Matthew R Reynolds

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Improvements in symptoms and quality of life in patients with paroxysmal atrial fibrillation treated with radiofrequency catheter ablation versus antiarrhythmic drugs
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Harvard Clinical Research Institute, Boston, Mass, USA
    Circ Cardiovasc Qual Outcomes 3:615-23. 2010
  2. pmc Cost-effectiveness of dronedarone and standard of care compared with standard of care alone: US results of an ATHENA lifetime model
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, VA Boston Healthcare System, Boston, MA, USA
    Clinicoecon Outcomes Res 5:19-28. 2013
  3. pmc Influence of age, sex, and atrial fibrillation recurrence on quality of life outcomes in a population of patients with new-onset atrial fibrillation: the Fibrillation Registry Assessing Costs, Therapies, Adverse events and Lifestyle (FRACTAL) study
    Matthew R Reynolds
    Division of Cardiology, Beth Israel Deaconess Medical Center, 185 Pilgrim Road Baker 4, Boston, MA 02215, USA
    Am Heart J 152:1097-103. 2006
  4. pmc Healthcare resource utilization and costs associated with recurrent episodes of atrial fibrillation: the FRACTAL registry
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Division of Cardiology, Boston, MA 02215, USA
    J Cardiovasc Electrophysiol 18:628-33. 2007
  5. pmc The frequency and incremental cost of major complications among medicare beneficiaries receiving implantable cardioverter-defibrillators
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 47:2493-7. 2006
  6. doi request reprint Impact of hospitalization on health-related quality of life in atrial fibrillation patients in Canada and the United States: results from an observational registry
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Harvard Clinical Research Institute, Boston, MA 02215, USA
    Am Heart J 160:752-8. 2010
  7. pmc Cost-effectiveness of radiofrequency catheter ablation compared with antiarrhythmic drug therapy for paroxysmal atrial fibrillation
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Circ Arrhythm Electrophysiol 2:362-9. 2009
  8. ncbi request reprint Relationship of baseline electrocardiographic characteristics with the response to cardiac resynchronization therapy for heart failure
    Matthew R Reynolds
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Pacing Clin Electrophysiol 27:1513-8. 2004
  9. pmc Quality of life in atrial fibrillation: measurement tools and impact of interventions
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Cardiovasc Electrophysiol 19:762-8. 2008
  10. doi request reprint Cost-effectiveness of transcatheter aortic valve replacement compared with surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results of the PARTNER (Placement of Aortic Transcatheter Valves) trial (Cohort A)
    Matthew R Reynolds
    Harvard Clinical Research Institute, Boston, Massachusetts, USA
    J Am Coll Cardiol 60:2683-92. 2012

