P M Ridker

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Prospective study of Chlamydia pneumoniae IgG seropositivity and risks of future myocardial infarction
    P M Ridker
    Divisions of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 99:1161-4. 1999
  2. ncbi request reprint Homocysteine and risk of cardiovascular disease among postmenopausal women
    P M Ridker
    Division of Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 281:1817-21. 1999
  3. ncbi request reprint G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men
    P M Ridker
    Divisions of Preventive Medicine and Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 99:999-1004. 1999
  4. ncbi request reprint Evaluating novel cardiovascular risk factors: can we better predict heart attacks?
    P M Ridker
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:933-7. 1999
  5. ncbi request reprint Prospective study of herpes simplex virus, cytomegalovirus, and the risk of future myocardial infarction and stroke
    P M Ridker
    Divisions of Preventive Medicine, Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 98:2796-9. 1998
  6. ncbi request reprint Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 98:839-44. 1998
  7. ncbi request reprint Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women
    P M Ridker
    Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 98:731-3. 1998
  8. ncbi request reprint Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
    Circulation 97:425-8. 1998
  9. ncbi request reprint Intrinsic fibrinolytic capacity and systemic inflammation: novel risk factors for arterial thrombotic disease
    P M Ridker
    Cardiovascular Division, Brigham and Womens Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Haemostasis 27:2-11. 1997
  10. ncbi request reprint Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men
    P M Ridker
    Division of Cardiovascular Disease, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Lancet 351:88-92. 1998

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint Prospective study of Chlamydia pneumoniae IgG seropositivity and risks of future myocardial infarction
    P M Ridker
    Divisions of Cardiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 99:1161-4. 1999
    ..Chlamydia pneumoniae has been hypothesized to play a role in atherothrombosis. However, prospective data relating exposure to Chlamydia pneumoniae and risks of future myocardial infarction (MI) are sparse...
  2. ncbi request reprint Homocysteine and risk of cardiovascular disease among postmenopausal women
    P M Ridker
    Division of Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    JAMA 281:1817-21. 1999
    ..Individuals with elevated levels of homocysteine tend to have higher prevalence of cardiovascular disease. However, prospective studies of homocysteine are inconsistent and data among women are limited...
  3. ncbi request reprint G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men
    P M Ridker
    Divisions of Preventive Medicine and Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 99:999-1004. 1999
    ..Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial...
  4. ncbi request reprint Evaluating novel cardiovascular risk factors: can we better predict heart attacks?
    P M Ridker
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:933-7. 1999
    ..Background is also provided to assist physicians in deciding whether one or more of these novel markers deserve clinical consideration in general outpatient settings...
  5. ncbi request reprint Prospective study of herpes simplex virus, cytomegalovirus, and the risk of future myocardial infarction and stroke
    P M Ridker
    Divisions of Preventive Medicine, Cardiovascular Diseases, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 98:2796-9. 1998
    ..However, prospective data relating evidence of prior exposure to these agents with risks of future myocardial infarction (MI) and stroke are sparse...
  6. ncbi request reprint Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circulation 98:839-44. 1998
    ..We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and whether randomized treatment with pravastatin reduces that risk...
  7. ncbi request reprint Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women
    P M Ridker
    Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 98:731-3. 1998
    ..C-reactive protein (CRP) predicts risk of myocardial infarction (MI) and stroke among apparently healthy men, but in women, virtually no data are available...
  8. ncbi request reprint Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115 1204, USA
    Circulation 97:425-8. 1998
    ..Whether increased levels of CRP are also associated with the development of symptomatic peripheral arterial disease (PAD) is unknown...
  9. ncbi request reprint Intrinsic fibrinolytic capacity and systemic inflammation: novel risk factors for arterial thrombotic disease
    P M Ridker
    Cardiovascular Division, Brigham and Womens Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Haemostasis 27:2-11. 1997
    ..However, novel markers will probably provide new directions in both thrombosis research and disease prevention...
