development 133:675-84. 2006..Together with the in situ data, this supports the notion that extracellular nucleotides contribute to the control of adult neurogenesis... - alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 monthsYau-Lin Tseng
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Transplantation 80:1493-500. 2005..However, function of a pig organ in a baboon for a period approaching six months, which has not been reported previously, lends encouragement that the barriers to xenotransplantation will eventually be overcome... - Recipient levels and function of von Willebrand factor prior to liver transplantation and its consumption in the course of grafting correlate with hepatocellular damage and outcomeJan Schulte Am Esch
Department of General Surgery, Heinrich Heine University, Duesseldorf, Germany
Transpl Int 18:1258-65. 2005..In summary, these data suggest that vWF may serve as a significant mediator of platelet recruitment and hepatocellular injury in the graft following reperfusion... - Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenograftsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA
J Am Soc Nephrol 16:2732-45. 2005..Also, anti-alphaGal IgM deposition and subsequent complement activation play an important role in the mechanism of glomerular endothelial injury and activation and the formation of multiple microthrombi... - The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migrationKatrin Färber
Cellular Neuroscience, Max Delbruck Center for Molecular Medicine, Berlin, Germany
Glia 56:331-41. 2008..We conclude that the co-stimulation of purinergic and adenosine receptors is a requirement for microglial migration and that the expression of cd39 controls the ATP/adenosine balance... - Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injuryAlmut Grenz
Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany
FASEB J 21:2863-73. 2007..Moreover, the present studies suggest apyrase treatment as a novel pharmacological approach to renal diseases precipitated by limited oxygen availability... - The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathyDavid J Friedman
Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 56:2371-9. 2007..We conclude that ENTPD1 is a vascular protective factor in diabetic nephropathy that modulates glomerular inflammation and thromboregulation... - Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitisGuido Beldi
Liver and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Hepatology 48:841-52. 2008..Deletion of CD39 is protective in [corrected] Con A-induced hepatitis. This study illustrates a [corrected] role for purinergic signaling in NKT-mediated mechanisms that result in liver immune injury... - Deletion of cd39/entpd1 results in hepatic insulin resistanceKeiichi Enjyoji
Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 57:2311-20. 2008..CD39/ENTPD1 is the dominant vascular and immune cell ectoenzyme that hydrolyzes extracellular nucleotides to regulate purinergic signaling... - Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboonsAkira Shimizu
Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
Am J Pathol 172:1471-81. 2008.... - The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cellsZoltan Derdak
Division of Gastroenterology and Liver Research Center, Brown Medical School and Rhode Island Hospital, Providence, Rhode Island, USA
Cancer Res 68:2813-9. 2008..These findings link UCP2 with molecular mechanisms of chemoresistance. Targeting UCP2 may be considered a novel treatment strategy for cancer... 
Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient miceMona Oppermann
National Institute of Digestive and Diabetes and Kidney Diseases, National Institute of Health, 10 Center Drive MSC 1370, Bethesda, MD 20892, USA
Am J Physiol Renal Physiol 294:F965-70. 2008....- Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null miceBeat M Künzli
Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, USA
Gastroenterology 134:292-305. 2008..Because the role of extracellular nucleotides and CD39 in mediating inflammation and fibrosis are understood poorly, we studied the impact of CD39 gene deletion in a model of pancreatic disease... - The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolismGuido Beldi
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA
Front Biosci 13:2588-603. 2008.... - CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injuryDavid Kohler
Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tubingen, Germany
Circulation 116:1784-94. 2007..In the present study, we studied ecto-enzymatic ATP/ADP-phosphohydrolysis by select members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family during myocardial ischemia... - Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null miceShaun W Jackson
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Am J Pathol 171:1395-404. 2007..Our data indicate novel links between CD39/ENTPD1, extracellular nucleotide-mediated signaling, and vascular endothelial cell integrin function that impact on angiogenesis and tumor growth... - GalT-KO pigs: is the cup half empty or half full?David H Sachs
Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA
Transplantation 84:12-4. 2007 - Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppressionSilvia Deaglio
Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Exp Med 204:1257-65. 2007..We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation... - Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathwaysElzbieta Kaczmarek
Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
Thromb Haemost 93:735-42. 2005..We propose that P2Y2 and possibly P2Y4 receptors mediate those responses that are important in vascular inflammation, atherosclerosis and angiogenesis... - Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signalingBellamkonda K Kishore
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
Am J Physiol Renal Physiol 288:F1032-43. 2005..NTPDases may modulate regulatory effects of ATP and degradation products within the vasculature and other sites and thereby potentially influence physiological as well as multiple pathological events in the kidney... - CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsivenessNorikatsu Mizumoto
Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Nat Med 8:358-65. 2002.... - Relative effects of GAL+ and GALlow/- porcine hematopoietic cells on primate platelet aggregation and endothelial cell activation: implications for the induction of mixed hematopoietic chimerism in the pig-to-primate modelChristoph Knosalla
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
Xenotransplantation 11:72-7. 2004..The induction of tolerance through mixed hematopoietic cell chimerism may be facilitated when alpha-galactosyltransferase-knockout pigs become available... - Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cellsJonathan A Dranoff
Yale Univ School of Medicine, Section of Digestive Diseases, 333 Cedar St LMP 1080, New Haven, CT 06520, USA
Am J Physiol Gastrointest Liver Physiol 287:G417-24. 2004..Because activation of P2Y receptors in activated HSC regulates procollagen-1 transcription, P2Y receptors may be an attractive target to prevent or treat liver fibrosis... - Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous systemNorbert Braun
Biozentrum der J W Goethe Universitaet, AK Neurochemie, Zoologisches Institut, Marie Curie Strasse 9, D 60439 Frankfurt am Main, Germany
Glia 45:124-32. 2004..Our results suggest that NTPDase2 plays an important role in the control of nucleotide-mediated activation of peripheral neurons or glia and in the dialogue between these two cell types... - Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboonsChristoph Knosalla
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Am J Transplant 3:1510-9. 2003..Noninvasive parameters were identified that have predictive potential for AHXR. Monitoring of these might enable therapeutic intervention to reverse rejection... - Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptorsHolger K Eltzschig
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Exp Med 198:783-96. 2003..Taken together, these results demonstrate transcription coordination of adenine nucleotide and nucleoside signaling at the vascular interface during hypoxia... - Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantationBernd Gollackner
Transplantation Biology Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, MA 02114, USA
Transplantation 75:1841-7. 2003..Although the data do not exclude a contributory role of PCMV in CC, other mechanisms are also likely to contribute to coagulopathies observed in pig-to-primate xenotransplantation... - Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injurySteffen Pfeiffer
, , 90471 Nuremberg, Germany
Transplantation 75:953-9. 2003..Inhibiting recruitment of platelets at the site of initial immunologic injury to endothelial cells may protect porcine organs against thrombosis and inflammation during the initial exposure to human blood... - NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: implications for regulation of p2 receptor signalingSrdjan M Vlajkovic
Discipline of Audiology and Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
J Histochem Cytochem 50:1435-42. 2002..This differential expression of NTPDase1 and 2 in the cochlea suggests spatial regulation of P2 receptor signaling, potentially involving different nucleotide species and hydrolysis kinetics... - The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liverJonathan A Dranoff
Yale University School of Medicine and Liver Center, New Haven, CT, USA
Hepatology 36:1135-44. 2002..This distribution may represent a previously unrecognized mechanism for regulation of nucleotide signaling in bile ducts and other epithelia... - Induction of xenograft accommodation by modulation of elicited antibody responses1 2Ning Wang
Immunobiology Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Transplantation 74:334-45. 2002..CONCLUSIONS: Delayed and relatively low levels of XAb IgM promote expression of protective genes in the graft and thereby aid in the progress of accommodation. Expression of HO-1 protects xenoserum-mediated endothelial cell destruction... - Activation of human endothelial cells by mobilized porcine leukocytes in vitro: implications for mixed chimerism in xenotransplantationJames Z Appel
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02215, USA
Transplantation 73:1302-9. 2002..Removal of CD2- cells before the administration of PBPC or the use of agents that interrupt PBPC-endothelial cell interactions may prevent or treat TM in baboons... - Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulationJean Sevigny
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Blood 99:2801-9. 2002..g., P2Y(1), P2Y(3), P2Y(12)) and uridine diphosphate (P2Y(6))... - Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injuryOlaf Guckelberger
Department of Visceral and Transplantation Surgery, Charite Campus Virchow Clinic, Humboldt University, Berlin, Germany
Thromb Haemost 91:576-86. 2004..The potential of NTPDases to maintain vascular integrity suggests potential pharmacological benefit of these agents in mesenteric ischemic injury... - Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary glandAgnes Kittel
Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, 1450 Budapest, Hungary
J Histochem Cytochem 52:861-71. 2004..Because NTPDase1 is expressed in non-vascular cell types, this finding suggests that NTPDase1 may have functions in the gastrointestinal tract that differ from those demonstrated in the vascular system... - Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolismHolger K Eltzschig
Brigham and Women s Hospital, Harvard Medical School, Thorn Building 704, 75 Francis Street, Boston, MA 02115, USA
Blood 104:3986-92. 2004..These findings identify CD39 and CD73 as critical control points for endogenous adenosine generation and implicate this pathway as an innate mechanism to attenuate excessive tissue PMN accumulation... - Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activityBernd Gollackner
Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Transplantation 77:1735-41. 2004.... - Potential target molecules on pig kidneys recognized by naïve and elicited baboon antibodiesBernd Gollackner
