P M Ridker

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
  2. ncbi request reprint Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, The Children s Hospital Medical Center, Boston, MA, USA
    Circulation 100:230-5. 1999
  3. ncbi request reprint Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians
    C J O'Donnell
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:1132-7. 1997
  4. ncbi request reprint Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
    Circulation 97:425-8. 1998
  5. ncbi request reprint Hormone replacement therapy and increased plasma concentration of C-reactive protein
    P M Ridker
    Division of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 100:713-6. 1999
  6. ncbi request reprint Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 98:839-44. 1998
  7. ncbi request reprint Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 95:1777-82. 1997
  8. ncbi request reprint Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    J Thromb Haemost 4:2199-203. 2006
  9. ncbi request reprint A prospective evaluation of lipoprotein-associated phospholipase A(2) levels and the risk of future cardiovascular events in women
    G J Blake
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 38:1302-6. 2001
  10. ncbi request reprint Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke
    R Y Zee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 99:340-3. 1999

Detail Information

Publications77

  1. ncbi request reprint C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
    ..Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events...
  2. ncbi request reprint Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, The Children s Hospital Medical Center, Boston, MA, USA
    Circulation 100:230-5. 1999
    ..We evaluated whether long-term therapy with pravastatin, an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter...
  3. ncbi request reprint Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians
    C J O'Donnell
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:1132-7. 1997
    ..The objective of this study was to examine whether definite hypertension and borderline isolated systolic hypertension predict subsequent cardiovascular disease and mortality...
  4. ncbi request reprint Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
    Circulation 97:425-8. 1998
    ..Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown...
  5. ncbi request reprint Hormone replacement therapy and increased plasma concentration of C-reactive protein
    P M Ridker
    Division of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 100:713-6. 1999
    ..However, data evaluating this hypothesis are sparse and limited to older women...
  6. ncbi request reprint Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 98:839-44. 1998
    ..We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and whether randomized treatment with pravastatin reduces that risk...
  7. ncbi request reprint Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 95:1777-82. 1997
    ....
  8. ncbi request reprint Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    J Thromb Haemost 4:2199-203. 2006
    ..In some but not all studies, men with venous thrombosis had a higher risk of recurrence than women. Information on women with initial hormone-related thrombosis is scant...
  9. ncbi request reprint A prospective evaluation of lipoprotein-associated phospholipase A(2) levels and the risk of future cardiovascular events in women
    G J Blake
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 38:1302-6. 2001
    ..CONCLUSIONS: In contrast to prior data among hyperlipidemic men, the current data suggest that Lp-PLA(2) is not a strong predictor of future cardiovascular risk among unselected women...
  10. ncbi request reprint Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke
    R Y Zee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 99:340-3. 1999
    ..We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study...
  11. ncbi request reprint Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men
    P M Ridker
    Division of Cardiovascular Disease, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Lancet 351:88-92. 1998
    ..Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown...
  12. ncbi request reprint Alu-repeat polymorphism in the gene coding for tissue-type plasminogen activator (t-PA) and risks of myocardial infarction among middle-aged men
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 17:1687-90. 1997
    ..In this cohort of middle-aged US men, the presence of the insertion allele of the Alu-repeat polymorphism of the tissue-type plasminogen activator gene is not associated with future risks of myocardial infarction...
  13. ncbi request reprint Clinical efficacy of an automated high-sensitivity C-reactive protein assay
    N Rifai
    Department of Laboratory Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 45:2136-41. 1999
    ..Prospective studies have shown that C-reactive protein (CRP) can be used to predict risk of future cardiovascular events. High-sensitivity methods for CRP (hs-CRP) measurement are needed for this purpose...
  14. ncbi request reprint Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease
    P M Ridker
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 285:2481-5. 2001
    ..Several novel risk factors for atherosclerosis have recently been proposed, but few comparative data exist to guide clinical use of these emerging biomarkers...
  15. ncbi request reprint Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein
    D I Chasman
    Division of Preventive Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
    Genes Immun 7:211-9. 2006
    ..Quantitative analysis suggested that the effect on CRP is more likely a consequence of intrinsic functional differences among the E2, E3, and E4 apoE proteins than different levels of apoE protein or LDL-C in the plasma...