Research Grants

Detail Information

Publications38

  1. ncbi request reprint Improvements in symptoms and quality of life in patients with paroxysmal atrial fibrillation treated with radiofrequency catheter ablation versus antiarrhythmic drugs
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Harvard Clinical Research Institute, Boston, Mass, USA
    Circ Cardiovasc Qual Outcomes 3:615-23. 2010
    ..In patients with paroxysmal atrial fibrillation (AF), catheter ablation maintains sinus rhythm more effectively than antiarrhythmic drugs (AADs), but its effect on symptoms and quality of life (QOL) has not been fully characterized...
  2. pmc Cost-effectiveness of dronedarone and standard of care compared with standard of care alone: US results of an ATHENA lifetime model
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, VA Boston Healthcare System, Boston, MA, USA
    Clinicoecon Outcomes Res 5:19-28. 2013
    ..The potential cost-effectiveness of dronedarone in this patient population has not been reported in a US context. This study assesses the cost-effectiveness of dronedarone from a US health care payers' perspective...
  3. pmc Influence of age, sex, and atrial fibrillation recurrence on quality of life outcomes in a population of patients with new-onset atrial fibrillation: the Fibrillation Registry Assessing Costs, Therapies, Adverse events and Lifestyle (FRACTAL) study
    Matthew R Reynolds
    Division of Cardiology, Beth Israel Deaconess Medical Center, 185 Pilgrim Road Baker 4, Boston, MA 02215, USA
    Am Heart J 152:1097-103. 2006
    ..We sought to characterize symptoms and QoL in a large inception cohort of unselected patients with AF and explore the impact of age, sex, and AF clinical course on QoL measures over time...
  4. pmc Healthcare resource utilization and costs associated with recurrent episodes of atrial fibrillation: the FRACTAL registry
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Division of Cardiology, Boston, MA 02215, USA
    J Cardiovasc Electrophysiol 18:628-33. 2007
    ..We sought to characterize the resource utilization and costs of treating new-onset AF, with emphasis on the incremental costs associated with recurrent episodes of AF over time...
  5. pmc The frequency and incremental cost of major complications among medicare beneficiaries receiving implantable cardioverter-defibrillators
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 47:2493-7. 2006
    ..We aimed to quantify the frequency and nature of early complications after implantable cardioverter-defibrillator (ICD) implantation in general practice, and estimate the incremental costs of those complications to the health care system...
  6. doi request reprint Impact of hospitalization on health-related quality of life in atrial fibrillation patients in Canada and the United States: results from an observational registry
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Harvard Clinical Research Institute, Boston, MA 02215, USA
    Am Heart J 160:752-8. 2010
    ..Hospitalization is recognized as an important end point in atrial fibrillation (AF). The association between hospitalization and reduced health-related quality of life (HRQOL) has not been previously studied...
  7. pmc Cost-effectiveness of radiofrequency catheter ablation compared with antiarrhythmic drug therapy for paroxysmal atrial fibrillation
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Circ Arrhythm Electrophysiol 2:362-9. 2009
    ..The potential cost-effectiveness of RFA for AF, relative to antiarrhythmic drug (AAD) therapy, has not been fully explored from a US perspective...
  8. ncbi request reprint Relationship of baseline electrocardiographic characteristics with the response to cardiac resynchronization therapy for heart failure
    Matthew R Reynolds
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Pacing Clin Electrophysiol 27:1513-8. 2004
    ..ECG markers of anterior infarction and RV dilation may help identify CHF patients unlikely to benefit from biventricular pacing. Further assessment is needed of these and other predictors of therapeutic response to CRT...
  9. pmc Quality of life in atrial fibrillation: measurement tools and impact of interventions
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Cardiovasc Electrophysiol 19:762-8. 2008
    ..This paper will review the rationale, design, strengths, and limitations of the questionnaires most commonly used to assess QoL in AF studies, and present QoL outcomes from major studies of AF interventions...
  10. doi request reprint Cost-effectiveness of transcatheter aortic valve replacement compared with surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results of the PARTNER (Placement of Aortic Transcatheter Valves) trial (Cohort A)
    Matthew R Reynolds
    Harvard Clinical Research Institute, Boston, Massachusetts, USA
    J Am Coll Cardiol 60:2683-92. 2012
    ..The aim of this study was to evaluate the cost-effectiveness of transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (AVR) for patients with severe aortic stenosis and high surgical risk...
  11. ncbi request reprint Healthcare utilization and expenditures in patients with atrial fibrillation treated with catheter ablation
    Joseph A Ladapo
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Cardiovasc Electrophysiol 23:1-8. 2012
    ..The aim was to estimate the impact of catheter ablation on short- and long-term healthcare utilization and expenditures among atrial fibrillation (AF) patients in general and Medicare populations...
  12. ncbi request reprint Impact of a practice guideline for patients with atrial fibrillation on medical resource utilization and costs
    Peter Zimetbaum
    Division of Cardiology, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, MA 02215, USA
    Am J Cardiol 92:677-81. 2003