  10. ncbi request reprint Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men
    P M Ridker
    Division of Cardiovascular Disease, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Lancet 351:88-92. 1998
    ..Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown...
  11. ncbi request reprint Alu-repeat polymorphism in the gene coding for tissue-type plasminogen activator (t-PA) and risks of myocardial infarction among middle-aged men
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 17:1687-90. 1997
    ..In this cohort of middle-aged US men, the presence of the insertion allele of the Alu-repeat polymorphism of the tissue-type plasminogen activator gene is not associated with future risks of myocardial infarction...
  12. ncbi request reprint C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 97:2007-11. 1998
    ..However, whether measurement of CRP adds to the predictive value of total cholesterol (TC) and HDL cholesterol (HDL-C) in determining risk is uncertain...
  13. ncbi request reprint Ethnic distribution of factor V Leiden in 4047 men and women. Implications for venous thromboembolism screening
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    JAMA 277:1305-7. 1997
    ..To estimate ethnic-specific prevalence rates of factor V Leiden, an inherited defect of hemostasis associated with risk of venous thrombosis...
  14. ncbi request reprint Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 95:1777-82. 1997
    ....
  15. ncbi request reprint Hormone replacement therapy and increased plasma concentration of C-reactive protein
    P M Ridker
    Division of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 100:713-6. 1999
    ..However, data evaluating this hypothesis are sparse and limited to older women...
  16. ncbi request reprint C-reactive protein, inflammation, and coronary risk
    Paul M Ridker
    Center for Cardiovascular Disease in Women, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Cardiol Clin 21:315-25. 2003
    ..Ongoing and future investigation will clarify the specific pathophysiologic relationships through which these markers correlate with adverse prognosis...
  17. ncbi request reprint Inflammation, atherosclerosis, and cardiovascular risk: an epidemiologic view
    P M Ridker
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood Coagul Fibrinolysis 10:S9-12. 1999
    ..Taken together, these data raise the possibility that therapies targeting chronic low-grade inflammation may provide novel future strategies for cardiovascular disease prevention...
  18. ncbi request reprint C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
    ..Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events...
  19. ncbi request reprint Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians
    C J O'Donnell
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:1132-7. 1997
    ..The objective of this study was to examine whether definite hypertension and borderline isolated systolic hypertension predict subsequent cardiovascular disease and mortality...
  20. ncbi request reprint A prospective evaluation of lipoprotein-associated phospholipase A(2) levels and the risk of future cardiovascular events in women
    G J Blake
    Center for Cardiovascular Disease Prevention, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 38:1302-6. 2001
    ..CONCLUSIONS: In contrast to prior data among hyperlipidemic men, the current data suggest that Lp-PLA(2) is not a strong predictor of future cardiovascular risk among unselected women...
  21. ncbi request reprint Prospective evaluation of the angiotensin-converting enzyme insertion/deletion polymorphism and the risk of stroke
    R Y Zee
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 99:340-3. 1999
    ..We investigated the association between ACE genotype and the incidence of stroke in a large, prospective, matched case-control sample from the Physicians' Health Study...
  22. ncbi request reprint Clinical efficacy of an automated high-sensitivity C-reactive protein assay
    N Rifai
    Department of Laboratory Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 45:2136-41. 1999
    ..Prospective studies have shown that C-reactive protein (CRP) can be used to predict risk of future cardiovascular events. High-sensitivity methods for CRP (hs-CRP) measurement are needed for this purpose...
  23. ncbi request reprint Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach
    H H Hegener
    Center for Cardiovascular Disease Prevention, The Donald W Reynolds Center for Cardiovascular Research, The Leducq Center for Molecular and Genetic Epidemiology, Boston, MA 02215, USA
    J Thromb Haemost 4:1718-22. 2006
    ..Recent data have shown an association between polymorphisms of prostaglandin-endoperoxide synthase-2 gene (PTGS2; alias COX-2), and prostaglandin-E receptor-2 gene (PTGER2) and risk of atherothrombotic disorders...