  16. ncbi request reprint Influence of genetic variation in the C-reactive protein gene on the inflammatory response during and after acute coronary ischemia
    J Suk Danik
    The Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02115, USA
    Ann Hum Genet 70:705-16. 2006
    ..Assessment of CRP genetic variants identified patients with higher and lower CRP elevation after acute coronary syndrome...
  17. ncbi request reprint High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease
    P M Ridker
    Center for Cardiovascular Disease Prevention, Divisions of Cardiovascular Diseases and Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02214, USA
    Circulation 103:1813-8. 2001
    ....
  18. ncbi request reprint Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
    ..We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia...
  19. ncbi request reprint Inflammatory bio-markers and cardiovascular risk prediction
    G J Blake
    Center for Cardiovascular Disease Prevention and the Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    J Intern Med 252:283-94. 2002
    ..Further trials are needed to confirm the potential benefits of statins amongst individuals with elevated CRP levels...
  20. ncbi request reprint Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach
    H H Hegener
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Boston, MA 02215, USA
    J Thromb Haemost 4:1718-22. 2006
    ..Recent data have shown an association between polymorphisms of prostaglandin-endoperoxide synthase-2 gene (PTGS2; alias COX-2), and prostaglandin-E receptor-2 gene (PTGER2) and risk of atherothrombotic disorders...
  21. ncbi request reprint Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men
    P M Ridker
    Division of Cardiovascular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 95:59-62. 1997
    ..In a small group of young Swedish men, this allele has been reported to predict risk of myocardial infarction. Whether this polymorphism increases risk of arterial and venous thrombosis among middle-aged men is unknown...
  22. ncbi request reprint Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    JAMA 277:1305-7. 1997
    ..To estimate ethnic-specific prevalence rates of factor V Leiden, an inherited defect of hemostasis associated with risk of venous thrombosis...
  23. ncbi request reprint Novel clinical markers of vascular wall inflammation
    G J Blake
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Res 89:763-71. 2001
    ..The addition of CRP screening to traditional lipid testing has the potential to identify individuals at high risk for future cardiovascular events who may benefit from targeted preventive interventions...
  24. ncbi request reprint Homocysteine and risk of cardiovascular disease among postmenopausal women
    P M Ridker
    Division of Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 281:1817-21. 1999
    ..Individuals with elevated levels of homocysteine tend to have higher prevalence of cardiovascular disease. However, prospective studies of homocysteine are inconsistent and data among women are limited...
  25. pmc Biomarkers and functional outcomes from ischaemic cerebral events in women: a prospective cohort study
    P M Rist
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Neurol 20:375-81. 2013
    ..We aimed to assess the patterns of association between cardiovascular disease biomarkers and functional outcomes after incident ischaemic cerebral events in women...
  26. pmc Comparison of associations of adherence to a Dietary Approaches to Stop Hypertension (DASH)-style diet with risks of cardiovascular disease and venous thromboembolism
    K C Fitzgerald
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 10:189-98. 2012
    ..Objective: To compare the relationships of adherence to a Dietary Approaches to Stop Hypertension (DASH)-style diet with the risks of CVD and VTE...
  27. ncbi request reprint A prospective evaluation of the interleukin-1 receptor antagonist intron 2 gene polymorphism and the risk of myocardial infarction
    R Y Zee
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Thromb Haemost 86:1141-3. 2001
    ..These data also highlight the importance of hypothesis testing studies in genetic epidemiology, particularly for hypotheses generated from small samples or post hoc subgroup analyses...
  28. ncbi request reprint Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study
    D Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Intern Med 263:376-85. 2008
    ..The aim of this study was to assess the relationship between a set of well-characterized genetic variants of the renin-angiotensin system and the endothelial nitric oxide synthase (NOS3) gene and the incidence of type 2 diabetes...
  29. ncbi request reprint Soluble P-selectin and the risk of future cardiovascular events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 103:491-5. 2001
    ..However, little clinical data are available evaluating the role of soluble P-selectin in determining vascular risk...
  30. ncbi request reprint Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    P M Ridker
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 101:1767-72. 2000
    ..Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse...