    ..We conclude that the implementation of our practice guideline was feasible, safe, and effective. Widespread adoption of such practices may have large financial implications for the health care system...
  13. pmc Bi-directional electrical pulmonary vein isolation as an endpoint for ablation of paroxysmal atrial fibrillation
    Vidal Essebag
    Harvard Thorndike Electrophysiology Institute Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Interv Card Electrophysiol 17:111-7. 2006
    ..The purpose of this study is to report the efficacy and safety of routine isolation of all PVs using an endpoint of bi-directional electrical block...
  14. pmc Characteristics and outcomes of patients receiving new and replacement implantable cardioverter-defibrillators: results from the NCDR
    Daniel B Kramer
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    Circ Cardiovasc Qual Outcomes 6:488-97. 2013
    ..Little is known about the clinical features, procedural risks, or survival of patients receiving replacement versus new implantable cardioverter-defibrillators (ICDs)...
  15. doi request reprint Health-related quality of life after transcatheter or surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results from the PARTNER (Placement of AoRTic TraNscathetER Valve) Trial (Cohort A)
    Matthew R Reynolds
    Harvard Clinical Research Institute, Boston VA Healthcare System, Boston, Massachusetts, USA
    J Am Coll Cardiol 60:548-58. 2012
    ....
  16. pmc Cost-effectiveness of sirolimus-eluting stents compared with vascular brachytherapy for the treatment of in-stent restenosis
    Matthew R Reynolds
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am Heart J 154:1221-7. 2007
    ..Sirolimus-eluting stents (SESs) were recently shown to be superior to vascular brachytherapy for the treatment of restenosis within a bare metal stent. No economic comparison of these alternative strategies has yet been reported...
  17. ncbi request reprint Patterns and predictors of warfarin use in patients with new-onset atrial fibrillation from the FRACTAL Registry
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Am J Cardiol 97:538-43. 2006
    ..The discontinuation of warfarin in a large number of patients with AF over time is a cause for concern in light of data from recent clinical trials...
  18. doi request reprint Health outcomes with catheter ablation or antiarrhythmic drug therapy in atrial fibrillation: results of a propensity-matched analysis
    Matthew R Reynolds
    Department of Cardiology, Beth Israel Deaconess Medical Center and the VA Boston Healthcare System, Boston, MA, USA
    Circ Cardiovasc Qual Outcomes 5:171-81. 2012
    ..The objective of this study was to determine whether AF ablation reduces the long-term risk of stroke or heart failure compared with antiarrhythmic drug therapy...
  19. pmc Inducibility of atrial fibrillation with a synchronized external low energy shock post-pulmonary vein isolation predicts recurrent atrial fibrillation
    John V Wylie
    Harvard Thorndike Electrophysiology Institute, Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Cardiovasc Electrophysiol 20:29-36. 2009
    ..Inducibility of atrial fibrillation (AF) with burst pacing after pulmonary vein (PV) isolation is associated with recurrent AF...
  20. pmc Non-inducibility post-pulmonary vein isolation achieving exit block predicts freedom from atrial fibrillation
    Vidal Essebag
    Harvard Thorndike Electrophysiology Institute, Cardiovascular Division, Beth Israel Deaconess Medical Center, 185 Pilgrim Road, Baker 4, Boston, MA 02215, USA
    Eur Heart J 26:2550-5. 2005
    ..This study evaluates whether non-inducibility of atrial fibrillation (AF) after achieving bi-directional electrical pulmonary vein (PV) isolation is a useful predictor of freedom from AF recurrence...
  21. pmc A cost-minimization analysis of the angio-seal vascular closure device following percutaneous coronary intervention
    Frederic S Resnic
    Cardiovascular Division, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 99:766-70. 2007
    ..This cost savings was in addition to the previously demonstrated advantages of Angio-Seal in terms of patient comfort and preference...
  22. ncbi request reprint Clinical and economic outcomes of multivessel coronary stenting compared with bypass surgery: a single-center US experience
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am Heart J 145:334-42. 2003
    ..The impact of these alternative strategies on overall medical care costs is uncertain, particularly within the US health care system...
  23. pmc Prophylactic catheter ablation for the prevention of defibrillator therapy
    Vivek Y Reddy
    Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, USA
    N Engl J Med 357:2657-65. 2007
    ..We designed this randomized trial to examine whether prophylactic radiofrequency catheter ablation of arrhythmogenic ventricular tissue would reduce the incidence of ICD therapy...
  24. pmc Trends in utilization and complications of catheter ablation for atrial fibrillation in Medicare beneficiaries
    Ethan R Ellis
    Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Heart Rhythm 6:1267-73. 2009
    ..Utilization of radiofrequency catheter ablation (RFA) for treatment of atrial fibrillation (AF) is increasing. Data regarding the safety of RFA for AF outside of selected centers of excellence and in older patients are limited...
  25. doi request reprint Economic evaluation of bivalirudin with or without glycoprotein IIb/IIIa inhibition versus heparin with routine glycoprotein IIb/IIIa inhibition for early invasive management of acute coronary syndromes
    Duane S Pinto
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 52:1758-68. 2008