Xenotransplantation 11:380-1. 2004 - Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantationKaren M Dwyer
Immunology Research Center and Department of Medicine, St Vincent s Hospital, University of Melbourne, Victoria, Australia
J Clin Invest 113:1440-6. 2004.... - O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptorsJan Schulte Am Esch
Department of General Surgery, Heinrich Heine University Duesseldorf, Germany
Xenotransplantation 12:30-7. 2005..Here, we address the functional impact of O-linked glycosylation of the vWF A1 domain on primate platelet activation... - Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experienceKenji Kuwaki
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, MGH-East, 13th Street, Boston, Massachusetts 02129, USA
Nat Med 11:29-31. 2005..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies... - Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochleaSrdjan M Vlajkovic
Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
Hear Res 170:127-38. 2002.... - C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulationCarol J H Wang
Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Park Road, Grafton, Private Bag 92019, Auckland, New Zealand
Biochem J 385:729-36. 2005..These findings advance the molecular physiology of this enzyme system by characterizing the contribution of the C-terminal domain to many of the enzyme's signature properties... - Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulenceFiona M Sansom
Department of Microbiology and Immunology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
J Biol Chem 283:12909-18. 2008..pneumophila infection. Overall, the kinetic studies undertaken here demonstrated important differences to mammalian NTPDases and different sensitivities to NTPDase inhibitors that may reflect underlying structural variations... - Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampusVarsha Shukla
Biocenter, J W Goethe University, AK Neurochemistry, Frankfurt am Main, Germany
J Neurosci Res 80:600-10. 2005..Our results identify the ecto-nucleotidase NTPDase2 and functional P2X receptors at hippocampal progenitor cells. We infer that signaling pathways via extracellular nucleotides may play a role in the control of hippocampal neurogenesis... - Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injuryYara Banz
Department of Clinical Research, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland
Eur Heart J 26:2334-43. 2005.... - The transgenic expression of human CD39 on murine islets inhibits clotting of human bloodKaren M Dwyer
Immunology Research Centre, St. Vincent's Hospital, Melbourne, Victoria, Australia
Transplantation 82:428-32. 2006..These results suggest that transgenic expression of human CD39 does not interfere with islet function and may be a useful strategy to inhibit thrombosis induced by intraportal administration of islet xenografts... - Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brainNorbert Braun
Biozentrum der J W Goethe Universitaet, AK Neurochemie, Zoologisches Institut, Marie Curie Str 9, D 60439 Frankfurt am Main, Germany
Eur J Neurosci 17:1355-64. 2003.... - Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoeneKatsuhito Teranishi
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, MGH East, Building 149-9019, Boston, MA 02129, USA
Xenotransplantation 10:374-9. 2003..However, it would seem worthy of further investigation when used in combination with other agents... - RanBPM associates with CD39 and modulates ecto-nucleotidase activityYan Wu
Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Biochem J 396:23-30. 2006..We conclude that CD39 associations with RanBPM have the potential to regulate NTPDase catalytic activity. This intermolecular interaction may have important implications for the regulation of extracellular nucleotide-mediated signalling... - Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8François Bigonnesse
Centre de Recherche en Rhumatologie et Immunologie, Universite Laval, Sainte Foy, Quebec, Canada
Biochemistry 43:5511-9. 2004..Enzymatic properties of NTPDase8 differ from those of other NTPDases suggesting an alternative way to modulate nucleotide levels and consequently P2 receptor activation... - Carbon monoxide orchestrates a protective response through PPARgammaMartin Bilban
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Immunity 24:601-10. 2006.... - Overlap between systemic lupus erythematosus and nonalcoholic steatohepatitisWissam Bleibel
J Clin Gastroenterol 40:561-2; author reply 562. 2006 - Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitisPascal O Berberat
Immunobiology Research Center, Department of Surgery, Beth Israel Deconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Inflamm Bowel Dis 11:350-9. 2005..Novel therapeutic strategies based on HO-1 and/or biliverdin administration may have use in inflammatory bowel disease...
Research Grants
- Purinergic ThromboregulationSimon C Robson; Fiscal Year: 2010..d) Study thrombus formation in hyperlipidemic Cd39 mutant mice. This work will provide insights into the central thromboregulatory mechanisms impacting platelet activation and vascular injury in vivo. ..
- Thromboregulatory strategies to prolong xenograft survival.Simon Robson; Fiscal Year: 2007..These studies will be judged successful if novel, clinically relevant antithrombotic therapies can be then developed and applied. ..
- FUNCTIONAL ANALYSIS OF VASCULAR NTPDASESSimon Robson; Fiscal Year: 2007..Information gleaned from these studies may direct new therapeutic strategies for inflammatory vascular disorders, including atherosclerotic cardiovascular disease. ..
- VASCULAR NTPDASES AND TRANSPLANTATIONSimon Robson; Fiscal Year: 2004..These experiments should delineate involvement of NTPDases and P2signaling in inflammation associated with arterial/venous injury and also culminating in allograft failure. ..
- FUNCTIONAL ANALYSIS OF VASCULAR NTPDASESSimon Robson; Fiscal Year: 2003..These experiments should indicate the involvement of the vascular NTPDase/CD39, and also elucidate interactions with NOS systems, in certain vascular inflammatory disorders observed in human disease states. ..