  24. ncbi request reprint Hormonal factors and risk of recurrent venous thrombosis: the prevention of recurrent venous thromboembolism trial
    M Cushman
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    J Thromb Haemost 4:2199-203. 2006
    ..In some but not all studies, men with venous thrombosis had a higher risk of recurrence than women. Information on women with initial hormone-related thrombosis is scant...
  25. ncbi request reprint Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease
    P M Ridker
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 285:2481-5. 2001
    ..Several novel risk factors for atherosclerosis have recently been proposed, but few comparative data exist to guide clinical use of these emerging biomarkers...
  26. ncbi request reprint High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease
    P M Ridker
    Center for Cardiovascular Disease Prevention, Divisions of Cardiovascular Diseases and Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02214, USA
    Circulation 103:1813-8. 2001
    ....
  27. ncbi request reprint Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
    ..We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia...
  28. ncbi request reprint Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein
    D I Chasman
    Division of Preventive Medicine and Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02215, USA
    Genes Immun 7:211-9. 2006
    ..Quantitative analysis suggested that the effect on CRP is more likely a consequence of intrinsic functional differences among the E2, E3, and E4 apoE proteins than different levels of apoE protein or LDL-C in the plasma...
  29. ncbi request reprint Influence of genetic variation in the C-reactive protein gene on the inflammatory response during and after acute coronary ischemia
    J Suk Danik
    The Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02115, USA
    Ann Hum Genet 70:705-16. 2006
    ..Assessment of CRP genetic variants identified patients with higher and lower CRP elevation after acute coronary syndrome...
  30. pmc Lipid levels and the risk of ischemic stroke in women
    T Kurth
    Brigham and Women s Hospital, Division of Preventive Medicine, Harvard Medical School, Boston, MA 02215, USA
    Neurology 68:556-62. 2007
    ....
  31. ncbi request reprint Mutation in the promoter region of the beta-fibrinogen gene and the risk of future myocardial infarction, stroke and venous thrombosis
    G J Blake
    The Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Eur Heart J 22:2262-6. 2001
    ..We investigated whether the distribution of the C148T polymorphism is associated with an increase in cardiovascular risk...
  32. ncbi request reprint Inflammatory bio-markers and cardiovascular risk prediction
    G J Blake
    Center for Cardiovascular Disease Prevention and the Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    J Intern Med 252:283-94. 2002
    ..Further trials are needed to confirm the potential benefits of statins amongst individuals with elevated CRP levels...
  33. ncbi request reprint A prospective evaluation of the CD14 C(-260)T gene polymorphism and the risk of myocardial infarction
    R Y Zee
    Center of Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Atherosclerosis 154:699-702. 2001
    ..Thus, in contrast to prior studies, these data indicate that screening for CD14 C(-260)T genotypes is unlikely to be a useful tool for risk assessment...
  34. ncbi request reprint Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men
    P M Ridker
    Division of Cardiovascular Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Circulation 95:59-62. 1997
    ..In a small group of young Swedish men, this allele has been reported to predict risk of myocardial infarction. Whether this polymorphism increases risk of arterial and venous thrombosis among middle-aged men is unknown...
  35. ncbi request reprint Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators
    P M Ridker
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, The Children s Hospital Medical Center, Boston, MA, USA
    Circulation 100:230-5. 1999
    ..We evaluated whether long-term therapy with pravastatin, an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter...
  36. ncbi request reprint Renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study
    D Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Intern Med 263:376-85. 2008
    ..The aim of this study was to assess the relationship between a set of well-characterized genetic variants of the renin-angiotensin system and the endothelial nitric oxide synthase (NOS3) gene and the incidence of type 2 diabetes...
  37. ncbi request reprint Novel clinical markers of vascular wall inflammation
    G J Blake
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circ Res 89:763-71. 2001
    ..The addition of CRP screening to traditional lipid testing has the potential to identify individuals at high risk for future cardiovascular events who may benefit from targeted preventive interventions...
