Perry F Renshaw

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression
    P F Renshaw
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 158:2048-55. 2001
  2. pmc Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
  3. pmc Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 64:718-26. 2008
  4. pmc Effects of sleep deprivation on brain bioenergetics, sleep, and cognitive performance in cocaine-dependent individuals
    George H Trksak
    Behavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Sleep Research Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    ScientificWorldJournal 2013:947879. 2013
  5. ncbi request reprint Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:217-26. 2004
  6. ncbi request reprint Prefrontal and temporal gray matter density decreases in opiate dependence
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Psychopharmacology (Berl) 184:139-44. 2006
  7. ncbi request reprint In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease
    Blaise D Frederick
    McLean Hospital Brain Imaging Center, Belmont, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:1313-22. 2004
  8. pmc Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy study
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Geriatr Psychiatry 17:13-23. 2009
  9. ncbi request reprint Oral methylphenidate challenge selectively decreases putaminal T2 in healthy subjects
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 76:173-80. 2004
  10. doi request reprint T2 relaxation time abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 63:1-8. 2010

Research Grants

  1. Magnetic Resonance, EEG, and Behavior After Cocaine
    Marc Kaufman; Fiscal Year: 2007
  2. MENTORING IN DRUG ABUSE NEUROIMAGING
    Perry Renshaw; Fiscal Year: 2007

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Multinuclear magnetic resonance spectroscopy studies of brain purines in major depression
    P F Renshaw
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 158:2048-55. 2001
    ....
  2. pmc Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Affect Disord 99:19-25. 2007
    ..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone...
  3. pmc Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 64:718-26. 2008
    ..We examined the glutamine/glutamate ratio and levels of other metabolites in acute mania and schizophrenia in this exploratory study...
  4. pmc Effects of sleep deprivation on brain bioenergetics, sleep, and cognitive performance in cocaine-dependent individuals
    George H Trksak
    Behavioral Psychopharmacology Research Lab, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA McLean Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Sleep Research Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    ScientificWorldJournal 2013:947879. 2013
    ....
  5. ncbi request reprint Cerebral phosphorus metabolite and transverse relaxation time abnormalities in heroin-dependent subjects at onset of methadone maintenance treatment
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:217-26. 2004
    ..Taken together, these cross-sectional data suggest that the first month of MM treatment may be associated with altered cerebral bioenergetics and phospholipid metabolite levels...
  6. ncbi request reprint Prefrontal and temporal gray matter density decreases in opiate dependence
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Psychopharmacology (Berl) 184:139-44. 2006
    ..There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects...
  7. ncbi request reprint In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer's disease
    Blaise D Frederick
    McLean Hospital Brain Imaging Center, Belmont, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:1313-22. 2004
    ..4-ml anterior temporal lobe voxel...
  8. pmc Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy study
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Geriatr Psychiatry 17:13-23. 2009
    ..In addition, the authors investigated the association between brain lithium and serum lithium with frontal lobe functioning and mood in a subgroup of older subjects...
  9. ncbi request reprint Oral methylphenidate challenge selectively decreases putaminal T2 in healthy subjects
    Marisa M Silveri
    Brain Imaging Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 76:173-80. 2004
    ..These data suggest that T2 relaxometry can be used to study the time course of regional cerebral blood volume responses to MPH and perhaps to other stimulant drugs...
  10. doi request reprint T2 relaxation time abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 63:1-8. 2010
    ....
  11. pmc Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 163:316-8. 2006
    ....
  12. ncbi request reprint Selective serotonin reuptake inhibitor discontinuation syndrome is associated with a rostral anterior cingulate choline metabolite decrease: a proton magnetic resonance spectroscopic imaging study
    Marc J Kaufman
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 54:534-9. 2003
    ..31, p =.021). Discontinuation syndrome is associated with a rostral anterior cingulate Cho/Cre metabolite ratio decrease that may reflect dynamics of rostral anterior cingulate function...
  13. doi request reprint Age-related changes in brain energetics and phospholipid metabolism
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA
    NMR Biomed 23:242-50. 2010
    ..Unlike some previous studies of aging and brain chemistry, this study examined healthy, non-demented and psychiatrically stable older adults and specifically analyzed gray-white matter differences in brain metabolism...