  31. ncbi request reprint Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women
    P M Ridker
    Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 98:731-3. 1998
    ..C-reactive protein (CRP) predicts risk of myocardial infarction (MI) and stroke among apparently healthy men, but in women, virtually no data are available...
  32. ncbi request reprint Prospective study of herpes simplex virus, cytomegalovirus, and the risk of future myocardial infarction and stroke
    P M Ridker
    Divisions of Preventive Medicine, Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 98:2796-9. 1998
    ..However, prospective data relating evidence of prior exposure to these agents with risks of future myocardial infarction (MI) and stroke are sparse...
  33. pmc Lipid biomarkers, hormone therapy and the risk of venous thromboembolism in women
    B M Everett
    The Center for Cardiovascular Disease Prevention, Harvard Medical School, and the Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Thromb Haemost 7:588-96. 2009
    ..Published reports of a relationship between lipids and incident venous thromboembolism (VTE) are conflicting...
  34. ncbi request reprint Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial
    M A Pfeffer
    Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:2643-51. 1997
    ..Although ACE inhibitor therapy has been shown to reduce mortality in patients with acute myocardial infarction (MI), the optimal dose and the timing of its initiation have not been determined...
  35. ncbi request reprint Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study
    M A Albert
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 286:64-70. 2001
    ..These data provide evidence that statins may have anti-inflammatory effects in addition to lipid-lowering effects...
  36. ncbi request reprint The pravastatin inflammation CRP evaluation (PRINCE): rationale and design
    M A Albert
    Center for Cardiovascular Disease Prevention, Division of Cardiology and Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am Heart J 141:893-8. 2001
    ..However, the time course and magnitude of this effect in both primary and secondary prevention is controversial...
  37. pmc HbA1c measured in stored erythrocytes and mortality rate among middle-aged and older women
    E B Levitan
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, 375 Longwood Avenue, MS 443, Boston, MA 02215, USA
    Diabetologia 51:267-75. 2008
    ..We examined the association between HbA1c measured in stored erythrocytes and mortality rate in women with and without diabetes...
  38. ncbi request reprint A prospective evaluation of the CD14 C(-260)T gene polymorphism and the risk of myocardial infarction
    R Y Zee
    Center of Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Atherosclerosis 154:699-702. 2001
    ..Thus, in contrast to prior studies, these data indicate that screening for CD14 C(-260)T genotypes is unlikely to be a useful tool for risk assessment...
  39. ncbi request reprint Association of common CRP gene variants with CRP levels and cardiovascular events
    D T Miller
    Division of Hematology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Ann Hum Genet 69:623-38. 2005
    ..001). Taken together, these data imply significant interactions between both genetic and environmental contributions to the increased CRP levels that predict a greater risk of future atherothrombotic events in epidemiological studies...
  40. ncbi request reprint Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis
    R Y L Zee
    Center for Cardiovascular Disease Prevention, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 4:341-8. 2006
    ..Polymorphisms in candidate genes related to lipid metabolism, thrombosis, hemostasis, cell-matrix adhesion, and inflammation have been suggested clinically useful in risk assessment of cardiovascular disease...
  41. pmc Lipid levels and the risk of ischemic stroke in women
    T Kurth
    Brigham and Women s Hospital, Division of Preventive Medicine, Harvard Medical School, Boston, MA 02215, USA
    Neurology 68:556-62. 2007
    ....
  42. ncbi request reprint Migraine and biomarkers of cardiovascular disease in women
    T Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Cephalalgia 28:49-56. 2008
    ..In this large cohort of women, only a modest association was found between migraine and adverse levels of certain cardiovascular biomarkers...
  43. ncbi request reprint C-reactive protein gene polymorphisms and the risk of venous thromboembolism: a haplotype-based analysis
    R Y L Zee
    Center for Cardiovascular Disease Prevention, Harvard Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 2:1240-3. 2004
    ..66, P = 0.72) yielded similar null findings. In conclusion, we found no evidence for an association between the CRP polymorphisms/haplotypes tested and the risk of venous thromboembolism...
  44. ncbi request reprint D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism
    S Shrivastava
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA, USA
    J Thromb Haemost 4:1208-14. 2006
    ..Elevated plasma D-dimer and factor VIII coagulant activity (FVIIIc) may be associated with the risk of recurrent venous thromboembolism (VTE)...