  38. ncbi request reprint D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism
    S Shrivastava
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA, USA
    J Thromb Haemost 4:1208-14. 2006
    ..Elevated plasma D-dimer and factor VIII coagulant activity (FVIIIc) may be associated with the risk of recurrent venous thromboembolism (VTE)...
  39. pmc Biomarkers and functional outcomes from ischaemic cerebral events in women: a prospective cohort study
    P M Rist
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Neurol 20:375-81. 2013
    ..We aimed to assess the patterns of association between cardiovascular disease biomarkers and functional outcomes after incident ischaemic cerebral events in women...
  40. pmc Comparison of associations of adherence to a Dietary Approaches to Stop Hypertension (DASH)-style diet with risks of cardiovascular disease and venous thromboembolism
    K C Fitzgerald
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 10:189-98. 2012
    ..Objective: To compare the relationships of adherence to a Dietary Approaches to Stop Hypertension (DASH)-style diet with the risks of CVD and VTE...
  41. ncbi request reprint Soluble P-selectin and the risk of future cardiovascular events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 103:491-5. 2001
    ..However, little clinical data are available evaluating the role of soluble P-selectin in determining vascular risk...
  42. ncbi request reprint A prospective evaluation of the interleukin-1 receptor antagonist intron 2 gene polymorphism and the risk of myocardial infarction
    R Y Zee
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Thromb Haemost 86:1141-3. 2001
    ..These data also highlight the importance of hypothesis testing studies in genetic epidemiology, particularly for hypotheses generated from small samples or post hoc subgroup analyses...
  43. ncbi request reprint Multi-locus candidate gene polymorphisms and risk of myocardial infarction: a population-based, prospective genetic analysis
    R Y L Zee
    Center for Cardiovascular Disease Prevention, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 4:341-8. 2006
    ..Polymorphisms in candidate genes related to lipid metabolism, thrombosis, hemostasis, cell-matrix adhesion, and inflammation have been suggested clinically useful in risk assessment of cardiovascular disease...
  44. pmc Lipid biomarkers, hormone therapy and the risk of venous thromboembolism in women
    B M Everett
    The Center for Cardiovascular Disease Prevention, Harvard Medical School, and the Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Thromb Haemost 7:588-96. 2009
    ..Published reports of a relationship between lipids and incident venous thromboembolism (VTE) are conflicting...
  45. ncbi request reprint Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study
    M A Albert
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 286:64-70. 2001
    ..These data provide evidence that statins may have anti-inflammatory effects in addition to lipid-lowering effects...
  46. ncbi request reprint Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    P M Ridker
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 101:1767-72. 2000
    ..Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse...
  47. ncbi request reprint Lack of association of C-reactive protein and coronary calcium by electron beam computed tomography in postmenopausal women: implications for coronary artery disease screening
    R F Redberg
    Division of Cardiology, University of California, San Francisco 94143 0124, USA
    J Am Coll Cardiol 36:39-43. 2000
    ..We sought to test the hypothesis that C-reactive protein, a marker of inflammation, would correlate positively with coronary calcium, a marker of atherosclerosis, in postmenopausal women...
  48. ncbi request reprint Blood pressure and inflammation in apparently healthy men
    C U Chae
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Hypertension 38:399-403. 2001
    ..These data suggest that increased blood pressure may be a stimulus for inflammation and that this is a possible mechanism underlying the well-established role of hypertension as a risk factor for atherosclerotic disease...
  49. pmc HbA1c measured in stored erythrocytes and mortality rate among middle-aged and older women
    E B Levitan
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, 375 Longwood Avenue, MS 443, Boston, MA 02215, USA
    Diabetologia 51:267-75. 2008
    ..We examined the association between HbA1c measured in stored erythrocytes and mortality rate in women with and without diabetes...