  14. pmc Effects of sleep deprivation on sleep homeostasis and restoration during methadone-maintenance: a [31]P MRS brain imaging study
    George H Trksak
    Behavioral Pharmacology Research Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02472, USA
    Drug Alcohol Depend 106:79-91. 2010
    ..Results suggest that differences in sleep and brain chemistry during RE in MM participants may be reflective of a disruption in homeostatic sleep function...
  15. ncbi request reprint Triacetyluridine (TAU) decreases depressive symptoms and increases brain pH in bipolar patients
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478 9106, USA
    Exp Clin Psychopharmacol 16:199-206. 2008
    ..These results suggest that TAU treatment may decrease symptoms of depression and improve mitochondrial functioning...
  16. doi request reprint A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression
    Brian P Brennan
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychopharmacol 33:627-35. 2013
    ....
  17. pmc Anterior cingulate proton spectroscopy glutamate levels differ as a function of smoking cessation outcome
    Yasmin Mashhoon
    McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:1709-13. 2011
    ..Growing evidence suggests that glutamate neurotransmission is involved in mediating nicotine dependence. We hypothesized that prior to a cessation attempt, dACC glutamate levels would be lower in relapse vulnerable smokers...
  18. doi request reprint Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    Bipolar Disord 10:691-700. 2008
    ..We investigated the relationship between brain lithium levels and the metabolites N-acetyl aspartate (NAA) and myo-inositol (myo-Ino) in the anterior cingulate cortex of a group of older adults with bipolar disorder (BD)...
  19. ncbi request reprint Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 57:571-6. 2005
    ..We examined whether a low-energy component of EP-MRSI (low-field magnetic stimulation [LFMS]) has antidepressant-like, locomotor-stimulating, or amnestic effects in rats...
  20. pmc Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 46:524-34. 2007
    ..We hypothesized that unmedicated children with BPD would have reduced glutamine and glutamate levels compared with HCSs and medicated children with BPD...
  21. pmc Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats
    Perry F Renshaw
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Pharmacol Biochem Behav 92:88-92. 2009
    ..Altered cholesterol levels can affect serotonergic neurotransmission, which might be involved in the clinical efficacy of standard antidepressants...
  22. pmc A therapeutic dose of zolpidem reduces thalamic GABA in healthy volunteers: a proton MRS study at 4 T
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 203:819-29. 2009
    ..A great deal is known about the behavioral effects of this drug in humans and laboratory animals, but little is known about zolpidem's specific effects on neurochemistry in vivo...
  23. pmc Neurochemistry of drug action: insights from proton magnetic resonance spectroscopic imaging and their relevance to addiction
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 1187:148-71. 2010
    ....
  24. pmc Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys
    Xiaoxu Liu
    Brain Imaging Center, McLean Hospital, Harvard Medical School, 115 Mill, St Belmont, MA 02478, USA
    Psychopharmacology (Berl) 217:367-75. 2011
    ..Chronic cocaine exposure has been associated with progressive brain structural and functional changes. Clarifying mechanisms underlying cocaine's progressive brain effects may help in the development of effective cocaine abuse treatments...
  25. pmc Water and metabolite transverse T2 relaxation time abnormalities in the white matter in schizophrenia
    Fei Du
    McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 137:241-5. 2012
    ..980, p=0.039). Prolongation of water T2 and shortening of NAA T2 is consistent with an impoverishment of white matter macromolecule structures (including myelin) and abnormal intra-axonal milieu and volume in SZ...
  26. ncbi request reprint White matter hyperintensities and their association with suicidality in depressed young adults
    Stefan Ehrlich
    Laboratory of Developmental Psychology and Developmental Psychopathology, McLean Hospital, Harvard Medical School, Boston, MA, USA
    J Affect Disord 86:281-7. 2005
    ....
  27. pmc Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivo
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 70:169-74. 2011
    ..Accumulating evidence suggests that the Gln/Glu ratio is a putative index of glutamatergic neurotransmission but interpretation of changes in the Gln/Glu ratio depends on the conditions of the system, including ammonia levels...
