Simon Robson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Factors in xenograft rejection
    S C Robson
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 875:261-76. 1999
  2. pmc CD39 and control of cellular immune responses
    Karen M Dwyer
    Immunology Research Centre, St Vincent s Health, Melbourne, Australia
    Purinergic Signal 3:171-80. 2007
  3. ncbi request reprint Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation
    Simon C Robson
    Vascular Biology and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Research North, 99 Brookline Avenue, Boston, MA 02215, USA
    Semin Thromb Hemost 31:217-33. 2005
  4. ncbi request reprint Hepatic colorectal cancer metastases: imaging initial steps of formation in mice
    Jonathan B Kruskal
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, West Clinical Center CC302B, 1 Deaconess Rd, Boston, MA 02215, USA
    Radiology 243:703-11. 2007
  5. ncbi request reprint ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Germany
    Circ Res 99:1100-8. 2006
  6. ncbi request reprint Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease
    Beat M Künzli
    Liver and Transplantation Centers, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, 02215, USA
    Am J Physiol Gastrointest Liver Physiol 292:G223-30. 2007
  7. ncbi request reprint Reconstitution of CD39 in liposomes amplifies nucleoside triphosphate diphosphohydrolase activity and restores thromboregulatory properties
    Carolyn A Haller
    Department of Surgery, Emory University, Atlanta, GA 30322, USA
    J Vasc Surg 43:816-23. 2006
  8. ncbi request reprint Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets
    Ben Atkinson
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood Cells Mol Dis 36:217-22. 2006
  9. ncbi request reprint Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation
    Santosh K Mishra
    Biocenter, J W Goethe University, AK Neurochemistry, Frankfurt am Main, Germany
    Development 133:675-84. 2006
  10. ncbi request reprint alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months
    Yau Lin Tseng
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 80:1493-500. 2005

Research Grants

  1. Purinergic Thromboregulation
    Simon C Robson; Fiscal Year: 2010
  2. Thromboregulatory strategies to prolong xenograft survival.
    Simon Robson; Fiscal Year: 2007
  3. FUNCTIONAL ANALYSIS OF VASCULAR NTPDASES
    Simon Robson; Fiscal Year: 2007
  4. VASCULAR NTPDASES AND TRANSPLANTATION
    Simon Robson; Fiscal Year: 2004
  5. FUNCTIONAL ANALYSIS OF VASCULAR NTPDASES
    Simon Robson; Fiscal Year: 2003

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Factors in xenograft rejection
    S C Robson
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 875:261-76. 1999
    ....
  2. pmc CD39 and control of cellular immune responses
    Karen M Dwyer
    Immunology Research Centre, St Vincent s Health, Melbourne, Australia
    Purinergic Signal 3:171-80. 2007
    ..Our findings also suggest novel therapeutic strategies for immune-mediated diseases...
  3. ncbi request reprint Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation
    Simon C Robson
    Vascular Biology and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Research North, 99 Brookline Avenue, Boston, MA 02215, USA
    Semin Thromb Hemost 31:217-33. 2005
    ..Administration of soluble CD39 or targeted expression may have future therapeutic application in transplantation-associated and other vascular diseases...
  4. ncbi request reprint Hepatic colorectal cancer metastases: imaging initial steps of formation in mice
    Jonathan B Kruskal
    Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, West Clinical Center CC302B, 1 Deaconess Rd, Boston, MA 02215, USA
    Radiology 243:703-11. 2007
    ..To prospectively use optical imaging to study the cell-specific mechanisms of entrapment and subsequent growth of two human colon cancer cell lines differing in their propensity to form hepatic metastases...
  5. ncbi request reprint ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function
    Holger K Eltzschig
    Department of Anesthesiology and Intensive Care Medicine, Tubingen University Hospital, Germany
    Circ Res 99:1100-8. 2006
    ..01). Taken together, our results identify a previously unappreciated role for Cx43 in activated PMN ATP release, therein contributing to the innate metabolic control of the inflammatory milieu...