  50. ncbi request reprint Migraine and biomarkers of cardiovascular disease in women
    T Kurth
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Cephalalgia 28:49-56. 2008
    ..In this large cohort of women, only a modest association was found between migraine and adverse levels of certain cardiovascular biomarkers...
  51. ncbi request reprint Association of common CRP gene variants with CRP levels and cardiovascular events
    D T Miller
    Division of Hematology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Ann Hum Genet 69:623-38. 2005
    ..001). Taken together, these data imply significant interactions between both genetic and environmental contributions to the increased CRP levels that predict a greater risk of future atherothrombotic events in epidemiological studies...
  52. ncbi request reprint C-reactive protein gene polymorphisms and the risk of venous thromboembolism: a haplotype-based analysis
    R Y L Zee
    Center for Cardiovascular Disease Prevention, Harvard Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 2:1240-3. 2004
    ..66, P = 0.72) yielded similar null findings. In conclusion, we found no evidence for an association between the CRP polymorphisms/haplotypes tested and the risk of venous thromboembolism...
  53. doi request reprint Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  54. ncbi request reprint The pravastatin inflammation CRP evaluation (PRINCE): rationale and design
    M A Albert
    Center for Cardiovascular Disease Prevention, Division of Cardiology and Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am Heart J 141:893-8. 2001
    ..However, the time course and magnitude of this effect in both primary and secondary prevention is controversial...
  55. ncbi request reprint Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trial
    M A Pfeffer
    Brigham and Women s Hospital, Boston, Mass, USA
    Circulation 95:2643-51. 1997
    ..Although ACE inhibitor therapy has been shown to reduce mortality in patients with acute myocardial infarction (MI), the optimal dose and the timing of its initiation have not been determined...
  56. ncbi request reprint Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk
    J A de Lemos
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 36:423-6. 2000
    ..The purpose of this study was to evaluate whether soluble vascular cell adhesion molecule-1 (sVCAM-1) is a marker for increased cardiovascular risk...
  57. ncbi request reprint G20210A mutation in the prothrombin gene and the risk of recurrent venous thromboembolism
    J S Miles
    Leducq Center for Molecular and Genetic Epidemiology of Cardiovascular Disorders, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 37:215-8. 2001
    ..The study was done to determine whether the G20210A mutation in the prothrombin gene increases the risk of recurrent venous thromboembolism (VTE), both alone and in combination with factor V Leiden...
  58. ncbi request reprint Variability and classification accuracy of serial high-sensitivity C-reactive protein measurements in healthy adults
    I S Ockene
    Department of Medicine, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Clin Chem 47:444-50. 2001
    ..Because of its relationship to inflammation, hs-CRP has considerable biologic variation. This study was carried out to characterize CRP variation and to compare it to another risk factor, total serum cholesterol...
  59. ncbi request reprint Current issues concerning thrombolytic therapy for acute myocardial infarction
    C H Hennekens
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 25:18S-22S. 1995
    ..Whether or not accelerated t-PA has a small advantage for mortality is less conclusive.(ABSTRACT TRUNCATED AT 250 WORDS)..
  60. ncbi request reprint A prospective study of Helicobacter pylori seropositivity and the risk for future myocardial infarction among socioeconomically similar U.S. men
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Ann Intern Med 135:184-8. 2001
    ..The role of Helicobacter pylori as a determinant of cardiovascular disease is controversial...
  61. ncbi request reprint Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction
    L M Hines
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    N Engl J Med 344:549-55. 2001
    ..We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, and the risk of myocardial infarction in a nested case-control study based on data from the prospective Physicians' Health Study...
  62. ncbi request reprint Soluble CD40L and cardiovascular risk in women
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:2266-8. 2001
    ..It is unknown, however, whether elevations of circulating sCD40L precede the onset of acute cardiovascular symptoms...
  63. pmc A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans
    D Voora
    Department of Medicine, Washington University in St Louis, St Louis, Missouri, USA
    Clin Pharmacol Ther 87:445-51. 2010
    ..14, one-sided P = 0.03). CALU rs339097 A>G is associated with higher warfarin dose requirements, independent of known genetic and nongenetic predictors of warfarin dose in African Americans...