  28. pmc Elevated gamma-aminobutyric acid levels in chronic schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 68:667-70. 2010
    ..We used proton magnetic resonance spectroscopy to measure tissue GABA levels in participants with schizophrenia and healthy control subjects in the anterior cingulate cortex and parieto-occipital cortex...
  29. doi request reprint Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla
    J Eric Jensen
    McLean Hospital, Belmont, MA 02478, USA
    NMR Biomed 22:762-9. 2009
    ..These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction...
  30. pmc Oral glycine administration increases brain glycine/creatine ratios in men: a proton magnetic resonance spectroscopy study
    Marc J Kaufman
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, United States
    Psychiatry Res 173:143-9. 2009
    ....
  31. doi request reprint Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    J Geriatr Psychiatry Neurol 25:43-50. 2012
    ....
  32. ncbi request reprint Frontal lobe gray matter density decreases in bipolar I disorder
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 55:648-51. 2004
    ..This study was conducted to explore differences in gray and white matter density between bipolar and healthy comparison groups using voxel-based morphometry (VBM)...
  33. pmc Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole
    Brian P Brennan
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:834-46. 2010
    ..Further investigation of the Gln/Glu ratio as a possible early biomarker of response to glutamate-modulating therapies is warranted...
  34. ncbi request reprint White matter hyperintensities in subjects with bipolar disorder
    Kyung Heup Ahn
    Mclean Brain Imaging Center and Harvard Medical School, Belmont, MA, USA
    Psychiatry Clin Neurosci 58:516-21. 2004
    ..Differences of small-sized WMH abnormalities between groups were successfully detected using a large number of bipolar subjects and thinner sliced MR images with FLAIR...
  35. ncbi request reprint A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: A 19-F MRS study
    Michael E Henry
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 30:1576-83. 2005
    ....
  36. ncbi request reprint Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine
    Deborah A Yurgelun-Todd
    Cognitive Neuroimaging Laboratory, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 138:23-31. 2005
    ..These results suggest that the addition of D-cycloserine to conventional neuroleptics may improve negative symptoms through enhanced temporal lobe function...
  37. pmc Reduced T2* values in soleus muscle of patients with type 2 diabetes mellitus
    Chun S Zuo
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, United States of America
    PLoS ONE 7:e49337. 2012
    ..This finding is consistent with results of previous perfusion studies and suggests that the soleus in individuals with T2DM is likely under tissue oxygenation stress...
  38. pmc Brain metabolite concentrations across cortical regions in healthy adults
    Bethany K Bracken
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Brain Res 1369:89-94. 2011
    ..MRS may be a useful tool for studying physical properties of the living human brain...
  39. ncbi request reprint Oral choline decreases brain purine levels in lithium-treated subjects with rapid-cycling bipolar disorder: a double-blind trial using proton and lithium magnetic resonance spectroscopy
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, Belmont, MA, USA
    Bipolar Disord 5:300-6. 2003
    ....
  40. pmc Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence
    Amy C Janes
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 17:365-73. 2009
    ..In some brain regions, fMRI smoking cue reactivity is increased during extended smoking abstinence in comparison to the prequit state, which may contribute to persisting relapse vulnerability...
  41. doi request reprint 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression
    Brent P Forester
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA
    Int J Geriatr Psychiatry 24:788-97. 2009
    ....
  42. pmc Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods
    William D S Killgore
    Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA, USA
    Int J Eat Disord 43:6-13. 2010
    ..In cocaine-addicted individuals, citicoline has been shown to increase brain dopamine levels and reduce cravings. The effects of this compound on appetite, food cravings, and brain responses to food are unknown...
  43. pmc A method for conducting functional MRI studies in alert nonhuman primates: initial results with opioid agonists in male cynomolgus monkeys
    Marc J Kaufman
    McLean Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 21:323-31. 2013
    ..Our results suggest that our fMRI approach could be informative for comparing effects of opioid agonists...
  44. ncbi request reprint Cerebellar vermis involvement in cocaine-related behaviors
    Carl M Anderson
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 31:1318-26. 2006
    ....