  6. ncbi request reprint Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease
    Beat M Künzli
    Liver and Transplantation Centers, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, 02215, USA
    Am J Physiol Gastrointest Liver Physiol 292:G223-30. 2007
    ..Our data suggest distinct roles for CD39 and P2-purinergic signaling in both tissue remodeling and fibrogenesis with respect to human pancreatic diseases...
  7. ncbi request reprint Reconstitution of CD39 in liposomes amplifies nucleoside triphosphate diphosphohydrolase activity and restores thromboregulatory properties
    Carolyn A Haller
    Department of Surgery, Emory University, Atlanta, GA 30322, USA
    J Vasc Surg 43:816-23. 2006
    ..Optimization of CD39 enzymatic activity appears dependent upon the expression of both transmembrane domains within plasma membranes. Thus, motivation exists to examine therapeutic antiplatelet formulations that consist of liposomal CD39...
  8. ncbi request reprint Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets
    Ben Atkinson
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Blood Cells Mol Dis 36:217-22. 2006
    ..Future clinical applications will involve the development of new therapeutic strategies to various inflammatory vascular diseases and in transplantation...
  9. ncbi request reprint Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation
    Santosh K Mishra
    Biocenter, J W Goethe University, AK Neurochemistry, Frankfurt am Main, Germany
    Development 133:675-84. 2006
    ..Together with the in situ data, this supports the notion that extracellular nucleotides contribute to the control of adult neurogenesis...
  10. ncbi request reprint alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months
    Yau Lin Tseng
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Transplantation 80:1493-500. 2005
    ..The recent generation of alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs has allowed investigation of the survival of GalT-KO pig organs in nonhuman primates...
  11. ncbi request reprint Recipient levels and function of von Willebrand factor prior to liver transplantation and its consumption in the course of grafting correlate with hepatocellular damage and outcome
    Jan Schulte Am Esch
    Department of General Surgery, Heinrich Heine University, Duesseldorf, Germany
    Transpl Int 18:1258-65. 2005
    ..In summary, these data suggest that vWF may serve as a significant mediator of platelet recruitment and hepatocellular injury in the graft following reperfusion...
  12. ncbi request reprint Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Am Soc Nephrol 16:2732-45. 2005
    ..Also, anti-alphaGal IgM deposition and subsequent complement activation play an important role in the mechanism of glomerular endothelial injury and activation and the formation of multiple microthrombi...
  13. ncbi request reprint The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration
    Katrin Färber
    Cellular Neuroscience, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Glia 56:331-41. 2008
    ..We conclude that the co-stimulation of purinergic and adenosine receptors is a requirement for microglial migration and that the expression of cd39 controls the ATP/adenosine balance...
  14. ncbi request reprint Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury
    Almut Grenz
    Department of Pharmacology and Toxicology, Tubingen University Hospital, Tubingen, Germany
    FASEB J 21:2863-73. 2007
    ..Moreover, the present studies suggest apyrase treatment as a novel pharmacological approach to renal diseases precipitated by limited oxygen availability...
  15. ncbi request reprint The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy
    David J Friedman
    Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 56:2371-9. 2007
    ..We conclude that ENTPD1 is a vascular protective factor in diabetic nephropathy that modulates glomerular inflammation and thromboregulation...
  16. pmc Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis
    Guido Beldi
    Liver and Transplantation Centers, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hepatology 48:841-52. 2008
    ..Hepatic NKT cells express most P2X and P2Y receptors; exceptions include P2X3 and P2Y11. Heightened levels of apoptosis of CD39 null NKT cells in vivo and in vitro appear to be driven by unimpeded activation of the P2X7 receptor...
  17. pmc Deletion of cd39/entpd1 results in hepatic insulin resistance
    Keiichi Enjyoji
    Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:2311-20. 2008
    ..CD39/ENTPD1 is the dominant vascular and immune cell ectoenzyme that hydrolyzes extracellular nucleotides to regulate purinergic signaling...
