EILEEN REMOLD-O'DONNELL

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients
    E REMOLD-O'DONNELL
    Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:4021-5. 1997
  2. ncbi Wiskott-Aldrich syndrome in a female
    Maxim I Lutskiy
    Center for Blood Research, and the Division of Immunology, Children s Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:2763-8. 2002
  3. pmc Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice
    J Michael Stolley
    Immune Disease Institute, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:792-9. 2012
  4. pmc Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The CBR Institute for Biomedical Research, Inc, Boston, MA 02115, USA
    Blood 106:2815-7. 2005
  5. ncbi Genotype-proteotype linkage in the Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA
    J Immunol 175:1329-36. 2005
  6. pmc SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells
    Picheng Zhao
    5 3 Blackfan Circle, Boston, MA 02115, USA
    J Leukoc Biol 95:521-30. 2014
  7. ncbi An Alu-mediated deletion at Xp11.23 leading to Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The Center for Blood Research, Harvard Medical School, Huntington Avenue, Boston, MA 02115, USA
    Hum Genet 110:515-9. 2002
  8. ncbi SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia
    Ryuji Yasumatsu
    Division of Newborn Medicine, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 291:L619-27. 2006
  9. pmc A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation
    Kalamo Farley
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA 02115, USA
    J Immunol 189:4574-81. 2012
  10. pmc WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling
    Anna Shcherbina
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Br J Haematol 148:416-27. 2010

Research Grants

  1. Defects of Thymic Output in Wiskott-Aldrich Syndrome
    EILEEN REMOLD O DONNELL; Fiscal Year: 2006
  2. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007
  3. SERPINB1/MNEI: Role in innate immune defense against influenza virus infection
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. ncbi Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients
    E REMOLD-O'DONNELL
    Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 158:4021-5. 1997
    ..The findings suggest that the clinical variability of the WAS can partially be explained by the level of WASP protein in the patient's cells...
  2. ncbi Wiskott-Aldrich syndrome in a female
    Maxim I Lutskiy
    Center for Blood Research, and the Division of Immunology, Children s Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Blood 100:2763-8. 2002
    ....
  3. pmc Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice
    J Michael Stolley
    Immune Disease Institute, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:792-9. 2012
    ....
  4. pmc Mosaicism of NK cells in a patient with Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The CBR Institute for Biomedical Research, Inc, Boston, MA 02115, USA
    Blood 106:2815-7. 2005
    ..The importance of reconstituting the NK-cell lineage is discussed...
  5. ncbi Genotype-proteotype linkage in the Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA
    J Immunol 175:1329-36. 2005
    ..Knowledge of the molecular effect of mutations would aid also in identifying disease-modifying genes...
  6. pmc SerpinB1 regulates homeostatic expansion of IL-17+ γδ and CD4+ Th17 cells
    Picheng Zhao
    5 3 Blackfan Circle, Boston, MA 02115, USA
    J Leukoc Biol 95:521-30. 2014
    ....
  7. ncbi An Alu-mediated deletion at Xp11.23 leading to Wiskott-Aldrich syndrome
    Maxim I Lutskiy
    The Center for Blood Research, Harvard Medical School, Huntington Avenue, Boston, MA 02115, USA
    Hum Genet 110:515-9. 2002
    ..A heptanucleotide of unknown origin, CAGGGGG, links the 5' and 3' breakpoints. To our knowledge this is the largest deletion in a WAS patient...
  8. ncbi SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia
    Ryuji Yasumatsu
    Division of Newborn Medicine, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 291:L619-27. 2006
    ..Thus SERPINB1 upregulation in new BPD may be protective by contributing to the regulation of neutrophil proteases NE and cat G...
  9. pmc A serpinB1 regulatory mechanism is essential for restricting neutrophil extracellular trap generation
    Kalamo Farley
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA 02115, USA
    J Immunol 189:4574-81. 2012
    ..The findings identify a previously unrecognized regulatory mechanism involving SerpinB1 that restricts the production of NETs...
  10. pmc WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling
    Anna Shcherbina
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Br J Haematol 148:416-27. 2010
    ..The collective results reveal a novel function for WASP in regulating pro-aggregatory and pro-coagulant responses downstream of integrin outside-in signalling...
  11. pmc The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection
    Charaf Benarafa
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1901-9. 2007
    ..Thus, regulation of pulmonary innate immunity by serpinb1 is nonredundant and is required to protect two key components, the neutrophil and SP-D, from NSP damage during the host response to infection...
  12. pmc Evolution of highly polymorphic T cell populations in siblings with the Wiskott-Aldrich Syndrome
    Maxim I Lutskiy
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3444. 2008
    ....
  13. pmc Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection
    Dapeng Gong
    Immune Disease Institute and Program in Cellular and Molecular Medicine at Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 204:592-600. 2011
    ....
  14. pmc Platelets amplify inflammation in arthritis via collagen-dependent microparticle production
    Eric Boilard
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 327:580-3. 2010
    ..Thus, these findings demonstrate a previously unappreciated role for platelets and their activation-induced microparticles in inflammatory joint diseases...
  15. pmc Inflammation induces hemorrhage in thrombocytopenia
    Tobias Goerge
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 111:4958-64. 2008
    ..Based on our observations, we propose that inflammation may cause life-threatening hemorrhage during thrombocytopenia...

Research Grants3

  1. Defects of Thymic Output in Wiskott-Aldrich Syndrome
    EILEEN REMOLD O DONNELL; Fiscal Year: 2006
    ....
  2. MNEI/SerpinB1: A modulator of innate pulmonary defense
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007
    ..Indeed, mnei, the central molecule under study in the project, is a candidate therapeutic for inflammatory lung disease. ..
  3. SERPINB1/MNEI: Role in innate immune defense against influenza virus infection
    EILEEN REMOLD O DONNELL; Fiscal Year: 2007
    ..In the proposed R21 (Exploratory/- Developmental Grant) project, we will use a mouse model developed in our laboratory to test the hypothesis that MNEI will prove useful in protecting against influenza. ..