    ..The aim of this study was to determine the economic impact of several anticoagulation strategies for moderate- and high-risk non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients managed invasively...
  26. doi request reprint Health-related quality of life after transcatheter aortic valve replacement in inoperable patients with severe aortic stenosis
    Matthew R Reynolds
    Harvard Clinical Research Institute, Boston VA Healthcare System, Boston, MA, USA
    Circulation 124:1964-72. 2011
    ..Clinical Trials Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00530894...
  27. pmc Resynchronization: considering device-based cardiac therapy in older adults
    Daniel B Kramer
    Hebrew Senior Life Institute for Aging Research, Boston, MA 02215, USA
    J Am Geriatr Soc 61:615-21. 2013
    ..Informed decision-making by clinicians, policy-makers, and patients will require greater understanding of the use and outcomes of CRT in older persons...
  28. ncbi request reprint MADIT II (second Multicenter Automated Defibrillator Implantation Trial) debate: risk stratification, costs, and public policy
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    Circulation 108:1779-83. 2003
  29. pmc Prevalence and predictors of off-label use of cardiac resynchronization therapy in patients enrolled in the National Cardiovascular Data Registry Implantable Cardiac-Defibrillator Registry
    Adam S Fein
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 56:766-73. 2010
    ..The purpose of the study was to define the extent and nature of cardiac resynchronization therapy (CRT) device usage outside consensus guidelines using national data...
  30. ncbi request reprint Current clinical characteristics and economic impact of subacute stent thrombosis
    Matthew R Reynolds
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Invasive Cardiol 14:364-8. 2002
    ..Conclusions. Despite its low overall frequency, the clinical and economic costs of SAT are substantial. Specific strategies at preventing its occurrence are warranted, particularly in high-risk situations...
  31. doi request reprint Development and validation of a risk score to predict early mortality in recipients of implantable cardioverter-defibrillators
    Daniel B Kramer
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02446, USA
    Heart Rhythm 9:42-6. 2012
    ..Better methods are needed for identifying patients at high risk for early mortality despite ICD therapy...
  32. pmc Security and privacy qualities of medical devices: an analysis of FDA postmarket surveillance
    Daniel B Kramer
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 7:e40200. 2012
    ..These computing capabilities introduce security and privacy risks, yet little is known about the prevalence of such risks within the clinical setting...
  33. pmc Mortality following defibrillator implantation in patients with renal insufficiency
    Robert E Eckart
    Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    J Cardiovasc Electrophysiol 17:940-3. 2006
    ..Due to under-representation of patients with renal disease in large clinical trials, outcomes of implantable cardioverter defibrillator (ICD) implantation in this group remain unclear...
  34. ncbi request reprint Atrial fibrillation: epidemiology, prognosis and therapy
    H Rutzen-Lopez
    Beth Israel Deaconess Medical Center, VA Boston Healthcare System, Boston, MA, USA
    Minerva Med 102:187-207. 2011
    ....
  35. pmc Sex differences in the relationship between amiodarone use and the need for permanent pacing in patients with atrial fibrillation
    Vidal Essebag
    Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada
    Arch Intern Med 167:1648-53. 2007
    ..The aims of this study were to determine prospectively whether amiodarone increases the need for pacemakers in a general population of patients with AF and whether this effect is modified by sex...
  36. ncbi request reprint Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease
    Peleg M Horowitz
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 24:7895-902. 2004
    ..Collectively, these results suggest a role for caspase-6 and N-terminal truncation of tau during neurofibrillary tangle evolution and the progression of Alzheimer's disease...
  37. ncbi request reprint Ossified pseudomeningocele following Chiari decompression surgery in a patient with Kleeblattsch├Ądel deformity
    Matthew R Reynolds
    Department of Neurosurgery, Washington University, St Louis Children s Hospital, St Louis, MO 63110, USA
    J Neurosurg Pediatr 2:203-6. 2008
    ..A genetic basis for the ossification process seems likely given the child's history of premature cranial suture closure. The authors draw attention to this rare complication and review the available body of literature on this topic...
  38. doi request reprint The frequency and cost of complications associated with coronary artery bypass grafting surgery: results from the United States Medicare program
    Phillip P Brown
    Cardiac Data Solutions, Inc, Atlanta, Georgia, USA
    Ann Thorac Surg 85:1980-6. 2008
    ..We estimate the incremental hospital resource consumption associated with treating selected complications experienced by Medicare beneficiaries undergoing coronary artery bypass grafting (CABG)...

Research Grants3

  1. Tau Nitration in Alzheimer's Pathogenesis
    Matthew Reynolds; Fiscal Year: 2007
    ..In this proposal, we will characterize the specific sites of T nitration in vitro and in situ, and determine the effects of nitration on T folding and function. ..
  2. Cost Effectiveness of Catheter Ablation for Atrial Fibrillation (AF)
    Matthew Reynolds; Fiscal Year: 2007
    ..Once all of this data is collected, the necessary inputs will combined in a Markov model comparing AF ablation with antiarrhythmic drug therapy, and atrio-ventricular junctional ablation with pacemaker implantation. ..