  18. pmc Thrombotic microangiopathy associated with humoral rejection of cardiac xenografts from alpha1,3-galactosyltransferase gene-knockout pigs in baboons
    Akira Shimizu
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Am J Pathol 172:1471-81. 2008
    ....
  19. pmc The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells
    Zoltan Derdak
    Division of Gastroenterology and Liver Research Center, Brown Medical School and Rhode Island Hospital, Providence, Rhode Island, USA
    Cancer Res 68:2813-9. 2008
    ..These findings link UCP2 with molecular mechanisms of chemoresistance. Targeting UCP2 may be considered a novel treatment strategy for cancer...
  20. doi request reprint Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice
    Mona Oppermann
    National Institute of Digestive and Diabetes and Kidney Diseases, National Institute of Health, 10 Center Drive MSC 1370, Bethesda, MD 20892, USA
    Am J Physiol Renal Physiol 294:F965-70. 2008
    ....
  21. pmc Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice
    Beat M Künzli
    Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, USA
    Gastroenterology 134:292-305. 2008
    ..Because the role of extracellular nucleotides and CD39 in mediating inflammation and fibrosis are understood poorly, we studied the impact of CD39 gene deletion in a model of pancreatic disease...
  22. pmc The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism
    Guido Beldi
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA 02215, USA
    Front Biosci 13:2588-603. 2008
    ....
  23. ncbi request reprint CD39/ectonucleoside triphosphate diphosphohydrolase 1 provides myocardial protection during cardiac ischemia/reperfusion injury
    David Kohler
    Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tubingen, Germany
    Circulation 116:1784-94. 2007
    ..In the present study, we studied ecto-enzymatic ATP/ADP-phosphohydrolysis by select members of the ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) family during myocardial ischemia...
  24. pmc Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice
    Shaun W Jackson
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Pathol 171:1395-404. 2007
    ..Our data indicate novel links between CD39/ENTPD1, extracellular nucleotide-mediated signaling, and vascular endothelial cell integrin function that impact on angiogenesis and tumor growth...
  25. ncbi request reprint GalT-KO pigs: is the cup half empty or half full?
    David H Sachs
    Transplantation Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Transplantation 84:12-4. 2007
  26. pmc Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    Silvia Deaglio
    Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 204:1257-65. 2007
    ..We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation...
  27. pmc Modulation of endothelial cell migration by extracellular nucleotides: involvement of focal adhesion kinase and phosphatidylinositol 3-kinase-mediated pathways
    Elzbieta Kaczmarek
    Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Thromb Haemost 93:735-42. 2005
    ..We propose that P2Y2 and possibly P2Y4 receptors mediate those responses that are important in vascular inflammation, atherosclerosis and angiogenesis...
  28. ncbi request reprint Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling
    Bellamkonda K Kishore
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Am J Physiol Renal Physiol 288:F1032-43. 2005
    ..NTPDases may modulate regulatory effects of ATP and degradation products within the vasculature and other sites and thereby potentially influence physiological as well as multiple pathological events in the kidney...
  29. ncbi request reprint CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness
    Norikatsu Mizumoto
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Med 8:358-65. 2002
    ....
  30. ncbi request reprint Relative effects of GAL+ and GALlow/- porcine hematopoietic cells on primate platelet aggregation and endothelial cell activation: implications for the induction of mixed hematopoietic chimerism in the pig-to-primate model
    Christoph Knosalla
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Xenotransplantation 11:72-7. 2004
    ....
  31. ncbi request reprint Expression of P2Y nucleotide receptors and ectonucleotidases in quiescent and activated rat hepatic stellate cells
    Jonathan A Dranoff
    Yale Univ School of Medicine, Section of Digestive Diseases, 333 Cedar St LMP 1080, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 287:G417-24. 2004
    ..Because activation of P2Y receptors in activated HSC regulates procollagen-1 transcription, P2Y receptors may be an attractive target to prevent or treat liver fibrosis...