  64. ncbi request reprint Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 103:1191-3. 2001
    ..However, the generalizability, speed of onset, and dose-response characteristics of this effect are uncertain...
  65. pmc Cystatin C deficiency in human atherosclerosis and aortic aneurysms
    G P Shi
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 104:1191-7. 1999
    ..The findings highlight a potentially important role for imbalance between cysteine proteases and cystatin C in arterial wall remodeling and establish that cystatin C deficiency occurs in vascular disease...
  66. ncbi request reprint Cocaine-induced erythrocytosis and increase in von Willebrand factor: evidence for drug-related blood doping and prothrombotic effects
    A J Siegel
    Department of Medicine, McLean Hospital, Belmont, Mass 02478, USA
    Arch Intern Med 159:1925-9. 1999
    ..Mechanisms that mediate cocaine-induced cardiovascular events following vasoconstriction are incompletely understood...
  67. ncbi request reprint Vasectomy and subsequent cardiovascular disease in US physicians
    J E Manson
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Contraception 59:181-6. 1999
    ..12 (0.94-1.35) for angina/revascularization. These results provide reassuring evidence that vasectomy does not materially increase the risk of subsequent cardiovascular disease, even 15 or more years following the procedure...
  68. ncbi request reprint Plasma levels of cystatin-C and mannose binding protein are not associated with risk of developing systemic atherosclerosis
    M A Albert
    Center for Cardiovascular Disease Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Vasc Med 6:145-9. 2001
    ..05). In contrast with prior retrospective and cross-sectional studies, no evidence was found that baseline levels of cystatin-C or mannose binding protein are associated with an increased risk of future arterial disease...
  69. ncbi request reprint High-sensitivity C-reactive protein: a novel and promising marker of coronary heart disease
    N Rifai
    Department of Laboratory Medicine, Children s Hospital, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 47:403-11. 2001
    ..C-Reactive protein (CRP), an acute phase reactant that reflects low-grade systemic inflammation, has been studied in a variety of cardiovascular diseases...
  70. ncbi request reprint Lipid lowering and beyond: results from the CARE study on lipoproteins and inflammation. Cholesterol and Recurrent Events
    F M Sacks
    Department of Medicine, Harvard Medical School, USA
    Herz 24:51-6. 1999
    ..These findings also raise the possibility that the efficacy of pravastatin may partly result from anti-inflammatory as well as lipid lowering properties...
  71. ncbi request reprint Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study
    Hillary H Hegener
    Center for Cardiovascular Disease Prevention, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Clin Chem 52:2021-7. 2006
    ..No prospective data are available, however, on the risk of atherothrombotic disorders in persons with ADIPOQ variations who do not have diabetes...
  72. doi request reprint Genetic variation of the androgen receptor and risk of myocardial infarction and ischemic stroke in women
    Kathryn M Rexrode
    Stroke 39:1590-2. 2008
    ..Some studies suggest an association between AR gene variation and risk of cardiovascular disease (CVD) in men; however, the relationship has not been examined in women...
  73. doi request reprint Genetic variants of tumor necrosis factor superfamily, member 4 (TNFSF4), and risk of incident atherothrombosis and venous thromboembolism
    Anders Malarstig
    Atherosclerosis Research Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Clin Chem 54:833-40. 2008
    ..Recent data have implicated tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) gene variation in myocardial infarction in women; however, no prospective data are available on either incident arterial or venous disorders...
  74. pmc Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 82:1185-92. 2008
    ....
  75. ncbi request reprint Additive value of immunoassay-measured fibrinogen and high-sensitivity C-reactive protein levels for predicting incident cardiovascular events
    Samia Mora
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215
    Circulation 114:381-7. 2006
    ..Whether other inflammatory biomarkers, such as fibrinogen, add further prognostic information is uncertain...