  45. pmc Nicotine related brain activity: the influence of smoking history and blood nicotine levels, an exploratory study
    RINAH T YAMAMOTO
    Brain Imaging Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478, United States
    Drug Alcohol Depend 129:137-44. 2013
    ..In this study, we sought to explore brain activity in nicotine-dependent men in response to acute intravenous nicotine using pharmacological magnetic resonance imaging (phMRI)...
  46. ncbi request reprint A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence
    Doug Hyun Han
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Compr Psychiatry 49:387-92. 2008
    ..In the present study, the association between dopamine D2 polymorphisms, NS, and frontal executive function was studied...
  47. ncbi request reprint Topiramate raises anterior cingulate cortex glutamine levels in healthy men; a 4.0 T magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, and Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Psychopharmacology (Berl) 188:236-43. 2006
    ..In particular, topiramate has been shown to increase occipital cortex GABA levels, as measured using proton magnetic resonance spectroscopy (MRS)...
  48. pmc Default mode network abnormalities in bipolar disorder and schizophrenia
    Dost Ongur
    McLean Hospital, Belmont, MA and Harvard Medical School, Boston, MA, United States
    Psychiatry Res 183:59-68. 2010
    ..Further studies are needed to determine how these abnormalities are related to specific symptoms of each condition...
  49. pmc Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease
    Yosef A Berlow
    Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA, USA
    Int J Geriatr Psychiatry 25:780-8. 2010
    ..To investigate the association of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD) and magnetic resonance imaging (MRI) measures of brain atrophy and white matter hyperintensities (WMH)...
  50. ncbi request reprint White matter hyperintensities in subjects with cocaine and opiate dependence and healthy comparison subjects
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center and Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:135-45. 2004
    ..Also, there was a trend for lower WMH severity in substance-dependent women relative to the healthy comparison group, possibly due to estrogen's protective effect against cerebrovascular accidents...
  51. ncbi request reprint Omega-3 fatty acid treatment and T(2) whole brain relaxation times in bipolar disorder
    Fuyuki Hirashima
    Brain Imaging Center, McLean Hospital, Belmont, MA, USA
    Am J Psychiatry 161:1922-4. 2004
    ..The authors hypothesized that changes in brain membrane composition resulting from omega-3 fatty acid administration in patients with bipolar disorder would result in greater membrane fluidity, as detected by reductions in T(2) values...
  52. pmc Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers
    Stephanie C Licata
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    J Addict Med 5:57-64. 2011
    ..We demonstrated previously that citicoline, a compound used to repair neuronal damage in stroke and brain injury, is safe in cocaine-abusing volunteers...
  53. doi request reprint MRI assessment of drug-induced fluid accumulation in humans: validation of the technology
    Chun S Zuo
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Magn Reson Imaging 26:629-37. 2008
    ....
  54. pmc Quantification of brain voriconazole levels in healthy adults using fluorine magnetic resonance spectroscopy
    Michael E Henry
    McLean Hospital, McLean Imaging Center, Belmont, Massachusetts, USA
    Antimicrob Agents Chemother 57:5271-6. 2013
    ..9 postdose. We found that voriconazole is able to penetrate the brain tissue, which can be quantified using a noninvasive MRS technique. (This study has been registered at ClinicalTrials.gov under registration no. NCT00300677.). ..
  55. pmc T2 relaxation effects on apparent N-acetylaspartate concentration in proton magnetic resonance studies of schizophrenia
    Bethany K Bracken
    Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Belmont, MA 02138, USA
    Psychiatry Res 213:142-53. 2013
    ..In addition, as metabolite concentration and T2 relaxation times are completely independent variables, this could offer distinct information about the metabolite of interest. ..
  56. doi request reprint Craving for alcohol and food during treatment for alcohol dependence: modulation by T allele of 1519T>C GABAAalpha6
    Doug Hyun Han
    Brain Imaging Center, McLean Hospital, Harvard Medical University, Belmont, Massachusetts 02478, USA
    Alcohol Clin Exp Res 32:1593-9. 2008
    ..We further hypothesized that the T allele of the 1519T>C GABA(A)alpha6 gene would modulate the extent of changes in craving for alcohol and food...
