S C Robson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Identification and characterization of CD39/vascular ATP diphosphohydrolase
    E Kaczmarek
    Sandoz Center for Immunobiology, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:33116-22. 1996
  2. pmc Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons
    Y Hisashi
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Am J Transplant 8:2516-26. 2008
  3. ncbi request reprint Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation
    I P Alwayn
    The Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
    Transplantation 71:1601-9. 2001
  4. ncbi request reprint Long-term survival of hamster hearts in presensitized rats
    Y Lin
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 164:4883-92. 2000
  5. ncbi request reprint Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy
    L Buhler
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, USA
    Bone Marrow Transplant 27:1227-36. 2001
  6. ncbi request reprint Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
    K Sato
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 166:4185-94. 2001
  7. ncbi request reprint Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase
    J Sevigny
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:5640-7. 2000
  8. pmc CD39 modulates endothelial cell activation and apoptosis
    C Goepfert
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Med 6:591-603. 2000
  9. ncbi request reprint Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. II. The effects of cyclophosphamide on pig peripheral blood progenitor cell-induced aggregation
    J Z Appel
    Transplantation Biology Research Center, Massachusetts General Hospital / Harvard Medical School, Boston, Massachusetts 01129, USA
    Transplantation 72:1306-10. 2001
  10. pmc Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation
    C Knosalla
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:1006-16. 2009

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Identification and characterization of CD39/vascular ATP diphosphohydrolase
    E Kaczmarek
    Sandoz Center for Immunobiology, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:33116-22. 1996
    ..Because ATPDase activity is lost with endothelial cell activation, overexpression of the functional enzyme, or a truncated mutant thereof, may prevent platelet activation associated with vascular inflammation...
  2. pmc Rejection of cardiac xenografts transplanted from alpha1,3-galactosyltransferase gene-knockout (GalT-KO) pigs to baboons
    Y Hisashi
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Am J Transplant 8:2516-26. 2008
    ..In conclusion, despite the absence of the Gal epitope, acute and chronic antibody and cell-mediated rejection developed in grafts, maintained by chronic immunosupression, presumably due to de novo responses to non-Gal antigens...
  3. ncbi request reprint Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation
    I P Alwayn
    The Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
    Transplantation 71:1601-9. 2001
    ..Eptifibatide can fully abrogate platelet aggregation induced by porcine PBPC in vitro. Purification of the progenitor cells from porcine PBPC and/or treatment of baboons with eptifibatide may be beneficial...
  4. ncbi request reprint Long-term survival of hamster hearts in presensitized rats
    Y Lin
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 164:4883-92. 2000
    ..Th2 responses and protective genes are associated with resistance to IgM- and IgG-mediated, complement-dependent and -independent forms of rejection...
  5. ncbi request reprint Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy
    L Buhler
    Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, USA
    Bone Marrow Transplant 27:1227-36. 2001
    ....
  6. ncbi request reprint Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
    K Sato
    Immunobiology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 166:4185-94. 2001
    ..Additional mechanisms by which CO overcomes graft rejection may involve its ability to suppress endothelial cell apoptosis...
  7. ncbi request reprint Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase
    J Sevigny
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:5640-7. 2000
    ..The different biochemical properties and localization of the hepatic ATPDase suggest pathophysiological functions that are distinct from the vascular ATPDase/cd39...
  8. pmc CD39 modulates endothelial cell activation and apoptosis
    C Goepfert
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Med 6:591-603. 2000
    ..The effects of NTPDases on endothelial cell (EC) activation and apoptosis remain unexplored...
  9. ncbi request reprint Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. II. The effects of cyclophosphamide on pig peripheral blood progenitor cell-induced aggregation
    J Z Appel
    Transplantation Biology Research Center, Massachusetts General Hospital / Harvard Medical School, Boston, Massachusetts 01129, USA
    Transplantation 72:1306-10. 2001
    ..CPP has direct anti-aggregatory properties and may provide an alternative strategy to WBI in this pig-to-primate model intended to induce mixed hematopoietic cell chimerism...
  10. pmc Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation
    C Knosalla
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:1006-16. 2009
    ..These findings suggest that therapeutic targets may differ for renal and cardiac xenotransplants...
  11. ncbi request reprint Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells
    J Z Appel
    Transplantation Biology Research Center, Massachusetts General Hospital / Harvard Medical School, Boston, Massachusetts 01129, USA
    Transplantation 72:1299-305. 2001
    ..GPIIb/IIIa antagonists, such as eptifibatide, interfere directly with xenogeneic PBPC-platelet interactions and may further ameliorate TM in the pig-to-primate model...