  76. pmc Risk of cardiovascular events among women with high normal blood pressure or blood pressure progression: prospective cohort study
    David Conen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 900 Commonwealth Avenue, Boston, MA 02215, USA
    BMJ 335:432. 2007
    ..To compare cardiovascular risk among women with high normal blood pressure (130-9/85-9 mm Hg) against those with normal blood pressure (120-9/75-84 mm Hg) and those with baseline hypertension...
  77. ncbi request reprint Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women
    Samia Mora
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    JAMA 295:1412-9. 2006
    ..There are few data directly comparing the effects of physical activity and body weight on cardiovascular biomarkers...
  78. pmc Polymorphisms and haplotypes of the estrogen receptor-beta gene (ESR2) and cardiovascular disease in men and women
    Kathryn M Rexrode
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 53:1749-56. 2007
    ..Cohort studies suggest an association between variation in the estrogen receptor-alpha gene (ESR1) and cardiovascular disease (CVD), but data are lacking for the effect of variation in the estrogen receptor-beta gene (ESR2)...
  79. ncbi request reprint Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Diabetes Care 28:2926-32. 2005
    ..To examine whether and to what extent intakes of calcium and vitamin D are related to the metabolic syndrome in middle-aged or older women...
  80. ncbi request reprint Genetic determinants of C-reactive protein
    Jacqueline Suk Danik
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Curr Atheroscler Rep 9:195-203. 2007
    ..Work on the relation of genetic variants within CRP to cardiovascular disease has had varied results. Whole-genome association studies to investigate the genetic determinants of CRP levels in an unbiased manner are ongoing...
  81. pmc Low sex hormone-binding globulin is associated with the metabolic syndrome in postmenopausal women
    Melissa E Weinberg
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Metabolism 55:1473-80. 2006
    ..7 kg/m2. An androgenic hormone profile is associated with both the individual components of the metabolic syndrome and clustering of metabolic abnormalities in postmenopausal women...
  82. pmc Physical activity and reduced risk of cardiovascular events: potential mediating mechanisms
    Samia Mora
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Circulation 116:2110-8. 2007
    ..Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect...
  83. ncbi request reprint Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity
    Paul M Ridker
    Harvard Medical School, Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Nutr Rev 65:S253-9. 2007
    ..Several novel methods to reduce CRP have been proposed, including direct inhibitors as well as antisense technologies...
  84. ncbi request reprint Alcohol consumption and plasma concentration of C-reactive protein
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 107:443-7. 2003
    ..Moderate alcohol intake has been associated with lower cardiovascular mortality. However, data evaluating the relationship between C-reactive protein (CRP), a predictor of cardiovascular risk, and alcohol consumption are sparse...
  85. ncbi request reprint Interrelationships between inflammation, C-reactive protein, and insulin resistance
    Chiadi E Ndumele
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Cardiometab Syndr 1:190-6. 2006
    ..Multiple clinical studies are now underway that are evaluating whether agents traditionally used to improve glycemic control may also significantly reduce hs-CRP...
  86. pmc Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Division of Cardiovascular Medicine, VA Boston Medical Center, Boston, Mass, USA
    Am J Med 120:720-7. 2007
    ..Whether mild elevations of this biomarker provide prognostic information for development of clinically evident type 2 diabetes and cardiovascular disease among individuals at usual risk for these disorders is uncertain...
  87. pmc Differential effect of soluble intercellular adhesion molecule-1 on the progression of atherosclerosis as compared to arterial thrombosis: a prospective analysis of the Women's Health Study
    Michelle A Albert
    Center for Cardiovascular Disease Prevention, Donald W Reynolds Center for Cardiovascular Disease Research, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Atherosclerosis 197:297-302. 2008
    ....
  88. ncbi request reprint C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, the Division of Preventive Medicine, Brigham and Women s Hospital, The Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 49:2129-38. 2007
    ..In the meantime, however, this consensus position on hsCRP should be one to which both advocates and critics of the inflammatory hypothesis of atherosclerosis can adhere because it is one that can immediately improve patient care...
