Research Topics
Species | E RimmSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Dietary protein and risk of ischemic heart disease in womenF B Hu
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 70:221-7. 1999..Prospective data on the relation of protein intake to risk of ischemic heart disease are sparse...- Snoring and risk of cardiovascular disease in womenF B Hu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 35:308-13. 2000..To examine prospectively the association between snoring and incidence of cardiovascular disease (CVD) in women... - Alcohol and cardiovascular diseaseE Rimm
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Curr Atheroscler Rep 2:529-35. 2000.... - Prospective study of zinc intake and the risk of age-related macular degenerationE Cho
Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Ann Epidemiol 11:328-36. 2001..Zinc is found in high concentrations in the retina and is hypothesized to reduce the risk of age-related macular degeneration (AMD). Any long-term benefit associated with dietary zinc intake has not been evaluated... 
Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factorsE B Rimm
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
BMJ 319:1523-8. 1999..To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk...- Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among womenE B Rimm
Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
JAMA 279:359-64. 1998..Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart disease (CHD) are not available... - Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in menM L McCullough
Departments of Nutrition, Epidemiology, and Biostatistics, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 72:1223-31. 2000..The healthy eating index (HEI) measures the concordance of dietary patterns with these guidelines... - Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health StudyS Liu
Division of Preventive Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Am J Clin Nutr 70:412-9. 1999..Although current dietary guidelines for Americans recommend increased intake of grain products to prevent coronary heart disease (CHD), epidemiologic data relating whole-grain intake to the risk of CHD are sparse... - Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight menN F Chu
Department of Epidemiology, Harvard School Public Health, Boston, MA, USA
Int J Obes Relat Metab Disord 25:106-14. 2001..The purpose of this study is to evaluate whether modifiable dietary and lifestyle factors are associated with plasma leptin concentrations among US men... - Racial variation in prostate cancer incidence and in hormonal system markers among male health professionalsE A Platz
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
J Natl Cancer Inst 92:2009-17. 2000..Whether differences in the distribution of known or suspected risk factors among racial groups explain this variation is unknown... - A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular diseaseG Tuncman
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:6970-5. 2006..Taken together, our results indicate that reduction in aP2 activity in humans generate a metabolically favorable phenotype that is similar to aP2 deficiency in experimental models... - Assessment of questionnaire validity for measuring total fat intake using plasma lipid levels as criteriaW Willett
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 154:1107-12. 2001..These data provide additional evidence that informative measurements of dietary fat can be obtained by carefully constructed food frequency questionnaires... - Risk of bladder cancer by geographic region in a U.S. cohort of male health professionalsD S Michaud
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
Epidemiology 12:719-26. 2001..77, 95% CI = 1.15-2.71, adjusted for smoking). Diet and other known characteristics do not appear to be responsible for the regional variations in bladder cancer rates in the United States... - Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US menN F Chu
Department of Epidemiology, Harvard School Public Health, Boston, MA, USA
Int J Obes Relat Metab Disord 24:1085-92. 2000..The purpose of this study was to evaluate the potential role of glycemic status and adipose-derived cytokines in regulating plasma leptin levels among normal and overweight men... - Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaireF B Hu
Department of Nutrition, Harvard School of Public Health, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Clin Nutr 69:243-9. 1999..Recently, the analysis of dietary patterns has emerged as a possible approach to examining diet-disease relations... - Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease riskT T Fung
Department of Nutrition, Harvard School of Public Health, Boston, USA
Am J Clin Nutr 73:61-7. 2001..Although the effects of individual foods or nutrients on the development of diseases and their risk factors have been investigated in many studies, little attention has been given to the effect of overall dietary patterns... - The association of serum lipids and inflammatory biomarkers with renal function in men with type II diabetes mellitusJ Lin
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Kidney Int 69:336-42. 2006.... - The effect of fruit and vegetable intake on risk for coronary heart diseaseK J Joshipura
Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Ann Intern Med 134:1106-14. 2001..CONCLUSIONS: Consumption of fruits and vegetables, particularly green leafy vegetables and vitamin C-rich fruits and vegetables, appears to have a protective effect against coronary heart disease... - Dietary fat intake and risk of type 2 diabetes in womenJ Salmeron
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston 02115, USA
Am J Clin Nutr 73:1019-26. 2001..The long-term relations between specific types of dietary fat and risk of type 2 diabetes remain unclear... - Impact of overweight on the risk of developing common chronic diseases during a 10-year periodA E Field
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
Arch Intern Med 161:1581-6. 2001..Overweight adults are at an increased risk of developing numerous chronic diseases... 