  57. ncbi request reprint Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study
    Ronald L Cowan
    Brain Imaging Center, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Drug Alcohol Depend 72:225-35. 2003
    ....
  58. ncbi request reprint Oral choline increases choline metabolites in human brain
    Suzann M Babb
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 130:1-9. 2004
    ..In conclusion, a significant increase in choline-containing compounds in human brain can be detected by (1)H-MRS after choline ingestion in young subjects...
  59. ncbi request reprint Two-dimensional, J-resolved spectroscopic imaging of GABA at 4 Tesla in the human brain
    J Eric Jensen
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Magn Reson Med 54:783-8. 2005
    ..Six healthy human subjects underwent scanning at 4T with this sequence, yielding a global brain GABA concentration of 0.76 +/- 0.20 mM after correction for 12% macromolecule contribution...
  60. ncbi request reprint In vivo detection of brain glycine with echo-time-averaged (1)H magnetic resonance spectroscopy at 4.0 T
    Andrew P Prescot
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Magn Reson Med 55:681-6. 2006
    ..LC-model analysis provided a means for quantifying TE-averaged (1)H-MRS spectra and a mean test-retest variability measure of 15% was established for brain Gly* levels in studies of six healthy subjects...
  61. ncbi request reprint Methadone maintenance improves cognitive performance after two months of treatment
    Staci A Gruber
    Cognitive Neuroimaging Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 14:157-64. 2006
    ..Results suggest that opiate-dependent subjects exhibit significant improvement in cognitive function after MM treatment. Future investigations are needed to confirm these findings...
  62. ncbi request reprint Amygdala and hippocampus volumes in pediatric major depression
    Isabelle M Rosso
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Biol Psychiatry 57:21-6. 2005
    ..The purpose of this study was to measure amygdala and hippocampus volumes in pediatric major depressive disorder (MDD) and to address the question of neuroanatomical continuity with adult-onset depression...
  63. doi request reprint Magnetic resonance imaging findings in Hunter syndrome
    Chelsea T Finn
    Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Acta Paediatr Suppl 97:61-8. 2008
    ..Similar findings have been reported in other mucopolysaccharide disorders. Enzyme replacement therapy is a novel treatment which has had success in treating peripheral disease in mice and humans...
  64. doi request reprint Activation of suprachiasmatic nuclei and primary visual cortex depends upon time of day
    Ram L P Vimal
    Brain Imaging Center, McLean Hospital, Belmont, MA, USA
    Eur J Neurosci 29:399-410. 2009
    ..3 (2003) 945] for the SCN activity at critical intensity threshold; and (ii) the interaction of the melanopsin-based signals with the rod-cone signals at the 'giant' retinal ganglion cells [Nature, 433 (2005) 749] for the V1 activity...
  65. ncbi request reprint Reduced Plasma Nitric Oxide End Products in Cocaine-dependent Men
    Marc J Kaufman
    From the Brain Imaging Center MJK, CCS, TLB, EDR, MLB, PFR, McLean Hospital, Harvard Medical School, Belmont, MA and Psychopharmacology Special Studies Program CCS, Oss, MA, HT, KKBF, CAA, DAC, Boston University School of Medicine, Boston, MA
    J Addict Med 1:96-103. 2007
    ....
  66. doi request reprint EVP-ABD-enhanced MRI to evaluate diffuse liver disease in a rat model
    Chun S Zuo
    Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Magn Reson Imaging 27:1317-21. 2008
    ..To evaluate the feasibility of using manganese-based MR imaging contrast agent EVP-ABD to detect diffuse liver disease in an established rat hepatitis model...
  67. ncbi request reprint Brain phosphorus magnetic resonance spectroscopy imaging of sleep homeostasis and restoration in drug dependence
    George H Trksak
    Behavioral Pharmacology Research Laboratory, McLean Hospital, Belmont, MA, USA
    ScientificWorldJournal 7:217-22. 2007
    ..Additional sleep studies in drug abusing populations are needed, particularly those that examine potential differential effects of sleep deprivation...