  32. ncbi request reprint Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system
    Norbert Braun
    Biozentrum der J W Goethe Universitaet, AK Neurochemie, Zoologisches Institut, Marie Curie Strasse 9, D 60439 Frankfurt am Main, Germany
    Glia 45:124-32. 2004
    ..Our results suggest that NTPDase2 plays an important role in the control of nucleotide-mediated activation of peripheral neurons or glia and in the dialogue between these two cell types...
  33. ncbi request reprint Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons
    Christoph Knosalla
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Am J Transplant 3:1510-9. 2003
    ..Noninvasive parameters were identified that have predictive potential for AHXR. Monitoring of these might enable therapeutic intervention to reverse rejection...
  34. pmc Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors
    Holger K Eltzschig
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Exp Med 198:783-96. 2003
    ..Taken together, these results demonstrate transcription coordination of adenine nucleotide and nucleoside signaling at the vascular interface during hypoxia...
  35. ncbi request reprint Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation
    Bernd Gollackner
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Transplantation 75:1841-7. 2003
    ..The activation of porcine (P) cytomegalovirus (PCMV) and baboon (B) CMV infections has been documented in pig-to-primate xenotransplantation. The purpose of this study was to determine the contribution of PCMV and BCMV to CC...
  36. ncbi request reprint Hyperacute lung rejection in the pig-to-human model. III. Platelet receptor inhibitors synergistically modulate complement activation and lung injury
    Steffen Pfeiffer
    Zentrum für Herzchirurgie Erlangen Nürnberg, Klinikum Nürnberg Süd, 90471 Nuremberg, Germany
    Transplantation 75:953-9. 2003
    ..The influence of platelet von Willebrand factor (vWF)-glycoprotein (GP)Ib-V-IX and GPIIb-IIIa receptor interactions in the context of hyperacute rejection (HAR) of pulmonary xenografts has not previously been explored...
  37. ncbi request reprint NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: implications for regulation of p2 receptor signaling
    Srdjan M Vlajkovic
    Discipline of Audiology and Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Histochem Cytochem 50:1435-42. 2002
    ..This differential expression of NTPDase1 and 2 in the cochlea suggests spatial regulation of P2 receptor signaling, potentially involving different nucleotide species and hydrolysis kinetics...
  38. ncbi request reprint The ecto-nucleoside triphosphate diphosphohydrolase NTPDase2/CD39L1 is expressed in a novel functional compartment within the liver
    Jonathan A Dranoff
    Yale University School of Medicine and Liver Center, New Haven, CT, USA
    Hepatology 36:1135-44. 2002
    ..This distribution may represent a previously unrecognized mechanism for regulation of nucleotide signaling in bile ducts and other epithelia...
  39. ncbi request reprint Induction of xenograft accommodation by modulation of elicited antibody responses1 2
    Ning Wang
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Transplantation 74:334-45. 2002
    ..This model has been used to test our hypothesis that modulation of XAb responses without perturbation of complement may influence the development of graft accommodation...
  40. ncbi request reprint Activation of human endothelial cells by mobilized porcine leukocytes in vitro: implications for mixed chimerism in xenotransplantation
    James Z Appel
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02215, USA
    Transplantation 73:1302-9. 2002
    ..Because the mechanisms responsible for TM are unclear, we have explored the effects of PBPC on human umbilical vein endothelial cell (HUVEC) activation...
  41. ncbi request reprint Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation
    Jean Sevigny
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Blood 99:2801-9. 2002
    ..g., P2Y(1), P2Y(3), P2Y(12)) and uridine diphosphate (P2Y(6))...
  42. ncbi request reprint Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury
    Olaf Guckelberger
    Department of Visceral and Transplantation Surgery, Charite Campus Virchow Clinic, Humboldt University, Berlin, Germany
    Thromb Haemost 91:576-86. 2004
    ..The potential of NTPDases to maintain vascular integrity suggests potential pharmacological benefit of these agents in mesenteric ischemic injury...