Brian MacMahon (1923-2007): founder of modern epidemiologyD Trichopoulos
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Cancer Causes Control 19:329-37. 2008..He made major scientific contributions, received several distinguished prizes and awards, and continued to publish insightful papers until the very end. Brian MacMahon was the first editor-in-chief of Cancer Causes and Control...- Vitamin supplement use and the risk of non-Hodgkin's lymphoma among women and menS M Zhang
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 153:1056-63. 2001..Because an elevated risk among multivitamin users was not observed consistently in the two cohorts and the pooled data were not significant, the elevated risk among women may be the result of chance... - Frequent nut consumption and risk of coronary heart disease in women: prospective cohort studyF B Hu
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
BMJ 317:1341-5. 1998..To examine the relation between nut consumption and risk of coronary heart disease in a cohort of women from the Nurses' Health Study... - A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and womenI Baik
Harvard School of Public Health, Department of Nutrition, 665 Huntington Ave, Bldg 2, Room 329, Boston, MA 02115, USA
Arch Intern Med 160:3082-8. 2000..We examined the associations of age, smoking status, body mass index (BMI), weight change during adulthood, physical activity, and alcohol intake with risk of CAP among men and women... - Genetic variation in the hepatic lipase gene and the risk of coronary heart disease among US diabetic men: potential interaction with obesityC Zhang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA
Diabetologia 49:1552-9. 2006..Moreover, data on this association among diabetic patients are limited. We investigated the association of the LIPC polymorphism with CHD risk among US diabetic men and evaluated whether this association was modified by adiposity status... - Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic menI Shai
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetologia 47:1760-7. 2004..It remains to be determined whether there is an association between alcohol and inflammation in individuals with diabetes... - Periodontal disease and biomarkers related to cardiovascular diseaseK J Joshipura
Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA 02115, USA
J Dent Res 83:151-5. 2004..Based on our data, periodontal disease showed significant associations with biomarkers of endothelial dysfunction and dyslipidemia, which may potentially mediate the association between periodontal and cardiovascular disease... - Blood donations and risk of coronary heart disease in menA Ascherio
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 103:52-7. 2001..In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent... - Alcohol consumption increases periodontitis riskW Pitiphat
Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
J Dent Res 82:509-13. 2003..24 (1.09, 1.42); 5.0 to 14.9 g/day, 1.18 (1.04, 1.35); 15 to 29.9 g/day, 1.18 (1.01, 1.38); and > 30 g/day, 1.27 (1.08, 1.49). The results suggest that alcohol consumption is an independent modifiable risk factor for periodontitis... - Prospective study of dietary fat and the risk of age-related macular degenerationE Cho
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 73:209-18. 2001..The relation between intakes of total fat and specific types of fat and age-related macular degeneration (AMD) remains unclear... - Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarctionL M Hines
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
N Engl J Med 344:549-55. 2001..We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study... - Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitusM Tanasescu
Nutrition, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 38:1836-42. 2001..The goal of this study was to examine the relationship between alcohol intake and risk of coronary heart disease (CHD) among men with type 2 diabetes... - Exposure to alcohol, drugs and tobacco and the risk of subsequent suicidality: findings from the Mexican Adolescent Mental Health SurveyM Miller
Department of Health Policy and Management, Harvard School of Public Health, 677 Huntington Avenue, Room 305, Kresge Building, Boston, MA 02115, United States
Drug Alcohol Depend 113:110-7. 2011..e. without disorder), (3) applies to tobacco use and dependence independent of illicit drugs and alcohol use/disorder, and (4) is confounded by comorbid mental illness... - Plasma leptin concentrations and four-year weight gain among US menN F Chu
Department of Epidemiology, Harvard School Public Health, Boston, MA, USA
Int J Obes Relat Metab Disord 25:346-53. 2001..The purpose of this study is to evaluate the relationship between circulating plasma leptin levels and regulation of body weight over time among US men... - Physical activity and television watching in relation to risk for type 2 diabetes mellitus in menF B Hu
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 161:1542-8. 2001..Television (TV) watching, a major sedentary behavior in the United States, has been associated with obesity. We hypothesized that prolonged TV watching may increase risk for type 2 diabetes... - Whole grain consumption and risk of ischemic stroke in women: A prospective studyS Liu
Division of Preventive Medicine, Bringham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