  68. ncbi request reprint Low-field magnetic stimulation in bipolar depression using an MRI-based stimulator
    Michael Rohan
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 161:93-8. 2004
    ..This study evaluated possible mood improvement associated with this procedure...
  69. ncbi request reprint White matter hyperintensities and their associations with suicidality in psychiatrically hospitalized children and adolescents
    Stefan Ehrlich
    McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
    J Am Acad Child Adolesc Psychiatry 43:770-6. 2004
    ..The objective of this study was to compare white matter hyperintensities in psychiatrically hospitalized children and youth with and without a history of suicide attempt while controlling for other variables...
  70. ncbi request reprint Proton and sodium MRI assessment of fluid level in calf tissue
    Chun S Zuo
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
    J Magn Reson Imaging 24:191-6. 2006
    ..To investigate the feasibility of using (1)H and (23)Na MRI to detect fluid levels in the lower leg muscle...
  71. ncbi request reprint Brain proton magnetic resonance spectroscopy in Alzheimer disease: changes after treatment with xanomeline
    Blaise deB Frederick
    MacLean Hospital Brain Imaging Center, Belmont, MA 02478, USA
    Am J Geriatr Psychiatry 10:81-8. 2002
    ..Specifically, increased levels of cytosolic choline, a precursor pool for acetylcholine synthesis, were associated with greater progression in memory impairment during treatment...
  72. ncbi request reprint Lateral visual field stimulation reveals extrastriate cortical activation in the contralateral hemisphere: an fMRI study
    Fredric Schiffer
    Department of Psychiatry, Harvard Medical School, and the Developmental Biopsychiatry Research Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 131:1-9. 2004
    ..LSTM appears to increase contralateral fMRI activation in striate and extrastriate cortical areas as predicted by earlier studies reporting differential cognitive and/or emotional effects from unilateral sensory or motor stimulation...
  73. ncbi request reprint Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness
    Janis L Breeze
    McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 11:269-83. 2003
    ....
  74. ncbi request reprint Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood: potential role of the vermis in stress-enhanced risk for drug abuse
    Carl M Anderson
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychoneuroendocrinology 27:231-44. 2002
    ..Together these findings suggest that early trauma may interfere with the development of the vermis, and produce neuropsychiatric symptoms associated with drug use...
  75. ncbi request reprint Antidepressant-like effects of cytidine in the forced swim test in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 51:882-9. 2002
    ..Because antidepressants can reduce cocaine craving, we explored in rats the possibility that citicoline has antidepressant effects. We also tested the primary metabolites of citicoline, cytidine and choline...
  76. pmc Brain-to-serum lithium ratio and age: an in vivo magnetic resonance spectroscopy study
    Constance M Moore
    Brain Imaging Center, Consolidated Department of Psychiatry, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Am J Psychiatry 159:1240-2. 2002
    ..The authors' goal was to determine if there is an association between brain-to-serum lithium ratios and age...
  77. ncbi request reprint Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate
    In Kyoon Lyoo
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 123:87-100. 2003
    ....
  78. ncbi request reprint Emotional task-dependent low-frequency fluctuations and methylphenidate: Wavelet scaling analysis of 1/f-type fluctuations in fMRI of the cerebellar vermis
    Carl M Anderson
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Neurosci Methods 151:52-61. 2006
    ....
  79. ncbi request reprint Effects of methylphenidate on functional magnetic resonance relaxometry of the cerebellar vermis in boys with ADHD
    Carl M Anderson
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Am J Psychiatry 159:1322-8. 2002
    ..Also, in preclinical studies, the vermis has been shown to modulate forebrain dopamine systems, to influence locomotor activity, and to contain a significant density of dopamine transporters...
  80. ncbi request reprint Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry
    Gail Musen
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetes 55:326-33. 2006
    ..Our study represents the first comprehensive study of gray matter density changes in type 1 diabetes and suggests that persistent hyperglycemia and acute severe hypoglycemia have an impact on brain structure...
  81. ncbi request reprint Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
    Biol Psychiatry 57:343-50. 2005
    ..We also examined the effects of omega-3 fatty acids (OMG), which increase membrane fluidity and reportedly have antidepressant effects in humans, alone and in combination with uridine...
