S M Reppert

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Molecular analysis of mammalian circadian rhythms
    S M Reppert
    Laboratory of Developmental Chronobiology, Mass General Hospital for Children, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Physiol 63:647-76. 2001
  2. ncbi Cellular and molecular basis of circadian timing in mammals
    S M Reppert
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, and Harvard Medical School, Boston 02114, USA
    Semin Perinatol 24:243-6. 2000
  3. ncbi Interacting molecular loops in the mammalian circadian clock
    L P Shearman
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Science 288:1013-9. 2000
  4. ncbi mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
    K Kume
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Cell 98:193-205. 1999
  5. ncbi Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock
    K Bae
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and, Harvard Medical School, 02114, Boston, MA, USA
    Neuron 30:525-36. 2001
  6. ncbi A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
    X Jin
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Cell 96:57-68. 1999
  7. ncbi Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei
    L P Shearman
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 19:1261-9. 1997
  8. pmc Targeted disruption of the mPer3 gene: subtle effects on circadian clock function
    L P Shearman
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 20:6269-75. 2000
  9. ncbi A time-less function for mouse timeless
    A L Gotter
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Neurosci 3:755-6. 2000
  10. ncbi Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches
    M J Zylka
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Brain Res Mol Brain Res 74:175-81. 1999

Collaborators

Detail Information

Publications31

  1. ncbi Molecular analysis of mammalian circadian rhythms
    S M Reppert
    Laboratory of Developmental Chronobiology, Mass General Hospital for Children, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Physiol 63:647-76. 2001
    ..Greater understanding of the cellular and molecular mechanisms of the SCN clockwork provides opportunities for pharmacological manipulation of circadian timing...
  2. ncbi Cellular and molecular basis of circadian timing in mammals
    S M Reppert
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, and Harvard Medical School, Boston 02114, USA
    Semin Perinatol 24:243-6. 2000
    ..Greater understanding of the cellular and molecular control of the suprachiasmatic nuclei provides opportunities for pharmacological manipulation of circadian timing...
  3. ncbi Interacting molecular loops in the mammalian circadian clock
    L P Shearman
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Science 288:1013-9. 2000
    ..PERIOD2 is a positive regulator of the Bmal1 loop, and CRYPTOCHROMES are the negative regulators of the Period and Cryptochrome cycles...
  4. ncbi mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
    K Kume
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Cell 98:193-205. 1999
    ..Luciferase reporter gene assays show that mCRY1 or mCRY2 alone abrogates CLOCK:BMAL1-E box-mediated transcription. The mPER and mCRY proteins appear to inhibit the transcriptional complex differentially...
  5. ncbi Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock
    K Bae
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and, Harvard Medical School, 02114, Boston, MA, USA
    Neuron 30:525-36. 2001
    ..Thus, mPER1 influences rhythmicity primarily through interaction with other clock proteins, while mPER2 positively regulates rhythmic gene expression, and there is partial compensation between products of these two genes...
  6. ncbi A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock
    X Jin
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Cell 96:57-68. 1999
    ..These data indicate that the transcriptional machinery of the core clockwork directly regulates a clock-controlled output rhythm...
  7. ncbi Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei
    L P Shearman
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 19:1261-9. 1997
    ..Both Per1 and Per2 RNAs in the SCN are increased by light exposure during subjective night but not during subjective day. The results advance our knowledge of candidate clock elements in mammals...
  8. pmc Targeted disruption of the mPer3 gene: subtle effects on circadian clock function
    L P Shearman
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 20:6269-75. 2000
    ..5 h) shorter than that in controls. The results demonstrate that mPer3 is not necessary for circadian rhythms in mice...
  9. ncbi A time-less function for mouse timeless
    A L Gotter
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Neurosci 3:755-6. 2000
    ..A putative mouse homolog, mTimeless (mTim), has been difficult to place in the circadian clock of mammals. Here we show that mTim is essential for embryonic development, but does not have substantiated circadian function...
  10. ncbi Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppression subtractive hybridization and database searches
    M J Zylka
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Brain Res Mol Brain Res 74:175-81. 1999
    ..Molecular analysis of the mammalian and chicken proteins suggests SOUL and HBP are members of a new family of heme-binding proteins...
  11. ncbi Cloning of a melatonin-related receptor from human pituitary
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114
    FEBS Lett 386:219-24. 1996
    ..H9 mRNA is expressed in hypothalamus and pituitary, suggesting that the encoded receptor and its natural ligand are involved in neuroendocrine function...
  12. ncbi Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    Neuron 13:1177-85. 1994
    ..The cloned high affinity receptor likely mediates the reproductive and circadian actions of melatonin in mammals...
  13. ncbi Molecular analysis of mammalian timeless
    M J Zylka