  45. ncbi request reprint Mutation in the promoter region of the beta-fibrinogen gene and the risk of future myocardial infarction, stroke and venous thrombosis
    G J Blake
    The Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Eur Heart J 22:2262-6. 2001
    ..We investigated whether the distribution of the C148T polymorphism is associated with an increase in cardiovascular risk...
  46. ncbi request reprint Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk
    J A de Lemos
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 36:423-6. 2000
    ..The purpose of this study was to evaluate whether soluble vascular cell adhesion molecule-1 (sVCAM-1) is a marker for increased cardiovascular risk...
  47. ncbi request reprint Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults
    I S Ockene
    Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Clin Chem 47:444-50. 2001
    ..Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another risk factor, total serum cholesterol...
  48. ncbi request reprint Current issues concerning thrombolytic therapy for acute myocardial infarction
    C H Hennekens
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 25:18S-22S. 1995
    ..Whether or not accelerated t-PA has a small advantage for mortality is less conclusive.(ABSTRACT TRUNCATED AT 250 WORDS)..
  49. ncbi request reprint Blood pressure and inflammation in apparently healthy men
    C U Chae
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hypertension 38:399-403. 2001
    ..These data suggest that increased blood pressure may be a stimulus for inflammation and that this is a possible mechanism underlying the well-established role of hypertension as a risk factor for atherosclerotic disease...
  50. ncbi request reprint Evaluating novel cardiovascular risk factors: can we better predict heart attacks?
    P M Ridker
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:933-7. 1999
    ..Background is also provided to assist physicians in deciding whether one or more of these novel markers deserve clinical consideration in general outpatient settings...
  51. ncbi request reprint C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 97:2007-11. 1998
    ..However, whether measurement of CRP adds to the predictive value of total cholesterol (TC) and HDL cholesterol (HDL-C) in determining risk is uncertain...
  52. ncbi request reprint Inflammation, atherosclerosis, and cardiovascular risk: an epidemiologic view
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood Coagul Fibrinolysis 10:S9-12. 1999
    ..Taken together, these data raise the possibility that therapies targeting chronic low-grade inflammation may provide novel future strategies for cardiovascular disease prevention...
  53. doi request reprint Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  54. ncbi request reprint Prospective study of Chlamydia pneumoniae IgG seropositivity and risks of future myocardial infarction
    P M Ridker
    Divisions of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 99:1161-4. 1999
    ..Chlamydia pneumoniae has been hypothesized to play a role in atherothrombosis. However, prospective data relating exposure to Chlamydia pneumoniae and risks of future myocardial infarction (MI) are sparse...
  55. pmc A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans
    D Voora
    Department of Medicine, Washington University in St Louis, St Louis, Missouri, USA
    Clin Pharmacol Ther 87:445-51. 2010
    ..14, one-sided P = 0.03). CALU rs339097 A>G is associated with higher warfarin dose requirements, independent of known genetic and nongenetic predictors of warfarin dose in African Americans...
  56. ncbi request reprint G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men
    P M Ridker
    Divisions of Preventive Medicine and Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 99:999-1004. 1999
    ..Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial...
  57. ncbi request reprint Soluble CD40L and cardiovascular risk in women
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:2266-8. 2001
    ..It is unknown, however, whether elevations of circulating sCD40L precede the onset of acute cardiovascular symptoms...
  58. ncbi request reprint A prospective study of Helicobacter pylori seropositivity and the risk for future myocardial infarction among socioeconomically similar U.S. men
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Ann Intern Med 135:184-8. 2001
    ..The role of Helicobacter pylori as a determinant of cardiovascular disease is controversial...
  59. ncbi request reprint High-sensitivity C-reactive protein: a novel and promising marker of coronary heart disease
    N Rifai
    Department of Laboratory Medicine, Children s Hospital, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 47:403-11. 2001
    ..C-Reactive protein (CRP), an acute phase reactant that reflects low-grade systemic inflammation, has been studied in a variety of cardiovascular diseases...