  82. ncbi request reprint Phosphorous31 magnetic resonance spectroscopy after total sleep deprivation in healthy adult men
    Cynthia M Dorsey
    Sleep Disorders Center, Behavioral Psychopharmacology Research Laboratory, McLean Hospital, Harvard Medical School, Belmont 02478, USA
    Sleep 26:573-7. 2003
    ..To investigate chemical changes in the brains of healthy adults after sleep deprivation and recovery sleep, using phosphorous magnetic resonance spectroscopy...
  83. ncbi request reprint Mesial temporal lobe Cho to Cr(PCr) ratio asymmetry in chronic schizophrenics
    Constance M Moore
    Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Res 57:35-42. 2002
    ..No such correlations were noted on the right side. No significant difference was found between Cho/Cr(PCr) in the left temporal lobe or in the right temporal lobe of the schizophrenia subjects vs. the control group...
  84. pmc Regional brain activation during hypoglycemia in type 1 diabetes
    Gail Musen
    Research Division, Joslin Diabetes Center, 1 Joslin Place Room 350, Boston, Massachusetts 02215, USA
    J Clin Endocrinol Metab 93:1450-7. 2008
    ..Mechanisms underlying the brain response to hypoglycemia are not well understood...
  85. ncbi request reprint Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study
    Yong Ke
    Brain Imaging Center, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Psychiatry Res 130:283-93. 2004
    ..However, cocaine-dependent subjects without an alcohol disorder (N=12) also had lower GABA levels (1.04 mM/kg) than the comparison subjects (t [d.f.=30]=2.09, P=0.045), suggesting that cocaine dependence alone can decrease GABA levels...
  86. ncbi request reprint Cerebral blood volume and clinical changes on the third day of placebo substitution for SSRI treatment
    Michael E Henry
    Brain Imaging Center, McLean Hospital and Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 53:100-5. 2003
    ..We hypothesized that brain regions implicated in depression, with extensive serotonergic innervation, would exhibit changes in activity associated with emergence of symptoms following drug discontinuation...
  87. ncbi request reprint Regional cerebral cortical thinning in bipolar disorder
    In Kyoon Lyoo
    McLean Hospital Brain Imaging Center, Harvarrd Medical School, Boston, MA, USA
    Bipolar Disord 8:65-74. 2006
    ..This study was conducted to explore differences in cortical thickness between subjects with bipolar disorder and healthy comparison subjects using cortical surface-based analysis...
  88. pmc Clinical response of quetiapine in rapid cycling manic bipolar patients and lactate level changes in proton magnetic resonance spectroscopy
    Dajung J Kim
    Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yongon Dong, Chongno Gu, Seoul, 110 744, Republic of Korea
    Prog Neuropsychopharmacol Biol Psychiatry 31:1182-8. 2007
    ..52, p=0.003). Our findings suggest that quetiapine's antimanic and antidepressant efficacy in patients with rapid cycling bipolar disorder may potentially be related to decreased lactate levels in frontal regions of the brain...
  89. ncbi request reprint Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment
    Chris C Streeter
    Division of Psychiatry, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA
    Psychopharmacology (Berl) 182:516-26. 2005
    ..There is evidence that prefrontal lobe GABA levels are low in cocaine-dependent (CD) individuals, and treatment with GABA agonists decreases cocaine self-administration...
  90. ncbi request reprint Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder
    Seth D Friedman
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Biol Psychiatry 56:340-8. 2004
    ..This study examined whether lithium (Li) and valproic acid (VPA) treatment modulated these chemicals...
  91. ncbi request reprint Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy study
    Aysegul Yildiz
    Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
    Psychiatry Res 138:51-9. 2005
    ..The theoretical relevance of the lithium-induced alterations on brain high-energy phosphates to the lithium-induced modifications of neuroplasticity is discussed...
  92. ncbi request reprint S-adenosyl-L-methionine: effects on brain bioenergetic status and transverse relaxation time in healthy subjects
    Marisa M Silveri
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Biol Psychiatry 54:833-9. 2003
    ....
