Research Topics
Genomes and Genes
| S M ReppertSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loopK Kume
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Cell 98:193-205. 1999..Luciferase reporter gene assays show that mCRY1 or mCRY2 alone abrogates CLOCK:BMAL1-E box-mediated transcription. The mPER and mCRY proteins appear to inhibit the transcriptional complex differentially...- Interacting molecular loops in the mammalian circadian clockL P Shearman
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Science 288:1013-9. 2000..PERIOD2 is a positive regulator of the Bmal1 loop, and CRYPTOCHROMES are the negative regulators of the Period and Cryptochrome cycles... - Cloning of a melatonin-related receptor from human pituitaryS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114
FEBS Lett 386:219-24. 1996..H9 mRNA is expressed in hypothalamus and pituitary, suggesting that the encoded receptor and its natural ligand are involved in neuroendocrine function... - Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clockK Bae
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and, Harvard Medical School, 02114, Boston, MA, USA
Neuron 30:525-36. 2001..Thus, mPER1 influences rhythmicity primarily through interaction with other clock proteins, while mPER2 positively regulates rhythmic gene expression, and there is partial compensation between products of these two genes... - Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responsesS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114
Neuron 13:1177-85. 1994..The cloned high affinity receptor likely mediates the reproductive and circadian actions of melatonin in mammals... - A time-less function for mouse timelessA L Gotter
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nat Neurosci 3:755-6. 2000..A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function... 
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptorS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 92:8734-8. 1995..The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects of melatonin in mammals...- Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searchesM J Zylka
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
Brain Res Mol Brain Res 74:175-81. 1999..Molecular analysis of the mammalian and chicken proteins suggests SOUL and HBP are members of a new family of heme-binding proteins... - Targeted disruption of the mPer3 gene: subtle effects on circadian clock functionL P Shearman
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Mol Cell Biol 20:6269-75. 2000..5 h) shorter than that in controls. The results demonstrate that mPer3 is not necessary for circadian rhythms in mice... - Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brainS M Reppert
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Neuron 15:1003-15. 1995..Expression of CKA and CKB results in similar ligand binding and functional characteristics. The widespread distribution of CKA and CKB mRNA in brain provides a molecular substrate for the profound actions of melatonin in birds... - Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophoresT Ebisawa
Laboratory of Developmental Chronobiology, Children s Service, Massachusetts General Hospital, Boston
Proc Natl Acad Sci U S A 91:6133-7. 1994..Structural analysis revealed that the receptor protein is a newly discovered member of the guanine nucleotide binding protein-coupled receptor family... - Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cordS M Reppert
Laboratory of Developmental Chronobiology, Children s Service, Massachusetts General Hospital, Boston
Mol Endocrinol 5:1037-48. 1991..The cloned A1-adenosine receptor may thus mediate many of the modulatory actions of adenosine in neural and endocrine systems... - Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distributionJ Linden
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston
Mol Pharmacol 44:524-32. 1993.... - Molecular analysis of mammalian circadian rhythmsS M Reppert
Laboratory of Developmental Chronobiology, Mass General Hospital for Children, and Harvard Medical School, Boston, Massachusetts 02114, USA
Annu Rev Physiol 63:647-76. 2001..Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing... - Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtypeJ H Stehle
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114
Mol Endocrinol 6:384-93. 1992..In situ hybridization studies of RFL9 mRNA showed no specific hybridization pattern in brain, but a hybridization signal was readily observed in the hypophyseal pars tuberalis. Thus, RFL9 encodes a novel A2-adenosine receptor subtype... - The Mel1a melatonin receptor is coupled to parallel signal transduction pathwaysC Godson
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Endocrinology 138:397-404. 1997..Thus, we show that the melatonin signal is transduced by parallel pathways involving inhibition of adenylyl cyclase and potentiation of phospholipase activation... - Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamstersD R Weaver
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, USA
Mol Endocrinol 10:1478-87. 1996..These data support the hypothesis that the Mel1a receptor, which does encode a functional receptor in this species, mediates reproductive and circadian responses to melatonin... - Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptorA L Roca
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
Endocrinology 137:3469-77. 1996..These results provide information on Mel1a receptor gene structure essential for designing transgenic and gene knock-out studies and analyzing the transcriptional regulation of receptor gene expression... - Analysis of human Per4A L Gotter
Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Boston, MA 02114, USA
Brain Res Mol Brain Res 92:19-26. 2001..We conclude that hPer4 and RmPer4 are pseudogenes and descended from the retrotransposition of an ancestral Per3 gene... - Definition of the developmental transition from dopaminergic to photic regulation of c-fos gene expression in the rat suprachiasmatic nucleusD R Weaver
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
Brain Res Mol Brain Res 33:136-48. 1995..The developmental transition from dopaminergic to photic regulation of c-fos gene expression roughly parallels the developmental transition from maternal to photic entrainment of the developing biological clock... - c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulationD R Weaver
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
Brain Res Dev Brain Res 85:293-7. 1995..In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock... - RFL9 encodes an A2b-adenosine receptorS A Rivkees
Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston
Mol Endocrinol 6:1598-604. 1992..The identification of the cDNA for an A2b-adenosine receptor will allow more rigorous characterization of its anatomical distribution and functional properties... - Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)A K Gubitz
Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA
Genomics 55:248-51. 1999..The mouse gene (Gpr50) was determined to lie in the proximal portion of chromosome X by means of interspecific backcross analysis. These loci might be relevant to genetically based neuroendocrine disorders... - Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)S A Slaugenhaupt
Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston 02114, USA
Genomics 27:355-7. 1995..1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders... - Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brainM J Zylka
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Neuron 20:1103-10. 1998..The results highlight the differential light responses among the three mammalian Per genes in the SCN and raise the possibility of circadian oscillators in mammals outside of brain and retina... - Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clockC Liu
Laboratory of Developmental Chronobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Neuron 19:91-102. 1997..The results provide a molecular basis for two distinct, mechanistically separable effects of melatonin on SCN physiology... - Differential regulation of mPER1 and mTIM proteins in the mouse suprachiasmatic nuclei: new insights into a core clock mechanismM H Hastings
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
J Neurosci 19:RC11. 1999.... - Molecular analysis of mammalian timelessM J Zylka
Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Neuron 21:1115-22. 1998..The data suggest that PER-PER interactions have replaced the function of PER-TIM dimers in the molecular workings of the mammalian circadian clock... - Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatumJ S Fink
Laboratory of Molecular Neurobiology, Massachusetts General Hospital, Charlestown 02129
Brain Res Mol Brain Res 14:186-95. 1992..The co-expression of D2 dopamine and A2 adenosine receptors in a subset of striatal cells provides an anatomical basis for dopaminergic-adenosinergic interactions on motor behavior...