  12. ncbi request reprint Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae
    K Koziak
    Department of Medicine, Center for Immunobiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:2057-62. 2000
    ..We suggest that palmitoylation could modulate the function of CD39 in regulating cellular signal transduction pathways...
  13. ncbi request reprint Tyrosine phosphorylation following lectin mediated endothelial cell stimulation
    A Palmetshofer
    Novartis Center for Immunobiology, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Xenotransplantation 5:61-6. 1998
    ..Binding of XNA and subsequently the elicited xenoreactive antibodies to carbohydrate epitopes may therefore contribute to xenograft rejection even in the absence of complement inactivation...
  14. pmc Results of gal-knockout porcine thymokidney xenografts
    A D Griesemer
    Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:2669-78. 2009
    ..These results show that xenogeneic thymus transplantation can support early primate thymopoiesis, which in turn may induce T-cell tolerance to solid organ xenografts...
  15. ncbi request reprint Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation
    L Buhler
    Transplantation Biology Research Center, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 02129, USA
    Transplantation 72:1743-52. 2001
    ....
  16. pmc Loss of ATP diphosphohydrolase activity with endothelial cell activation
    S C Robson
    Sandoz Center for Immunobiology, Boston, Massachusetts, USA
    J Exp Med 185:153-63. 1997
    ..Because platelet activation and aggregation are important components of the hemostatic changes that accompany inflammatory diseases, we suggest that the loss of vascular ATPDase may be crucial for the progression of vascular injury...
  17. ncbi request reprint Targeting platelet aggregation: CD39 gene transfer augments nucleoside triphosphate diphosphohydrolase activity in injured rabbit arteries
    S P Gangadharan
    Division of Vascular Surgery, Brigham and Women's Hospital and Harvard Institute for Human Genetics, Boston, MA 02115, USA
    Surgery 130:296-303. 2001
    ..Further studies are required to determine whether targeted delivery of CD39 could convey thromboprotective properties to an injured vessel...
  18. pmc Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations
    Q Zhou
    Department of Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:2303-11. 2009
    ..Thus, besides Tregs, CD39 is also expressed on pre-existing memory T cells of Th1-, Th2- and Th17-types with heightened alloreactivity...
  19. ncbi request reprint Disordered regulation of coagulation and platelet activation in xenotransplantation
    S C Robson
    Department of Medicine, Research North, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA, USA
    Xenotransplantation 7:166-76. 2000
    ..Disordered thromboregulation could have deleterious effects, comparable to unregulated complement activation, in the pathogenesis of xenograft rejection and may therefore represent a substantive barrier to xenotransplantation...
  20. ncbi request reprint Delayed xenograft rejection
    F H Bach
    Sandoz Center for Immunobiology, Harvard Medical School, New England Deaconess Hospital, Boston, MA 02215, USA
    Immunol Today 17:379-84. 1996
    ....
  21. ncbi request reprint Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor
    J Schulte Am Esch
    Sandoz Center for Immunobiology and Departments of Medicine and Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, MA, USA
    Blood 90:4425-37. 1997
    ..Putative conformational changes in the porcine A1-domain could result in the heightened, ristocetin-independent interactions observed with human platelets and may be of importance for xenograft survival...
  22. ncbi request reprint Factors in xenograft rejection
    S C Robson
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 875:261-76. 1999
    ....
  23. pmc Helicobacter pylori infection stimulates plasminogen activator inhibitor 1 production by gastric epithelial cells
    A C Keates
    Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Infect Immun 76:3992-9. 2008
    ..pylori-mediated PAI-1 upregulation. These findings suggest that the upregulation of PAI-1 in H. pylori-infected gastric epithelial cells may contribute to the carcinogenic process...
  24. pmc Mitochondrial recoupling: a novel therapeutic strategy for cancer?
    G Baffy
    Department of Medicine, VA Boston Healthcare System and Brigham and Women s Hospital, Harvard Medical School, 150 S Huntington Avenue, Room A6 46, Boston, MA 02130, USA
    Br J Cancer 105:469-74. 2011
    ..Here we review current evidence to suggest that inhibition of mitochondrial uncoupling may eliminate these responses and reveal novel anti-cancer strategies...
