Keith Reimann

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Pathogenicity of simian-human immunodeficiency virus SHIV-89.6P and SIVmac is attenuated in cynomolgus macaques and associated with early T-lymphocyte responses
    Keith A Reimann
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 79:8878-85. 2005
  2. ncbi request reprint Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques
    Robert A Rasmussen
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    AIDS 16:829-38. 2002
  3. pmc Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus
    Jörn E Schmitz
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:2165-73. 2003
  4. ncbi request reprint Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 190:998-1005. 2004
  5. pmc Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:4396-400. 2003
  6. pmc In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys
    Elisa I Choi
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 82:6758-61. 2008
  7. pmc Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques
    Elisa I Choi
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Immunology 124:215-22. 2008
  8. ncbi request reprint A humanized, nondepleting anti-CD4 antibody that blocks virus entry inhibits virus replication in rhesus monkeys chronically infected with simian immunodeficiency virus
    Keith A Reimann
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East 113, 330 Brookline Avenue, Boston, MA 02215, USA
    AIDS Res Hum Retroviruses 18:747-55. 2002
  9. pmc Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 113, 330 Brookline Ave, Boston, Massacusetts 02215, USA
    J Virol 79:8131-41. 2005
  10. ncbi request reprint Development of anti-CD4 MAb hu5A8 for treatment of HIV-1 infection: preclinical assessment in non-human primates
    Louis Boon
    Tanox Pharma B V, Amsterdam, The Netherlands
    Toxicology 172:191-203. 2002

Collaborators

Detail Information

Publications16

  1. pmc Pathogenicity of simian-human immunodeficiency virus SHIV-89.6P and SIVmac is attenuated in cynomolgus macaques and associated with early T-lymphocyte responses
    Keith A Reimann
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 79:8878-85. 2005
    ....
  2. ncbi request reprint Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques
    Robert A Rasmussen
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    AIDS 16:829-38. 2002
    ..To directly examine the role of CD8+ T cells in controlling viremia and disease during chronic, low-level primate immunodeficiency virus infection in DNA prime/protein boost-vaccinated macaques...
  3. pmc Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus
    Jörn E Schmitz
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:2165-73. 2003
    ..However, the inverse correlation between neutralizing antibodies and plasma virus level during the postacute phases of infection suggests that humoral immune responses may contribute to the control of SIV replication...
  4. ncbi request reprint Limited contribution of humoral immunity to the clearance of measles viremia in rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 190:998-1005. 2004
    ....
  5. pmc Role of CD8(+) lymphocytes in control and clearance of measles virus infection of rhesus monkeys
    Sallie R Permar
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Virol 77:4396-400. 2003
    ..These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies...
  6. pmc In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys
    Elisa I Choi
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Virol 82:6758-61. 2008
    ..These findings are consistent with a limited role for cytotoxic CD16(+) NK cells in the control of primary SIV viremia...
  7. pmc Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques
    Elisa I Choi
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Immunology 124:215-22. 2008
    ..These studies describe a non-human primate model for in vivo NK-cell depletion and suggest a limited role for cytotoxic CD16(+) NK cells in controlling AIDS virus replication during chronic infection...
  8. ncbi request reprint A humanized, nondepleting anti-CD4 antibody that blocks virus entry inhibits virus replication in rhesus monkeys chronically infected with simian immunodeficiency virus
    Keith A Reimann
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Research East 113, 330 Brookline Avenue, Boston, MA 02215, USA
    AIDS Res Hum Retroviruses 18:747-55. 2002
    ..These results support the overall concept of anti-CD4 monoclonal antibody treatment to suppress AIDS virus replication in vivo while demonstrating important issues as to its clinical feasibility...
  9. pmc Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques
    Jörn E Schmitz
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, RE 113, 330 Brookline Ave, Boston, Massacusetts 02215, USA
    J Virol 79:8131-41. 2005
    ....
  10. ncbi request reprint Development of anti-CD4 MAb hu5A8 for treatment of HIV-1 infection: preclinical assessment in non-human primates
    Louis Boon
    Tanox Pharma B V, Amsterdam, The Netherlands
    Toxicology 172:191-203. 2002
    ..Together, the results from these preclinical studies support the studies of the anti-HIV-1 effect of hu5A8 in HIV-1 infected individuals...
  11. ncbi request reprint CD8+ cell depletion amplifies the acute retroviral syndrome
    Lisa J Madden
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurovirol 10:58-66. 2004
    ..CD8+ cell depletion, therefore, appears to enhance symptoms of the acute retroviral syndrome and alters several of the immunological factors associated with the early phase of infection...
  12. ncbi request reprint Antiretroviral activity of the anti-CD4 monoclonal antibody TNX-355 in patients infected with HIV type 1
    Daniel R Kuritzkes
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    J Infect Dis 189:286-91. 2004
    ..We wished to determine the safety and anti-human immunodeficiency virus (HIV) type 1 activity of single doses of TNX-355, a humanized IgG4 anti-CD4 monoclonal antibody with potent activity against HIV-1 in vitro, in HIV-infected subjects...
  13. pmc Reduced protection from simian immunodeficiency virus SIVmac251 infection afforded by memory CD8+ T cells induced by vaccination during CD4+ T-cell deficiency
    Monica Vaccari
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bldg 41, Room D804, Bethesda, MD 20892, USA
    J Virol 82:9629-38. 2008
    ....
  14. ncbi request reprint Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus
    Yvette Edghill-Smith
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, 41 D804, Bethesda, Maryland 20892, USA
    Nat Med 11:740-7. 2005
    ..Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax)...
  15. pmc Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection
    Naglaa H Shoukry
    Center for Vaccines and Immunity, Columbus Children s Research Institute, Columbus, OH 43205, USA
    J Exp Med 197:1645-55. 2003
    ..These experiments demonstrate an essential role for memory CD8+ T cells in long-term protection from chronic hepatitis C...
  16. pmc CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    Robert Thimme
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 77:68-76. 2003
    ....

Research Grants23

  1. IMMUNOLOGIC MECHANISMS CONTROLLING SIV REPLICATION
    Keith Reimann; Fiscal Year: 2002
    ....
  2. RESOURCE FOR NONHUMAN PRIMATE CELL DEPLETING ANTIBODIES
    Keith Reimann; Fiscal Year: 2004
    ....
  3. RESOURCE FOR NONHUMAN PRIMATE CELL DEPLETING ANTIBODIES
    Keith Reimann; Fiscal Year: 2009
    ....
  4. RESOURCE FOR NONHUMAN PRIMATE CELL DEPLETING ANTIBODIES
    Keith Reimann; Fiscal Year: 2009
    ....
  5. RESOURCE FOR NONHUMAN PRIMATE CELL DEPLETING ANTIBODIES
    Keith A Reimann; Fiscal Year: 2010
    ....
  6. CHIMERIC SHIV MODEL FOR EVALUATING HIV IMMUNOTHERAPIES
    Keith Reimann; Fiscal Year: 2001
    ..II. Utilize this model to evaluate a unique, humanized anti-CD4 antibody as an anti-viral therapy for the treatment and prevention of HIV infection. ..
  7. RESOURCE FOR NONHUMAN PRIMATE CELL DEPLETING ANTIBODIES
    Keith A Reimann; Fiscal Year: 2010
    ....