  43. ncbi request reprint Localization of nucleoside triphosphate diphosphohydrolase-1 (NTPDase1) and NTPDase2 in pancreas and salivary gland
    Agnes Kittel
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, PO Box 67, 1450 Budapest, Hungary
    J Histochem Cytochem 52:861-71. 2004
    ..Because NTPDase1 is expressed in non-vascular cell types, this finding suggests that NTPDase1 may have functions in the gastrointestinal tract that differ from those demonstrated in the vascular system...
  44. ncbi request reprint Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism
    Holger K Eltzschig
    Brigham and Women s Hospital, Harvard Medical School, Thorn Building 704, 75 Francis Street, Boston, MA 02115, USA
    Blood 104:3986-92. 2004
    ..These findings identify CD39 and CD73 as critical control points for endogenous adenosine generation and implicate this pathway as an innate mechanism to attenuate excessive tissue PMN accumulation...
  45. ncbi request reprint Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity
    Bernd Gollackner
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Transplantation 77:1735-41. 2004
    ..The aim of this study was to determine associations between humoral responses to the xenograft and the induction of AVR, coagulopathy, or both...
  46. ncbi request reprint Potential target molecules on pig kidneys recognized by naïve and elicited baboon antibodies
    Bernd Gollackner
    Xenotransplantation 11:380-1. 2004
  47. pmc Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
    Karen M Dwyer
    Immunology Research Center and Department of Medicine, St Vincent s Hospital, University of Melbourne, Victoria, Australia
    J Clin Invest 113:1440-6. 2004
    ....
  48. ncbi request reprint O-linked glycosylation and functional incompatibility of porcine von Willebrand factor for human platelet GPIb receptors
    Jan Schulte Am Esch
    Department of General Surgery, Heinrich Heine University Duesseldorf, Germany
    Xenotransplantation 12:30-7. 2005
    ..Here, we address the functional impact of O-linked glycosylation of the vWF A1 domain on primate platelet activation...
  49. ncbi request reprint Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience
    Kenji Kuwaki
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, 13th Street, Boston, Massachusetts 02129, USA
    Nat Med 11:29-31. 2005
    ..There were no infectious complications directly related to the immunosuppressive regimen. The transplantation of hearts from GalT-KO pigs increased graft survival over previous studies...
  50. ncbi request reprint Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea
    Srdjan M Vlajkovic
    Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Hear Res 170:127-38. 2002
    ....
  51. pmc C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation
    Carol J H Wang
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Park Road, Grafton, Private Bag 92019, Auckland, New Zealand
    Biochem J 385:729-36. 2005
    ..These findings advance the molecular physiology of this enzyme system by characterizing the contribution of the C-terminal domain to many of the enzyme's signature properties...
  52. pmc Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence
    Fiona M Sansom
    Department of Microbiology and Immunology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    J Biol Chem 283:12909-18. 2008
    ..pneumophila infection. Overall, the kinetic studies undertaken here demonstrated important differences to mammalian NTPDases and different sensitivities to NTPDase inhibitors that may reflect underlying structural variations...
  53. ncbi request reprint Functional expression of the ecto-ATPase NTPDase2 and of nucleotide receptors by neuronal progenitor cells in the adult murine hippocampus
    Varsha Shukla
    Biocenter, J W Goethe University, AK Neurochemistry, Frankfurt am Main, Germany
    J Neurosci Res 80:600-10. 2005
    ..Our results identify the ecto-nucleotidase NTPDase2 and functional P2X receptors at hippocampal progenitor cells. We infer that signaling pathways via extracellular nucleotides may play a role in the control of hippocampal neurogenesis...
  54. ncbi request reprint Locally targeted cytoprotection with dextran sulfate attenuates experimental porcine myocardial ischaemia/reperfusion injury
    Yara Banz
    Department of Clinical Research, University of Bern, Murtenstrasse 31, 3010 Bern, Switzerland
    Eur Heart J 26:2334-43. 2005
    ..We propose that locally targeted cytoprotection of ischaemic myocardium with the glycosaminoglycan analogue dextran sulfate (DXS, MW 5000) may protect damaged tissue from reperfusion injury by functional restoration of HSPG...