  25. ncbi request reprint P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide
    M Warny
    Gastroenterology Divison, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:26051-6. 2001
    ..Furthermore, lipopolysaccharide mediates IL-8 production at least in part by autocrine P2Y(6) activation. These findings indicate a novel role for P2Y(6) in innate immune defenses...
  26. ncbi request reprint Potential of aspirin to inhibit thrombotic microangiopathy in alpha1,3-galactosyltransferase gene-knockout pig hearts after transplantation in baboons
    F J M F Dor
    Transplantation Biology Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
    Transplant Proc 37:489-90. 2005
    ..Function of a pig organ in a baboon for a period approaching 6 months has not been reported previously and lends encouragement that the barriers to xenotransplantation will be overcome, but TM requires investigation...
  27. pmc Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells
    M Sitkovsky
    New England Inflammation and Tissue Protection Institute, Consortium at Northeastern University, 113 Mugar Building, 360 Huntington Avenue, Boston, MA 02115, USA
    Br J Pharmacol 153:S457-64. 2008
    ..This review addresses several possible pharmacological modalities to block adenosinergic pathways and speculates on their future application together with impacts on human disease...
  28. ncbi request reprint CD39 as a caveolar-associated ectonucleotidase
    A Kittel
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1450, Hungary
    Biochem Biophys Res Commun 262:596-9. 1999
    ..g., palmitoylation) we hypothesize the same to be the case for CD39. Furthermore, its presence in the caveolae supports its participation in signalling events...
  29. ncbi request reprint Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta
    A Kittel
    Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, P O BOX 67, Budapest, Hungary
    Eur J Histochem 48:253-9. 2004
    ..The differential localization of these P2 receptors might indicate their unique roles in the regulation of extracellular nucleotide concentrations in human placental tissues and consequent effects on vascular tone and blood fluidity...
  30. ncbi request reprint Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation
    K Enjyoji
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Med 5:1010-7. 1999
    ..Our data indicate a dual role for adenosine triphosphate diphosphohydrolase in modulating hemostasis and thrombotic reactions...
  31. pmc Overexpression of CD39/nucleoside triphosphate diphosphohydrolase-1 decreases smooth muscle cell proliferation and prevents neointima formation after angioplasty
    K Koziak
    Department of General and Nutritional Biochemistry, The Medical University of Warsaw, Warsaw, Poland
    J Thromb Haemost 6:1191-7. 2008
    ..The consequent increase in extracellular nucleotide concentrations triggers signaling events leading to prothrombotic responses and increased VSMC proliferation...
  32. ncbi request reprint Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
    Q Y Li
    Department of Genetics, University of Nottingham, Queen s Medical Centre, UK
    Nat Genet 15:21-9. 1997
    ..Tissue in situ hybridization studies on human embryos from days 26 to 52 of gestation reveal expression of TBX5 in heart and limb, consistent with a role in human embryonic development...
  33. ncbi request reprint Effects of nitric oxide (NO) and soluble nucleoside triphosphate diphosphohydrolase (NTPDase) on inhibition of platelet deposition in vitro
    A Ramamurthi
    Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Thromb Res 102:331-41. 2001
    ..The inaction of NO on the activity of NTPDase confirmed that NO or reaction products in the presence of O(2) do not interact with NTPDase directly...
  34. ncbi request reprint Isolation, characterisation and embryonic expression of WNT11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung
    M Lako
    Department of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Gene 219:101-10. 1998
    ..We have mapped WNT11 to 11q13.5 and this together with its expression in the perichondrium of the developing skeleton, makes it a plausible candidate gene for HBM, which has been previously linked to markers from this region...
  35. ncbi request reprint Noise exposure induces up-regulation of ecto-nucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea
    S M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Neuroscience 126:763-73. 2004
    ..The changes in NTPDases expression may reflect adaptive response of cochlear tissues to limit ATP signaling during noise exposure...
  36. ncbi request reprint NTPDase and 5' ecto-nucleotidase expression profiles and the pattern of extracellular ATP metabolism in the Walker 256 tumor
    A Buffon
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, ICBS, Rua Ramiro Barcelos, Porto Alegre, RS, Brazil
    Biochim Biophys Acta 1770:1259-65. 2007
    ..Results demonstrate that the presence of NTPDases and 5'-nucleotidase enzymes in Walker 256 tumor cells may be important for regulation of the extracellular adenine nucleotides/adenine nucleoside ratio, therefore leading to tumor growth...