  60. ncbi request reprint Plasma levels of cystatin-C and mannose binding protein are not associated with risk of developing systemic atherosclerosis
    M A Albert
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 6:145-9. 2001
    ..05). In contrast with prior retrospective and cross-sectional studies, no evidence was found that baseline levels of cystatin-C or mannose binding protein are associated with an increased risk of future arterial disease...
  61. ncbi request reprint Effect of valsartan compared with valsartan/hydrochlorothiazide on plasma levels of cellular adhesion molecules: the Val-MARC trial
    D Conen
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Heart 94:e13. 2008
    ....
  62. ncbi request reprint Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 103:1191-3. 2001
    ..However, the generalizability, speed of onset, and dose-response characteristics of this effect are uncertain...
  63. ncbi request reprint Lipid lowering and beyond: results from the CARE study on lipoproteins and inflammation. Cholesterol and Recurrent Events
    F M Sacks
    Department of Medicine, Harvard Medical School, USA
    Herz 24:51-6. 1999
    ..These findings also raise the possibility that the efficacy of pravastatin may partly result from anti-inflammatory as well as lipid lowering properties...
  64. ncbi request reprint Vasectomy and subsequent cardiovascular disease in US physicians
    J E Manson
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Contraception 59:181-6. 1999
    ..12 (0.94-1.35) for angina/revascularization. These results provide reassuring evidence that vasectomy does not materially increase the risk of subsequent cardiovascular disease, even 15 or more years following the procedure...
  65. ncbi request reprint Do atherosclerosis and type 2 diabetes share a common inflammatory basis?
    A D Pradhan
    Eur Heart J 23:831-4. 2002
  66. pmc Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin
    B F Gage
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Pharmacol Ther 84:326-31. 2008
    ..To facilitate use of these pharmacogenetic and clinical algorithms, we developed a nonprofit website, http://www.WarfarinDosing.org...
  67. ncbi request reprint C-reactive protein and prognosis after percutaneous coronary intervention
    G J Blake
    Eur Heart J 23:923-5. 2002
  68. ncbi request reprint Carboxypeptidase B2 gene polymorphisms and the risk of venous thromboembolism
    R Y L Zee
    J Thromb Haemost 3:2819-21. 2005
  69. ncbi request reprint Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction
    L M Hines
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    N Engl J Med 344:549-55. 2001
    ..We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study...
  70. ncbi request reprint G20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism
    J S Miles
    Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 37:215-8. 2001
    ..The study was done to determine whether the G20210A mutation in the prothrombin gene increases the risk of recurrent venous thromboembolism (VTE), both alone and in combination with factor V Leiden...
  71. ncbi request reprint Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study
    J S Rana
    Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    J Intern Med 262:678-89. 2007
    ..There is paucity of data on the differential leucocyte count and its relationship with the risk of CHD and CVD...
  72. ncbi request reprint A prospective replication study of five gene variants previously associated with risk of myocardial infarction
    R Y L Zee
    J Thromb Haemost 4:2093-5. 2006
  73. pmc Cystatin C deficiency in human atherosclerosis and aortic aneurysms
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:1191-7. 1999
    ..The findings highlight a potentially important role for imbalance between cysteine proteases and cystatin C in arterial wall remodeling and establish that cystatin C deficiency occurs in vascular disease...
  74. ncbi request reprint Long-term low-dose warfarin use is effective in the prevention of recurrent venous thromboembolism: yes
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thromb Haemost 2:1034-7. 2004
  75. ncbi request reprint Tumour necrosis factor-alpha, inflammatory biomarkers, and atherogenesis
    G J Blake
    Eur Heart J 23:345-7. 2002
  76. ncbi request reprint Inflammatory mechanisms in atherosclerosis: from laboratory evidence to clinical application
    G J Blake
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women's Hospital, Havard Medical School, Boston, MA 02215, USA
    Ital Heart J 2:796-800. 2001
    ..The role of statin therapy for plaque stabilization in acute coronary syndromes, and for prevention of future plaque rupture among healthy individuals with evidence of vascular inflammation, is an area of active research...
  77. ncbi request reprint Increased inflammatory markers in children with familial hypercholesterolaemia
    T Ueland
    Research Institute for Internal Medicine, Section of Endocrinology, Rikshospitalet, University of Oslo, Norway
    Eur J Clin Invest 36:147-52. 2006
    ....