  55. ncbi request reprint The transgenic expression of human CD39 on murine islets inhibits clotting of human blood
    Karen M Dwyer
    Immunology Research Centre, St Vincent s Hospital, Melbourne, Victoria, Australia
    Transplantation 82:428-32. 2006
    ..These results suggest that transgenic expression of human CD39 does not interfere with islet function and may be a useful strategy to inhibit thrombosis induced by intraportal administration of islet xenografts...
  56. ncbi request reprint Expression of the ecto-ATPase NTPDase2 in the germinal zones of the developing and adult rat brain
    Norbert Braun
    Biozentrum der J W Goethe Universitaet, AK Neurochemie, Zoologisches Institut, Marie Curie Str 9, D 60439 Frankfurt am Main, Germany
    Eur J Neurosci 17:1355-64. 2003
    ....
  57. ncbi request reprint Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene
    Katsuhito Teranishi
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, MGH East, Building 149 9019, Boston, MA 02129, USA
    Xenotransplantation 10:374-9. 2003
    ..To assess its potential use in models of xenotransplantation, this agent was tested for its effect on baboon platelet aggregation in vitro and in vivo...
  58. pmc RanBPM associates with CD39 and modulates ecto-nucleotidase activity
    Yan Wu
    Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biochem J 396:23-30. 2006
    ..We conclude that CD39 associations with RanBPM have the potential to regulate NTPDase catalytic activity. This intermolecular interaction may have important implications for the regulation of extracellular nucleotide-mediated signalling...
  59. ncbi request reprint Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8
    François Bigonnesse
    Centre de Recherche en Rhumatologie et Immunologie, Universite Laval, Sainte Foy, Quebec, Canada
    Biochemistry 43:5511-9. 2004
    ..Enzymatic properties of NTPDase8 differ from those of other NTPDases suggesting an alternative way to modulate nucleotide levels and consequently P2 receptor activation...
  60. ncbi request reprint Carbon monoxide orchestrates a protective response through PPARgamma
    Martin Bilban
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 24:601-10. 2006
    ....
  61. ncbi request reprint Overlap between systemic lupus erythematosus and nonalcoholic steatohepatitis
    Wissam Bleibel
    J Clin Gastroenterol 40:561-2; author reply 562. 2006
  62. ncbi request reprint Heme oxygenase-1-generated biliverdin ameliorates experimental murine colitis
    Pascal O Berberat
    Immunobiology Research Center, Department of Surgery, Beth Israel Deconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Inflamm Bowel Dis 11:350-9. 2005
    ..We tested whether HO-1 has protective effects in the development of colitis and determined that specific enzymatic products of HO-1 are responsible for these effects...

Research Grants21

  1. Purinergic Thromboregulation
    Simon C Robson; Fiscal Year: 2010
    ..d) Study thrombus formation in hyperlipidemic Cd39 mutant mice. This work will provide insights into the central thromboregulatory mechanisms impacting platelet activation and vascular injury in vivo. ..
  2. Thromboregulatory strategies to prolong xenograft survival.
    Simon Robson; Fiscal Year: 2007
    ..These studies will be judged successful if novel, clinically relevant antithrombotic therapies can be then developed and applied. ..
  3. FUNCTIONAL ANALYSIS OF VASCULAR NTPDASES
    Simon Robson; Fiscal Year: 2007
    ..Information gleaned from these studies may direct new therapeutic strategies for inflammatory vascular disorders, including atherosclerotic cardiovascular disease. ..
  4. VASCULAR NTPDASES AND TRANSPLANTATION
    Simon Robson; Fiscal Year: 2004
    ..These experiments should delineate involvement of NTPDases and P2signaling in inflammation associated with arterial/venous injury and also culminating in allograft failure. ..
  5. FUNCTIONAL ANALYSIS OF VASCULAR NTPDASES
    Simon Robson; Fiscal Year: 2003
    ..These experiments should indicate the involvement of the vascular NTPDase/CD39, and also elucidate interactions with NOS systems, in certain vascular inflammatory disorders observed in human disease states. ..