L V Riella

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint T-cell co-stimulatory blockade in transplantation: two steps forward one step back!
    Leonardo V Riella
    Brigham and Women s Hospital, Boston Children s Hospital, Harvard Medical School, Transplantation Research Center, Renal Division, 221 Longwood Ave, Boston MA 02115, USA 1 617 732 5259 1 617 732 5254
    Expert Opin Biol Ther 13:1557-68. 2013
  2. doi request reprint Jagged2-signaling promotes IL-6-dependent transplant rejection
    Leonardo V Riella
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 43:1449-58. 2013
  3. pmc Role of the PD-1 pathway in the immune response
    L V Riella
    Schuster Family Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:2575-87. 2012
  4. doi request reprint Dyslipidemia and its therapeutic challenges in renal transplantation
    L V Riella
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:1975-82. 2012
  5. doi request reprint Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model
    L V Riella
    Renal Division, Transplantation Research Center, Brigham and Women s Hospital, Children s Hospital Boston, Harvard Medical School, Boston, MA
    Am J Transplant 12:846-55. 2012
  6. doi request reprint Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts
    L V Riella
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Children s Hospital Boston, MA, USA
    Am J Transplant 11:832-40. 2011
  7. pmc Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model
    J Yang
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:2837-44. 2009

Detail Information

Publications7

  1. ncbi request reprint T-cell co-stimulatory blockade in transplantation: two steps forward one step back!
    Leonardo V Riella
    Brigham and Women s Hospital, Boston Children s Hospital, Harvard Medical School, Transplantation Research Center, Renal Division, 221 Longwood Ave, Boston MA 02115, USA 1 617 732 5259 1 617 732 5254
    Expert Opin Biol Ther 13:1557-68. 2013
    ..However, some unexpected findings were noticed in the recent clinical trials of belatacept, including a higher rate of rejection, which warranted further investigation with some interesting concepts emerging from the bench...
  2. doi request reprint Jagged2-signaling promotes IL-6-dependent transplant rejection
    Leonardo V Riella
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 43:1449-58. 2013
    ..Our findings therefore suggest that Jagged2 signaling can affect graft acceptance by upregulation of IL-6 and consequent resistance to Treg-cell suppression. ..
  3. pmc Role of the PD-1 pathway in the immune response
    L V Riella
    Schuster Family Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:2575-87. 2012
    ..In this review, we discuss the current knowledge of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential in transplantation...
  4. doi request reprint Dyslipidemia and its therapeutic challenges in renal transplantation
    L V Riella
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:1975-82. 2012
    ..We will also evaluate the reasons for and consequences of the latest Food and Drug Administration (FDA) warnings regarding the use of simvastatin...
  5. doi request reprint Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model
    L V Riella
    Renal Division, Transplantation Research Center, Brigham and Women s Hospital, Children s Hospital Boston, Harvard Medical School, Boston, MA
    Am J Transplant 12:846-55. 2012
    ..This study confirms the importance of the B7:CD28 pathway in Treg homeostasis in an in vivo transplant model and suggests that hCTLA4Ig therapy may be deleterious in circumstances where engraftment is dependent on Tregs...
  6. doi request reprint Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts
    L V Riella
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Children s Hospital Boston, MA, USA
    Am J Transplant 11:832-40. 2011
    ..These findings demonstrate that PDL1 expression mainly on donor endothelium is functionally important in a fully allogeneic mismatched model for the induction of cardiac allograft tolerance...
  7. pmc Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model
    J Yang
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Am J Transplant 9:2837-44. 2009
    ....