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 21:1115-22. 1998
    ..The data suggest that PER-PER interactions have replaced the function of PER-TIM dimers in the molecular workings of the mammalian circadian clock...
  14. ncbi Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain
    M J Zylka
    Laboratory of Developmental Chronobiology, Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 20:1103-10. 1998
    ..The results highlight the differential light responses among the three mammalian Per genes in the SCN and raise the possibility of circadian oscillators in mammals outside of brain and retina...
  15. pmc Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 92:8734-8. 1995
    ..The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects of melatonin in mammals...
  16. ncbi Molecular cloning and functional expression of a sheep A3 adenosine receptor with widespread tissue distribution
    J Linden
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston
    Mol Pharmacol 44:524-32. 1993
    ....
  17. ncbi Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock
    C Liu
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 19:91-102. 1997
    ..The results provide a molecular basis for two distinct, mechanistically separable effects of melatonin on SCN physiology...
  18. ncbi Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50)
    A K Gubitz
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA
    Genomics 55:248-51. 1999
    ..The mouse gene (Gpr50) was determined to lie in the proximal portion of chromosome X by means of interspecific backcross analysis. These loci might be relevant to genetically based neuroendocrine disorders...
  19. ncbi Melatonin receptors are for the birds: molecular analysis of two receptor subtypes differentially expressed in chick brain
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Neuron 15:1003-15. 1995
    ..Expression of CKA and CKB results in similar ligand binding and functional characteristics. The widespread distribution of CKA and CKB mRNA in brain provides a molecular substrate for the profound actions of melatonin in birds...
  20. ncbi A clockwork explosion!
    S M Reppert
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 21:1-4. 1998
  21. ncbi The Mel1a melatonin receptor is coupled to parallel signal transduction pathways
    C Godson
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Endocrinology 138:397-404. 1997
    ..Thus, we show that the melatonin signal is transduced by parallel pathways involving inhibition of adenylyl cyclase and potentiation of phospholipase activation...
  22. ncbi Circadian clock neurons in the silkmoth Antheraea pernyi: novel mechanisms of Period protein regulation
    I Sauman
    Pediatric Service, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Neuron 17:889-900. 1996
    ..Differences in the molecular details of PER expression and regulation between the brains of silkmoths and fruitflies provide insights into the mechanisms of clock gene regulation...
  23. ncbi Structure, characterization, and expression of the gene encoding the mouse Mel1a melatonin receptor
    A L Roca
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
    Endocrinology 137:3469-77. 1996
    ..These results provide information on Mel1a receptor gene structure essential for designing transgenic and gene knock-out studies and analyzing the transcriptional regulation of receptor gene expression...
  24. ncbi Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters
    D R Weaver
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, USA
    Mol Endocrinol 10:1478-87. 1996
    ..These data support the hypothesis that the Mel1a receptor, which does encode a functional receptor in this species, mediates reproductive and circadian responses to melatonin...
  25. ncbi Analysis of human Per4
    A L Gotter
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Boston, MA 02114, USA
    Brain Res Mol Brain Res 92:19-26. 2001
    ..We conclude that hPer4 and RmPer4 are pseudogenes and descended from the retrotransposition of an ancestral Per3 gene...
  26. ncbi c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation
    D R Weaver
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA
    Brain Res Dev Brain Res 85:293-7. 1995
    ..In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock...
  27. pmc Expression cloning of a high-affinity melatonin receptor from Xenopus dermal melanophores
    T Ebisawa
    Laboratory of Developmental Chronobiology, Children s Service, Massachusetts General Hospital, Boston
    Proc Natl Acad Sci U S A 91:6133-7. 1994
    ..Structural analysis revealed that the receptor protein is a newly discovered member of the guanine nucleotide binding protein-coupled receptor family...
  28. ncbi Definition of the developmental transition from dopaminergic to photic regulation of c-fos gene expression in the rat suprachiasmatic nucleus
    D R Weaver
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Brain Res Mol Brain Res 33:136-48. 1995
    ..The developmental transition from dopaminergic to photic regulation of c-fos gene expression roughly parallels the developmental transition from maternal to photic entrainment of the developing biological clock...
  29. ncbi period and timeless tango: a dance of two clock genes
    S M Reppert
    Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Neuron 15:983-6. 1995
  30. ncbi Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)
    S A Slaugenhaupt
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston 02114, USA
    Genomics 27:355-7. 1995
    ..1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders...
  31. ncbi Molecular cloning and characterization of a rat A1-adenosine receptor that is widely expressed in brain and spinal cord
    S M Reppert
    Laboratory of Developmental Chronobiology, Children s Service, Massachusetts General Hospital, Boston
    Mol Endocrinol 5:1037-48. 1991
    ..The cloned A1-adenosine receptor may thus mediate many of the modulatory actions of adenosine in neural and endocrine systems...