  93. ncbi request reprint Brain metabolic alterations in medication-free patients with bipolar disorder
    Stephen R Dager
    Department of Radiology, University of Washington, Seattle 98105, USA
    Arch Gen Psychiatry 61:450-8. 2004
    ..Bipolar disorder (BD) has substantial morbidity and incompletely understood neurobiological underpinnings...
  94. ncbi request reprint Increased medial thalamic creatine-phosphocreatine found by proton magnetic resonance spectroscopy in children with obsessive-compulsive disorder versus major depression and healthy controls
    Yousha Mirza
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Child Neurol 21:106-11. 2006
    ..Although these results must be considered preliminary, further study of the diagnostic specificity of creatine-phosphocreatine in obsessive-compulsive disorder is indicated...
  95. ncbi request reprint Hippocampal volume, PTSD, and alcoholism in combat veterans
    Steven H Woodward
    National Center for PTSD, Clinical Laboratory and Education Division, Mail Code 334 PTSD, VA Palo Alto HCS, 3801 Miranda Ave, Palo Alto, CA 94304, USA
    Am J Psychiatry 163:674-81. 2006
    ..Further examination of the role of alcoholism and other comorbid conditions in studies of brain structure and function in PTSD appears warranted...
  96. ncbi request reprint Advances in magnetic resonance imaging methods for the evaluation of bipolar disorder
    In Kyoon Lyoo
    Department of Psychiatry, Seoul National University, South Korea, Seoul, South Korea
    CNS Spectr 11:269-80. 2006
    ..Integrative issues and future directions in this relatively young field, including multi-modal approaches enabling us to produce more comprehensive results, are discussed...
  97. doi request reprint Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder
    Dan V Iosifescu
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Biol Psychiatry 63:1127-34. 2008
    ..We assessed whether changes in brain bioenergetics measured with phosphorus magnetic resonance spectroscopy ((31)P MRS) correlate with treatment outcome during augmentation treatment with triiodothyronine (T3) in MDD...
  98. doi request reprint High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: response to treatment with levetiracetam
    Mark H Pollack
    Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, United States
    Prog Neuropsychopharmacol Biol Psychiatry 32:739-43. 2008
    ..Abnormalities in brain gamma-aminobutyric acid (GABA) and glutamate may be relevant to the underlying pathophysiology of anxiety disorders including social anxiety disorder (SAD)...
  99. ncbi request reprint A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naïve first-episode mania
    Lakshmi N Yatham
    Division of Mood Disorders, University of British Columbia, Vancouver, BC, Canada
    Bipolar Disord 9:693-7. 2007
    ..Studies in first-episode (FE) manic patients have the potential to provide answers to these questions...
  100. ncbi request reprint Greater depression severity in elderly patients with memory complaints is associated with decreased left temporal-parietal dominance indicated by dynamic susceptibility contrast magnetic resonance imaging cerebral blood volume measures
    Helen H Kyomen
    Division on Aging, Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Geriatr Psychiatry 15:604-10. 2007
    ..To assess the relationships among depressive signs and symptoms and left versus right temporal-parietal cerebral blood volumes (CBVs) in elderly patients with a primary complaint of memory loss...
  101. pmc Occipital cortical proton MRS at 4 Tesla in human moderate MDMA polydrug users
    Ronald L Cowan
    Psychiatric Neuroimaging Program, Department of Psychiatry, Vanderbilt University Medical Center, 1601 23rd Avenue South, Suite 3057, Nashville, TN 37212, USA
    Psychiatry Res 155:179-88. 2007
    ..These findings are not supportive of MDMA-induced alterations in NAA or MI levels in this small sample of moderate MDMA users. Limitations to this study suggest caution in the interpretation of these results...

Research Grants4

  1. Magnetic Resonance, EEG, and Behavior After Cocaine
    Marc Kaufman; Fiscal Year: 2007
    ..This work will facilitate the direct comparison of neurochemical data across species. ..
  2. MENTORING IN DRUG ABUSE NEUROIMAGING
    Perry Renshaw; Fiscal Year: 2007
    ..Further, new patient oriented research programs extending funded studies by combining MRS/MRI with fMRI to more comprehensively address brain chemistry, structure and function are proposed in this application. ..