JAMA 284:1534-40. 2000..Although increased intake of grain products has been recommended to prevent cardiovascular disease (CVD), prospective data examining the relation of whole grain intake to risk of ischemic stroke are sparse, especially among women... - A prospective study of egg consumption and risk of cardiovascular disease in men and womenF B Hu
Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
JAMA 281:1387-94. 1999..Reduction in egg consumption has been widely recommended to lower blood cholesterol levels and prevent coronary heart disease (CHD). Epidemiologic studies on egg consumption and risk of CHD are sparse... - Smoking and risk of total and fatal prostate cancer in United States health professionalsE Giovannucci
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 8:277-82. 1999..Our results indicate that although smoking was unrelated to prostate cancer incidence, recent tobacco use had a substantial impact on the occurrence of fatal prostate cancer... - Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohortD S Michaud
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
J Natl Cancer Inst 91:605-13. 1999..We examined total fruit and vegetable intake, as well as intakes of subtypes of fruits and vegetables, in relation to bladder cancer risk in a large male prospective cohort study... - Physical activity and benign prostatic hyperplasiaE A Platz
Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115, USA
Arch Intern Med 158:2349-56. 1998..Therefore, we assessed whether physical activity leads to fewer lower urinary tract symptoms in the Health Professionals Follow-up Study... - A prospective study of physical activity and prostate cancer in male health professionalsE Giovannucci
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 58:5117-22. 1998.... - Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US menA Ascherio
Department of Nutrition, Epidemiology and Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 98:1198-204. 1998..Animal experiments and epidemiological studies have suggested that high potassium intake may reduce the risk of stroke, but the evidence is inconclusive, and the role of other nutrients in potassium-rich foods remains unknown... - Clustering of cardiovascular disease risk factors among obese schoolchildren: the Taipei Children Heart StudyN F Chu
Department of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China
Am J Clin Nutr 67:1141-6. 1998..Childhood obesity increases the risk of obesity in adulthood and is associated with cardiovascular disease (CVD) risk factors such as hypertension, diabetes mellitus, and dyslipidemia... - Dietary fiber, glycemic load, and risk of NIDDM in menJ Salmeron
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Diabetes Care 20:545-50. 1997..Intake of carbohydrates that provide a large glycemic response has been hypothesized to increase the risk of NIDDM, whereas dietary fiber is suspected to reduce incidence. These hypotheses have not been evaluated prospectively... - Birth weight and adult hypertension, diabetes mellitus, and obesity in US menG C Curhan
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 94:3246-50. 1996..Further study of these diseases in a large cohort with information on a wide variety of risk factors is essential to determine more precisely the risks associated with birth weight... - Fluid intake and the risk of bladder cancer in menD S Michaud
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 340:1390-7. 1999..The data on fluid intake in relation to the risk of bladder cancer are inconclusive... - Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among womenF B Hu
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 69:890-7. 1999..Experimental studies in laboratory animals and humans suggest that alpha-linolenic acid (18:3n-3) may reduce the risk of arrhythmia... - A prospective study of coffee consumption and the risk of symptomatic gallstone disease in menM F Leitzmann
Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
JAMA 281:2106-12. 1999..Coffee has several metabolic effects that could reduce the risk of gallstone formation... - Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United StatesA Ascherio
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Ann Intern Med 130:963-70. 1999..Antioxidants increase the resistance of low-density lipoprotein to oxidation and may thereby reduce risk for atherosclerosis... - Racial variation in insulin-like growth factor-1 and binding protein-3 concentrations in middle-aged menE A Platz
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Cancer Epidemiol Biomarkers Prev 8:1107-10. 1999..Although differences in circulating IGF-1 do not seem to account for the greater prostate cancer risk among African-American men, their absolute lower levels of IGFBP-3 may be contributory... - Fruit and vegetable intake in relation to risk of ischemic strokeK J Joshipura
Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
JAMA 282:1233-9. 1999..Few studies have evaluated the relationship between fruit and vegetable intake and cardiovascular disease... - A prospective study of carotenoid intake and risk of cataract extraction in US menL Brown
Departments of Epidemiology, Nutrition, and Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 70:517-24. 1999..However, prospective epidemiologic data concerning this phenomenon are limited... - Prospective study of alcohol consumption and the risk of age-related macular degenerationE Cho
Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
Arch Ophthalmol 118:681-8. 2000..To describe the relationship between alcohol consumption and the incidence of age-related macular degeneration (AMD)... - Recreational physical activity and the risk of cholecystectomy in womenM F Leitzmann
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 341:777-84. 1999..Physical activity may be an important determinant of the risk of gallstone disease in women, both independently and as a result of its role in maintaining body weight... - Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitusC G Solomon
Division of Women s Health, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 102:494-9. 2000..We assessed prospectively the association between moderate alcohol intake and CHD risk in women with type 2 diabetes mellitus, a group at high risk for cardiovascular disease... - Cigarettes and suicide: a prospective study of 50,000 menM Miller
Department of Health Policy and Management, Harvard School of Public Health, Boston, Mass 02115, USA
Am J Public Health 90:768-73. 2000..This study examined the relation between smoking and suicide, controlling for various confounders... - Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among menN F Chu
Department of Epidemiology, Harvard School Public Health, Boston, MA, USA
Atherosclerosis 157:495-503. 2001..However, plasma leptin may still play a role in CVD through independent effects on lipid metabolism... - Nephrolithiasis and risk of hypertensionF Madore
Renal Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Am J Hypertens 11:46-53. 1998..99, 95% CI: 0.82 to 1.21). These data support the hypothesis that prior occurrence of nephrolithiasis increases the risk of subsequent hypertension... - A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancerJ Chen
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Cancer Res 56:4862-4. 1996..In contrast, when 5-methyltetrahydrofolate is depleted by alcohol consumption, val/val individuals may be less able to compensate, leading to potentially oncogenic alterations in DNA methylation... - A prospective study of drinking patterns in relation to risk of type 2 diabetes among menK M Conigrave
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes 50:2390-5. 2001..Our findings suggested that frequent alcohol consumption conveys the greatest protection against type 2 diabetes, even if the level of consumption per drinking day is low. Beverage choice did not alter risk... - The correlates of dietary intake among HIV-positive adultsJ H Kim
Departments of Population and International Health, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 74:852-61. 2001..It may be worthwhile to study dietary intake as a potential determinant of the clinical outcomes of HIV infection... - Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman TriathlonN Rifai
Department of Laboratory Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
Am J Cardiol 83:1085-9. 1999..002). Thus, ultraendurance exercise may cause myocardial damage as indicated by biochemical cardiac-specific markers and echocardiography. The cellular nature of this damage and whether it is transient or permanent is unclear at present... - Race and gender differences in cord blood lipoproteinsC M Loughrey
Department of Laboratory Medicine, Children s Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
Atherosclerosis 148:57-65. 2000..These findings support the concept that the aetiology of the difference in lipoprotein concentration observed between race and gender groups includes a significant genetic component... - Use of acetaminophen and nonsteroidal anti-inflammatory drugs: a prospective study and the risk of symptomatic diverticular disease in menW H Aldoori
Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
Arch Fam Med 7:255-60. 1998..To examine prospectively the relationship between self-reported regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen and the risk of symptomatic diverticular disease... - A prospective study on intake of animal products and risk of prostate cancerD S Michaud
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Causes Control 12:557-67. 2001..We examine these associations among 51,529 men who contributed detailed dietary data... - Alcohol's effects on the risk for coronary heart diseaseK J Mukamal
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Alcohol Res Health 25:255-61. 2001..Finally, the relationship between alcohol consumption and heart disease may be modulated by genetic factors... - Gender differences in exercise-induced changes in sex hormone levels and lipid peroxidation in athletes participating in the Hawaii Ironman triathlon. Ginsburg-gender and exercise-induced lipid peroxidationG S Ginsburg
Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
Clin Chim Acta 305:131-9. 2001..These changes may in part explain the salutary effect of exercise on the development of vascular disease... - A retrospective study of the relationship between biomarkers of atherosclerosis and erectile dysfunction in 988 menC B Eaton
Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA
Int J Impot Res 19:218-25. 2007..Future studies evaluating the prospective association of ED, endothelial function and cardiovascular disease appear warranted...