EILEEN REMOLD-O'DONNELL

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients
    E REMOLD-O'DONNELL
    Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:4021-5. 1997
  2. ncbi Wiskott-Aldrich syndrome in a female
    Maxim I Lutskiy
    Center for Blood Research, and the Division of Immunology, Children s Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:2763-8. 2002
  3. pmc Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice
    J Michael Stolley
    Immune Disease Institute, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:792-9. 2012
  4. pmc Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The CBR Institute for Biomedical Research, Inc, Boston, MA 02115, USA
    Blood 106:2815-7. 2005
  5. ncbi Genotype-proteotype linkage in the Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA
    J Immunol 175:1329-36. 2005
  6. ncbi An Alu-mediated deletion at Xp11.23 leading to Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The Center for Blood Research, Harvard Medical School, Huntington Avenue, Boston, MA 02115, USA
    Hum Genet 110:515-9. 2002
  7. doi A SerpinB1 Regulatory Mechanism Is Essential for Restricting Neutrophil Extracellular Trap Generation
    Kalamo Farley
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA 02115
    J Immunol 189:4574-81. 2012
  8. pmc WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling
    Anna Shcherbina
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Br J Haematol 148:416-27. 2010
  9. pmc The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection
    Charaf Benarafa
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1901-9. 2007
  10. pmc Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome
    Maxim I Lutskiy
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3444. 2008

Research Grants

  1. Defects of Thymic Output in Wiskott-Aldrich Syndrome
    EILEEN REMOLD O DONNELL; Fiscal Year: 2006
  2. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007
  3. SERPINB1/MNEI: Role in innate immune defense against influenza virus infection
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007

Collaborators

Detail Information

Publications13

  1. ncbi Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients
    E REMOLD-O'DONNELL
    Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:4021-5. 1997
    ..The findings suggest that the clinical variability of the WAS can partially be explained by the level of WASP protein in the patient's cells...
  2. ncbi Wiskott-Aldrich syndrome in a female
    Maxim I Lutskiy
    Center for Blood Research, and the Division of Immunology, Children s Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:2763-8. 2002
    ....
  3. pmc Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice
    J Michael Stolley
    Immune Disease Institute, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:792-9. 2012
    ....
  4. pmc Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The CBR Institute for Biomedical Research, Inc, Boston, MA 02115, USA
    Blood 106:2815-7. 2005
    ..The importance of reconstituting the NK-cell lineage is discussed...
  5. ncbi Genotype-proteotype linkage in the Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA
    J Immunol 175:1329-36. 2005
    ..Knowledge of the molecular effect of mutations would aid also in identifying disease-modifying genes...
  6. ncbi An Alu-mediated deletion at Xp11.23 leading to Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The Center for Blood Research, Harvard Medical School, Huntington Avenue, Boston, MA 02115, USA
    Hum Genet 110:515-9. 2002
    ..A heptanucleotide of unknown origin, CAGGGGG, links the 5' and 3' breakpoints. To our knowledge this is the largest deletion in a WAS patient...
  7. doi A SerpinB1 Regulatory Mechanism Is Essential for Restricting Neutrophil Extracellular Trap Generation
    Kalamo Farley
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA 02115
    J Immunol 189:4574-81. 2012
    ..The findings identify a previously unrecognized regulatory mechanism involving SerpinB1 that restricts the production of NETs...
  8. pmc WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling
    Anna Shcherbina
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Br J Haematol 148:416-27. 2010
    ..The collective results reveal a novel function for WASP in regulating pro-aggregatory and pro-coagulant responses downstream of integrin outside-in signalling...
  9. pmc The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection
    Charaf Benarafa
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1901-9. 2007
    ..Thus, regulation of pulmonary innate immunity by serpinb1 is nonredundant and is required to protect two key components, the neutrophil and SP-D, from NSP damage during the host response to infection...
  10. pmc Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome
    Maxim I Lutskiy
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3444. 2008
    ....
  11. pmc Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection
    Dapeng Gong
    Immune Disease Institute and Program in Cellular and Molecular Medicine at Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 204:592-600. 2011
    ....
  12. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
    ..Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases...
  13. pmc Inflammation induces hemorrhage in thrombocytopenia
    Tobias Goerge
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 111:4958-64. 2008
    ..Based on our observations, we propose that inflammation may cause life-threatening hemorrhage during thrombocytopenia...

Research Grants3

  1. Defects of Thymic Output in Wiskott-Aldrich Syndrome
    EILEEN REMOLD O DONNELL; Fiscal Year: 2006
    ....
  2. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007
    ..Indeed, mnei, the central molecule under study in the project, is a candidate therapeutic for inflammatory lung disease. ..
  3. SERPINB1/MNEI: Role in innate immune defense against influenza virus infection
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007
    ..In the proposed R21 (Exploratory/- Developmental Grant) project, we will use a mouse model developed in our laboratory to test the hypothesis that MNEI will prove useful in protecting against influenza. ..