  89. doi request reprint A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    Dov Shiffman
    Celera, Alameda, California 94502, USA
    J Am Coll Cardiol 51:444-8. 2008
    ..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women...
  90. pmc Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...
  91. ncbi request reprint Prognostic significance of the Centers for Disease Control/American Heart Association high-sensitivity C-reactive protein cut points for cardiovascular and other outcomes in patients with stable coronary artery disease
    Marc S Sabatine
    Cardiovascular Division, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Circulation 115:1528-36. 2007
    ....
  92. pmc The relative strength of C-reactive protein and lipid levels as determinants of ischemic stroke compared with coronary heart disease in women
    Brendan M Everett
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 48:2235-42. 2006
    ..We sought to determine the relative strength of high-sensitivity C-reactive protein (hs-CRP) and lipid levels as markers for future ischemic stroke compared with coronary heart disease (CHD) in women...
  93. ncbi request reprint Risk factors for progression of peripheral arterial disease in large and small vessels
    Victor Aboyans
    Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093 0607, USA
    Circulation 113:2623-9. 2006
    ..Using noninvasive tests, we assessed the role of traditional and novel risk factors on PAD progression. We hypothesized that the risk factors for large-vessel PAD (LV-PAD) progression might differ from small-vessel PAD (SV-PAD)...
  94. ncbi request reprint Comparison of usefulness of inflammatory markers in patients with versus without peripheral arterial disease in predicting adverse cardiovascular outcomes (myocardial infarction, stroke, and death)
    Joshua A Beckman
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Cardiol 96:1374-8. 2005
    ..In conclusion, patients who have PAD and increased inflammation are at highest risk for adverse cardiovascular outcomes. Characterizing atherosclerosis on the basis of these parameters provides important prognostic information...
  95. ncbi request reprint Sex hormone-binding globulin and serum testosterone are inversely associated with C-reactive protein levels in postmenopausal women at high risk for cardiovascular disease
    Hylton V Joffe
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02215, USA
    Ann Epidemiol 16:105-12. 2006
    ..We hypothesized that high androgens, low estradiol, and low sex hormone-binding globulin (SHBG) would be associated with high CRP in postmenopausal women...
  96. ncbi request reprint Association between inflammatory markers, hemostatic, and lipid factors in postinfarction patients
    Tareq S Harb
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, New York 14642, USA
    Am J Cardiol 91:1120-3. 2003
  97. ncbi request reprint C-reactive protein is independently associated with fasting insulin in nondiabetic women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, Mass 02215 1204, USA
    Arterioscler Thromb Vasc Biol 23:650-5. 2003
    ..Insulin resistance is associated with chronic subclinical inflammation, and both conditions are linked with increased risk for type 2 diabetes mellitus and atherothrombotic cardiovascular disease...
  98. ncbi request reprint Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, 900 Commonwealth Ave East, Boston, Mass 02215, USA
    Arterioscler Thromb Vasc Biol 23:859-63. 2003
    ..Because diabetes and atherothrombosis share common antecedents, we sought evidence that this polymorphism might also be associated with reduced risk of myocardial infarction...
  99. ncbi request reprint Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 348:1425-34. 2003
    ..0 and 3.0. However, for long-term management, no therapeutic agent has shown an acceptable benefit-to-risk ratio...
  100. ncbi request reprint Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study with high-resolution MRI
    Gavin J Blake
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 23:e11-4. 2003
    ..We tested the hypothesis that plasma levels of soluble CD40 ligand are elevated in patients with evidence of a lipid pool on high-resolution magnetic resonance imaging (MRI) of carotid stenoses...
  101. ncbi request reprint Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 347:1557-65. 2002
    ..Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are elevated in persons at risk for cardiovascular events. However, population-based data directly comparing these two biologic markers are not available...